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PMID:16621978

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Citation

Sánchez-Sánchez, N, Riol-Blanco, L and Rodríguez-Fernández, JL (2006) The multiple personalities of the chemokine receptor CCR7 in dendritic cells. J. Immunol. 176:5153-9

Abstract

CCR7 was described initially as a potent leukocyte chemotactic receptor that was later shown to be responsible of directing the migration of dendritic cells (DCs) to the lymph nodes where these cells play an important role in the initiation of the immune response. Recently, a variety of reports have indicated that, apart from chemotaxis, CCR7 controls the cytoarchitecture, the rate of endocytosis, the survival, the migratory speed, and the maturation of the DCs. Some of these functions of CCR7 and additional ones also have been described in other cell types. Herein we discuss how this receptor may contribute to modulate the immune response by regulating different functions in DCs. Finally, we also suggest a possible mechanism whereby CCR7 may control its multiple tasks in these cells.

Links

PubMed

Keywords

Animals; Chemokine CCL19; Chemokine CCL21; Chemokines, CC/metabolism; Dendritic Cells/immunology; Dendritic Cells/metabolism; Humans; Receptors, CCR7; Receptors, Chemokine/genetics; Receptors, Chemokine/metabolism; Signal Transduction; T-Lymphocytes/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:CXCR1

involved_in

GO:0002407: dendritic cell chemotaxis

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:CXCR2

involved_in

GO:0002407: dendritic cell chemotaxis

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:CCR7

involved_in

GO:0007186: G protein-coupled receptor signaling pathway

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:CCR7

enables

GO:0004930: G protein-coupled receptor activity

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

HUMAN:CCR2

involved_in

GO:0002407: dendritic cell chemotaxis

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

MOUSE:CCR7

involved_in

GO:0030036: actin cytoskeleton organization

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

MOUSE:CCR7

involved_in

GO:0001768: establishment of T cell polarity

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

MOUSE:CCR7

involved_in

GO:0006954: inflammatory response

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

MOUSE:CCR7

enables

GO:0004930: G protein-coupled receptor activity

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

MOUSE:CCR7

involved_in

GO:0051491: positive regulation of filopodium assembly

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

MOUSE:CCR7

involved_in

GO:0071731: response to nitric oxide

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

MOUSE:CCR7

involved_in

GO:2000147: positive regulation of cell motility

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

MOUSE:CCR7

involved_in

GO:2000107: negative regulation of leukocyte apoptotic process

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

MOUSE:CCR7

involved_in

GO:0034695: response to prostaglandin E

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:CCR6

involved_in

GO:0002407: dendritic cell chemotaxis

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:CCR5

involved_in

GO:0002407: dendritic cell chemotaxis

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:CCR1

involved_in

GO:0002407: dendritic cell chemotaxis

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:CXCR4

involved_in

GO:0002407: dendritic cell chemotaxis

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete


See also

References

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