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HUMAN:CDX1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CDX1
Protein Name(s) Homeobox protein CDX-1

Caudal-type homeobox protein 1

External Links
UniProt P47902
EMBL U16360
U15212
U51095
AF239666
BC096251
CCDS CCDS4304.1
PIR I38868
I38881
RefSeq NP_001795.2
UniGene Hs.1545
ProteinModelPortal P47902
SMR P47902
BioGrid 107474
IntAct P47902
MINT MINT-6800278
STRING 9606.ENSP00000231656
PhosphoSite P47902
DMDM 116241291
PaxDb P47902
PRIDE P47902
Ensembl ENST00000231656
GeneID 1044
KEGG hsa:1044
UCSC uc003lrq.3
CTD 1044
GeneCards GC05P149526
HGNC HGNC:1805
HPA HPA055196
MIM 600746
neXtProt NX_P47902
PharmGKB PA26351
eggNOG NOG291290
GeneTree ENSGT00530000063388
HOGENOM HOG000115975
HOVERGEN HBG005302
InParanoid P47902
KO K09312
OMA DWHSYGT
OrthoDB EOG71P2BK
PhylomeDB P47902
TreeFam TF351605
SignaLink P47902
GeneWiki CDX1
GenomeRNAi 1044
NextBio 4377
PRO PR:P47902
Proteomes UP000005640
Bgee P47902
CleanEx HS_CDX1
Genevestigator P47902
GO GO:0005634
GO:0000980
GO:0001205
GO:0009952
GO:0060349
GO:0009887
GO:0045944
Gene3D 1.10.10.60
InterPro IPR006820
IPR017970
IPR001356
IPR020479
IPR009057
IPR000047
Pfam PF04731
PF00046
PRINTS PR00024
PR00031
SMART SM00389
SUPFAM SSF46689
PROSITE PS00027
PS50071

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[1]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[1]

ECO:0000255

match to sequence model evidence used in manual assertion

InterPro:IPR000047
InterPro:IPR001356
InterPro:IPR009057

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000113

ECO:0005556

multiple sequence alignment evidence used in manual assertion

UniProtKB:P20263

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:24623306[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0044212

transcription regulatory region DNA binding

PMID:24623306[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0014807

regulation of somitogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P18111

P

Seeded From UniProt

complete

enables

GO:0008327

methyl-CpG binding

PMID:28473536[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:15774940[4]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P09923)

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

PMID:15774940[4]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_at:(SO:0000165)

Seeded From UniProt

complete

enables

GO:0000980

RNA polymerase II distal enhancer sequence-specific DNA binding

PMID:15774940[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88361
PANTHER:PTN001216652

P

Seeded From UniProt

complete

involved_in

GO:0009948

anterior/posterior axis specification

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001216652
ZFIN:ZDB-GENE-980526-330

P

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88361
PANTHER:PTN001216652

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000251
MGI:MGI:88361
PANTHER:PTN001216652
RGD:621234
WB:WBGene00003912

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000251
MGI:MGI:88360
MGI:MGI:88361
PANTHER:PTN001216652
RGD:621234

F

Seeded From UniProt

complete

enables

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000251
PANTHER:PTN001216652
WB:WBGene00003912

F

Seeded From UniProt

complete

involved_in

GO:0060349

bone morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18111
ensembl:ENSMUSP00000025521

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18111
ensembl:ENSMUSP00000025521

P

Seeded From UniProt

complete

involved_in

GO:0014807

regulation of somitogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18111
ensembl:ENSMUSP00000025521

P

Seeded From UniProt

complete

involved_in

GO:0009952

anterior/posterior pattern specification

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18111
ensembl:ENSMUSP00000025521

P

Seeded From UniProt

complete

involved_in

GO:0007389

pattern specification process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18111
ensembl:ENSMUSP00000025521

P

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18111
ensembl:ENSMUSP00000025521

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000047
InterPro:IPR001356
InterPro:IPR009057
InterPro:IPR020479

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006820

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006820
InterPro:IPR017970

P

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006820

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017970

F

Seeded From UniProt

complete

involved_in

GO:0009887

animal organ morphogenesis

PMID:8530027[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037
GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238
UniProtKB-KW:KW-0371

F

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
  2. ↑ 2.0 2.1 Serra, RW et al. (2014) A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype. Elife 3 e02313 PubMed GONUTS page
  3. ↑ Yin, Y et al. (2017) Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science 356 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Alkhoury, F et al. (2005) Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2. Am. J. Physiol. Gastrointest. Liver Physiol. 289 G285-90 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. ↑ Bonner, CA et al. (1995) Isolation, characterization, and precise physical localization of human CDX1, a caudal-type homeobox gene. Genomics 28 206-11 PubMed GONUTS page
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