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HUMAN:IKZF1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) IKZF1 (synonyms: IK1, IKAROS, LYF1, ZNFN1A1)
Protein Name(s) DNA-binding protein Ikaros

Ikaros family zinc finger protein 1 Lymphoid transcription factor LyF-1

External Links
UniProt Q13422
EMBL U40462
S80876
AY377974
AK303586
BT009836
AC124014
AC233268
CH471128
CH471128
CH471128
CH236955
CH471128
BC018349
CCDS CCDS59055.1
CCDS69299.1
CCDS75596.1
CCDS75597.1
RefSeq NP_001207694.1
NP_001207696.1
NP_001207697.1
NP_001207699.1
NP_001207700.1
NP_001278766.1
NP_001278767.1
NP_001278768.1
NP_001278769.1
NP_001278770.1
NP_001278771.1
NP_001278772.1
NP_001278773.1
NP_006051.1
UniGene Hs.435949
Hs.488251
Hs.646004
Hs.731495
ProteinModelPortal Q13422
SMR Q13422
BioGrid 115604
IntAct Q13422
MINT MINT-129252
STRING 9606.ENSP00000331614
PhosphoSite Q13422
DMDM 3913926
MaxQB Q13422
PaxDb Q13422
PRIDE Q13422
DNASU 10320
Ensembl ENST00000331340
ENST00000343574
ENST00000349824
ENST00000357364
ENST00000359197
ENST00000438033
ENST00000439701
GeneID 10320
KEGG hsa:10320
UCSC uc003tow.4
uc003tox.4
uc003tpa.4
uc011kck.2
uc022acq.1
uc022acs.1
uc022acx.1
CTD 10320
GeneCards GC07P050343
HGNC HGNC:13176
HPA CAB009247
MIM 603023
neXtProt NX_Q13422
Orphanet 317473
99860
PharmGKB PA37748
eggNOG NOG244744
GeneTree ENSGT00550000074392
HOVERGEN HBG004752
InParanoid Q13422
KO K09220
OMA GDKCLSD
PhylomeDB Q13422
TreeFam TF331189
SignaLink Q13422
ChiTaRS IKZF1
GeneWiki IKZF1
GenomeRNAi 10320
NextBio 39123
PRO PR:Q13422
Proteomes UP000005640
Bgee Q13422
CleanEx HS_IKZF1
ExpressionAtlas Q13422
Genevestigator Q13422
GO GO:0005737
GO:0005634
GO:0005721
GO:0043234
GO:0003677
GO:0046872
GO:0043565
GO:0003700
GO:0030183
GO:0007049
GO:0016568
GO:0030900
GO:0048535
GO:0007498
GO:0001779
GO:0000122
GO:0048541
GO:0040018
GO:0045660
GO:0051138
GO:0045944
GO:0060041
GO:0030217
GO:0048538
GO:0006351
Gene3D 3.30.160.60
InterPro IPR007087
IPR015880
IPR013087
SMART SM00355
PROSITE PS00028
PS50157

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[1]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000113

ECO:0005556

multiple sequence alignment evidence used in manual assertion

UniProtKB:Q8VIG1

F

Seeded From UniProt

complete

involved_in

GO:0051291

protein heterooligomerization

PMID:15491138[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:21548011[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0031618

nuclear pericentric heterochromatin

PMID:21548011[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21548011[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

PMID:15491138[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0019904

protein domain specific binding

PMID:15491138[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9H2S9

F

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q03267

P

Seeded From UniProt

complete

involved_in

GO:0030098

lymphocyte differentiation

PMID:17934067[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:22106042[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:22106042[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030218

erythrocyte differentiation

PMID:17934067[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1332234
MGI:MGI:1342540
MGI:MGI:1342541
MGI:MGI:1342542
MGI:MGI:1343139
PANTHER:PTN000696108
UniProtKB:Q9UID6

P

Seeded From UniProt

complete

enables

GO:0044212

transcription regulatory region DNA binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1342540
PANTHER:PTN000696108
UniProtKB:O42410
UniProtKB:P49711
UniProtKB:Q99684
UniProtKB:Q9UID6

F

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000696108
UniProtKB:P49711
UniProtKB:Q13422
UniProtKB:Q9GZX5
UniProtKB:Q9H2S9
UniProtKB:Q9UID6
UniProtKB:Q9UKT9

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1332234
MGI:MGI:1342540
MGI:MGI:3029290
PANTHER:PTN000696108
UniProtKB:P49711
UniProtKB:Q9UID6

F

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

PMID:23071339[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013087

F

Seeded From UniProt

complete

involved_in

GO:0007498

mesoderm development

PMID:8543809[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:8543809[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006325

chromatin organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0156

P

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Westman, BJ et al. (2004) Structural studies on a protein-binding zinc-finger domain of Eos reveal both similarities and differences to classical zinc fingers. Biochemistry 43 13318-27 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Goldman, FD et al. (2012) Congenital pancytopenia and absence of B lymphocytes in a neonate with a mutation in the Ikaros gene. Pediatr Blood Cancer 58 591-7 PubMed GONUTS page
  4. ↑ 4.0 4.1 Dijon, M et al. (2008) The role of Ikaros in human erythroid differentiation. Blood 111 1138-46 PubMed GONUTS page
  5. ↑ 5.0 5.1 Li, Z et al. (2012) Cell cycle-specific function of Ikaros in human leukemia. Pediatr Blood Cancer 59 69-76 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  7. ↑ Uckun, FM et al. (2012) Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros. Proc. Natl. Acad. Sci. U.S.A. 109 18072-7 PubMed GONUTS page
  8. ↑ 8.0 8.1 Molnár, A et al. (1996) The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse. J. Immunol. 156 585-92 PubMed GONUTS page
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