HUMAN:FAK1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PTK2 (synonyms: FAK, FAK1)
Protein Name(s)	Focal adhesion kinase 1 FADK 1 Focal adhesion kinase-related nonkinase FRNK Protein phosphatase 1 regulatory subunit 71 PPP1R71 Protein-tyrosine kinase 2 p125FAK pp125FAK
External Links
UniProt	Q05397
EMBL	L13616 L05186 AK304356 AC067931 AC100860 AC105009 AC105235 KF458878 KF458882 BC035404
CCDS	CCDS56557.1 CCDS6381.1
PIR	I53012 PC1225
RefSeq	NP_001186578.1 NP_722560.1
UniGene	Hs.395482
PDB	1K04 1K05 1MP8 1OW6 1OW7 1OW8 2ETM 2IJM 2RA7 3B71 3BZ3 3PXK 3S9O 4EBV 4EBW 4GU6 4GU9 4I4E 4I4F 4K8A 4K9Y 4KAB 4KAO 4NY0 4Q9S
PDBsum	1K04 1K05 1MP8 1OW6 1OW7 1OW8 2ETM 2IJM 2RA7 3B71 3BZ3 3PXK 3S9O 4EBV 4EBW 4GU6 4GU9 4I4E 4I4F 4K8A 4K9Y 4KAB 4KAO 4NY0 4Q9S
ProteinModelPortal	Q05397
SMR	Q05397
BioGrid	111719
IntAct	Q05397
MINT	MINT-92695
STRING	9606.ENSP00000341189
BindingDB	Q05397
ChEMBL	CHEMBL2695
GuidetoPHARMACOLOGY	2180
PhosphoSite	Q05397
DMDM	3183518
MaxQB	Q05397
PaxDb	Q05397
PRIDE	Q05397
DNASU	5747
Ensembl	ENST00000340930 ENST00000521059 ENST00000522684
GeneID	5747
KEGG	hsa:5747
UCSC	uc003yvq.3 uc003yvu.3 uc011ljp.2 uc011ljr.2
CTD	5747
GeneCards	GC08M141667
HGNC	HGNC:9611
HPA	CAB004036 HPA001842
MIM	600758
neXtProt	NX_Q05397
PharmGKB	PA33955
eggNOG	COG0515
GeneTree	ENSGT00760000118799
HOGENOM	HOG000069938
HOVERGEN	HBG004018
InParanoid	Q05397
KO	K05725
OrthoDB	EOG7ZSHSB
PhylomeDB	Q05397
TreeFam	TF316643
BRENDA	2.7.10.2
Reactome	REACT_107 REACT_15381 REACT_15523 REACT_160086 REACT_18334 REACT_22351 REACT_22384 REACT_228063 REACT_228085 REACT_228166 REACT_23916
SignaLink	Q05397
ChiTaRS	PTK2
EvolutionaryTrace	Q05397
GeneWiki	PTK2
GenomeRNAi	5747
NextBio	22380
PMAP-CutDB	Q05397
PRO	PR:Q05397
Proteomes	UP000005640
Bgee	Q05397
CleanEx	HS_PTK2
ExpressionAtlas	Q05397
Genevestigator	Q05397
GO	GO:0016324 GO:0005938 GO:0005737 GO:0005856 GO:0005829 GO:0005925 GO:0030027 GO:0005815 GO:0005634 GO:0005886 GO:0001725 GO:0003779 GO:0005524 GO:0008432 GO:0004715 GO:0004672 GO:0019901 GO:0042169 GO:0004871 GO:0001525 GO:0006915 GO:0007411 GO:0007596 GO:0048870 GO:0006921 GO:0021955 GO:0009790 GO:0043542 GO:0048013 GO:0030010 GO:0040023 GO:0030198 GO:0038096 GO:0060396 GO:0003007 GO:0045087 GO:0007229 GO:0000226 GO:2000811 GO:0043066 GO:0050771 GO:0022408 GO:0046621 GO:0051964 GO:0038007 GO:0001764 GO:0018108 GO:0001890 GO:0030168 GO:0030335 GO:0008284 GO:0043552 GO:0014068 GO:0045860 GO:0051897 GO:0001934 GO:2000060 GO:0046777 GO:0033628 GO:0042127 GO:0008360 GO:0051493 GO:0010594 GO:0051893 GO:0045667 GO:0032319 GO:0007172 GO:0007179 GO:0001570
InterPro	IPR019749 IPR019748 IPR000299 IPR005189 IPR011009 IPR000719 IPR017441 IPR001245 IPR008266 IPR020635 IPR029071
Pfam	PF00373 PF03623 PF07714
PRINTS	PR00109
ProDom	PD006413
SMART	SM00295 SM00219
SUPFAM	SSF47031 SSF54236 SSF56112 SSF68993
PROSITE	PS00661 PS50057 PS00107 PS50011 PS00109

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0016477	cell migration	PMID:21703394^[1]	ECO:0000315			P		Figure 4A shows 26% decrease in lymphoblasts migration in mutant PTK2 (FAK1) compared to control. Figure 6A over expression of PTK2 rescued reduced migration of B-lymphoblast.	complete CACAO 2147
	GO:0007155	cell adhesion	PMID:21703394^[1]	ECO:0000315			P		Cell adhesion assay was used, in autistic patients with PTK2 (FAK1) showed lymphoblast adhesion to intercellular adhesion molecule 1 increased, figure 4B. Figure 6B over expression of PTK2, stopped the increase of B lymphoblast adhesion to intercellular adhesion molecule 1. Over expression rescued mutant PTK2 B lymphoblast cells.	complete CACAO 2148
enables	GO:0019903	protein phosphatase binding	PMID:28759036^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P51452	F		Seeded From UniProt	complete
involved_in	GO:0010632	regulation of epithelial cell migration	PMID:19913511^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9ULV4	P	occurs_in:(CL:0002563)	Seeded From UniProt	complete
involved_in	GO:0001932	regulation of protein phosphorylation	PMID:19913511^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9ULV4	P	occurs_in:(CL:0002563) has_input:(UniProtKB:P49023)	Seeded From UniProt	complete
involved_in	GO:0051893	regulation of focal adhesion assembly	PMID:19913511^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9ULV4	P	occurs_in:(CL:0002563)	Seeded From UniProt	complete
involved_in	GO:1900024	regulation of substrate adhesion-dependent cell spreading	PMID:19913511^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9ULV4	P	occurs_in:(CL:0002563)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21637765^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21637765^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:24036928^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P01137)	Seeded From UniProt	complete
part_of	GO:0001725	stress fiber	PMID:24036928^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007229	integrin-mediated signaling pathway	PMID:24036928^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060396	growth hormone receptor signaling pathway	PMID:10925297^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:21703394^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0022408	negative regulation of cell-cell adhesion	PMID:21703394^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008432	JUN kinase binding	PMID:10925297^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003779	actin binding	PMID:16803572^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000233)	Seeded From UniProt	complete
involved_in	GO:2000811	negative regulation of anoikis	PMID:22402981^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P34152	P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	PMID:15166238^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048013	ephrin receptor signaling pathway	PMID:10655584^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:11331870^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:10655584^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045860	positive regulation of protein kinase activity	PMID:11331870^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045667	regulation of osteoblast differentiation	PMID:16927379^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:15166238^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042169	SH2 domain binding	PMID:15077193^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P20936	F		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	PMID:18206965^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033628	regulation of cell adhesion mediated by integrin	PMID:10655584^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:11331870^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:19118217^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P21709	F		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:11331870^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:10655584^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	PMID:15166238^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008360	regulation of cell shape	PMID:10655584^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008360	regulation of cell shape	PMID:15166238^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P34152	P		Seeded From UniProt	complete
involved_in	GO:0007229	integrin-mediated signaling pathway	PMID:11331870^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:15855171^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:10655584^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:15855171^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15855171^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:11331870^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:10655584^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:15166238^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	PMID:23574715^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000700474 RGD:3443 RGD:628758	C		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87859 PANTHER:PTN001975310 UniProtKB:Q05397	P		Seeded From UniProt	complete
involved_in	GO:0038083	peptidyl-tyrosine autophosphorylation	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95481 PANTHER:PTN001975310 RGD:628758 UniProtKB:P00519 UniProtKB:Q14289	P		Seeded From UniProt	complete
involved_in	GO:0030155	regulation of cell adhesion	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001231249 UniProtKB:Q14289	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001975310 RGD:628758	P		Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001231249 RGD:628758	P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95481 PANTHER:PTN002400754 RGD:3443 RGD:628758 UniProtKB:Q00944 UniProtKB:Q05397 UniProtKB:Q14289	C		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000017 MGI:MGI:104908 MGI:MGI:1930958 MGI:MGI:95481 PANTHER:PTN001975310 UniProtKB:P00519 UniProtKB:Q05397 UniProtKB:Q14289 WB:WBGene00002213	F		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95481 PANTHER:PTN001231249 RGD:628758	P		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:12391143^[19]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34152 ensembl:ENSMUSP00000105663	P		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34152 ensembl:ENSMUSP00000105663	P		Seeded From UniProt	complete
involved_in	GO:0051964	negative regulation of synapse assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34152 ensembl:ENSMUSP00000105663	P		Seeded From UniProt	complete
involved_in	GO:0050771	negative regulation of axonogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34152 ensembl:ENSMUSP00000105663	P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34152 ensembl:ENSMUSP00000105663	P		Seeded From UniProt	complete
involved_in	GO:0046621	negative regulation of organ growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34152 ensembl:ENSMUSP00000105663	P		Seeded From UniProt	complete
involved_in	GO:0043542	endothelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34152 ensembl:ENSMUSP00000105663	P		Seeded From UniProt	complete
involved_in	GO:0038083	peptidyl-tyrosine autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34152 ensembl:ENSMUSP00000105663	P		Seeded From UniProt	complete
involved_in	GO:0030198	extracellular matrix organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34152 ensembl:ENSMUSP00000105663	P		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34152 ensembl:ENSMUSP00000105663	C		Seeded From UniProt	complete
involved_in	GO:0021955	central nervous system neuron axonogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34152 ensembl:ENSMUSP00000105663	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34152 ensembl:ENSMUSP00000105663	P		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34152 ensembl:ENSMUSP00000105663	C		Seeded From UniProt	complete
involved_in	GO:0010613	positive regulation of cardiac muscle hypertrophy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34152 ensembl:ENSMUSP00000105663	P		Seeded From UniProt	complete
involved_in	GO:0010507	negative regulation of autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34152 ensembl:ENSMUSP00000105663	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34152 ensembl:ENSMUSP00000105663	P		Seeded From UniProt	complete
involved_in	GO:0007097	nuclear migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34152 ensembl:ENSMUSP00000105663	P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34152 ensembl:ENSMUSP00000105663	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34152 ensembl:ENSMUSP00000105663	C		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34152 ensembl:ENSMUSP00000105663	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34152 ensembl:ENSMUSP00000105663	F		Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34152 ensembl:ENSMUSP00000105663	P		Seeded From UniProt	complete
involved_in	GO:0001570	vasculogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34152 ensembl:ENSMUSP00000105663	P		Seeded From UniProt	complete
involved_in	GO:0001568	blood vessel development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34152 ensembl:ENSMUSP00000105663	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34152 ensembl:ENSMUSP00000105663	P		Seeded From UniProt	complete
involved_in	GO:0000226	microtubule cytoskeleton organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34152 ensembl:ENSMUSP00000105663	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005189 InterPro:IPR020635 InterPro:IPR036137	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000299	C		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005189 InterPro:IPR036137	C		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR005189 InterPro:IPR008266 InterPro:IPR020635 InterPro:IPR036137	P		Seeded From UniProt	complete
involved_in	GO:0007172	signal complex assembly	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005189 InterPro:IPR036137	P		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.2	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:G1NJW4	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:G1NJW1	F		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004713	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004713	P		Seeded From UniProt	complete
involved_in	GO:0007229	integrin-mediated signaling pathway	PMID:9636140^[20] PMID:15725728^[21]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	PMID:10801330^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051893	regulation of focal adhesion assembly	PMID:19525103^[23] PMID:16919435^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051493	regulation of cytoskeleton organization	PMID:15725728^[21]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048870	cell motility	PMID:15725728^[21]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	PMID:15725728^[21]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038007	netrin-activated signaling pathway	PMID:15725728^[21]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043087	regulation of GTPase activity	PMID:19525103^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030010	establishment of cell polarity	PMID:19525103^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010594	regulation of endothelial cell migration	PMID:20552554^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	PMID:15725728^[21] Reactome:R-HSA-422475	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003007	heart morphogenesis	PMID:20552554^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001890	placenta development	PMID:20552554^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:20552554^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048013	ephrin receptor signaling pathway	Reactome:R-HSA-2682334	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	Reactome:R-HSA-194138	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	Reactome:R-HSA-2029480	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8874083 Reactome:R-HSA-8874082 Reactome:R-HSA-8874080 Reactome:R-HSA-8874079 Reactome:R-HSA-8874078 Reactome:R-HSA-5672965 Reactome:R-HSA-5218851 Reactome:R-HSA-5218839 Reactome:R-HSA-5218838 Reactome:R-HSA-5218830 Reactome:R-HSA-5218826 Reactome:R-HSA-5218822 Reactome:R-HSA-5218820 Reactome:R-HSA-5218811 Reactome:R-HSA-5218809 Reactome:R-HSA-5218645 Reactome:R-HSA-5218643 Reactome:R-HSA-5218642 Reactome:R-HSA-5218640 Reactome:R-HSA-4420083 Reactome:R-HSA-418874 Reactome:R-HSA-418868 Reactome:R-HSA-418858 Reactome:R-HSA-418856 Reactome:R-HSA-418850 Reactome:R-HSA-3928598 Reactome:R-HSA-3928592 Reactome:R-HSA-392054 Reactome:R-HSA-392053 Reactome:R-HSA-392051 Reactome:R-HSA-374701 Reactome:R-HSA-373716 Reactome:R-HSA-372705 Reactome:R-HSA-372697 Reactome:R-HSA-372693 Reactome:R-HSA-354165 Reactome:R-HSA-354124 Reactome:R-HSA-354087 Reactome:R-HSA-354073 Reactome:R-HSA-354066 Reactome:R-HSA-2197698 Reactome:R-HSA-201634	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	Reactome:R-HSA-8874078	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	Reactome:R-HSA-354073	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	Reactome:R-HSA-5673001	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0138	C		Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0118	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Wei, H et al. (2011) Abnormal cell properties and down-regulated FAK-Src complex signaling in B lymphoblasts of autistic subjects. Am. J. Pathol. 179 66-74 PubMed GONUTS page
↑ Chen, YR et al. (2017) Deficiency in VHR/DUSP3, a suppressor of focal adhesion kinase, reveals its role in regulating cell adhesion and migration. Oncogene 36 6509-6517 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Samarin, SN et al. (2010) Coronin 1C negatively regulates cell-matrix adhesion and motility of intestinal epithelial cells. Biochem. Biophys. Res. Commun. 391 394-400 PubMed GONUTS page
↑ ^4.0 ^4.1 Fu, M et al. (2011) Epithelial membrane protein-2 promotes endometrial tumor formation through activation of FAK and Src. PLoS ONE 6 e19945 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Bianchi-Smiraglia, A et al. (2013) Integrin-β5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor β. Cell Cycle 12 3377-89 PubMed GONUTS page
↑ ^6.0 ^6.1 Ryu, H et al. (2000) Regulation of neutrophil adhesion by pituitary growth hormone accompanies tyrosine phosphorylation of Jak2, p125FAK, and paxillin. J. Immunol. 165 2116-23 PubMed GONUTS page
↑ Cerecedo, D et al. (2006) Role of dystrophins and utrophins in platelet adhesion process. Br. J. Haematol. 134 83-91 PubMed GONUTS page
↑ Beauséjour, M et al. (2012) Integrin/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial crypt cells: selective engagement and roles of PI3-K isoform complexes. Apoptosis 17 566-78 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Xia, H et al. (2004) Focal adhesion kinase is upstream of phosphatidylinositol 3-kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway. J. Biol. Chem. 279 33024-34 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 Miao, H et al. (2000) Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation. Nat. Cell Biol. 2 62-9 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Chen, R et al. (2001) Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain. Nat. Cell Biol. 3 439-44 PubMed GONUTS page
↑ Salasznyk, RM et al. (2007) Activation of FAK is necessary for the osteogenic differentiation of human mesenchymal stem cells on laminin-5. J. Cell. Biochem. 100 499-514 PubMed GONUTS page
↑ Hecker, TP et al. (2004) Overexpression of FAK promotes Ras activity through the formation of a FAK/p120RasGAP complex in malignant astrocytoma cells. Oncogene 23 3962-71 PubMed GONUTS page
↑ Lim, ST et al. (2008) Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation. Mol. Cell 29 9-22 PubMed GONUTS page
↑ Yamazaki, T et al. (2009) EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility. J. Cell. Sci. 122 243-55 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Golubovskaya, VM et al. (2005) Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53. J. Biol. Chem. 280 25008-21 PubMed GONUTS page
↑ Maier, B et al. (2013) The novel actin/focal adhesion-associated protein MISP is involved in mitotic spindle positioning in human cells. Cell Cycle 12 1457-71 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 ^18.7 ^18.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Toutant, M et al. (2002) Alternative splicing controls the mechanisms of FAK autophosphorylation. Mol. Cell. Biol. 22 7731-43 PubMed GONUTS page
↑ Slack, BE (1998) Tyrosine phosphorylation of paxillin and focal adhesion kinase by activation of muscarinic m3 receptors is dependent on integrin engagement by the extracellular matrix. Proc. Natl. Acad. Sci. U.S.A. 95 7281-6 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 ^21.4 ^21.5 Nikolopoulos, SN & Giancotti, FG (2005) Netrin-integrin signaling in epithelial morphogenesis, axon guidance and vascular patterning. Cell Cycle 4 e131-5 PubMed GONUTS page
↑ Ohmori, T et al. (2000) Tyrosine dephosphorylation, but not phosphorylation, of p130Cas is dependent on integrin alpha IIb beta 3-mediated aggregation in platelets: implication of p130Cas involvement in pathways unrelated to cytoskeletal reorganization. Biochemistry 39 5797-807 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 Tomar, A & Schlaepfer, DD (2009) Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility. Curr. Opin. Cell Biol. 21 676-83 PubMed GONUTS page
↑ Mitra, SK & Schlaepfer, DD (2006) Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr. Opin. Cell Biol. 18 516-23 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 ^25.3 Chatzizacharias, NA et al. (2010) The role of focal adhesion kinase in early development. Histol. Histopathol. 25 1039-55 PubMed GONUTS page

[PMID:21703394-1] 1.0 ^1.1 ^1.2 ^1.3 Wei, H et al. (2011) Abnormal cell properties and down-regulated FAK-Src complex signaling in B lymphoblasts of autistic subjects. Am. J. Pathol. 179 66-74 PubMed GONUTS page

[PMID:28759036-2] Chen, YR et al. (2017) Deficiency in VHR/DUSP3, a suppressor of focal adhesion kinase, reveals its role in regulating cell adhesion and migration. Oncogene 36 6509-6517 PubMed GONUTS page

[PMID:19913511-3] 3.0 ^3.1 ^3.2 ^3.3 Samarin, SN et al. (2010) Coronin 1C negatively regulates cell-matrix adhesion and motility of intestinal epithelial cells. Biochem. Biophys. Res. Commun. 391 394-400 PubMed GONUTS page

[PMID:21637765-4] 4.0 ^4.1 Fu, M et al. (2011) Epithelial membrane protein-2 promotes endometrial tumor formation through activation of FAK and Src. PLoS ONE 6 e19945 PubMed GONUTS page

[PMID:24036928-5] 5.0 ^5.1 ^5.2 Bianchi-Smiraglia, A et al. (2013) Integrin-β5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor β. Cell Cycle 12 3377-89 PubMed GONUTS page

[PMID:10925297-6] 6.0 ^6.1 Ryu, H et al. (2000) Regulation of neutrophil adhesion by pituitary growth hormone accompanies tyrosine phosphorylation of Jak2, p125FAK, and paxillin. J. Immunol. 165 2116-23 PubMed GONUTS page

[PMID:16803572-7] Cerecedo, D et al. (2006) Role of dystrophins and utrophins in platelet adhesion process. Br. J. Haematol. 134 83-91 PubMed GONUTS page

[PMID:22402981-8] Beauséjour, M et al. (2012) Integrin/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial crypt cells: selective engagement and roles of PI3-K isoform complexes. Apoptosis 17 566-78 PubMed GONUTS page

[PMID:15166238-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Xia, H et al. (2004) Focal adhesion kinase is upstream of phosphatidylinositol 3-kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway. J. Biol. Chem. 279 33024-34 PubMed GONUTS page

[PMID:10655584-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 Miao, H et al. (2000) Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation. Nat. Cell Biol. 2 62-9 PubMed GONUTS page

[PMID:11331870-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Chen, R et al. (2001) Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain. Nat. Cell Biol. 3 439-44 PubMed GONUTS page

[PMID:16927379-12] Salasznyk, RM et al. (2007) Activation of FAK is necessary for the osteogenic differentiation of human mesenchymal stem cells on laminin-5. J. Cell. Biochem. 100 499-514 PubMed GONUTS page

[PMID:15077193-13] Hecker, TP et al. (2004) Overexpression of FAK promotes Ras activity through the formation of a FAK/p120RasGAP complex in malignant astrocytoma cells. Oncogene 23 3962-71 PubMed GONUTS page

[PMID:18206965-14] Lim, ST et al. (2008) Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation. Mol. Cell 29 9-22 PubMed GONUTS page

[PMID:19118217-15] Yamazaki, T et al. (2009) EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility. J. Cell. Sci. 122 243-55 PubMed GONUTS page

[PMID:15855171-16] 16.0 ^16.1 ^16.2 Golubovskaya, VM et al. (2005) Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53. J. Biol. Chem. 280 25008-21 PubMed GONUTS page

[PMID:23574715-17] Maier, B et al. (2013) The novel actin/focal adhesion-associated protein MISP is involved in mitotic spindle positioning in human cells. Cell Cycle 12 1457-71 PubMed GONUTS page

[PMID:21873635-18] 18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 ^18.7 ^18.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12391143-19] Toutant, M et al. (2002) Alternative splicing controls the mechanisms of FAK autophosphorylation. Mol. Cell. Biol. 22 7731-43 PubMed GONUTS page

[PMID:9636140-20] Slack, BE (1998) Tyrosine phosphorylation of paxillin and focal adhesion kinase by activation of muscarinic m3 receptors is dependent on integrin engagement by the extracellular matrix. Proc. Natl. Acad. Sci. U.S.A. 95 7281-6 PubMed GONUTS page

[PMID:15725728-21] 21.0 ^21.1 ^21.2 ^21.3 ^21.4 ^21.5 Nikolopoulos, SN & Giancotti, FG (2005) Netrin-integrin signaling in epithelial morphogenesis, axon guidance and vascular patterning. Cell Cycle 4 e131-5 PubMed GONUTS page

[PMID:10801330-22] Ohmori, T et al. (2000) Tyrosine dephosphorylation, but not phosphorylation, of p130Cas is dependent on integrin alpha IIb beta 3-mediated aggregation in platelets: implication of p130Cas involvement in pathways unrelated to cytoskeletal reorganization. Biochemistry 39 5797-807 PubMed GONUTS page

[PMID:19525103-23] 23.0 ^23.1 ^23.2 Tomar, A & Schlaepfer, DD (2009) Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility. Curr. Opin. Cell Biol. 21 676-83 PubMed GONUTS page

[PMID:16919435-24] Mitra, SK & Schlaepfer, DD (2006) Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr. Opin. Cell Biol. 18 516-23 PubMed GONUTS page

[PMID:20552554-25] 25.0 ^25.1 ^25.2 ^25.3 Chatzizacharias, NA et al. (2010) The role of focal adhesion kinase in early development. Histol. Histopathol. 25 1039-55 PubMed GONUTS page

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HUMAN:FAK1

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