HUMAN:IL1B

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	IL1B (synonyms: IL1F2)
Protein Name(s)	Interleukin-1 beta IL-1 beta Catabolin
External Links
UniProt	P01584
EMBL	K02770 M54933 X02532 X04500 M15330 M15840 X56087 BN000002 BT007213 CR407679 AY137079 AC079753 CH471217 BC008678
CCDS	CCDS2102.1
PIR	A21851 A25542
RefSeq	NP_000567.1
UniGene	Hs.126256
PDB	1HIB 1I1B 1IOB 1ITB 1L2H 1S0L 1T4Q 1TOO 1TP0 1TWE 1TWM 21BI 2I1B 2KH2 2NVH 31BI 3LTQ 3O4O 3POK 41BI 4DEP 4G6J 4G6M 4GAF 4GAI 4I1B 5I1B 6I1B 7I1B 9ILB
PDBsum	1HIB 1I1B 1IOB 1ITB 1L2H 1S0L 1T4Q 1TOO 1TP0 1TWE 1TWM 21BI 2I1B 2KH2 2NVH 31BI 3LTQ 3O4O 3POK 41BI 4DEP 4G6J 4G6M 4GAF 4GAI 4I1B 5I1B 6I1B 7I1B 9ILB
ProteinModelPortal	P01584
SMR	P01584
BioGrid	109769
DIP	DIP-474N
IntAct	P01584
MINT	MINT-189806
STRING	9606.ENSP00000263341
BindingDB	P01584
ChEMBL	CHEMBL1909490
DrugBank	DB06168 DB05260 DB01017 DB06372
GuidetoPHARMACOLOGY	2623
DMDM	62906858
MaxQB	P01584
PaxDb	P01584
PRIDE	P01584
DNASU	3553
Ensembl	ENST00000263341
GeneID	3553
KEGG	hsa:3553
UCSC	uc002tih.1
CTD	3553
GeneCards	GC02M113587
HGNC	HGNC:5992
MIM	147720
neXtProt	NX_P01584
PharmGKB	PA29808
eggNOG	NOG40099
GeneTree	ENSGT00510000048687
HOVERGEN	HBG007328
InParanoid	P01584
KO	K04519
OMA	SNDKIPV
OrthoDB	EOG71P2BQ
PhylomeDB	P01584
TreeFam	TF300203
Reactome	REACT_22442 REACT_23950
SignaLink	P01584
ChiTaRS	IL1B
EvolutionaryTrace	P01584
GeneWiki	IL1B
GenomeRNAi	3553
NextBio	13872
PMAP-CutDB	P01584
PRO	PR:P01584
Proteomes	UP000005640
Bgee	P01584
CleanEx	HS_IL1B
ExpressionAtlas	P01584
Genevestigator	P01584
GO	GO:0005829 GO:0005576 GO:0005615 GO:0030141 GO:0005125 GO:0005149 GO:0019904 GO:0000187 GO:0006915 GO:0007267 GO:0035690 GO:0071260 GO:0071407 GO:0071310 GO:0019221 GO:0035234 GO:0007566 GO:0097192 GO:0001660 GO:0030213 GO:0006955 GO:0006954 GO:0032611 GO:0031663 GO:0000165 GO:0070487 GO:0070164 GO:0008285 GO:2001240 GO:0010829 GO:0046627 GO:0050995 GO:0045833 GO:0043407 GO:0030593 GO:0045766 GO:0060559 GO:0060355 GO:0045080 GO:0031622 GO:0010628 GO:0032725 GO:0034116 GO:0035066 GO:0033129 GO:0032729 GO:0045086 GO:0045410 GO:0032755 GO:0032757 GO:0046330 GO:0050996 GO:0051044 GO:0045840 GO:0071639 GO:0035505 GO:0042346 GO:0051092 GO:0045429 GO:0032308 GO:0046827 GO:0001934 GO:0051091 GO:0002711 GO:0042102 GO:0045944 GO:0045893 GO:0030949 GO:0010575 GO:0043491 GO:0043122 GO:0050796 GO:0033198 GO:0009743 GO:0030730 GO:0007165 GO:0014805
InterPro	IPR008996 IPR003294 IPR003296 IPR020877 IPR000975 IPR028142 IPR003502
PANTHER	PTHR10078:SF20
Pfam	PF00340 PF02394
PRINTS	PR00262 PR00264 PR01357
SUPFAM	SSF50353
PROSITE	PS00253

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0010628	positive regulation of gene expression	PMID:21246541^[1]	ECO:0000314			P		Figure 3. Different conditioned supernatants were screened to identify the agent that induced CD1 expression.	complete CACAO 6507
involved_in	GO:0050767	regulation of neurogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63264	P		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	PMID:29030430^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	PMID:19193853^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000451) part_of:(GO:0032496)	Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	PMID:29384235^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS0000424278_9606	P	regulates_o_occurs_in:(CL:0000127)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:29384235^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS0000424278_9606	P	regulates_o_occurs_in:(CL:0000127) regulates_expression_of:(ENSEMBL:ENSG00000155792)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:29384235^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS0000424278_9606	P	regulates_o_occurs_in:(CL:0000127) regulates_expression_of:(ENSEMBL:ENSG00000143537)	Seeded From UniProt	complete
involved_in	GO:0045917	positive regulation of complement activation	PMID:29384235^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS0000424278_9606	P	regulates_o_occurs_in:(CL:0000127) has_regulation_target:(UniProtKB:P01024) part_of:(GO:0070555) part_of:(GO:0050729)	Seeded From UniProt	complete
involved_in	GO:0031394	positive regulation of prostaglandin biosynthetic process	PMID:29384235^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS0000424278_9606	P	regulates_o_occurs_in:(CL:0000127) has_regulation_target:(UniProtKB:P35354) part_of:(GO:0070555) part_of:(GO:0050729)	Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	PMID:29384235^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS0000424278_9606	P	regulates_o_occurs_in:(CL:0000127)	Seeded From UniProt	complete
involved_in	GO:1902680	positive regulation of RNA biosynthetic process	PMID:29384235^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000284386) regulates_o_occurs_in:(CL:0000127)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:29384235^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000284386) regulates_o_occurs_in:(CL:0000127)	Seeded From UniProt	complete
involved_in	GO:0070555	response to interleukin-1	PMID:29441883^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000138)	Seeded From UniProt	complete
involved_in	GO:0060252	positive regulation of glial cell proliferation	PMID:1752215^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P01375	P	results_in_division_of:(CL:0000129)\|results_in_division_of:(CL:0000127)	Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:25204733^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:25204733^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	PMID:25204733^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070372	regulation of ERK1 and ERK2 cascade	PMID:25204733^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:25204733^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:26687115^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000149968)	Seeded From UniProt	complete
involved_in	GO:1900745	positive regulation of p38MAPK cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10749	P	occurs_in:(UBERON:0002728) regulates:(GO:0060292)	Seeded From UniProt	complete
involved_in	GO:0050805	negative regulation of synaptic transmission	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10749	P	occurs_in:(UBERON:0002728)	Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10749	P	occurs_in:(UBERON:0002728) regulates:(GO:0060292)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:23817958^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000134) has_regulation_target:(UniProtKB:O00182)	Seeded From UniProt	complete
involved_in	GO:0050999	regulation of nitric-oxide synthase activity	PMID:15899045^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903140	regulation of establishment of endothelial barrier	PMID:25816133^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050766	positive regulation of phagocytosis	PMID:18201371^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0032729	positive regulation of interferon-gamma production	PMID:10653850^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000556	positive regulation of T-helper 1 cell cytokine production	PMID:10653850^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:21559518^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:Q9H6S0)	Seeded From UniProt	complete
involved_in	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	PMID:10748004^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070164	negative regulation of adiponectin secretion	PMID:16865359^[16]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10749	P		Seeded From UniProt	complete
involved_in	GO:0060559	positive regulation of calcidiol 1-monooxygenase activity	PMID:17023519^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060559	positive regulation of calcidiol 1-monooxygenase activity	PMID:16720713^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060355	positive regulation of cell adhesion molecule production	PMID:19281832^[19]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:10383454^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:12958148^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:10748004^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	PMID:18373975^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050996	positive regulation of lipid catabolic process	PMID:16865359^[16]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10749	P		Seeded From UniProt	complete
involved_in	GO:0050995	negative regulation of lipid catabolic process	PMID:19032770^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050796	regulation of insulin secretion	PMID:8383325^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046827	positive regulation of protein export from nucleus	PMID:19281832^[19]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046627	negative regulation of insulin receptor signaling pathway	PMID:16865359^[16]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10749	P		Seeded From UniProt	complete
involved_in	GO:0045840	positive regulation of mitotic nuclear division	PMID:2989698^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045833	negative regulation of lipid metabolic process	PMID:16865359^[16]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10749	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10749	P		Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	PMID:8383325^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045086	positive regulation of interleukin-2 biosynthetic process	PMID:2989698^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043407	negative regulation of MAP kinase activity	PMID:16865359^[16]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10749	P		Seeded From UniProt	complete
involved_in	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	PMID:10748004^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901224	positive regulation of NIK/NF-kappaB signaling	PMID:18390750^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042102	positive regulation of T cell proliferation	PMID:1919436^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035505	positive regulation of myosin light chain kinase activity	PMID:18390750^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035066	positive regulation of histone acetylation	PMID:20018936^[28]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034116	positive regulation of heterotypic cell-cell adhesion	PMID:19281832^[19]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033129	positive regulation of histone phosphorylation	PMID:20018936^[28]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032729	positive regulation of interferon-gamma production	PMID:20027291^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production	PMID:20027291^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032308	positive regulation of prostaglandin secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10749	P		Seeded From UniProt	complete
involved_in	GO:0031622	positive regulation of fever generation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10749	P		Seeded From UniProt	complete
involved_in	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	PMID:12958148^[21]	ECO:0000305	curator inference used in manual assertion	GO:0010575	P		Seeded From UniProt	complete
involved_in	GO:0030730	sequestering of triglyceride	PMID:19032770^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	PMID:10748004^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014805	smooth muscle adaptation	PMID:16477012^[30]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010829	negative regulation of glucose transmembrane transport	PMID:16865359^[16]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10749	P		Seeded From UniProt	complete
involved_in	GO:0010575	positive regulation of vascular endothelial growth factor production	PMID:12958148^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010575	positive regulation of vascular endothelial growth factor production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10749	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:3493774^[31]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:10748004^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:3493774^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:12483741^[32]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:20041150^[33]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:2989698^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:1919436^[27]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002711	positive regulation of T cell mediated immunity	PMID:1919436^[27]	ECO:0000305	curator inference used in manual assertion	GO:0042102	P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:10748004^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:16477012^[30]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	PMID:10748004^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071639	positive regulation of monocyte chemotactic protein-1 production	PMID:19524870^[34]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071407	cellular response to organic cyclic compound	PMID:21147091^[35]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:1000742)	Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	PMID:19593445^[36]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070487	monocyte aggregation	PMID:15100360^[37]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15100360^[37]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q92819)	Seeded From UniProt	complete
involved_in	GO:0043491	protein kinase B signaling	PMID:21147091^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:1000742)	Seeded From UniProt	complete
involved_in	GO:0034116	positive regulation of heterotypic cell-cell adhesion	PMID:15100360^[37]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032757	positive regulation of interleukin-8 production	PMID:19524870^[34]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031663	lipopolysaccharide-mediated signaling pathway	PMID:21147091^[35]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:1000742)	Seeded From UniProt	complete
involved_in	GO:0030213	hyaluronan biosynthetic process	PMID:15100360^[37]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:16575408^[38]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O95361	F		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:21147091^[35]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:1000742)	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:1919436^[27]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:1919436^[27]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005149	interleukin-1 receptor binding	PMID:1919436^[27]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	PMID:21147091^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:1000742)	Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:21873635^[39]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000008572 RGD:2891	P		Seeded From UniProt	complete
involved_in	GO:0050999	regulation of nitric-oxide synthase activity	PMID:21873635^[39]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96543 PANTHER:PTN000008680 UniProtKB:P01584	P		Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	PMID:21873635^[39]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96543 PANTHER:PTN000008572 RGD:2891	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[39]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96543 PANTHER:PTN000008680 RGD:2891	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:21873635^[39]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96543 PANTHER:PTN000008680 UniProtKB:P01584	P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:21873635^[39]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96543 PANTHER:PTN000008572 RGD:2891	P		Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	PMID:21873635^[39]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1859324 MGI:MGI:1916927 MGI:MGI:2449929 MGI:MGI:96543 PANTHER:PTN000008572 RGD:2891	P		Seeded From UniProt	complete
involved_in	GO:0030593	neutrophil chemotaxis	PMID:21873635^[39]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96543 PANTHER:PTN000008572	P		Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	PMID:21873635^[39]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96543 PANTHER:PTN000008680	C		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	PMID:21873635^[39]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000008572 UniProtKB:P01584	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:21873635^[39]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96543 PANTHER:PTN000008680 RGD:2891 UniProtKB:P01584	P		Seeded From UniProt	complete
involved_in	GO:0010575	positive regulation of vascular endothelial growth factor production	PMID:21873635^[39]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96543 PANTHER:PTN000008680 UniProtKB:P01584	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[39]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1859324 MGI:MGI:1916927 MGI:MGI:2449929 MGI:MGI:96543 PANTHER:PTN000008572 RGD:2891 RGD:621159 UniProtKB:P01584 UniProtKB:P18510	C		Seeded From UniProt	complete
enables	GO:0005149	interleukin-1 receptor binding	PMID:21873635^[39]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000008572 RGD:621159 UniProtKB:P18510	F		Seeded From UniProt	complete
involved_in	GO:0071310	cellular response to organic substance	PMID:19158679^[40]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035690	cellular response to drug	PMID:19158679^[40]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:2000778	positive regulation of interleukin-6 secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10749 ensembl:ENSMUSP00000028881	P		Seeded From UniProt	complete
involved_in	GO:1900745	positive regulation of p38MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10749 ensembl:ENSMUSP00000028881	P		Seeded From UniProt	complete
involved_in	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10749 ensembl:ENSMUSP00000028881	P		Seeded From UniProt	complete
involved_in	GO:0070164	negative regulation of adiponectin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10749 ensembl:ENSMUSP00000028881	P		Seeded From UniProt	complete
involved_in	GO:0050999	regulation of nitric-oxide synthase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10749 ensembl:ENSMUSP00000028881	P		Seeded From UniProt	complete
involved_in	GO:0050996	positive regulation of lipid catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10749 ensembl:ENSMUSP00000028881	P		Seeded From UniProt	complete
involved_in	GO:0050900	leukocyte migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10749 ensembl:ENSMUSP00000028881	P		Seeded From UniProt	complete
involved_in	GO:0050805	negative regulation of synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10749 ensembl:ENSMUSP00000028881	P		Seeded From UniProt	complete
involved_in	GO:0050691	regulation of defense response to virus by host	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10749 ensembl:ENSMUSP00000028881	P		Seeded From UniProt	complete
involved_in	GO:0048143	astrocyte activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10749 ensembl:ENSMUSP00000028881	P		Seeded From UniProt	complete
involved_in	GO:0046627	negative regulation of insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10749 ensembl:ENSMUSP00000028881	P		Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10749 ensembl:ENSMUSP00000028881	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10749 ensembl:ENSMUSP00000028881	P		Seeded From UniProt	complete
involved_in	GO:0045833	negative regulation of lipid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10749 ensembl:ENSMUSP00000028881	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10749 ensembl:ENSMUSP00000028881	P		Seeded From UniProt	complete
involved_in	GO:0045410	positive regulation of interleukin-6 biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10749 ensembl:ENSMUSP00000028881	P		Seeded From UniProt	complete
involved_in	GO:0045080	positive regulation of chemokine biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10749 ensembl:ENSMUSP00000028881	P		Seeded From UniProt	complete
involved_in	GO:0043407	negative regulation of MAP kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10749 ensembl:ENSMUSP00000028881	P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10749 ensembl:ENSMUSP00000028881	P		Seeded From UniProt	complete
involved_in	GO:0035234	ectopic germ cell programmed cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10749 ensembl:ENSMUSP00000028881	P		Seeded From UniProt	complete
involved_in	GO:0033198	response to ATP	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10749 ensembl:ENSMUSP00000028881	P		Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10749 ensembl:ENSMUSP00000028881	P		Seeded From UniProt	complete
involved_in	GO:0032635	interleukin-6 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10749 ensembl:ENSMUSP00000028881	P		Seeded From UniProt	complete
involved_in	GO:0032611	interleukin-1 beta production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10749 ensembl:ENSMUSP00000028881	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10749 ensembl:ENSMUSP00000028881	P		Seeded From UniProt	complete
involved_in	GO:0032308	positive regulation of prostaglandin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10749 ensembl:ENSMUSP00000028881	P		Seeded From UniProt	complete
part_of	GO:0031982	vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10749 ensembl:ENSMUSP00000028881	C		Seeded From UniProt	complete
involved_in	GO:0031622	positive regulation of fever generation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10749 ensembl:ENSMUSP00000028881	P		Seeded From UniProt	complete
involved_in	GO:0030593	neutrophil chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10749 ensembl:ENSMUSP00000028881	P		Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10749 ensembl:ENSMUSP00000028881	C		Seeded From UniProt	complete
involved_in	GO:0010829	negative regulation of glucose transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10749 ensembl:ENSMUSP00000028881	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10749 ensembl:ENSMUSP00000028881	P		Seeded From UniProt	complete
involved_in	GO:0010575	positive regulation of vascular endothelial growth factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10749 ensembl:ENSMUSP00000028881	P		Seeded From UniProt	complete
involved_in	GO:0009743	response to carbohydrate	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10749 ensembl:ENSMUSP00000028881	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10749 ensembl:ENSMUSP00000028881	C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10749 ensembl:ENSMUSP00000028881	F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000975	F		Seeded From UniProt	complete
enables	GO:0005149	interleukin-1 receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003296 InterPro:IPR003502	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003296	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000975 InterPro:IPR020877	C		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000975 InterPro:IPR003296 InterPro:IPR003502	P		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000975 InterPro:IPR003296 InterPro:IPR003502	P		Seeded From UniProt	complete
involved_in	GO:0050768	negative regulation of neurogenesis	PMID:20018408^[41]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_agent:(CL:0000129)	Seeded From UniProt	complete
involved_in	GO:0150078	positive regulation of neuroinflammatory response	PMID:26753638^[42]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	PMID:2989698^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:9218611^[43] PMID:10786823^[44]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:9218611^[43]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	PMID:16865359^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007566	embryo implantation	PMID:16720713^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070498	interleukin-1-mediated signaling pathway	Reactome:R-HSA-9020702	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6785807 Reactome:R-HSA-6783783 Reactome:R-HSA-446652	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-5660663 Reactome:R-HSA-449058 Reactome:R-HSA-448703	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-6789524 Reactome:R-HSA-6789325 Reactome:R-HSA-6784160 Reactome:R-HSA-450133 Reactome:R-HSA-449058 Reactome:R-HSA-446894 Reactome:R-HSA-446868 Reactome:R-HSA-446862 Reactome:R-HSA-446701 Reactome:R-HSA-446694 Reactome:R-HSA-446692 Reactome:R-HSA-446684 Reactome:R-HSA-446648 Reactome:R-HSA-446634 Reactome:R-HSA-446130 Reactome:R-HSA-445753 Reactome:R-HSA-445752	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0051781	positive regulation of cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0497	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C		Seeded From UniProt	complete
involved_in	GO:0001660	fever generation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0666	P		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0458 UniProtKB-SubCell:SL-0158	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0466	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Yakimchuk, K et al. (2011) Borrelia burgdorferi infection regulates CD1 expression in human cells and tissues via IL1-β. Eur. J. Immunol. 41 694-705 PubMed GONUTS page
↑ Takada, YK et al. (2017) Direct binding to integrins and loss of disulfide linkage in interleukin-1β (IL-1β) are involved in the agonistic action of IL-1β. J. Biol. Chem. 292 20067-20075 PubMed GONUTS page
↑ Ceppi, M et al. (2009) MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells. Proc. Natl. Acad. Sci. U.S.A. 106 2735-40 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 van Scheppingen, J et al. (2018) miR147b: A novel key regulator of interleukin 1 beta-mediated inflammation in human astrocytes. Glia 66 1082-1097 PubMed GONUTS page
↑ Song, X et al. (2017) MiR-204 enhances the progression of osteoarthritis by suppressing the production of IL-1β. Pharmazie 72 587-592 PubMed GONUTS page
↑ Merrill, JE (1991) Effects of interleukin-1 and tumor necrosis factor-alpha on astrocytes, microglia, oligodendrocytes, and glial precursors in vitro. Dev. Neurosci. 13 130-7 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Lee, CH et al. (2015) IL-1β promotes malignant transformation and tumor aggressiveness in oral cancer. J. Cell. Physiol. 230 875-84 PubMed GONUTS page
↑ Le, LT et al. (2016) The microRNA-29 family in cartilage homeostasis and osteoarthritis. J. Mol. Med. 94 583-96 PubMed GONUTS page
↑ Gieseke, F et al. (2013) Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation. Eur. J. Immunol. 43 2741-9 PubMed GONUTS page
↑ Otero, M et al. (2005) Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1. Arthritis Res. Ther. 7 R581-91 PubMed GONUTS page
↑ Clark, PR et al. (2015) Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases. PLoS ONE 10 e0120075 PubMed GONUTS page
↑ Oviedo-Boyso, J et al. (2008) Internalization of Staphylococcus aureus by bovine endothelial cells is associated with the activity state of NF-kappaB and modulated by the pro-inflammatory cytokines TNF-alpha and IL-1beta. Scand. J. Immunol. 67 169-76 PubMed GONUTS page
↑ ^13.0 ^13.1 Tominaga, K et al. (2000) IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells. Int. Immunol. 12 151-60 PubMed GONUTS page
↑ Morohashi, K et al. (2011) Cyclosporin A associated helicase-like protein facilitates the association of hepatitis C virus RNA polymerase with its cellular cyclophilin B. PLoS ONE 6 e18285 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 Madge, LA & Pober, JS (2000) A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells. J. Biol. Chem. 275 15458-65 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 Lagathu, C et al. (2006) Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes. Diabetologia 49 2162-73 PubMed GONUTS page
↑ van Driel, M et al. (2006) Evidence for auto/paracrine actions of vitamin D in bone: 1alpha-hydroxylase expression and activity in human bone cells. FASEB J. 20 2417-9 PubMed GONUTS page
↑ ^18.0 ^18.1 Viganò, P et al. (2006) Cycling and early pregnant endometrium as a site of regulated expression of the vitamin D system. J. Mol. Endocrinol. 36 415-24 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 Luo, SF et al. (2009) Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells. Toxicol. Appl. Pharmacol. 237 8-21 PubMed GONUTS page
↑ Wesche, H et al. (1999) IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J. Biol. Chem. 274 19403-10 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 Jung, YJ et al. (2003) IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis. FASEB J. 17 2115-7 PubMed GONUTS page
↑ Schramme, A et al. (2008) The role of CXCL16 and its processing metalloproteinases ADAM10 and ADAM17 in the proliferation and migration of human mesangial cells. Biochem. Biophys. Res. Commun. 370 311-6 PubMed GONUTS page
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↑ ^27.0 ^27.1 ^27.2 ^27.3 ^27.4 ^27.5 Mizutani, H et al. (1991) Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase. J. Exp. Med. 174 821-5 PubMed GONUTS page
↑ ^28.0 ^28.1 Wang, B et al. (2010) Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription. Arterioscler. Thromb. Vasc. Biol. 30 536-45 PubMed GONUTS page
↑ ^29.0 ^29.1 van de Wetering, D et al. (2009) Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells. PLoS ONE 4 e8396 PubMed GONUTS page
↑ ^30.0 ^30.1 Chen, CN et al. (2006) Synergistic roles of platelet-derived growth factor-BB and interleukin-1beta in phenotypic modulation of human aortic smooth muscle cells. Proc. Natl. Acad. Sci. U.S.A. 103 2665-70 PubMed GONUTS page
↑ ^31.0 ^31.1 Nishida, T et al. (1987) cDNA cloning of IL-1 alpha and IL-1 beta from mRNA of U937 cell line. Biochem. Biophys. Res. Commun. 143 345-52 PubMed GONUTS page
↑ Aksentijevich, I et al. (2002) De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases. Arthritis Rheum. 46 3340-8 PubMed GONUTS page
↑ Feng, J et al. (2009) Missense mutations in the MEFV gene are associated with fibromyalgia syndrome and correlate with elevated IL-1beta plasma levels. PLoS ONE 4 e8480 PubMed GONUTS page
↑ ^34.0 ^34.1 Song, H et al. (2009) Induction of chemokine expression by adiponectin in vitro is isoform dependent. Transl Res 154 18-26 PubMed GONUTS page
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↑ Smith, AJ et al. (2009) Expression of the Bcl-2 protein BAD promotes prostate cancer growth. PLoS ONE 4 e6224 PubMed GONUTS page
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↑ Munding, C et al. (2006) The estrogen-responsive B box protein: a novel enhancer of interleukin-1beta secretion. Cell Death Differ. 13 1938-49 PubMed GONUTS page
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↑ ^40.0 ^40.1 Bürckstümmer, T et al. (2009) An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat. Immunol. 10 266-72 PubMed GONUTS page
↑ Bachstetter, AD et al. (2011) Fractalkine and CX 3 CR1 regulate hippocampal neurogenesis in adult and aged rats. Neurobiol. Aging 32 2030-44 PubMed GONUTS page
↑ Gu, Y et al. () Role of TNF in mast cell neuroinflammation and pain. J. Biol. Regul. Homeost. Agents 29 787-91 PubMed GONUTS page
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HUMAN:IL1B

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