HUMAN:GLI3

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	GLI3
Protein Name(s)	Transcriptional activator GLI3 GLI3 form of 190 kDa GLI3-190 GLI3 full length protein GLI3FL Transcriptional repressor GLI3R GLI3 C-terminally truncated form GLI3 form of 83 kDa GLI3-83
External Links
UniProt	P10071
EMBL	M57609 AJ250408 AC005026 AC005028 AC005158 AC073852 CH236951 M20674 BC113616 BC117168
CCDS	CCDS5465.1
PIR	A35927
RefSeq	NP_000159.3 XP_005249760.1 XP_005249761.1
UniGene	Hs.21509
PDB	4BLD
PDBsum	4BLD
ProteinModelPortal	P10071
SMR	P10071
BioGrid	108999
DIP	DIP-32538N
IntAct	P10071
MINT	MINT-189869
STRING	9606.ENSP00000379255
PhosphoSite	P10071
DMDM	269849770
MaxQB	P10071
PaxDb	P10071
PRIDE	P10071
Ensembl	ENST00000395925
GeneID	2737
KEGG	hsa:2737
UCSC	uc011kbg.2
CTD	2737
GeneCards	GC07M042000
GeneReviews	GLI3
H-InvDB	HIX0033636
HGNC	HGNC:4319
HPA	HPA005534
MIM	146510 165240 174200 174700 175700
neXtProt	NX_P10071
Orphanet	36 380 672 295161 295159 295165 295163 295169 295167
PharmGKB	PA28722
eggNOG	COG5048
GeneTree	ENSGT00760000118771
HOVERGEN	HBG005844
InParanoid	P10071
KO	K06230
OMA	PRDSGSH
OrthoDB	EOG7X6KZ8
PhylomeDB	P10071
TreeFam	TF350216
Reactome	REACT_231645 REACT_267634
SignaLink	P10071
ChiTaRS	GLI3
GeneWiki	GLI3
GenomeRNAi	2737
NextBio	10788
PRO	PR:P10071
Proteomes	UP000005640
Bgee	P10071
CleanEx	HS_GLI3
ExpressionAtlas	P10071
Genevestigator	P10071
GO	GO:0005929 GO:0005737 GO:0005829 GO:0016607 GO:0005634 GO:0072372 GO:0017053 GO:0008013 GO:0003682 GO:0035035 GO:0042826 GO:0046872 GO:0000978 GO:0003700 GO:0060873 GO:0009952 GO:0060840 GO:0007411 GO:0001658 GO:0048593 GO:0061005 GO:0021801 GO:0048589 GO:0048566 GO:0048557 GO:0042733 GO:0048704 GO:0021798 GO:0021861 GO:0060364 GO:0007507 GO:0007442 GO:0021766 GO:0001701 GO:0060366 GO:0022018 GO:0060875 GO:0035108 GO:0030324 GO:0060594 GO:0030318 GO:0001656 GO:0046639 GO:0043066 GO:0090090 GO:0008285 GO:0045665 GO:0045879 GO:0000122 GO:0045892 GO:0045060 GO:0043585 GO:0042475 GO:0048709 GO:0021631 GO:0060021 GO:0046638 GO:0032332 GO:0002052 GO:0045669 GO:0042307 GO:0045944 GO:0045893 GO:0016485 GO:0009954 GO:0043627 GO:0060367 GO:0007224 GO:0060831 GO:0021776 GO:0021775 GO:0033077 GO:0070242 GO:0043586 GO:0006351 GO:0042060
Gene3D	3.30.160.60
InterPro	IPR007087 IPR015880 IPR013087
Pfam	PF00096
SMART	SM00355
PROSITE	PS00028 PS50157

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045892	negative regulation of transcription, DNA-templated	PMID:16254602^[1]	ECO:0000314			P		Gli3 represses Gli1, which induces Ptch1 transcription, therefore Gli3 reduces Ptch1 transcription (Figure 3D).	complete CACAO 10739
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:E9Q3T6 UniProtKB:O14978 UniProtKB:O95125 UniProtKB:O95863 UniProtKB:P10071 UniProtKB:P10754 UniProtKB:P17028 UniProtKB:P28698 UniProtKB:P36508 UniProtKB:P41183 UniProtKB:P47806 UniProtKB:P52738 UniProtKB:Q02085 UniProtKB:Q05516 UniProtKB:Q08376 UniProtKB:Q0VDQ9 UniProtKB:Q16600 UniProtKB:Q61967 UniProtKB:Q6DJT9 UniProtKB:Q6NUN9 UniProtKB:Q86UQ0 UniProtKB:Q8CIV7 UniProtKB:Q8K0L9 UniProtKB:Q8K3J5 UniProtKB:Q8NI51 UniProtKB:Q91ZD1 UniProtKB:Q96RE9 UniProtKB:Q99684 UniProtKB:Q9BU19 UniProtKB:Q9ESP5 UniProtKB:Q9GZX5 UniProtKB:Q9H116 UniProtKB:Q9NQX1 UniProtKB:Q9NZL3 UniProtKB:Q9QY31 UniProtKB:Q9UM63 UniProtKB:Q9UPG8 UniProtKB:Q9UQR1 UniProtKB:Q9WTJ2 UniProtKB:Q9Y2X9 UniProtKB:Q9Y473 UniProtKB:Q9Y5A6	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:16254602^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000036	ECO:0000305	curator inference used in manual assertion	GO:0000978,GO:0045944	F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
involved_in	GO:0070242	thymocyte apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61602	P		Seeded From UniProt	complete
involved_in	GO:0046639	negative regulation of alpha-beta T cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61602	P		Seeded From UniProt	complete
involved_in	GO:0046638	positive regulation of alpha-beta T cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61602	P		Seeded From UniProt	complete
involved_in	GO:0045879	negative regulation of smoothened signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61602	P		Seeded From UniProt	complete
involved_in	GO:0045060	negative thymic T cell selection	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61602	P		Seeded From UniProt	complete
involved_in	GO:0033077	T cell differentiation in thymus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61602	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:17331723^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18559511^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17000779^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61602	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:19084012^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:12435627^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	PMID:12435627^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0035108	limb morphogenesis	PMID:9354785^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035108	limb morphogenesis	PMID:18478223^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035035	histone acetyltransferase binding	PMID:10075717^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P45481	F		Seeded From UniProt	complete
enables	GO:0036033	mediator complex binding	PMID:17000779^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:17331723^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q02248	F		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:19592253^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:18559511^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11238441^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10077605^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12435627^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11238441^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18559511^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12435627^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:17764085^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:17000779^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:10077605^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:19084012^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:12435627^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:16254602^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16254602^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10693759^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:2118997^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:18298960^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:10693759^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097421	liver regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M9H1 ensembl:ENSRNOP00000019396	P		Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M9H1 ensembl:ENSRNOP00000019396	P		Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M9H1 ensembl:ENSRNOP00000019396	P		Seeded From UniProt	complete
involved_in	GO:0030850	prostate gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M9H1 ensembl:ENSRNOP00000019396	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M9H1 ensembl:ENSRNOP00000019396	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M9H1 ensembl:ENSRNOP00000019396	C		Seeded From UniProt	complete
involved_in	GO:1903010	regulation of bone development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0070242	thymocyte apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0061005	cell differentiation involved in kidney development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0060875	lateral semicircular canal development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0060873	anterior semicircular canal development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0060840	artery development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0060594	mammary gland specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0060367	sagittal suture morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0060366	lambdoid suture morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0060364	frontal suture morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0060173	limb development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0060021	roof of mouth development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0048856	anatomical structure development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0048839	inner ear development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0048754	branching morphogenesis of an epithelial tube	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0048709	oligodendrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0048704	embryonic skeletal system morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0048663	neuron fate commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0048646	anatomical structure formation involved in morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0048598	embryonic morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0048593	camera-type eye morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0048589	developmental growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0048566	embryonic digestive tract development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0048557	embryonic digestive tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0046639	negative regulation of alpha-beta T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0046638	positive regulation of alpha-beta T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0045879	negative regulation of smoothened signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0045665	negative regulation of neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0045596	negative regulation of cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0045595	regulation of cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0045060	negative thymic T cell selection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0043586	tongue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	F		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0043010	camera-type eye development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0042733	embryonic digit morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0042475	odontogenesis of dentin-containing tooth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0042307	positive regulation of protein import into nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0035295	tube development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0035108	limb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0033077	T cell differentiation in thymus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0032332	positive regulation of chondrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0030900	forebrain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0030879	mammary gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0030326	embryonic limb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0030324	lung development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0030318	melanocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0022018	lateral ganglionic eminence cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0021915	neural tube development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0021861	forebrain radial glial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0021819	layer formation in cerebral cortex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0021801	cerebral cortex radial glia guided migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0021798	forebrain dorsal/ventral pattern formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0021776	smoothened signaling pathway involved in spinal cord motor neuron cell fate specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0021775	smoothened signaling pathway involved in ventral spinal cord interneuron specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0021766	hippocampus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0021631	optic nerve morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0021544	subpallium development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0021543	pallium development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0021537	telencephalon development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0021522	spinal cord motor neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0021513	spinal cord dorsal/ventral patterning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
part_of	GO:0017053	transcriptional repressor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	C		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	C		Seeded From UniProt	complete
involved_in	GO:0016485	protein processing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0009954	proximal/distal pattern formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0007442	hindgut morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0007389	pattern specification process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
part_of	GO:0005930	axoneme	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	F		Seeded From UniProt	complete
involved_in	GO:0002052	positive regulation of neuroblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0001658	branching involved in ureteric bud morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
involved_in	GO:0001656	metanephros development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61602 ensembl:ENSMUSP00000106137	P		Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013087	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032851	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032851	P		Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032851	P		Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032851	P		Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032851	P		Seeded From UniProt	complete
involved_in	GO:0048568	embryonic organ development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032851	P		Seeded From UniProt	complete
involved_in	GO:0048566	embryonic digestive tract development	PMID:11001584^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043585	nose morphogenesis	PMID:11001584^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042733	embryonic digit morphogenesis	PMID:11001584^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	PMID:11001584^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0097546	ciliary base	Reactome:R-HSA-5610766 Reactome:R-HSA-5610754 Reactome:R-HSA-5610746 Reactome:R-HSA-5610732 Reactome:R-HSA-5610722 Reactome:R-HSA-5610720	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0097542	ciliary tip	Reactome:R-HSA-5635860 Reactome:R-HSA-5635859 Reactome:R-HSA-5635843 Reactome:R-HSA-5635842 Reactome:R-HSA-5610767 Reactome:R-HSA-5610766	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-5635860 Reactome:R-HSA-5610767 Reactome:R-HSA-5610754 Reactome:R-HSA-5610752 Reactome:R-HSA-5610723	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-5635856 Reactome:R-HSA-5635855 Reactome:R-HSA-5635854 Reactome:R-HSA-5635848 Reactome:R-HSA-5635846 Reactome:R-HSA-5635845 Reactome:R-HSA-5635843 Reactome:R-HSA-5635841 Reactome:R-HSA-5617410 Reactome:R-HSA-5617408 Reactome:R-HSA-5612508 Reactome:R-HSA-5610752	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0969 UniProtKB-SubCell:SL-0066	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Haycraft, CJ et al. (2005) Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet. 1 e53 PubMed GONUTS page
↑ Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ ^3.0 ^3.1 Ulloa, F et al. (2007) Inhibitory Gli3 activity negatively regulates Wnt/beta-catenin signaling. Curr. Biol. 17 545-50 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Krauss, S et al. (2008) Protein phosphatase 2A and rapamycin regulate the nuclear localization and activity of the transcription factor GLI3. Cancer Res. 68 4658-65 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Zhou, H et al. (2006) Mediator modulates Gli3-dependent Sonic hedgehog signaling. Mol. Cell. Biol. 26 8667-82 PubMed GONUTS page
↑ ^6.0 ^6.1 Tsanev, R et al. (2009) Identification of the gene transcription repressor domain of Gli3. FEBS Lett. 583 224-8 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Dai, P et al. (2002) Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3. Genes Dev. 16 2843-8 PubMed GONUTS page
↑ Radhakrishna, U et al. (1997) Mutation in GLI3 in postaxial polydactyly type A. Nat. Genet. 17 269-71 PubMed GONUTS page
↑ Kos, S et al. (2008) Hydrometrocolpos, postaxial polydactyly, and hypothalamic hamartoma in a patient with confirmed Pallister-Hall syndrome: a clinical overlap with McKusick-Kaufman syndrome. Pediatr Radiol 38 902-6 PubMed GONUTS page
↑ Dai, P et al. (1999) Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3. J. Biol. Chem. 274 8143-52 PubMed GONUTS page
↑ Endoh-Yamagami, S et al. (2009) The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development. Curr. Biol. 19 1320-6 PubMed GONUTS page
↑ ^12.0 ^12.1 Koyabu, Y et al. (2001) Physical and functional interactions between Zic and Gli proteins. J. Biol. Chem. 276 6889-92 PubMed GONUTS page
↑ ^13.0 ^13.1 Shin, SH et al. (1999) GLI3 mutations in human disorders mimic Drosophila cubitus interruptus protein functions and localization. Proc. Natl. Acad. Sci. U.S.A. 96 2880-4 PubMed GONUTS page
↑ Zhu, L et al. (2008) Characterization of the interactions of human ZIC3 mutants with GLI3. Hum. Mutat. 29 99-105 PubMed GONUTS page
↑ ^15.0 ^15.1 Wang, B et al. (2000) Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Cell 100 423-34 PubMed GONUTS page
↑ Ruppert, JM et al. (1990) GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity. Mol. Cell. Biol. 10 5408-15 PubMed GONUTS page
↑ Sakai-Kato, K et al. () CD spectra show the relational style between Zic-, Gli-, Glis-zinc finger protein and DNA. Biochim. Biophys. Acta 1784 1011-9 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 Villavicencio, EH et al. (2000) The sonic hedgehog-patched-gli pathway in human development and disease. Am. J. Hum. Genet. 67 1047-54 PubMed GONUTS page

[PMID:16254602-1] 1.0 ^1.1 ^1.2 ^1.3 Haycraft, CJ et al. (2005) Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet. 1 e53 PubMed GONUTS page

[PMID:19274049-2] Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:17331723-3] 3.0 ^3.1 Ulloa, F et al. (2007) Inhibitory Gli3 activity negatively regulates Wnt/beta-catenin signaling. Curr. Biol. 17 545-50 PubMed GONUTS page

[PMID:18559511-4] 4.0 ^4.1 ^4.2 Krauss, S et al. (2008) Protein phosphatase 2A and rapamycin regulate the nuclear localization and activity of the transcription factor GLI3. Cancer Res. 68 4658-65 PubMed GONUTS page

[PMID:17000779-5] 5.0 ^5.1 ^5.2 Zhou, H et al. (2006) Mediator modulates Gli3-dependent Sonic hedgehog signaling. Mol. Cell. Biol. 26 8667-82 PubMed GONUTS page

[PMID:19084012-6] 6.0 ^6.1 Tsanev, R et al. (2009) Identification of the gene transcription repressor domain of Gli3. FEBS Lett. 583 224-8 PubMed GONUTS page

[PMID:12435627-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Dai, P et al. (2002) Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3. Genes Dev. 16 2843-8 PubMed GONUTS page

[PMID:9354785-8] Radhakrishna, U et al. (1997) Mutation in GLI3 in postaxial polydactyly type A. Nat. Genet. 17 269-71 PubMed GONUTS page

[PMID:18478223-9] Kos, S et al. (2008) Hydrometrocolpos, postaxial polydactyly, and hypothalamic hamartoma in a patient with confirmed Pallister-Hall syndrome: a clinical overlap with McKusick-Kaufman syndrome. Pediatr Radiol 38 902-6 PubMed GONUTS page

[PMID:10075717-10] Dai, P et al. (1999) Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3. J. Biol. Chem. 274 8143-52 PubMed GONUTS page

[PMID:19592253-11] Endoh-Yamagami, S et al. (2009) The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development. Curr. Biol. 19 1320-6 PubMed GONUTS page

[PMID:11238441-12] 12.0 ^12.1 Koyabu, Y et al. (2001) Physical and functional interactions between Zic and Gli proteins. J. Biol. Chem. 276 6889-92 PubMed GONUTS page

[PMID:10077605-13] 13.0 ^13.1 Shin, SH et al. (1999) GLI3 mutations in human disorders mimic Drosophila cubitus interruptus protein functions and localization. Proc. Natl. Acad. Sci. U.S.A. 96 2880-4 PubMed GONUTS page

[PMID:17764085-14] Zhu, L et al. (2008) Characterization of the interactions of human ZIC3 mutants with GLI3. Hum. Mutat. 29 99-105 PubMed GONUTS page

[PMID:10693759-15] 15.0 ^15.1 Wang, B et al. (2000) Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Cell 100 423-34 PubMed GONUTS page

[PMID:2118997-16] Ruppert, JM et al. (1990) GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity. Mol. Cell. Biol. 10 5408-15 PubMed GONUTS page

[PMID:18298960-17] Sakai-Kato, K et al. () CD spectra show the relational style between Zic-, Gli-, Glis-zinc finger protein and DNA. Biochim. Biophys. Acta 1784 1011-9 PubMed GONUTS page

[PMID:11001584-18] 18.0 ^18.1 ^18.2 ^18.3 Villavicencio, EH et al. (2000) The sonic hedgehog-patched-gli pathway in human development and disease. Am. J. Hum. Genet. 67 1047-54 PubMed GONUTS page

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