HUMAN:IF16

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	IFI16 (synonyms: IFNGIP1)
Protein Name(s)	Gamma-interferon-inducible protein 16 Ifi-16 Interferon-inducible myeloid differentiation transcriptional activator
External Links
UniProt	Q16666
EMBL	M63838 S75433 S75417 S75419 S75421 S75423 S75424 S75426 S75429 S75431 AF208043 AY138863 AK094968 AK296228 AB208989 AL359753 AL359753 AL359753 AL359753 AL359753 AL359753 BC017059
CCDS	CCDS1180.3 CCDS58039.1
PIR	I54501
RefSeq	NP_001193496.1 NP_005522.2
UniGene	Hs.380250
PDB	2OQ0 3B6Y 3RLN 3RLO 3RNU
PDBsum	2OQ0 3B6Y 3RLN 3RLO 3RNU
ProteinModelPortal	Q16666
SMR	Q16666
BioGrid	109654
DIP	DIP-42868N
IntAct	Q16666
MINT	MINT-1781545
PhosphoSite	Q16666
DMDM	118572657
MaxQB	Q16666
PaxDb	Q16666
PRIDE	Q16666
DNASU	3428
Ensembl	ENST00000295809 ENST00000359709 ENST00000368131 ENST00000368132 ENST00000448393
GeneID	3428
KEGG	hsa:3428
UCSC	uc001ftg.3
CTD	3428
GeneCards	GC01P158969
H-InvDB	HIX0001194
HGNC	HGNC:5395
HPA	CAB016293 HPA002134
MIM	147586
neXtProt	NX_Q16666
PharmGKB	PA29642
eggNOG	NOG81691
GeneTree	ENSGT00390000013296
HOVERGEN	HBG006122
InParanoid	Q16666
OMA	GPFMTSI
OrthoDB	EOG7ZD1V8
PhylomeDB	Q16666
TreeFam	TF337385
Reactome	REACT_147841 REACT_163993
ChiTaRS	IFI16
EvolutionaryTrace	Q16666
GeneWiki	IFI16
GenomeRNAi	3428
NextBio	13516
PRO	PR:Q16666
Proteomes	UP000005640
Bgee	Q16666
ExpressionAtlas	Q16666
Genevestigator	Q16666
GO	GO:0005737 GO:0005829 GO:0016020 GO:0016607 GO:0005730 GO:0005654 GO:0005634 GO:0001047 GO:0003690 GO:0042802 GO:0044822 GO:0008134 GO:0097202 GO:0002218 GO:0006914 GO:0008283 GO:0042149 GO:0071479 GO:0051607 GO:0030097 GO:0006954 GO:0045087 GO:0072332 GO:0042771 GO:0030224 GO:0030099 GO:2000117 GO:0043392 GO:0045824 GO:0000122 GO:0045892 GO:0045071 GO:0001819 GO:0032731 GO:0045944 GO:0032481 GO:0010506 GO:0040029 GO:0006351
Gene3D	2.40.50.140
InterPro	IPR004020 IPR004021 IPR012340
Pfam	PF02760 PF02758
PROSITE	PS50824 PS50834

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0043027	caspase inhibitor activity	PMID:22046441^[1]	ECO:0000315			F		Fig. 4, Fig. 5, and Fig. 6	complete CACAO 2713
colocalizes_with	GO:0005829	cytosol	PMID:24531343^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:W6CW81	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24531343^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	PMID:21478870^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:24413532^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:24413532^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:24413532^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24413532^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0040029	regulation of gene expression, epigenetic	PMID:24413532^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000117	negative regulation of cysteine-type endopeptidase activity	PMID:22046441^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097202	activation of cysteine-type endopeptidase activity	PMID:21575908^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	PMID:21573174^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071479	cellular response to ionizing radiation	PMID:14654789^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	PMID:21575908^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21575908^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:11146555^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:9642285^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045824	negative regulation of innate immune response	PMID:22046441^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045071	negative regulation of viral genome replication	PMID:22291595^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22658674^[12]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043392	negative regulation of DNA binding	PMID:22291595^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042149	cellular response to glucose starvation	PMID:21573174^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032731	positive regulation of interleukin-1 beta production	PMID:21575908^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030224	monocyte differentiation	PMID:9766636^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030099	myeloid cell differentiation	PMID:7536752^[14]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030097	hemopoiesis	PMID:9766636^[13]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010506	regulation of autophagy	PMID:21573174^[7]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	PMID:9766636^[13]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:22291595^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:12894224^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:7536752^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	PMID:7536752^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002218	activation of innate immune response	PMID:21575908^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:22046441^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:12894224^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	PMID:14654789^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	PMID:19158679^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:14654789^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:14654789^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19158679^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002218	activation of innate immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR040205	P		Seeded From UniProt	complete
involved_in	GO:0035458	cellular response to interferon-beta	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR040205	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:9718316^[17]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q16666-2	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:24237704^[18]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q16666-2	F		Seeded From UniProt	complete
involved_in	GO:0001819	positive regulation of cytokine production	PMID:22046441^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032481	positive regulation of type I interferon production	Reactome:R-HSA-1834941	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-1834951	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0072	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Veeranki, S et al. (2011) IFI16 protein mediates the anti-inflammatory actions of the type-I interferons through suppression of activation of caspase-1 by inflammasomes. PLoS ONE 6 e27040 PubMed GONUTS page
↑ ^2.0 ^2.1 Khare, S et al. (2014) The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses. Nat. Immunol. 15 343-53 PubMed GONUTS page
↑ Schoggins, JW et al. (2011) A diverse range of gene products are effectors of the type I interferon antiviral response. Nature 472 481-5 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Kang, HJ et al. (2014) Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1. Cancer Res. 74 1484-94 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Kerur, N et al. (2011) IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection. Cell Host Microbe 9 363-75 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Duan, X et al. (2011) IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway. PLoS ONE 6 e19532 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Aglipay, JA et al. (2003) A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway. Oncogene 22 8931-8 PubMed GONUTS page
↑ Johnstone, RW et al. (2000) Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16. Oncogene 19 6033-42 PubMed GONUTS page
↑ Johnstone, RW et al. (1998) The human interferon-inducible protein, IFI 16, is a repressor of transcription. J. Biol. Chem. 273 17172-7 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Gariano, GR et al. (2012) The intracellular DNA sensor IFI16 gene acts as restriction factor for human cytomegalovirus replication. PLoS Pathog. 8 e1002498 PubMed GONUTS page
↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Dawson, MJ et al. (1998) The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations. J. Leukoc. Biol. 64 546-54 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Dawson, MJ & Trapani, JA (1995) IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell lines. J. Cell. Biochem. 57 39-51 PubMed GONUTS page
↑ ^15.0 ^15.1 Xin, H et al. (2003) Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence. Oncogene 22 4831-40 PubMed GONUTS page
↑ ^16.0 ^16.1 Bürckstümmer, T et al. (2009) An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat. Immunol. 10 266-72 PubMed GONUTS page
↑ Johnstone, RW et al. (1998) Isotypic variants of the interferon-inducible transcriptional repressor IFI 16 arise through differential mRNA splicing. Biochemistry 37 11924-31 PubMed GONUTS page
↑ Li, T et al. (2013) Human cytomegalovirus tegument protein pUL83 inhibits IFI16-mediated DNA sensing for immune evasion. Cell Host Microbe 14 591-9 PubMed GONUTS page

[PMID:22046441-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Veeranki, S et al. (2011) IFI16 protein mediates the anti-inflammatory actions of the type-I interferons through suppression of activation of caspase-1 by inflammasomes. PLoS ONE 6 e27040 PubMed GONUTS page

[PMID:24531343-2] 2.0 ^2.1 Khare, S et al. (2014) The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses. Nat. Immunol. 15 343-53 PubMed GONUTS page

[PMID:21478870-3] Schoggins, JW et al. (2011) A diverse range of gene products are effectors of the type I interferon antiviral response. Nature 472 481-5 PubMed GONUTS page

[PMID:24413532-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Kang, HJ et al. (2014) Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1. Cancer Res. 74 1484-94 PubMed GONUTS page

[PMID:19946888-5] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:21575908-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Kerur, N et al. (2011) IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection. Cell Host Microbe 9 363-75 PubMed GONUTS page

[PMID:21573174-7] 7.0 ^7.1 ^7.2 Duan, X et al. (2011) IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway. PLoS ONE 6 e19532 PubMed GONUTS page

[PMID:14654789-8] 8.0 ^8.1 ^8.2 ^8.3 Aglipay, JA et al. (2003) A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway. Oncogene 22 8931-8 PubMed GONUTS page

[PMID:11146555-9] Johnstone, RW et al. (2000) Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16. Oncogene 19 6033-42 PubMed GONUTS page

[PMID:9642285-10] Johnstone, RW et al. (1998) The human interferon-inducible protein, IFI 16, is a repressor of transcription. J. Biol. Chem. 273 17172-7 PubMed GONUTS page

[PMID:22291595-11] 11.0 ^11.1 ^11.2 Gariano, GR et al. (2012) The intracellular DNA sensor IFI16 gene acts as restriction factor for human cytomegalovirus replication. PLoS Pathog. 8 e1002498 PubMed GONUTS page

[PMID:22658674-12] Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page

[PMID:9766636-13] 13.0 ^13.1 ^13.2 Dawson, MJ et al. (1998) The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations. J. Leukoc. Biol. 64 546-54 PubMed GONUTS page

[PMID:7536752-14] 14.0 ^14.1 ^14.2 Dawson, MJ & Trapani, JA (1995) IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell lines. J. Cell. Biochem. 57 39-51 PubMed GONUTS page

[PMID:12894224-15] 15.0 ^15.1 Xin, H et al. (2003) Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence. Oncogene 22 4831-40 PubMed GONUTS page

[PMID:19158679-16] 16.0 ^16.1 Bürckstümmer, T et al. (2009) An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat. Immunol. 10 266-72 PubMed GONUTS page

[PMID:9718316-17] Johnstone, RW et al. (1998) Isotypic variants of the interferon-inducible transcriptional repressor IFI 16 arise through differential mRNA splicing. Biochemistry 37 11924-31 PubMed GONUTS page

[PMID:24237704-18] Li, T et al. (2013) Human cytomegalovirus tegument protein pUL83 inhibits IFI16-mediated DNA sensing for immune evasion. Cell Host Microbe 14 591-9 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

HUMAN:IF16

Contents

Annotations

Notes

References

a

c

d

e

h

i

m

n

o

p

r

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools