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HUMAN:FAF1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | FAF1 (synonyms: UBXD12, UBXN3A) | |
| Protein Name(s) | FAS-associated factor 1
hFAF1 UBX domain-containing protein 12 UBX domain-containing protein 3A | |
| External Links | ||
| UniProt | Q9UNN5 | |
| EMBL | AF106798 AF094700 AF136173 AJ271408 AF132938 AL359977 AC091610 AC118557 AL049637 AL603746 AL603746 AC091610 AC118557 AL049637 AL359977 CH471059 BC004970 BC067100 AL133631 | |
| CCDS | CCDS554.1 | |
| PIR | JC7093 T43466 | |
| RefSeq | NP_008982.1 | |
| UniGene | Hs.530402 | |
| PDB | 1H8C 2DZM 2EC4 3E21 3QC8 3QCA 3QQ8 3QWZ 3QX1 3R3M | |
| PDBsum | 1H8C 2DZM 2EC4 3E21 3QC8 3QCA 3QQ8 3QWZ 3QX1 3R3M | |
| ProteinModelPortal | Q9UNN5 | |
| SMR | Q9UNN5 | |
| BioGrid | 116298 | |
| DIP | DIP-38245N | |
| IntAct | Q9UNN5 | |
| MINT | MINT-88745 | |
| STRING | 9606.ENSP00000379457 | |
| PhosphoSite | Q9UNN5 | |
| DMDM | 20454906 | |
| MaxQB | Q9UNN5 | |
| PaxDb | Q9UNN5 | |
| PRIDE | Q9UNN5 | |
| DNASU | 11124 | |
| Ensembl | ENST00000396153 | |
| GeneID | 11124 | |
| KEGG | hsa:11124 | |
| UCSC | uc001cse.1 | |
| CTD | 11124 | |
| GeneCards | GC01M050905 | |
| HGNC | HGNC:3578 | |
| HPA | HPA018253 HPA019008 | |
| MIM | 604460 | |
| neXtProt | NX_Q9UNN5 | |
| PharmGKB | PA27976 | |
| eggNOG | NOG288188 | |
| GeneTree | ENSGT00530000063422 | |
| HOGENOM | HOG000043073 | |
| HOVERGEN | HBG002876 | |
| InParanoid | Q9UNN5 | |
| OMA | VLSNVFC | |
| OrthoDB | EOG72NRPV | |
| PhylomeDB | Q9UNN5 | |
| TreeFam | TF314172 | |
| SignaLink | Q9UNN5 | |
| ChiTaRS | FAF1 | |
| EvolutionaryTrace | Q9UNN5 | |
| GeneWiki | FAF1 | |
| GenomeRNAi | 11124 | |
| NextBio | 42280 | |
| PRO | PR:Q9UNN5 | |
| Proteomes | UP000005640 | |
| Bgee | Q9UNN5 | |
| CleanEx | HS_FAF1 | |
| ExpressionAtlas | Q9UNN5 | |
| Genevestigator | Q9UNN5 | |
| GO | GO:0031265 GO:0034098 GO:0005829 GO:0005635 GO:0005634 GO:0048471 GO:0031072 GO:0051059 GO:0019901 GO:0019887 GO:0043130 GO:0031625 GO:0006915 GO:0008219 GO:0007253 GO:0043065 GO:1902043 GO:0031334 GO:0043161 GO:0030155 GO:0042176 GO:0045859 | |
| InterPro | IPR012336 IPR006577 IPR029071 IPR001012 | |
| Pfam | PF00789 | |
| SMART | SM00594 SM00166 | |
| SUPFAM | SSF52833 SSF54236 | |
| PROSITE | PS50033 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0010942 |
positive regulation of cell death |
ECO:0000314 |
P |
Figure 9 demonstrates hFAF1 ability to induce apoptosis, specifically through heat shock. The graph in figure 9 shows that HSP+ hFAF1 had the lowest cell viability of all samples proposed and cell viability was confirmed through 3-2, 5-diphenyltetrazolium bromide assay. |
complete | |||||
| GO:0008219 |
cell death |
ECO:0000315 |
P |
Figure 4 B & C shows the pro-apoptosis abilities of hFAF1. The plates show that in those cells where hFAF1 was knocked out there was a significant increase in cell growth, in contrast those plates where the hFAF1 was left functioning properly there was a lack of cell growth, which was due to hFAF1 ability to break down HSP 70. This is again shown in the table, which specifically points out the amount of colonies. |
complete | |||||
|
involved_in |
GO:0010942 |
positive regulation of cell death |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1903364 |
positive regulation of cellular protein catabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:Q9H211) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045740 |
positive regulation of DNA replication |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043130 |
ubiquitin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0034098 |
VCP-NPL4-UFD1 AAA ATPase complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031625 |
ubiquitin protein ligase binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0051059 |
NF-kappaB binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042176 |
regulation of protein catabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031334 |
positive regulation of protein complex assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031265 |
CD95 death-inducing signaling complex |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031072 |
heat shock protein binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019901 |
protein kinase binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019887 |
protein kinase regulator activity |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008219 |
cell death |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007253 |
cytoplasmic sequestering of NF-kappaB |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045859 |
regulation of protein kinase activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0019887 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1902043 |
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54731 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030155 |
regulation of cell adhesion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54731 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019904 |
protein domain specific binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54731 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54731 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005635 |
nuclear envelope |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54731 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008219 |
cell death |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Kim, HJ et al. (2005) Human Fas-associated factor 1 interacts with heat shock protein 70 and negatively regulates chaperone activity. J. Biol. Chem. 280 8125-33 PubMed GONUTS page
- ↑ Lee, JJ et al. (2012) Ubiquitin-associated (UBA) domain in human Fas associated factor 1 inhibits tumor formation by promoting Hsp70 degradation. PLoS ONE 7 e40361 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Franz, A et al. (2016) Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression. Nat Commun 7 10612 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Alexandru, G et al. (2008) UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover. Cell 134 804-16 PubMed GONUTS page
- ↑ 5.0 5.1 Park, MY et al. (2004) Fas-associated factor-1 inhibits nuclear factor-kappaB (NF-kappaB) activity by interfering with nuclear translocation of the RelA (p65) subunit of NF-kappaB. J. Biol. Chem. 279 2544-9 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Guerra, B et al. (2001) FAS-associated factor 1 interacts with protein kinase CK2 in vivo upon apoptosis induction. Int. J. Oncol. 19 1117-26 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Song, EJ et al. (2005) Human Fas-associated factor 1, interacting with ubiquitinated proteins and valosin-containing protein, is involved in the ubiquitin-proteasome pathway. Mol. Cell. Biol. 25 2511-24 PubMed GONUTS page
- ↑ Ryu, SW et al. (1999) Identification and characterization of human Fas associated factor 1, hFAF1. Biochem. Biophys. Res. Commun. 262 388-94 PubMed GONUTS page
- ↑ Park, MY et al. (2005) Fas-associated factor-1 mediates chemotherapeutic-induced apoptosis via death effector filament formation. Int. J. Cancer 115 412-8 PubMed GONUTS page
- ↑ Ryu, SW et al. (2003) Fas-associated factor 1, FAF1, is a member of Fas death-inducing signaling complex. J. Biol. Chem. 278 24003-10 PubMed GONUTS page
c
p
- GO:0048471 ! perinuclear region of cytoplasm
- GO:1902043 ! positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
- GO:0043065 ! positive regulation of apoptotic process
- GO:1903364 ! positive regulation of cellular protein catabolic process
- GO:0045740 ! positive regulation of DNA replication
- GO:0031334 ! positive regulation of protein-containing complex assembly
- Primates
- GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process
- GO:0019904 ! protein domain specific binding
- GO:0019901 ! protein kinase binding
- GO:0019887 ! protein kinase regulator activity
r
