HUMAN:CREB1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CREB1
Protein Name(s)	Cyclic AMP-responsive element-binding protein 1 CREB-1 cAMP-responsive element-binding protein 1
External Links
UniProt	P16220
EMBL	S72459 X55545 M34356 M34356 M27691 X60003 AY347527 BC010636 S53724
CCDS	CCDS2374.1 CCDS2375.1
PIR	A37340 B37340 S22298
RefSeq	NP_004370.1 NP_604391.1
UniGene	Hs.516646
PDB	2LXT
PDBsum	2LXT
ProteinModelPortal	P16220
SMR	P16220
BioGrid	107775
DIP	DIP-765N
IntAct	P16220
MINT	MINT-1338714
STRING	9606.ENSP00000387699
ChEMBL	CHEMBL5587
DrugBank	DB00131 DB01183
PhosphoSite	P16220
DMDM	117434
MaxQB	P16220
PaxDb	P16220
PRIDE	P16220
DNASU	1385
Ensembl	ENST00000353267 ENST00000430624 ENST00000432329
GeneID	1385
KEGG	hsa:1385
UCSC	uc002vcc.3
CTD	1385
GeneCards	GC02P208394
HGNC	HGNC:2345
HPA	CAB003803 HPA019150
MIM	123810 612160
neXtProt	NX_P16220
Orphanet	97338
PharmGKB	PA26864
eggNOG	NOG300199
HOGENOM	HOG000007365
HOVERGEN	HBG011077
InParanoid	P16220
KO	K05870
OMA	QXISTIA
OrthoDB	EOG72G18D
PhylomeDB	P16220
TreeFam	TF106464
Reactome	REACT_120966 REACT_12442 REACT_12524 REACT_147727 REACT_15497 REACT_15502 REACT_163910 REACT_18334 REACT_200608 REACT_20568 REACT_20625 REACT_20642 REACT_20661 REACT_24941
SignaLink	P16220
ChiTaRS	CREB1
GeneWiki	CREB1
GenomeRNAi	1385
NextBio	5625
PMAP-CutDB	P16220
PRO	PR:P16220
Proteomes	UP000005640
Bgee	P16220
CleanEx	HS_CREB1
ExpressionAtlas	P16220
Genevestigator	P16220
GO	GO:0005719 GO:0005654 GO:0005634 GO:0005667 GO:0035497 GO:0019899 GO:0001102 GO:0000978 GO:0001077 GO:0000980 GO:0003705 GO:0001190 GO:0003700 GO:0003712 GO:0007202 GO:0007411 GO:0071294 GO:0007623 GO:0007173 GO:0038095 GO:0008543 GO:0045087 GO:0007595 GO:0060430 GO:0007613 GO:0002755 GO:0002756 GO:0010944 GO:0048011 GO:0007219 GO:0048015 GO:0021983 GO:0045600 GO:0046887 GO:0046889 GO:0040018 GO:0045672 GO:0045944 GO:0045893 GO:0006468 GO:0050821 GO:0008361 GO:0042493 GO:0033762 GO:0010033 GO:0033363 GO:0007165 GO:0051403 GO:0007268 GO:0034166 GO:0034134 GO:0034138 GO:0034142 GO:0034146 GO:0034162 GO:0002224 GO:0038123 GO:0038124 GO:0006366 GO:0035666 GO:0060509 GO:0016032
InterPro	IPR004827 IPR003102 IPR029802 IPR001630
PANTHER	PTHR22952:SF104
Pfam	PF00170 PF02173
PRINTS	PR00041
SMART	SM00338
PROSITE	PS50217 PS00036 PS50953

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR001630 InterPro:IPR004827	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:P15337	F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q01147	F	has_regulation_target:(ENSEMBL:ENSG00000140836) part_of:(GO:0071300)	Seeded From UniProt	complete
involved_in	GO:0071300	cellular response to retinoic acid	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q01147	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q01147	P	regulates_transcription_of:(ENSEMBL:ENSG00000140836) part_of:(GO:0071300)	Seeded From UniProt	complete
part_of	GO:1990589	ATF4-CREB1 transcription factor complex	PMID:12871976^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0034976)	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:23382074^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q96EB6	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:1655749^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(NCBI_Gene:24797)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000036	ECO:0000305	curator inference used in manual assertion	GO:0000978,GO:0045944	F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:9065434^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19861239^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035497	cAMP response element binding	PMID:19861239^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010944	negative regulation of transcription by competitive promoter binding	PMID:19861239^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005719	nuclear euchromatin	PMID:19861239^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19861239^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0000165)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:19861239^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001102	RNA polymerase II activating transcription factor binding	PMID:19861239^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P15336	F		Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	PMID:19861239^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q01147	P		Seeded From UniProt	complete
involved_in	GO:0046889	positive regulation of lipid biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q01147	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q01147	P		Seeded From UniProt	complete
involved_in	GO:0045600	positive regulation of fat cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q01147	P		Seeded From UniProt	complete
involved_in	GO:0033762	response to glucagon	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q01147	P		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q01147	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1298366 MGI:MGI:88494 MGI:MGI:88495 PANTHER:PTN001119557 RGD:1307360 RGD:620218	C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:8798441^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	PMID:8798441^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:8798441^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:8798441^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:8798441^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25609649^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P16220	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20102225^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P16220	F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:1990763	arrestin family protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	F		Seeded From UniProt	complete
involved_in	GO:1990314	cellular response to insulin-like growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:1990090	cellular response to nerve growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:1902065	response to L-glutamate	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:1900273	positive regulation of long-term synaptic potentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:0071398	cellular response to fatty acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:0060251	regulation of glial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:0048145	regulation of fibroblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	F		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:0036120	cellular response to platelet-derived growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
enables	GO:0035035	histone acetyltransferase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	F		Seeded From UniProt	complete
involved_in	GO:0034670	chemotaxis to arachidonic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:0032916	positive regulation of transforming growth factor beta3 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
enables	GO:0030544	Hsp70 protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	F		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	C		Seeded From UniProt	complete
involved_in	GO:0014823	response to activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:0008542	visual learning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	F		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:0007613	memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
part_of	GO:0005759	mitochondrial matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	F		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
enables	GO:0001225	RNA polymerase II transcription coactivator binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	C		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	C		Seeded From UniProt	complete
involved_in	GO:1990830	cellular response to leukemia inhibitory factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01147 ensembl:ENSMUSP00000059973	P		Seeded From UniProt	complete
part_of	GO:1990589	ATF4-CREB1 transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01147 ensembl:ENSMUSP00000059973	C		Seeded From UniProt	complete
involved_in	GO:0071363	cellular response to growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01147 ensembl:ENSMUSP00000059973	P		Seeded From UniProt	complete
involved_in	GO:0071300	cellular response to retinoic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01147 ensembl:ENSMUSP00000059973	P		Seeded From UniProt	complete
involved_in	GO:0071294	cellular response to zinc ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01147 ensembl:ENSMUSP00000059973	P		Seeded From UniProt	complete
involved_in	GO:0060509	type I pneumocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01147 ensembl:ENSMUSP00000059973	P		Seeded From UniProt	complete
involved_in	GO:0060430	lung saccule development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01147 ensembl:ENSMUSP00000059973	P		Seeded From UniProt	complete
involved_in	GO:0060428	lung epithelium development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01147 ensembl:ENSMUSP00000059973	P		Seeded From UniProt	complete
involved_in	GO:0055025	positive regulation of cardiac muscle tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01147 ensembl:ENSMUSP00000059973	P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01147 ensembl:ENSMUSP00000059973	P		Seeded From UniProt	complete
involved_in	GO:0046889	positive regulation of lipid biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01147 ensembl:ENSMUSP00000059973	P		Seeded From UniProt	complete
involved_in	GO:0046887	positive regulation of hormone secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01147 ensembl:ENSMUSP00000059973	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01147 ensembl:ENSMUSP00000059973	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01147 ensembl:ENSMUSP00000059973	P		Seeded From UniProt	complete
involved_in	GO:0045672	positive regulation of osteoclast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01147 ensembl:ENSMUSP00000059973	P		Seeded From UniProt	complete
involved_in	GO:0045600	positive regulation of fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01147 ensembl:ENSMUSP00000059973	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01147 ensembl:ENSMUSP00000059973	F		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01147 ensembl:ENSMUSP00000059973	P		Seeded From UniProt	complete
involved_in	GO:0040018	positive regulation of multicellular organism growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01147 ensembl:ENSMUSP00000059973	P		Seeded From UniProt	complete
involved_in	GO:0035729	cellular response to hepatocyte growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01147 ensembl:ENSMUSP00000059973	P		Seeded From UniProt	complete
involved_in	GO:0033762	response to glucagon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01147 ensembl:ENSMUSP00000059973	P		Seeded From UniProt	complete
involved_in	GO:0033363	secretory granule organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01147 ensembl:ENSMUSP00000059973	P		Seeded From UniProt	complete
involved_in	GO:0030879	mammary gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01147 ensembl:ENSMUSP00000059973	P		Seeded From UniProt	complete
involved_in	GO:0021983	pituitary gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01147 ensembl:ENSMUSP00000059973	P		Seeded From UniProt	complete
involved_in	GO:0008361	regulation of cell size	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01147 ensembl:ENSMUSP00000059973	P		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01147 ensembl:ENSMUSP00000059973	P		Seeded From UniProt	complete
involved_in	GO:0007613	memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01147 ensembl:ENSMUSP00000059973	P		Seeded From UniProt	complete
involved_in	GO:0007595	lactation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01147 ensembl:ENSMUSP00000059973	P		Seeded From UniProt	complete
involved_in	GO:0007409	axonogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01147 ensembl:ENSMUSP00000059973	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01147 ensembl:ENSMUSP00000059973	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01147 ensembl:ENSMUSP00000059973	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01147 ensembl:ENSMUSP00000059973	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01147 ensembl:ENSMUSP00000059973	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01147 ensembl:ENSMUSP00000059973	F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01147 ensembl:ENSMUSP00000059973	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01147 ensembl:ENSMUSP00000059973	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001630	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001630 InterPro:IPR004827	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001630	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001630 InterPro:IPR003102 InterPro:IPR004827	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:2974179^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003712	transcription coregulator activity	PMID:8552098^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-442724 Reactome:R-HSA-2399996 Reactome:R-HSA-199935 Reactome:R-HSA-199917 Reactome:R-HSA-199895 Reactome:R-HSA-199298	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ Luo, S et al. (2003) Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements. J. Biol. Chem. 278 37375-85 PubMed GONUTS page
↑ Armour, SM et al. (2013) A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. Mol. Cell. Biol. 33 1487-502 PubMed GONUTS page
↑ Rehfuss, RP et al. (1991) The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A. J. Biol. Chem. 266 18431-4 PubMed GONUTS page
↑ Nirula, A et al. (1997) Constitutive binding of the transcription factor interleukin-2 (IL-2) enhancer binding factor to the IL-2 promoter. J. Biol. Chem. 272 7736-45 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Kodeboyina, S et al. (2010) cJun modulates Ggamma-globin gene expression via an upstream cAMP response element. Blood Cells Mol. Dis. 44 7-15 PubMed GONUTS page
↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Ji, L et al. (1996) CREB proteins function as positive regulators of the translocated bcl-2 allele in t(14;18) lymphomas. J. Biol. Chem. 271 22687-91 PubMed GONUTS page
↑ Li, X et al. (2015) Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Mol. Syst. Biol. 11 775 PubMed GONUTS page
↑ Reinke, AW et al. (2010) Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays. Biochemistry 49 1985-97 PubMed GONUTS page
↑ Hoeffler, JP et al. (1988) Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA. Science 242 1430-3 PubMed GONUTS page
↑ Parker, D et al. (1996) Phosphorylation of CREB at Ser-133 induces complex formation with CREB-binding protein via a direct mechanism. Mol. Cell. Biol. 16 694-703 PubMed GONUTS page

[PMID:19274049-1] 1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:12871976-2] Luo, S et al. (2003) Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements. J. Biol. Chem. 278 37375-85 PubMed GONUTS page

[PMID:23382074-3] Armour, SM et al. (2013) A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. Mol. Cell. Biol. 33 1487-502 PubMed GONUTS page

[PMID:1655749-4] Rehfuss, RP et al. (1991) The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A. J. Biol. Chem. 266 18431-4 PubMed GONUTS page

[PMID:9065434-5] Nirula, A et al. (1997) Constitutive binding of the transcription factor interleukin-2 (IL-2) enhancer binding factor to the IL-2 promoter. J. Biol. Chem. 272 7736-45 PubMed GONUTS page

[PMID:19861239-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Kodeboyina, S et al. (2010) cJun modulates Ggamma-globin gene expression via an upstream cAMP response element. Blood Cells Mol. Dis. 44 7-15 PubMed GONUTS page

[PMID:21873635-7] Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:8798441-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Ji, L et al. (1996) CREB proteins function as positive regulators of the translocated bcl-2 allele in t(14;18) lymphomas. J. Biol. Chem. 271 22687-91 PubMed GONUTS page

[PMID:25609649-9] Li, X et al. (2015) Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Mol. Syst. Biol. 11 775 PubMed GONUTS page

[PMID:20102225-10] Reinke, AW et al. (2010) Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays. Biochemistry 49 1985-97 PubMed GONUTS page

[PMID:2974179-11] Hoeffler, JP et al. (1988) Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA. Science 242 1430-3 PubMed GONUTS page

[PMID:8552098-12] Parker, D et al. (1996) Phosphorylation of CREB at Ser-133 induces complex formation with CREB-binding protein via a direct mechanism. Mol. Cell. Biol. 16 694-703 PubMed GONUTS page

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