HUMAN:ERCC3

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ERCC3 (synonyms: XPB, XPBC)
Protein Name(s)	TFIIH basal transcription factor complex helicase XPB subunit Basic transcription factor 2 89 kDa subunit BTF2 p89 DNA excision repair protein ERCC-3 DNA repair protein complementing XP-B cells TFIIH basal transcription factor complex 89 kDa subunit TFIIH 89 kDa subunit TFIIH p89 Xeroderma pigmentosum group B-complementing protein
External Links
UniProt	P19447
EMBL	M31899 AY163769 AC110926 CH471103 BC008820
CCDS	CCDS2144.1
PIR	A35661
RefSeq	NP_000113.1
UniGene	Hs.469872
PDB	4ERN
PDBsum	4ERN
ProteinModelPortal	P19447
SMR	P19447
BioGrid	108383
DIP	DIP-83N
IntAct	P19447
MINT	MINT-3009064
STRING	9606.ENSP00000285398
PhosphoSite	P19447
DMDM	119541
MaxQB	P19447
PaxDb	P19447
PRIDE	P19447
DNASU	2071
Ensembl	ENST00000285398
GeneID	2071
KEGG	hsa:2071
UCSC	uc002toe.1
CTD	2071
GeneCards	GC02M128014
GeneReviews	ERCC3
HGNC	HGNC:3435
HPA	CAB037153 HPA046077
MIM	133510 601675 610651
neXtProt	NX_P19447
Orphanet	33364 276252
PharmGKB	PA27849
eggNOG	COG1061
GeneTree	ENSGT00390000002204
HOGENOM	HOG000160172
HOVERGEN	HBG051499
InParanoid	P19447
KO	K10843
OMA	APSKHVH
OrthoDB	EOG7DNNTM
PhylomeDB	P19447
TreeFam	TF101233
Reactome	REACT_1074 REACT_1470 REACT_1655 REACT_1851 REACT_1913 REACT_1941 REACT_200856 REACT_2089 REACT_2204 REACT_22107 REACT_22201 REACT_2222 REACT_257 REACT_311 REACT_6162 REACT_6233 REACT_6237 REACT_6253 REACT_6319 REACT_6332 REACT_6346 REACT_833 REACT_834 REACT_846 REACT_953 REACT_975
ChiTaRS	ERCC3
GeneWiki	XPB
GenomeRNAi	2071
NextBio	8425
PRO	PR:P19447
Proteomes	UP000005640
Bgee	P19447
CleanEx	HS_ERCC3
ExpressionAtlas	P19447
Genevestigator	P19447
GO	GO:0000439 GO:0005675 GO:0005654 GO:0005634 GO:0043138 GO:0005524 GO:0004003 GO:0016887 GO:0003684 GO:0032564 GO:0003677 GO:0005525 GO:0042277 GO:0008022 GO:0047485 GO:0008353 GO:0008134 GO:0006370 GO:0006915 GO:0006281 GO:0006265 GO:0010467 GO:0035315 GO:0006289 GO:0000718 GO:0000717 GO:0033683 GO:0043065 GO:0045944 GO:0050434 GO:0008104 GO:1901990 GO:0001666 GO:0006979 GO:0009411 GO:0006363 GO:0006362 GO:0006368 GO:0006360 GO:0006366 GO:0006361 GO:0006367 GO:0006283 GO:0009650 GO:0016032
Gene3D	3.40.50.300
InterPro	IPR006935 IPR014001 IPR001650 IPR001161 IPR027417
Pfam	PF00271 PF04851
PRINTS	PR00851
SMART	SM00487 SM00490
SUPFAM	SSF52540
TIGRFAMs	TIGR00603
PROSITE	PS51192 PS51194

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0005669	transcription factor TFIID complex	PMID:27193682^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:1901990	regulation of mitotic cell cycle phase transition	PMID:17088560^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	PMID:8652557^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13888	F	Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	PMID:8652557^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P32780	F	Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	PMID:8652557^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P18074	F	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:8692841^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0043138	3'-5' DNA helicase activity	PMID:8663148^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0043138	3'-5' DNA helicase activity	PMID:17466626^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:16914395^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035315	hair cell differentiation	PMID:11335038^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033683	nucleotide-excision repair, DNA incision	PMID:17466626^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033683	nucleotide-excision repair, DNA incision	PMID:8692841^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	PMID:17466626^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0009411	response to UV	PMID:17509950^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
contributes_to	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	PMID:9852112^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0008104	protein localization	PMID:17509950^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
contributes_to	GO:0008094	DNA-dependent ATPase activity	PMID:8663148^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
contributes_to	GO:0008094	DNA-dependent ATPase activity	PMID:9852112^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:17466626^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q92759	F	Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:10801852^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P51948	F	Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	PMID:17614221^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:8675009^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	PMID:8663148^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	PMID:9852112^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006289	nucleotide-excision repair	PMID:17509950^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006283	transcription-coupled nucleotide-excision repair	PMID:8663148^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	PMID:2167179^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006265	DNA topological change	PMID:8663148^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005675	transcription factor TFIIH holo complex	PMID:8692842^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005675	transcription factor TFIIH holo complex	PMID:9852112^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
contributes_to	GO:0004672	protein kinase activity	PMID:9852112^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003684	damaged DNA binding	PMID:2167179^[14]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0000717	nucleotide-excision repair, DNA duplex unwinding	PMID:17466626^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0097550	transcriptional preinitiation complex	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000138598 SGD:S000001405	C	Seeded From UniProt	complete
involved_in	GO:0048568	embryonic organ development	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000138607 RGD:1307139	P	Seeded From UniProt	complete
enables	GO:0043138	3'-5' DNA helicase activity	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000138598 UniProtKB:P19447	F	Seeded From UniProt	complete
involved_in	GO:0035315	hair cell differentiation	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000138606 UniProtKB:P19447	P	Seeded From UniProt	complete
involved_in	GO:0033683	nucleotide-excision repair, DNA incision	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000138598 SGD:S000001405 UniProtKB:P19447	P	Seeded From UniProt	complete
involved_in	GO:0009411	response to UV	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001179 MGI:MGI:95414 PANTHER:PTN000138598 TAIR:locus:2177891 TAIR:locus:2177901 UniProtKB:P19447 dictyBase:DDB_G0278729	P	Seeded From UniProt	complete
contributes_to	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000138598 UniProtKB:P19447	F	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000138598 UniProtKB:P19447	F	Seeded From UniProt	complete
involved_in	GO:0006367	transcription initiation from RNA polymerase II promoter	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000138598 PomBase:SPAC17A5.06 SGD:S000001405	P	Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001179 PANTHER:PTN000138598 PomBase:SPAC17A5.06 SGD:S000001405 UniProtKB:P19447	P	Seeded From UniProt	complete
part_of	GO:0005675	transcription factor TFIIH holo complex	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001179 PANTHER:PTN000138598 SGD:S000001405 UniProtKB:P19447	C	Seeded From UniProt	complete
enables	GO:0004003	ATP-dependent DNA helicase activity	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000138598 SGD:S000001405	F	Seeded From UniProt	complete
colocalizes_with	GO:0000439	transcription factor TFIIH core complex	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000138598 RGD:1307139 SGD:S000001405	C	Seeded From UniProt	complete
part_of	GO:0000112	nucleotide-excision repair factor 3 complex	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000138598 SGD:S000001405	C	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:9173976^[17]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008353	P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008353	P	Seeded From UniProt	complete
involved_in	GO:0009650	UV protection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49135 ensembl:ENSMUSP00000025241	P	Seeded From UniProt	complete
involved_in	GO:0048568	embryonic organ development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4G005 ensembl:ENSRNOP00000018422	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4G005 ensembl:ENSRNOP00000018422	C	Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4G005 ensembl:ENSRNOP00000018422	P	Seeded From UniProt	complete
part_of	GO:0000439	transcription factor TFIIH core complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4G005 ensembl:ENSRNOP00000018422	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006935	F	Seeded From UniProt	complete
enables	GO:0004003	ATP-dependent DNA helicase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001161	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006935	F	Seeded From UniProt	complete
involved_in	GO:0006289	nucleotide-excision repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001161	P	Seeded From UniProt	complete
involved_in	GO:0006367	transcription initiation from RNA polymerase II promoter	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001161	P	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006935	F	Seeded From UniProt	complete
part_of	GO:0005675	transcription factor TFIIH holo complex	PMID:7663514^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:8663148^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:8663148^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0070911	global genome nucleotide-excision repair	Reactome:R-HSA-5696399	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033683	nucleotide-excision repair, DNA incision	Reactome:R-HSA-5696400	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006370	7-methylguanosine mRNA capping	Reactome:R-HSA-72086	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006368	transcription elongation from RNA polymerase II promoter	Reactome:R-HSA-75955 Reactome:R-HSA-73776 Reactome:R-HSA-112382	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006367	transcription initiation from RNA polymerase II promoter	Reactome:R-HSA-75953 Reactome:R-HSA-73779	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	Reactome:R-HSA-73857	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006363	termination of RNA polymerase I transcription	Reactome:R-HSA-73863	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006362	transcription elongation from RNA polymerase I promoter	Reactome:R-HSA-73777	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006361	transcription initiation from RNA polymerase I promoter	Reactome:R-HSA-73772 Reactome:R-HSA-73762	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion	Reactome:R-HSA-5690988	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion	Reactome:R-HSA-5690990	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006294	nucleotide-excision repair, preincision complex assembly	Reactome:R-HSA-5691000 Reactome:R-HSA-5689861 Reactome:R-HSA-5689317	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006293	nucleotide-excision repair, preincision complex stabilization	Reactome:R-HSA-5690991	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006283	transcription-coupled nucleotide-excision repair	Reactome:R-HSA-6781827	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-9613497 Reactome:R-HSA-9613494 Reactome:R-HSA-77090 Reactome:R-HSA-77085 Reactome:R-HSA-77083 Reactome:R-HSA-77081 Reactome:R-HSA-77078 Reactome:R-HSA-77077 Reactome:R-HSA-77073 Reactome:R-HSA-77071 Reactome:R-HSA-77069 Reactome:R-HSA-77068 Reactome:R-HSA-76576 Reactome:R-HSA-75949 Reactome:R-HSA-75891 Reactome:R-HSA-75873 Reactome:R-HSA-75869 Reactome:R-HSA-75866 Reactome:R-HSA-75864 Reactome:R-HSA-75862 Reactome:R-HSA-75861 Reactome:R-HSA-75856 Reactome:R-HSA-75850 Reactome:R-HSA-74994 Reactome:R-HSA-74993 Reactome:R-HSA-74992 Reactome:R-HSA-74986 Reactome:R-HSA-73946 Reactome:R-HSA-73769 Reactome:R-HSA-73758 Reactome:R-HSA-6797616 Reactome:R-HSA-6797606 Reactome:R-HSA-6790487 Reactome:R-HSA-6790454 Reactome:R-HSA-6782234 Reactome:R-HSA-6782227 Reactome:R-HSA-6782224 Reactome:R-HSA-6782211 Reactome:R-HSA-6782208 Reactome:R-HSA-6782204 Reactome:R-HSA-6782141 Reactome:R-HSA-6782138 Reactome:R-HSA-6782131 Reactome:R-HSA-6782069 Reactome:R-HSA-6782004 Reactome:R-HSA-6781867 Reactome:R-HSA-6781840 Reactome:R-HSA-6781833 Reactome:R-HSA-6781824 Reactome:R-HSA-6781818 Reactome:R-HSA-5696670 Reactome:R-HSA-5691000 Reactome:R-HSA-5690996 Reactome:R-HSA-5690991 Reactome:R-HSA-5690990 Reactome:R-HSA-5690988 Reactome:R-HSA-5690213 Reactome:R-HSA-5689861 Reactome:R-HSA-5689317 Reactome:R-HSA-113430 Reactome:R-HSA-112385 Reactome:R-HSA-112383 Reactome:R-HSA-112379 Reactome:R-HSA-111264 Reactome:R-HSA-109639	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004386	helicase activity	Reactome:R-HSA-9613497 Reactome:R-HSA-9613494 Reactome:R-HSA-75949	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0000717	nucleotide-excision repair, DNA duplex unwinding	Reactome:R-HSA-5690996	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
enables	GO:0004386	helicase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0347	F	Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ He, Y et al. (2016) Near-atomic resolution visualization of human transcription promoter opening. Nature 533 359-65 PubMed GONUTS page
↑ Marini, F et al. (2006) DNA nucleotide excision repair-dependent signaling to checkpoint activation. Proc. Natl. Acad. Sci. U.S.A. 103 17325-30 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Iyer, N et al. (1996) Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein. Biochemistry 35 2157-67 PubMed GONUTS page
↑ ^4.0 ^4.1 Reardon, JT et al. (1996) Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH. Proc. Natl. Acad. Sci. U.S.A. 93 6482-7 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Hwang, JR et al. (1996) A 3' --> 5' XPB helicase defect in repair/transcription factor TFIIH of xeroderma pigmentosum group B affects both DNA repair and transcription. J. Biol. Chem. 271 15898-904 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Coin, F et al. (2007) Distinct roles for the XPB/p52 and XPD/p44 subcomplexes of TFIIH in damaged DNA opening during nucleotide excision repair. Mol. Cell 26 245-56 PubMed GONUTS page
↑ Hu, GM et al. (2006) The role of XPB in cell apoptosis and viability and its relationship with p53, p21(waf1/cip1) and c-myc in hepatoma cells. Dig Liver Dis 38 755-61 PubMed GONUTS page
↑ Bergmann, E & Egly, JM (2001) Trichothiodystrophy, a transcription syndrome. Trends Genet. 17 279-86 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Oh, KS et al. (2007) Influence of XPB helicase on recruitment and redistribution of nucleotide excision repair proteins at sites of UV-induced DNA damage. DNA Repair (Amst.) 6 1359-70 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Kershnar, E et al. (1998) Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. J. Biol. Chem. 273 34444-53 PubMed GONUTS page
↑ Busso, D et al. (2000) Distinct regions of MAT1 regulate cdk7 kinase and TFIIH transcription activities. J. Biol. Chem. 275 22815-23 PubMed GONUTS page
↑ Decordier, I et al. (2007) Genetic susceptibility of newborn daughters to oxidative stress. Toxicol. Lett. 172 68-84 PubMed GONUTS page
↑ Wang, XW et al. (1996) The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway. Genes Dev. 10 1219-32 PubMed GONUTS page
↑ ^14.0 ^14.1 Weeda, G et al. (1990) A presumed DNA helicase encoded by ERCC-3 is involved in the human repair disorders xeroderma pigmentosum and Cockayne's syndrome. Cell 62 777-91 PubMed GONUTS page
↑ Drapkin, R et al. (1996) Human cyclin-dependent kinase-activating kinase exists in three distinct complexes. Proc. Natl. Acad. Sci. U.S.A. 93 6488-93 PubMed GONUTS page
↑ ^16.00 ^16.01 ^16.02 ^16.03 ^16.04 ^16.05 ^16.06 ^16.07 ^16.08 ^16.09 ^16.10 ^16.11 ^16.12 ^16.13 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Weeda, G et al. (1997) The XPB subunit of repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative transcription factor. Nucleic Acids Res. 25 2274-83 PubMed GONUTS page
↑ Wang, XW et al. (1995) p53 modulation of TFIIH-associated nucleotide excision repair activity. Nat. Genet. 10 188-95 PubMed GONUTS page

[PMID:27193682-1] He, Y et al. (2016) Near-atomic resolution visualization of human transcription promoter opening. Nature 533 359-65 PubMed GONUTS page

[PMID:17088560-2] Marini, F et al. (2006) DNA nucleotide excision repair-dependent signaling to checkpoint activation. Proc. Natl. Acad. Sci. U.S.A. 103 17325-30 PubMed GONUTS page

[PMID:8652557-3] 3.0 ^3.1 ^3.2 Iyer, N et al. (1996) Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein. Biochemistry 35 2157-67 PubMed GONUTS page

[PMID:8692841-4] 4.0 ^4.1 Reardon, JT et al. (1996) Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH. Proc. Natl. Acad. Sci. U.S.A. 93 6482-7 PubMed GONUTS page

[PMID:8663148-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Hwang, JR et al. (1996) A 3' --> 5' XPB helicase defect in repair/transcription factor TFIIH of xeroderma pigmentosum group B affects both DNA repair and transcription. J. Biol. Chem. 271 15898-904 PubMed GONUTS page

[PMID:17466626-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Coin, F et al. (2007) Distinct roles for the XPB/p52 and XPD/p44 subcomplexes of TFIIH in damaged DNA opening during nucleotide excision repair. Mol. Cell 26 245-56 PubMed GONUTS page

[PMID:16914395-7] Hu, GM et al. (2006) The role of XPB in cell apoptosis and viability and its relationship with p53, p21(waf1/cip1) and c-myc in hepatoma cells. Dig Liver Dis 38 755-61 PubMed GONUTS page

[PMID:11335038-8] Bergmann, E & Egly, JM (2001) Trichothiodystrophy, a transcription syndrome. Trends Genet. 17 279-86 PubMed GONUTS page

[PMID:17509950-9] 9.0 ^9.1 ^9.2 Oh, KS et al. (2007) Influence of XPB helicase on recruitment and redistribution of nucleotide excision repair proteins at sites of UV-induced DNA damage. DNA Repair (Amst.) 6 1359-70 PubMed GONUTS page

[PMID:9852112-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Kershnar, E et al. (1998) Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. J. Biol. Chem. 273 34444-53 PubMed GONUTS page

[PMID:10801852-11] Busso, D et al. (2000) Distinct regions of MAT1 regulate cdk7 kinase and TFIIH transcription activities. J. Biol. Chem. 275 22815-23 PubMed GONUTS page

[PMID:17614221-12] Decordier, I et al. (2007) Genetic susceptibility of newborn daughters to oxidative stress. Toxicol. Lett. 172 68-84 PubMed GONUTS page

[PMID:8675009-13] Wang, XW et al. (1996) The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway. Genes Dev. 10 1219-32 PubMed GONUTS page

[PMID:2167179-14] 14.0 ^14.1 Weeda, G et al. (1990) A presumed DNA helicase encoded by ERCC-3 is involved in the human repair disorders xeroderma pigmentosum and Cockayne's syndrome. Cell 62 777-91 PubMed GONUTS page

[PMID:8692842-15] Drapkin, R et al. (1996) Human cyclin-dependent kinase-activating kinase exists in three distinct complexes. Proc. Natl. Acad. Sci. U.S.A. 93 6488-93 PubMed GONUTS page

[PMID:21873635-16] 16.00 ^16.01 ^16.02 ^16.03 ^16.04 ^16.05 ^16.06 ^16.07 ^16.08 ^16.09 ^16.10 ^16.11 ^16.12 ^16.13 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9173976-17] Weeda, G et al. (1997) The XPB subunit of repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative transcription factor. Nucleic Acids Res. 25 2274-83 PubMed GONUTS page

[PMID:7663514-18] Wang, XW et al. (1995) p53 modulation of TFIIH-associated nucleotide excision repair activity. Nat. Genet. 10 188-95 PubMed GONUTS page

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