HUMAN:CXCR4

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CXCR4
Protein Name(s)	C-X-C chemokine receptor type 4 CXC-R4 CXCR-4 FB22 Fusin HM89 LCR1 Leukocyte-derived seven transmembrane domain receptor LESTR Lipopolysaccharide-associated protein 3 LAP-3 LPS-associated protein 3 NPYRL Stromal cell-derived factor 1 receptor SDF-1 receptor
External Links
UniProt	P61073
EMBL	L01639 M99293 X71635 L06797 D10924 AF005058 AF052572 AJ224869 AF025375 Y14739 AF147204 AF348491 AK312244 AY242129 BT006660 AY728138 AC068492 CH471058 BC020968
CCDS	CCDS33295.1 CCDS46420.1
PIR	A45747
RefSeq	NP_001008540.1 NP_003458.1
UniGene	Hs.593413
PDB	2K03 2K04 2K05 3ODU 3OE0 3OE6 3OE8 3OE9 4RWS
PDBsum	2K03 2K04 2K05 3ODU 3OE0 3OE6 3OE8 3OE9 4RWS
ProteinModelPortal	P61073
SMR	P61073
BioGrid	113607
DIP	DIP-34773N DIP-46290N
IntAct	P61073
MINT	MINT-6630550
STRING	9606.ENSP00000386884
BindingDB	P61073
ChEMBL	CHEMBL2107
DrugBank	DB00452 DB06809
GuidetoPHARMACOLOGY	71
iPTMnet	P61073
PhosphoSite	P61073
SwissPalm	P61073
BioMuta	CXCR4
DMDM	46577576
EPD	P61073
MaxQB	P61073
PaxDb	P61073
PRIDE	P61073
DNASU	7852
Ensembl	ENST00000241393 ENST00000409817
GeneID	7852
KEGG	hsa:7852
UCSC	uc002tuy.3
CTD	7852
GeneCards	CXCR4
HGNC	HGNC:2561
MalaCards	CXCR4
MIM	162643 193670
neXtProt	NX_P61073
Orphanet	51636
PharmGKB	PA27058
eggNOG	KOG3656 ENOG410XRW9
GeneTree	ENSGT00760000118785
HOVERGEN	HBG106917
InParanoid	P61073
KO	K04189
OMA	ILVMGYQ
OrthoDB	EOG73Z2TB
PhylomeDB	P61073
TreeFam	TF330966
Reactome	R-HSA-173107 R-HSA-380108 R-HSA-418594
SignaLink	P61073
ChiTaRS	CXCR4
EvolutionaryTrace	P61073
GeneWiki	CXCR4
GenomeRNAi	7852
NextBio	30286
PMAP-CutDB	P61073
PRO	PR:P61073
Proteomes	UP000005640
Bgee	P61073
CleanEx	HS_CXCR4
Genevisible	P61073
GO	GO:0030054 GO:0031252 GO:0009986 GO:0005737 GO:0031410 GO:0016023 GO:0005829 GO:0005769 GO:0070062 GO:0016021 GO:0005770 GO:0005764 GO:0005886 GO:0003779 GO:0016494 GO:0015026 GO:0008144 GO:0004930 GO:0032027 GO:0043130 GO:0031625 GO:0001618 GO:0000187 GO:0006915 GO:0019722 GO:0060048 GO:0071345 GO:0070098 GO:0002407 GO:0030260 GO:0002064 GO:0007186 GO:0006954 GO:0043217 GO:0001764 GO:0008038 GO:0042119 GO:0007204 GO:0048714 GO:0051924 GO:0050920 GO:0043067 GO:0001666 GO:0009615 GO:0022029 GO:0016032
InterPro	IPR022726 IPR000355 IPR033039 IPR001277 IPR000276 IPR017452
PANTHER	PTHR10489:SF594
Pfam	PF00001 PF12109
PRINTS	PR00657 PR00645 PR00237
PROSITE	PS00237 PS50262

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0038160	CXCL12-activated CXCR4 signaling pathway	PMID:24912431^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:25016030^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70658	P		Seeded From UniProt	complete
enables	GO:0038147	C-X-C motif chemokine 12 receptor activity	PMID:28978524^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0038160	CXCL12-activated CXCR4 signaling pathway	PMID:28978524^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030155	regulation of cell adhesion	PMID:19703720^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:25612609^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019957	C-C chemokine binding	PMID:25612609^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q98157	F		Seeded From UniProt	complete
colocalizes_with	GO:0005764	lysosome	PMID:24790097^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:1990869)	Seeded From UniProt	complete
colocalizes_with	GO:0005769	early endosome	PMID:24790097^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:1990869)	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:18308860^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000084)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000639)	Seeded From UniProt	complete
involved_in	GO:0048714	positive regulation of oligodendrocyte differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70658	P		Seeded From UniProt	complete
involved_in	GO:0043217	myelin maintenance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70658	P		Seeded From UniProt	complete
involved_in	GO:0071345	cellular response to cytokine stimulus	PMID:21540189^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050920	regulation of chemotaxis	PMID:19106094^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043130	ubiquitin binding	PMID:20228059^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0032027	myosin light chain binding	PMID:12421915^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:19116316^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q96J02	F		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:10521508^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
	GO:0016494	C-X-C chemokine receptor activity	PMID:27058821^[15]	ECO:0000316		PMID:27058821^[15] InterPro:IPR033039 UniProtKB:P61073	F		CXCR4 is a chemokine receptor that is recognized by C-X-C motif chemokine 12 (CXCL12) a.k.a stromal cell-divided factor 1 (SDF1). CXCL12 plays a big role in immune responses and metastatic cancer. Calculations and Virtual Screening with the help of the NMR complex structure was performed. This investigation proved that interfaces between proteins may often possess lead compounds for fragment-based optimization.	complete CACAO 11573
part_of	GO:0031252	cell leading edge	PMID:12421915^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0016494	C-X-C chemokine receptor activity	PMID:9468539^[16]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:19106094^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:19106094^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:10644702^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:10521508^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:10644702^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21540189^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	PMID:21540189^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:21540189^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:21540189^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003779	actin binding	PMID:12421915^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:15174142^[18]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060326	cell chemotaxis	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001200797 UniProtKB:P51684	P		Seeded From UniProt	complete
involved_in	GO:0022008	neurogenesis	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000659405 RGD:620465	P		Seeded From UniProt	complete
enables	GO:0019957	C-C chemokine binding	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104616 MGI:MGI:107182 MGI:MGI:1333797 MGI:MGI:1891697 PANTHER:PTN001200797 RGD:708446 UniProtKB:P32246 UniProtKB:P51677 UniProtKB:P51681 UniProtKB:P51684 UniProtKB:P61073	F		Seeded From UniProt	complete
enables	GO:0019956	chemokine binding	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001200797 UniProtKB:P49682 ZFIN:ZDB-GENE-031116-61	F		Seeded From UniProt	complete
involved_in	GO:0019722	calcium-mediated signaling	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001200797 RGD:621528 UniProtKB:P51681 UniProtKB:P51684 UniProtKB:P61073	P		Seeded From UniProt	complete
enables	GO:0016493	C-C chemokine receptor activity	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103011 MGI:MGI:104616 MGI:MGI:104618 MGI:MGI:106185 MGI:MGI:107182 MGI:MGI:107824 MGI:MGI:1096320 MGI:MGI:1201402 MGI:MGI:1333797 MGI:MGI:1341902 MGI:MGI:1891697 PANTHER:PTN001200797 UniProtKB:P32246 UniProtKB:P51681 UniProtKB:P51684	F		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103011 MGI:MGI:103567 MGI:MGI:106185 MGI:MGI:107182 MGI:MGI:107824 MGI:MGI:109563 MGI:MGI:1277207 MGI:MGI:1333797 PANTHER:PTN001200797 RGD:621528 RGD:708446 UniProtKB:P32246 UniProtKB:P51681	C		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109563 PANTHER:PTN000659405	P		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1096320 PANTHER:PTN001200797 RGD:1308562 RGD:2906 RGD:620596 RGD:621528 UniProtKB:P32246	P		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103011 MGI:MGI:106185 PANTHER:PTN001628461 UniProtKB:P32246	P		Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103011 MGI:MGI:104616 MGI:MGI:107824 MGI:MGI:1096320 MGI:MGI:1201402 MGI:MGI:1333797 MGI:MGI:1341902 MGI:MGI:1346338 PANTHER:PTN001200797 UniProtKB:F1R6D3 UniProtKB:P25025 UniProtKB:P51684 ZFIN:ZDB-GENE-031116-61	P		Seeded From UniProt	complete
involved_in	GO:0019722	calcium-mediated signaling	PMID:19064997^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:23620790^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1990478	response to ultrasound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08565 ensembl:ENSRNOP00000005143	P		Seeded From UniProt	complete
involved_in	GO:1905322	positive regulation of mesenchymal stem cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08565 ensembl:ENSRNOP00000005143	P		Seeded From UniProt	complete
involved_in	GO:1903861	positive regulation of dendrite extension	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08565 ensembl:ENSRNOP00000005143	P		Seeded From UniProt	complete
involved_in	GO:0061154	endothelial tube morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08565 ensembl:ENSRNOP00000005143	P		Seeded From UniProt	complete
involved_in	GO:0060048	cardiac muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08565 ensembl:ENSRNOP00000005143	P		Seeded From UniProt	complete
involved_in	GO:0051924	regulation of calcium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08565 ensembl:ENSRNOP00000005143	P		Seeded From UniProt	complete
involved_in	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08565 ensembl:ENSRNOP00000005143	P		Seeded From UniProt	complete
involved_in	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08565 ensembl:ENSRNOP00000005143	P		Seeded From UniProt	complete
involved_in	GO:0050921	positive regulation of chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08565 ensembl:ENSRNOP00000005143	P		Seeded From UniProt	complete
involved_in	GO:0050920	regulation of chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08565 ensembl:ENSRNOP00000005143	P		Seeded From UniProt	complete
involved_in	GO:0050792	regulation of viral process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08565 ensembl:ENSRNOP00000005143	P		Seeded From UniProt	complete
involved_in	GO:0050769	positive regulation of neurogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08565 ensembl:ENSRNOP00000005143	P		Seeded From UniProt	complete
involved_in	GO:0045446	endothelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08565 ensembl:ENSRNOP00000005143	P		Seeded From UniProt	complete
involved_in	GO:0043278	response to morphine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08565 ensembl:ENSRNOP00000005143	P		Seeded From UniProt	complete
involved_in	GO:0043067	regulation of programmed cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08565 ensembl:ENSRNOP00000005143	P		Seeded From UniProt	complete
involved_in	GO:0035690	cellular response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08565 ensembl:ENSRNOP00000005143	P		Seeded From UniProt	complete
involved_in	GO:0035470	positive regulation of vascular wound healing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08565 ensembl:ENSRNOP00000005143	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08565 ensembl:ENSRNOP00000005143	P		Seeded From UniProt	complete
involved_in	GO:0022029	telencephalon cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08565 ensembl:ENSRNOP00000005143	P		Seeded From UniProt	complete
involved_in	GO:0022008	neurogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08565 ensembl:ENSRNOP00000005143	P		Seeded From UniProt	complete
enables	GO:0016494	C-X-C chemokine receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08565 ensembl:ENSRNOP00000005143	F		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08565 ensembl:ENSRNOP00000005143	P		Seeded From UniProt	complete
involved_in	GO:0014823	response to activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08565 ensembl:ENSRNOP00000005143	P		Seeded From UniProt	complete
enables	GO:0008144	drug binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08565 ensembl:ENSRNOP00000005143	F		Seeded From UniProt	complete
involved_in	GO:0008038	neuron recognition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08565 ensembl:ENSRNOP00000005143	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08565 ensembl:ENSRNOP00000005143	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08565 ensembl:ENSRNOP00000005143	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08565 ensembl:ENSRNOP00000005143	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08565 ensembl:ENSRNOP00000005143	C		Seeded From UniProt	complete
involved_in	GO:0002064	epithelial cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08565 ensembl:ENSRNOP00000005143	P		Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08565 ensembl:ENSRNOP00000005143	P		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	F		Seeded From UniProt	complete
enables	GO:0004950	chemokine receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000355	F		Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000355	P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR000355	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR000355 InterPro:IPR001277 InterPro:IPR017452	C		Seeded From UniProt	complete
enables	GO:0019955	cytokine binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR022726	F		Seeded From UniProt	complete
enables	GO:0015026	coreceptor activity	PMID:10754293^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0009615	response to virus	PMID:10583963^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	PMID:10228019^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:8276799^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:10942389^[26]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:10393923^[27] Reactome:R-HSA-8986258 Reactome:R-HSA-749456 Reactome:R-HSA-749454 Reactome:R-HSA-380073 Reactome:R-HSA-374214 Reactome:R-HSA-164524 Reactome:R-HSA-164521 Reactome:R-HSA-164515 Reactome:R-HSA-164508 Reactome:R-HSA-164507 Reactome:R-HSA-164500	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10415069^[28]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	PMID:8276799^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	PMID:10570282^[29]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002407	dendritic cell chemotaxis	PMID:16621978^[30]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030260	entry into host cell	Reactome:R-HSA-173107	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019064	fusion of virus membrane with host plasma membrane	Reactome:R-HSA-164524	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	Reactome:R-HSA-422475	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965 UniProtKB-SubCell:SL-0038	C		Seeded From UniProt	complete
enables	GO:0001618	virus receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1183	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0458 UniProtKB-SubCell:SL-0158	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0094	C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0152	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Cao, Y et al. (2015) The WHIM-like CXCR4(S338X) somatic mutation activates AKT and ERK, and promotes resistance to ibrutinib and other agents used in the treatment of Waldenstrom's Macroglobulinemia. Leukemia 29 169-76 PubMed GONUTS page
↑ Yao, L et al. (2014) Deficiency in adipocyte chemokine receptor CXCR4 exacerbates obesity and compromises thermoregulatory responses of brown adipose tissue in a mouse model of diet-induced obesity. FASEB J. 28 4534-50 PubMed GONUTS page
↑ ^3.0 ^3.1 Lear, T et al. (2017) RING finger protein 113A regulates C-X-C chemokine receptor type 4 stability and signaling. Am. J. Physiol., Cell Physiol. 313 C584-C592 PubMed GONUTS page
↑ Crosby, HA et al. (2009) Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4. J. Hepatol. 51 734-49 PubMed GONUTS page
↑ ^5.0 ^5.1 Qin, L et al. (2015) Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine. Science 347 1117-22 PubMed GONUTS page
↑ ^6.0 ^6.1 Holleman, J & Marchese, A (2014) The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4. Mol. Biol. Cell 25 1892-904 PubMed GONUTS page
↑ Miles, A et al. (2008) CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow. Am. J. Physiol. Gastrointest. Liver Physiol. 294 G1257-67 PubMed GONUTS page
↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Cheng, SB et al. (2011) Down-modulation of the G-protein-coupled estrogen receptor, GPER, from the cell surface occurs via a trans-Golgi-proteasome pathway. J. Biol. Chem. 286 22441-55 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Mines, MA et al. (2009) Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation. J. Biol. Chem. 284 5742-52 PubMed GONUTS page
↑ Saini, V et al. (2010) CXC chemokine receptor 4 is a cell surface receptor for extracellular ubiquitin. J. Biol. Chem. 285 15566-76 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Rey, M et al. (2002) Cutting edge: association of the motor protein nonmuscle myosin heavy chain-IIA with the C terminus of the chemokine receptor CXCR4 in T lymphocytes. J. Immunol. 169 5410-4 PubMed GONUTS page
↑ Bhandari, D et al. (2009) The E3 ubiquitin ligase atrophin interacting protein 4 binds directly to the chemokine receptor CXCR4 via a novel WW domain-mediated interaction. Mol. Biol. Cell 20 1324-39 PubMed GONUTS page
↑ ^14.0 ^14.1 Orsini, MJ et al. (1999) Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-terminal tail that mediate receptor internalization. J. Biol. Chem. 274 31076-86 PubMed GONUTS page
↑ ^15.0 ^15.1 Smith, EW et al. (2016) Structure-based identification of novel ligands targeting multiple sites within a chemokine-G protein-coupled receptor interface. J. Med. Chem. PubMed GONUTS page
↑ Wegner, SA et al. (1998) Genomic organization and functional characterization of the chemokine receptor CXCR4, a major entry co-receptor for human immunodeficiency virus type 1. J. Biol. Chem. 273 4754-60 PubMed GONUTS page
↑ ^17.0 ^17.1 Cheng, ZJ et al. (2000) beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4. J. Biol. Chem. 275 2479-85 PubMed GONUTS page
↑ Scheurer, SB et al. (2004) Modulation of gene expression by hypoxia in human umbilical cord vein endothelial cells: A transcriptomic and proteomic study. Proteomics 4 1737-60 PubMed GONUTS page
↑ ^19.00 ^19.01 ^19.02 ^19.03 ^19.04 ^19.05 ^19.06 ^19.07 ^19.08 ^19.09 ^19.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Dubeykovskaya, Z et al. (2009) Secreted trefoil factor 2 activates the CXCR4 receptor in epithelial and lymphocytic cancer cell lines. J. Biol. Chem. 284 3650-62 PubMed GONUTS page
↑ Chiang, YJ et al. (2013) CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration. PLoS ONE 8 e61761 PubMed GONUTS page
↑ Secchiero, P et al. (2000) Engagement of CD28 modulates CXC chemokine receptor 4 surface expression in both resting and CD3-stimulated CD4+ T cells. J. Immunol. 164 4018-24 PubMed GONUTS page
↑ Lalani, AS et al. (1999) Use of chemokine receptors by poxviruses. Science 286 1968-71 PubMed GONUTS page
↑ Yasukawa, M et al. (1999) Down-regulation of CXCR4 by human herpesvirus 6 (HHV-6) and HHV-7. J. Immunol. 162 5417-22 PubMed GONUTS page
↑ ^25.0 ^25.1 Loetscher, M et al. (1994) Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes. J. Biol. Chem. 269 232-7 PubMed GONUTS page
↑ Ullrich, CK et al. (2000) HIV-1 gp120- and gp160-induced apoptosis in cultured endothelial cells is mediated by caspases. Blood 96 1438-42 PubMed GONUTS page
↑ Ling, K et al. (1999) Five-transmembrane domains appear sufficient for a G protein-coupled receptor: functional five-transmembrane domain chemokine receptors. Proc. Natl. Acad. Sci. U.S.A. 96 7922-7 PubMed GONUTS page
↑ Klein, RS et al. (1999) Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocytes: implications for the neuropathogenesis of AIDS. J. Immunol. 163 1636-46 PubMed GONUTS page
↑ Sotsios, Y et al. (1999) The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes. J. Immunol. 163 5954-63 PubMed GONUTS page
↑ Sánchez-Sánchez, N et al. (2006) The multiple personalities of the chemokine receptor CCR7 in dendritic cells. J. Immunol. 176 5153-9 PubMed GONUTS page

[PMID:24912431-1] Cao, Y et al. (2015) The WHIM-like CXCR4(S338X) somatic mutation activates AKT and ERK, and promotes resistance to ibrutinib and other agents used in the treatment of Waldenstrom's Macroglobulinemia. Leukemia 29 169-76 PubMed GONUTS page

[PMID:25016030-2] Yao, L et al. (2014) Deficiency in adipocyte chemokine receptor CXCR4 exacerbates obesity and compromises thermoregulatory responses of brown adipose tissue in a mouse model of diet-induced obesity. FASEB J. 28 4534-50 PubMed GONUTS page

[PMID:28978524-3] 3.0 ^3.1 Lear, T et al. (2017) RING finger protein 113A regulates C-X-C chemokine receptor type 4 stability and signaling. Am. J. Physiol., Cell Physiol. 313 C584-C592 PubMed GONUTS page

[PMID:19703720-4] Crosby, HA et al. (2009) Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4. J. Hepatol. 51 734-49 PubMed GONUTS page

[PMID:25612609-5] 5.0 ^5.1 Qin, L et al. (2015) Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine. Science 347 1117-22 PubMed GONUTS page

[PMID:24790097-6] 6.0 ^6.1 Holleman, J & Marchese, A (2014) The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4. Mol. Biol. Cell 25 1892-904 PubMed GONUTS page

[PMID:18308860-7] Miles, A et al. (2008) CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow. Am. J. Physiol. Gastrointest. Liver Physiol. 294 G1257-67 PubMed GONUTS page

[PMID:20458337-8] Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page

[PMID:21540189-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Cheng, SB et al. (2011) Down-modulation of the G-protein-coupled estrogen receptor, GPER, from the cell surface occurs via a trans-Golgi-proteasome pathway. J. Biol. Chem. 286 22441-55 PubMed GONUTS page

[PMID:19106094-10] 10.0 ^10.1 ^10.2 Mines, MA et al. (2009) Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation. J. Biol. Chem. 284 5742-52 PubMed GONUTS page

[PMID:20228059-11] Saini, V et al. (2010) CXC chemokine receptor 4 is a cell surface receptor for extracellular ubiquitin. J. Biol. Chem. 285 15566-76 PubMed GONUTS page

[PMID:12421915-12] 12.0 ^12.1 ^12.2 Rey, M et al. (2002) Cutting edge: association of the motor protein nonmuscle myosin heavy chain-IIA with the C terminus of the chemokine receptor CXCR4 in T lymphocytes. J. Immunol. 169 5410-4 PubMed GONUTS page

[PMID:19116316-13] Bhandari, D et al. (2009) The E3 ubiquitin ligase atrophin interacting protein 4 binds directly to the chemokine receptor CXCR4 via a novel WW domain-mediated interaction. Mol. Biol. Cell 20 1324-39 PubMed GONUTS page

[PMID:10521508-14] 14.0 ^14.1 Orsini, MJ et al. (1999) Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-terminal tail that mediate receptor internalization. J. Biol. Chem. 274 31076-86 PubMed GONUTS page

[PMID:27058821-15] 15.0 ^15.1 Smith, EW et al. (2016) Structure-based identification of novel ligands targeting multiple sites within a chemokine-G protein-coupled receptor interface. J. Med. Chem. PubMed GONUTS page

[PMID:9468539-16] Wegner, SA et al. (1998) Genomic organization and functional characterization of the chemokine receptor CXCR4, a major entry co-receptor for human immunodeficiency virus type 1. J. Biol. Chem. 273 4754-60 PubMed GONUTS page

[PMID:10644702-17] 17.0 ^17.1 Cheng, ZJ et al. (2000) beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4. J. Biol. Chem. 275 2479-85 PubMed GONUTS page

[PMID:15174142-18] Scheurer, SB et al. (2004) Modulation of gene expression by hypoxia in human umbilical cord vein endothelial cells: A transcriptomic and proteomic study. Proteomics 4 1737-60 PubMed GONUTS page

[PMID:21873635-19] 19.00 ^19.01 ^19.02 ^19.03 ^19.04 ^19.05 ^19.06 ^19.07 ^19.08 ^19.09 ^19.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19064997-20] Dubeykovskaya, Z et al. (2009) Secreted trefoil factor 2 activates the CXCR4 receptor in epithelial and lymphocytic cancer cell lines. J. Biol. Chem. 284 3650-62 PubMed GONUTS page

[PMID:23620790-21] Chiang, YJ et al. (2013) CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration. PLoS ONE 8 e61761 PubMed GONUTS page

[PMID:10754293-22] Secchiero, P et al. (2000) Engagement of CD28 modulates CXC chemokine receptor 4 surface expression in both resting and CD3-stimulated CD4+ T cells. J. Immunol. 164 4018-24 PubMed GONUTS page

[PMID:10583963-23] Lalani, AS et al. (1999) Use of chemokine receptors by poxviruses. Science 286 1968-71 PubMed GONUTS page

[PMID:10228019-24] Yasukawa, M et al. (1999) Down-regulation of CXCR4 by human herpesvirus 6 (HHV-6) and HHV-7. J. Immunol. 162 5417-22 PubMed GONUTS page

[PMID:8276799-25] 25.0 ^25.1 Loetscher, M et al. (1994) Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes. J. Biol. Chem. 269 232-7 PubMed GONUTS page

[PMID:10942389-26] Ullrich, CK et al. (2000) HIV-1 gp120- and gp160-induced apoptosis in cultured endothelial cells is mediated by caspases. Blood 96 1438-42 PubMed GONUTS page

[PMID:10393923-27] Ling, K et al. (1999) Five-transmembrane domains appear sufficient for a G protein-coupled receptor: functional five-transmembrane domain chemokine receptors. Proc. Natl. Acad. Sci. U.S.A. 96 7922-7 PubMed GONUTS page

[PMID:10415069-28] Klein, RS et al. (1999) Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocytes: implications for the neuropathogenesis of AIDS. J. Immunol. 163 1636-46 PubMed GONUTS page

[PMID:10570282-29] Sotsios, Y et al. (1999) The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes. J. Immunol. 163 5954-63 PubMed GONUTS page

[PMID:16621978-30] Sánchez-Sánchez, N et al. (2006) The multiple personalities of the chemokine receptor CCR7 in dendritic cells. J. Immunol. 176 5153-9 PubMed GONUTS page

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