HUMAN:CXA1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	GJA1 (synonyms: GJAL)
Protein Name(s)	Gap junction alpha-1 protein Connexin-43 Cx43 Gap junction 43 kDa heart protein
External Links
UniProt	P17302
EMBL	X52947 M65188 AF151980 CR541660 AK312324 AL139098 CH471051 BC026329
CCDS	CCDS5123.1
PIR	A35853
RefSeq	NP_000156.1
UniGene	Hs.700699 Hs.74471
PDB	2LL2
PDBsum	2LL2
ProteinModelPortal	P17302
SMR	P17302
BioGrid	108964
IntAct	P17302
MINT	MINT-147603
STRING	9606.ENSP00000282561
DrugBank	DB01136
GuidetoPHARMACOLOGY	728
PhosphoSite	P17302
DMDM	117706
MaxQB	P17302
PaxDb	P17302
PeptideAtlas	P17302
PRIDE	P17302
DNASU	2697
Ensembl	ENST00000282561
GeneID	2697
KEGG	hsa:2697
UCSC	uc003pyr.3
CTD	2697
GeneCards	GC06P121756
HGNC	HGNC:4274
HPA	CAB010753
MIM	121014 164200 186100 218400 234100 241550 257850 600309
neXtProt	NX_P17302
Orphanet	90636 1522 2248 2710 93404
PharmGKB	PA28685
eggNOG	NOG45368
GeneTree	ENSGT00760000118780
HOGENOM	HOG000231127
HOVERGEN	HBG009576
InParanoid	P17302
KO	K07372
OMA	GANVDMH
OrthoDB	EOG7P2XSS
PhylomeDB	P17302
TreeFam	TF329606
Reactome	REACT_11035 REACT_11039 REACT_11043 REACT_11049 REACT_9392 REACT_9398 REACT_9509
SignaLink	P17302
ChiTaRS	GJA1
GeneWiki	GJA1
GenomeRNAi	2697
NextBio	10668
PRO	PR:P17302
Proteomes	UP000005640
Bgee	P17302
CleanEx	HS_GJA1
ExpressionAtlas	P17302
Genevestigator	P17302
GO	GO:0016324 GO:0005922 GO:0043292 GO:0005829 GO:0005769 GO:0005789 GO:0070062 GO:0005916 GO:0005925 GO:0005921 GO:0005794 GO:0000139 GO:0030660 GO:0005887 GO:0014704 GO:0005882 GO:0016328 GO:0005764 GO:0045121 GO:0005741 GO:0005771 GO:0005886 GO:0005243 GO:0015075 GO:0004871 GO:0007512 GO:0006915 GO:0015867 GO:0086014 GO:0003294 GO:0048514 GO:0010643 GO:0010644 GO:0007267 GO:0071260 GO:0002544 GO:0042733 GO:0003158 GO:0002070 GO:0016264 GO:0007507 GO:0001947 GO:0001701 GO:0034220 GO:0002088 GO:0061024 GO:0060156 GO:0006936 GO:0060044 GO:2000279 GO:0001937 GO:0010629 GO:0061045 GO:0001764 GO:0048812 GO:0001649 GO:2000987 GO:0010652 GO:0007204 GO:0010628 GO:0003104 GO:0043123 GO:0032024 GO:0045732 GO:0045844 GO:0045907 GO:0045909 GO:0051259 GO:0060371 GO:0030500 GO:0046850 GO:0051924 GO:2000810 GO:0060373 GO:0060307 GO:0034405 GO:0009749 GO:0043434 GO:0009268 GO:0007165 GO:0043403 GO:0006810 GO:0010232
InterPro	IPR000500 IPR002261 IPR013124 IPR019570 IPR017990 IPR013092
PANTHER	PTHR11984
Pfam	PF00029 PF03508 PF10582
PRINTS	PR00206 PR01132
SMART	SM00037 SM01089
PROSITE	PS00407 PS00408

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0030054	cell junction	PMID:29366904^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0015631	tubulin binding	PMID:22558917^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23242	P		Seeded From UniProt	complete
enables	GO:0055077	gap junction hemi-channel activity	PMID:29366904^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23242	C		Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:27626200^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23242	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:29163229^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005922	connexin complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08050	C		Seeded From UniProt	complete
part_of	GO:0005922	connexin complex	PMID:15044680^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6S9C0	C	part_of:(UBERON:0002353)\|part_of:(UBERON:0018649)\|part_of:(UBERON:0004490)	Seeded From UniProt	complete
	GO:0005921	gap junction	PMID:9430691^[6]	ECO:0000314			C		Figure 1 shows northern blot analysis of RNA from transfected HEK294 cells,an immunoblot analysis of proteins from transfected HEK294 cells, and immunocytochemical localization of connexin-43 and ryanodine receptor in cultured cells.	complete CACAO 9437
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23242	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:15919068^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000746)	Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08050	P		Seeded From UniProt	complete
enables	GO:0005243	gap junction channel activity	PMID:1696265^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	part_of:(GO:0010644)	Seeded From UniProt	complete
involved_in	GO:0086064	cell communication by electrical coupling involved in cardiac conduction	PMID:1696265^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:1696265^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	PMID:1696265^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:1903763	gap junction channel activity involved in cell communication by electrical coupling	PMID:1696265^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005921	gap junction	PMID:1696265^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0086075	gap junction channel activity involved in cardiac conduction electrical coupling	PMID:1696265^[8]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010644	cell communication by electrical coupling	PMID:1696265^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	PMID:1696265^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	PMID:23381804^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0000948)	Seeded From UniProt	complete
involved_in	GO:0060348	bone development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23242	P		Seeded From UniProt	complete
involved_in	GO:0046849	bone remodeling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23242	P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:21423176^[10]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
enables	GO:0015075	ion transmembrane transporter activity	PMID:1696265^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08050	C		Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	PMID:22889254^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0006566)	Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23242	C		Seeded From UniProt	complete
involved_in	GO:0010644	cell communication by electrical coupling	PMID:23348765^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010644	cell communication by electrical coupling	PMID:16790700^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005921	gap junction	PMID:23348765^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005921	gap junction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08050	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08050	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08050	C		Seeded From UniProt	complete
enables	GO:0005243	gap junction channel activity	PMID:23348765^[12]	ECO:0000314	direct assay evidence used in manual assertion		F	part_of:(GO:0010644)	Seeded From UniProt	complete
enables	GO:0005243	gap junction channel activity	PMID:16790700^[13]	ECO:0000314	direct assay evidence used in manual assertion		F	part_of:(GO:0010644)	Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:12761501^[14]	ECO:0007001	high throughput mutant phenotypic evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000987	positive regulation of behavioral fear response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:2000810	regulation of bicellular tight junction assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:2000279	negative regulation of DNA biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:1905867	epididymis development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0097755	positive regulation of blood vessel diameter	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
enables	GO:0097718	disordered domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	F		Seeded From UniProt	complete
involved_in	GO:0071374	cellular response to parathyroid hormone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
enables	GO:0071253	connexin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	F		Seeded From UniProt	complete
involved_in	GO:0061045	negative regulation of wound healing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0060044	negative regulation of cardiac muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0051924	regulation of calcium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0051259	protein complex oligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0048812	neuron projection morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0046697	decidualization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0045907	positive regulation of vasoconstriction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	C		Seeded From UniProt	complete
involved_in	GO:0043434	response to peptide hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0034405	response to fluid shear stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	C		Seeded From UniProt	complete
involved_in	GO:0032526	response to retinoic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0032024	positive regulation of insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	F		Seeded From UniProt	complete
involved_in	GO:0022898	regulation of transmembrane transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	F		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	C		Seeded From UniProt	complete
involved_in	GO:0015867	ATP transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0010652	positive regulation of cell communication by chemical coupling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0010232	vascular transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0009268	response to pH	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0007154	cell communication	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
part_of	GO:0005922	connexin complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	C		Seeded From UniProt	complete
part_of	GO:0005921	gap junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	C		Seeded From UniProt	complete
part_of	GO:0005916	fascia adherens	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	C		Seeded From UniProt	complete
part_of	GO:0005771	multivesicular body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	C		Seeded From UniProt	complete
enables	GO:0005243	gap junction channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	F		Seeded From UniProt	complete
involved_in	GO:0003158	endothelium development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0003104	positive regulation of glomerular filtration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0002931	response to ischemia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0002544	chronic inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
involved_in	GO:0001937	negative regulation of endothelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08050 ensembl:ENSRNOP00000001054	P		Seeded From UniProt	complete
enables	GO:1990782	protein tyrosine kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	F		Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	F		Seeded From UniProt	complete
involved_in	GO:0071467	cellular response to pH	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0061337	cardiac conduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0060348	bone development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0060156	milk ejection reflex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0048514	blood vessel morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
enables	GO:0048487	beta-tubulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	F		Seeded From UniProt	complete
involved_in	GO:0046850	regulation of bone remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0046849	bone remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0045844	positive regulation of striated muscle tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0045216	cell-cell junction organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0043403	skeletal muscle tissue regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
part_of	GO:0043292	contractile fiber	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	C		Seeded From UniProt	complete
involved_in	GO:0042733	embryonic digit morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0042110	T cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0042098	T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0035050	embryonic heart tube development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0030500	regulation of bone mineralization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	C		Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	C		Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	C		Seeded From UniProt	complete
involved_in	GO:0010644	cell communication by electrical coupling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0010643	cell communication by chemical coupling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0008016	regulation of heart contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0007512	adult heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
part_of	GO:0005921	gap junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	C		Seeded From UniProt	complete
part_of	GO:0005916	fascia adherens	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	C		Seeded From UniProt	complete
part_of	GO:0005882	intermediate filament	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	C		Seeded From UniProt	complete
enables	GO:0005243	gap junction channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	F		Seeded From UniProt	complete
involved_in	GO:0003294	atrial ventricular junction remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0002088	lens development in camera-type eye	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0002070	epithelial cell maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0001649	osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
part_of	GO:0005922	connexin complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000500 InterPro:IPR002261 InterPro:IPR017990	C		Seeded From UniProt	complete
involved_in	GO:0007154	cell communication	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000500 InterPro:IPR017990	P		Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002261	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002261	P		Seeded From UniProt	complete
enables	GO:0022857	transmembrane transporter activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002261	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:24210816^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0043014	alpha-tubulin binding	PMID:29163229^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:30242148^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0099111	microtubule-based transport	PMID:29163229^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:29163229^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005243	gap junction channel activity	PMID:29366904^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005243	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	PMID:7715640^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	PMID:7715640^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006936	muscle contraction	PMID:7715640^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005922	connexin complex	PMID:1850831^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0086014	atrial cardiac muscle cell action potential	PMID:23348765^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016264	gap junction assembly	PMID:15709751^[19] Reactome:R-HSA-190861	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:15709751^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030660	Golgi-associated vesicle membrane	Reactome:R-HSA-190782 Reactome:R-HSA-190520	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-191656 Reactome:R-HSA-191654 Reactome:R-HSA-191636	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	Reactome:R-HSA-191072	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	Reactome:R-HSA-190782	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005921	gap junction	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0303 UniProtKB-SubCell:SL-0124	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Akanuma, SI et al. (2018) Expression and function of connexin 43 protein in mouse and human retinal pigment epithelial cells as hemichannels and gap junction proteins. Exp. Eye Res. 168 128-137 PubMed GONUTS page
↑ Saidi Brikci-Nigassa, A et al. (2012) Phosphorylation controls the interaction of the connexin43 C-terminal domain with tubulin and microtubules. Biochemistry 51 4331-42 PubMed GONUTS page
↑ Zhu, Y et al. (2016) Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals. Cell Metab. 24 420-433 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Fu, Y et al. (2017) Cx43 Isoform GJA1-20k Promotes Microtubule Dependent Mitochondrial Transport. Front Physiol 8 905 PubMed GONUTS page
↑ Kléber, AG & Rudy, Y (2004) Basic mechanisms of cardiac impulse propagation and associated arrhythmias. Physiol. Rev. 84 431-88 PubMed GONUTS page
↑ Toyofuku, T et al. (1998) Intercellular calcium signaling via gap junction in connexin-43-transfected cells. J. Biol. Chem. 273 1519-28 PubMed GONUTS page
↑ Boengler, K et al. (2005) Connexin 43 in cardiomyocyte mitochondria and its increase by ischemic preconditioning. Cardiovasc. Res. 67 234-44 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 ^8.8 ^8.9 Fishman, GI et al. (1990) Molecular characterization and functional expression of the human cardiac gap junction channel. J. Cell Biol. 111 589-98 PubMed GONUTS page
↑ Rasmussen, TB et al. (2013) Mutated desmoglein-2 proteins are incorporated into desmosomes and exhibit dominant-negative effects in arrhythmogenic right ventricular cardiomyopathy. Hum. Mutat. 34 697-705 PubMed GONUTS page
↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
↑ Roberts, JD et al. (2013) Detection of genomic deletions of PKP2 in arrhythmogenic right ventricular cardiomyopathy. Clin. Genet. 83 452-6 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Sun, Y et al. (2013) Novel germline GJA5/connexin40 mutations associated with lone atrial fibrillation impair gap junctional intercellular communication. Hum. Mutat. 34 603-9 PubMed GONUTS page
↑ ^13.0 ^13.1 Gollob, MH et al. (2006) Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillation. N. Engl. J. Med. 354 2677-88 PubMed GONUTS page
↑ Matsuda, A et al. (2003) Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene 22 3307-18 PubMed GONUTS page
↑ Smyth, JW & Shaw, RM (2013) Autoregulation of connexin43 gap junction formation by internally translated isoforms. Cell Rep 5 611-8 PubMed GONUTS page
↑ Kotini, M et al. (2018) Gap junction protein Connexin-43 is a direct transcriptional regulator of N-cadherin in vivo. Nat Commun 9 3846 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Britz-Cunningham, SH et al. (1995) Mutations of the Connexin43 gap-junction gene in patients with heart malformations and defects of laterality. N. Engl. J. Med. 332 1323-9 PubMed GONUTS page
↑ Fishman, GI et al. (1991) Functional analysis of human cardiac gap junction channel mutants. Proc. Natl. Acad. Sci. U.S.A. 88 3525-9 PubMed GONUTS page
↑ ^19.0 ^19.1 Lan, Z et al. (2005) Novel rab GAP-like protein, CIP85, interacts with connexin43 and induces its degradation. Biochemistry 44 2385-96 PubMed GONUTS page

[PMID:29366904-1] 1.0 ^1.1 ^1.2 Akanuma, SI et al. (2018) Expression and function of connexin 43 protein in mouse and human retinal pigment epithelial cells as hemichannels and gap junction proteins. Exp. Eye Res. 168 128-137 PubMed GONUTS page

[PMID:22558917-2] Saidi Brikci-Nigassa, A et al. (2012) Phosphorylation controls the interaction of the connexin43 C-terminal domain with tubulin and microtubules. Biochemistry 51 4331-42 PubMed GONUTS page

[PMID:27626200-3] Zhu, Y et al. (2016) Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals. Cell Metab. 24 420-433 PubMed GONUTS page

[PMID:29163229-4] 4.0 ^4.1 ^4.2 ^4.3 Fu, Y et al. (2017) Cx43 Isoform GJA1-20k Promotes Microtubule Dependent Mitochondrial Transport. Front Physiol 8 905 PubMed GONUTS page

[PMID:15044680-5] Kléber, AG & Rudy, Y (2004) Basic mechanisms of cardiac impulse propagation and associated arrhythmias. Physiol. Rev. 84 431-88 PubMed GONUTS page

[PMID:9430691-6] Toyofuku, T et al. (1998) Intercellular calcium signaling via gap junction in connexin-43-transfected cells. J. Biol. Chem. 273 1519-28 PubMed GONUTS page

[PMID:15919068-7] Boengler, K et al. (2005) Connexin 43 in cardiomyocyte mitochondria and its increase by ischemic preconditioning. Cardiovasc. Res. 67 234-44 PubMed GONUTS page

[PMID:1696265-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 ^8.8 ^8.9 Fishman, GI et al. (1990) Molecular characterization and functional expression of the human cardiac gap junction channel. J. Cell Biol. 111 589-98 PubMed GONUTS page

[PMID:23381804-9] Rasmussen, TB et al. (2013) Mutated desmoglein-2 proteins are incorporated into desmosomes and exhibit dominant-negative effects in arrhythmogenic right ventricular cardiomyopathy. Hum. Mutat. 34 697-705 PubMed GONUTS page

[PMID:21423176-10] Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page

[PMID:22889254-11] Roberts, JD et al. (2013) Detection of genomic deletions of PKP2 in arrhythmogenic right ventricular cardiomyopathy. Clin. Genet. 83 452-6 PubMed GONUTS page

[PMID:23348765-12] 12.0 ^12.1 ^12.2 ^12.3 Sun, Y et al. (2013) Novel germline GJA5/connexin40 mutations associated with lone atrial fibrillation impair gap junctional intercellular communication. Hum. Mutat. 34 603-9 PubMed GONUTS page

[PMID:16790700-13] 13.0 ^13.1 Gollob, MH et al. (2006) Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillation. N. Engl. J. Med. 354 2677-88 PubMed GONUTS page

[PMID:12761501-14] Matsuda, A et al. (2003) Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene 22 3307-18 PubMed GONUTS page

[PMID:24210816-15] Smyth, JW & Shaw, RM (2013) Autoregulation of connexin43 gap junction formation by internally translated isoforms. Cell Rep 5 611-8 PubMed GONUTS page

[PMID:30242148-16] Kotini, M et al. (2018) Gap junction protein Connexin-43 is a direct transcriptional regulator of N-cadherin in vivo. Nat Commun 9 3846 PubMed GONUTS page

[PMID:7715640-17] 17.0 ^17.1 ^17.2 Britz-Cunningham, SH et al. (1995) Mutations of the Connexin43 gap-junction gene in patients with heart malformations and defects of laterality. N. Engl. J. Med. 332 1323-9 PubMed GONUTS page

[PMID:1850831-18] Fishman, GI et al. (1991) Functional analysis of human cardiac gap junction channel mutants. Proc. Natl. Acad. Sci. U.S.A. 88 3525-9 PubMed GONUTS page

[PMID:15709751-19] 19.0 ^19.1 Lan, Z et al. (2005) Novel rab GAP-like protein, CIP85, interacts with connexin43 and induces its degradation. Biochemistry 44 2385-96 PubMed GONUTS page

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