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PMID:16919435

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Citation

Mitra, SK and Schlaepfer, DD (2006) Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr. Opin. Cell Biol. 18:516-23

Abstract

Integrins can alter cellular behavior through the recruitment and activation of signaling proteins such as non-receptor tyrosine kinases including focal adhesion kinase (FAK) and c-Src that form a dual kinase complex. The FAK-Src complex binds to and can phosphorylate various adaptor proteins such as p130Cas and paxillin. In normal cells, multiple integrin-regulated linkages exist to activate FAK or Src. Activated FAK-Src functions to promote cell motility, cell cycle progression and cell survival. Recent studies have found that the FAK-Src complex is activated in many tumor cells and generates signals leading to tumor growth and metastasis. As both FAK and Src catalytic activities are important in promoting VEGF-associated tumor angiogenesis and protease-associated tumor metastasis, support is growing that FAK and Src may be therapeutically relevant targets in the inhibition of tumor progression.

Links

PubMed Online version:10.1016/j.ceb.2006.08.011

Keywords

Animals; Cell Movement/physiology; Cell Survival; Disease Progression; Enzyme Activation; Focal Adhesion Protein-Tyrosine Kinases/metabolism; Integrins/metabolism; Neoplasms/metabolism; Neoplasms/pathology; Signal Transduction/physiology; src-Family Kinases/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:FAK1

involved_in

GO:0051893: regulation of focal adhesion assembly

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:FAK1

involved_in

GO:0051893: regulation of focal adhesion assembly

ECO:0000304: author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

See also

References

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