HUMAN:CDK1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CDK1 (synonyms: CDC2, CDC28A, CDKN1, P34CDC2)
Protein Name(s)	Cyclin-dependent kinase 1 CDK1 Cell division control protein 2 homolog Cell division protein kinase 1 p34 protein kinase
External Links
UniProt	P06493
EMBL	X05360 Y00272 D88357 AK291939 BT007004 AF512554 AC022390 CH471083 BC014563
CCDS	CCDS44408.1 CCDS7260.1
PIR	A29539
RefSeq	NP_001777.1 NP_203698.1 XP_005270360.1 XP_006718145.1
UniGene	Hs.732435
PDB	1LC9 4YC6
PDBsum	1LC9 4YC6
ProteinModelPortal	P06493
SMR	P06493
BioGrid	107420
DIP	DIP-35N
IntAct	P06493
MINT	MINT-5000894
STRING	9606.ENSP00000378699
BindingDB	P06493
ChEMBL	CHEMBL1907602
GuidetoPHARMACOLOGY	1961
PhosphoSite	P06493
BioMuta	CDK1
DMDM	334302921
SWISS-2DPAGE	P06493
MaxQB	P06493
PaxDb	P06493
PRIDE	P06493
DNASU	983
Ensembl	ENST00000395284
GeneID	983
UCSC	uc001jld.3 uc001jlg.3
CTD	983
GeneCards	GC10P062539
HGNC	HGNC:1722
HPA	CAB003799 HPA003387
MIM	116940
neXtProt	NX_P06493
PharmGKB	PA99
eggNOG	COG0515
GeneTree	ENSGT00790000122973
HOVERGEN	HBG014652
InParanoid	P06493
PhylomeDB	P06493
TreeFam	TF101021
BRENDA	2.7.11.22
Reactome	REACT_1100 REACT_111214 REACT_1321 REACT_1391 REACT_150182 REACT_150260 REACT_150425 REACT_15296 REACT_15364 REACT_15451 REACT_15510 REACT_160122 REACT_160315 REACT_163931 REACT_1846 REACT_1857 REACT_2101 REACT_263908 REACT_264303 REACT_267965 REACT_407 REACT_471 REACT_6362 REACT_6820 REACT_683 REACT_6837 REACT_6850 REACT_6875 REACT_6904
SignaLink	P06493
ChiTaRS	CDK1
GeneWiki	Cdk1 Cyclin-dependent_kinase_1
GenomeRNAi	983
NextBio	4122
PRO	PR:P06493
Proteomes	UP000005640
Bgee	P06493
CleanEx	HS_CDC2
ExpressionAtlas	P06493
Genevisible	P06493
GO	GO:0005813 GO:0005737 GO:0005829 GO:0070062 GO:0016020 GO:0030496 GO:0005739 GO:0072686 GO:0005654 GO:0005634 GO:0005876 GO:0005524 GO:0004693 GO:0004672 GO:0004674 GO:0008353 GO:0000187 GO:0000186 GO:0031145 GO:0006915 GO:0007411 GO:0051301 GO:0016477 GO:0007098 GO:0006281 GO:0006260 GO:0007173 GO:0030855 GO:0038095 GO:0008543 GO:0000082 GO:0000086 GO:0045087 GO:0008286 GO:0000165 GO:0000226 GO:0000278 GO:0007095 GO:0007067 GO:0007077 GO:0002755 GO:0002756 GO:0043066 GO:0048011 GO:0006996 GO:0018105 GO:0018107 GO:0051437 GO:0007344 GO:0034501 GO:0007265 GO:0045995 GO:0014038 GO:0000083 GO:0051439 GO:0007264 GO:0051403 GO:0034166 GO:0034134 GO:0034138 GO:0034142 GO:0034146 GO:0034162 GO:0002224 GO:0038123 GO:0038124 GO:0035666 GO:0048010
InterPro	IPR011009 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	PMID:23601106^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:27238018^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	PMID:27238018^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0097472	cyclin-dependent protein kinase activity	PMID:1312467^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	PMID:1312467^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0030332	cyclin binding	PMID:1312467^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P20248	F		Seeded From UniProt	complete
involved_in	GO:1905448	positive regulation of mitochondrial ATP synthesis coupled electron transport	PMID:24746669^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	PMID:24746669^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900182	positive regulation of protein localization to nucleus	PMID:21871177^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P23396)	Seeded From UniProt	complete
enables	GO:0035173	histone kinase activity	PMID:21871177^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21871177^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(UniProtKB:P23396)	Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	PMID:19135898^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0090166	Golgi disassembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P39951	P		Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:11298763^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q9H1E3)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[9]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
involved_in	GO:0030855	epithelial cell differentiation	PMID:21492153^[10]	ECO:0000270	expression pattern evidence used in manual assertion		P	results_in_acquisition_of_features_of:(CL:1000334)	Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:19879842^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:19879842^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:Q9XTF3)	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:24746669^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	PMID:24746669^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0030332	cyclin binding	PMID:24746669^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P14635	F		Seeded From UniProt	complete
part_of	GO:0097125	cyclin B1-CDK1 complex	PMID:24746669^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0005759	mitochondrial matrix	PMID:24746669^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:23509069^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:23509069^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:9001210^[13]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0034501	protein localization to kinetochore	PMID:18195732^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:11298763^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q9H1E3)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:11298763^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:Q9H1E3)	Seeded From UniProt	complete
part_of	GO:0072686	mitotic spindle	PMID:17488717^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:11069302^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030496	midbody	PMID:11069302^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	PMID:12721286^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005876	spindle microtubule	PMID:11069302^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:17488717^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	PMID:18477460^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	PMID:11069302^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:23574715^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:23574715^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0072686	mitotic spindle	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002373207 UniProtKB:P06493	C		Seeded From UniProt	complete
involved_in	GO:0044772	mitotic cell cycle phase transition	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88351 PANTHER:PTN002373207	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004106 FB:FBgn0005640 FB:FBgn0013435 FB:FBgn0013762 FB:FBgn0015618 FB:FBgn0263237 MGI:MGI:101765 MGI:MGI:104772 MGI:MGI:88351 MGI:MGI:88357 PANTHER:PTN000623091 RGD:621124 RGD:70514 SGD:S000001622 SGD:S000001865 SGD:S000005488 SGD:S000005952 SGD:S000005963 SGD:S000006365 TAIR:locus:2119961 UniProtKB:P06493 UniProtKB:P11802 UniProtKB:P21127 UniProtKB:P24941 UniProtKB:P50750 UniProtKB:Q00534 UniProtKB:Q00646 UniProtKB:Q9UQ88 WB:WBGene00000405 WB:WBGene00000407 WB:WBGene00019362 ZFIN:ZDB-GENE-040808-34 dictyBase:DDB_G0267442 dictyBase:DDB_G0272813 dictyBase:DDB_G0288677	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002373207 RGD:2319 WB:WBGene00000405	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015618 FB:FBgn0019949 FB:FBgn0263237 MGI:MGI:101765 MGI:MGI:102956 MGI:MGI:104772 MGI:MGI:1328368 MGI:MGI:88353 MGI:MGI:88357 MGI:MGI:894318 PANTHER:PTN000623091 PomBase:SPAC2F3.15 PomBase:SPBC11B10.09 PomBase:SPBC32H8.10 RGD:1305435 RGD:1359638 RGD:2319 RGD:619874 RGD:621120 RGD:621124 RGD:70486 RGD:70514 SGD:S000000364 SGD:S000001622 SGD:S000002266 SGD:S000005952 TAIR:locus:2008595 TAIR:locus:2027819 TAIR:locus:2033349 TAIR:locus:2080290 TAIR:locus:2084086 TAIR:locus:2099478 TAIR:locus:2119961 TAIR:locus:2158554 TAIR:locus:2194045 UniProtKB:O76039 UniProtKB:O94921 UniProtKB:P06493 UniProtKB:P11802 UniProtKB:P21127 UniProtKB:P24941 UniProtKB:P49336 UniProtKB:P50613 UniProtKB:P61075 UniProtKB:P79432 UniProtKB:Q00534 UniProtKB:Q00535 UniProtKB:Q00646 UniProtKB:Q5B3E4 UniProtKB:Q8IDW1 UniProtKB:Q8IIL5 UniProtKB:Q8IJQ1 UniProtKB:Q8RWN3 UniProtKB:Q8W4P1 UniProtKB:Q92772 UniProtKB:Q96VK3 UniProtKB:Q9NYV4 UniProtKB:Q9UQ88 WB:WBGene00000405 dictyBase:DDB_G0267442 dictyBase:DDB_G0288677	C		Seeded From UniProt	complete
enables	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004106 FB:FBgn0005640 FB:FBgn0013762 FB:FBgn0019949 FB:FBgn0263237 MGI:MGI:104772 MGI:MGI:88351 MGI:MGI:88357 PANTHER:PTN000623091 PomBase:SPAC23H4.17c PomBase:SPAC2F3.15 PomBase:SPBC11B10.09 PomBase:SPBC19F8.07 PomBase:SPBC32H8.10 RGD:2319 RGD:621120 RGD:621124 RGD:70486 RGD:70514 SGD:S000000364 SGD:S000001622 SGD:S000005952 SGD:S000005963 SGD:S000006365 TAIR:locus:2011761 UniProtKB:A0A1D8PDA6 UniProtKB:C9K505 UniProtKB:O94921 UniProtKB:P06493 UniProtKB:P11802 UniProtKB:P24941 UniProtKB:P50750 UniProtKB:P61075 UniProtKB:Q00534 UniProtKB:Q00646 UniProtKB:Q8IJQ1 WB:WBGene00000405 ZFIN:ZDB-GENE-010131-2 dictyBase:DDB_G0272813 dictyBase:DDB_G0288677	F		Seeded From UniProt	complete
enables	GO:0030332	cyclin binding	PMID:7739547^[21]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16109376^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:22854038^[23]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016572	histone phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0035173	P		Seeded From UniProt	complete
involved_in	GO:0016572	histone phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0035173	P		Seeded From UniProt	complete
involved_in	GO:0046718	viral entry into host cell	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0001618	P		Seeded From UniProt	complete
involved_in	GO:0044772	mitotic cell cycle phase transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11440 ensembl:ENSMUSP00000020099	P		Seeded From UniProt	complete
enables	GO:0030544	Hsp70 protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11440 ensembl:ENSMUSP00000020099	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11440 ensembl:ENSMUSP00000020099	F		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11440 ensembl:ENSMUSP00000020099	P		Seeded From UniProt	complete
involved_in	GO:0007095	mitotic G2 DNA damage checkpoint	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11440 ensembl:ENSMUSP00000020099	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11440 ensembl:ENSMUSP00000020099	P		Seeded From UniProt	complete
	GO:0004674	protein serine/threonine kinase activity	PMID:27030108^[24]	ECO:0000314			F		Figure 4	complete CACAO 11721
part_of	GO:0005759	mitochondrial matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11440 ensembl:ENSMUSP00000020099	C		Seeded From UniProt	complete
	GO:0005737	cytoplasm	PMID:15767402^[25]	ECO:0000314			C		HUMAN CDK1 // Cdk1 was found diffusely in the cytoplasm in uninfected cells and cells expressing β-galactosidase(Fig. 2B).	complete CACAO 12365
enables	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11440 ensembl:ENSMUSP00000020099	F		Seeded From UniProt	complete
	GO:0005634	nucleus	PMID:15767402^[25]	ECO:0000314			C		HUMAN CDK1 // Cdk1 was found diffusely in the nucleus of uninfected cells and in cells expressing β-galactosidase (Fig. 2B).	complete CACAO 12366
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11440 ensembl:ENSMUSP00000020099	F		Seeded From UniProt	complete
involved_in	GO:0090166	Golgi disassembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39951 ensembl:ENSRNOP00000070138	P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39951 ensembl:ENSRNOP00000070138	P		Seeded From UniProt	complete
involved_in	GO:0065003	protein-containing complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39951 ensembl:ENSRNOP00000070138	P		Seeded From UniProt	complete
involved_in	GO:0060045	positive regulation of cardiac muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39951 ensembl:ENSRNOP00000070138	P		Seeded From UniProt	complete
involved_in	GO:0055015	ventricular cardiac muscle cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39951 ensembl:ENSRNOP00000070138	P		Seeded From UniProt	complete
involved_in	GO:0048678	response to axon injury	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39951 ensembl:ENSRNOP00000070138	P		Seeded From UniProt	complete
involved_in	GO:0046688	response to copper ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39951 ensembl:ENSRNOP00000070138	P		Seeded From UniProt	complete
involved_in	GO:0046686	response to cadmium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39951 ensembl:ENSRNOP00000070138	P		Seeded From UniProt	complete
involved_in	GO:0045931	positive regulation of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39951 ensembl:ENSRNOP00000070138	P		Seeded From UniProt	complete
involved_in	GO:0045740	positive regulation of DNA replication	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39951 ensembl:ENSRNOP00000070138	P		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39951 ensembl:ENSRNOP00000070138	P		Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39951 ensembl:ENSRNOP00000070138	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39951 ensembl:ENSRNOP00000070138	P		Seeded From UniProt	complete
enables	GO:0035173	histone kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39951 ensembl:ENSRNOP00000070138	F		Seeded From UniProt	complete
involved_in	GO:0031100	animal organ regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39951 ensembl:ENSRNOP00000070138	P		Seeded From UniProt	complete
enables	GO:0030332	cyclin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39951 ensembl:ENSRNOP00000070138	F		Seeded From UniProt	complete
involved_in	GO:0030261	chromosome condensation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39951 ensembl:ENSRNOP00000070138	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39951 ensembl:ENSRNOP00000070138	P		Seeded From UniProt	complete
involved_in	GO:0014823	response to activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39951 ensembl:ENSRNOP00000070138	P		Seeded From UniProt	complete
involved_in	GO:0014075	response to amine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39951 ensembl:ENSRNOP00000070138	P		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39951 ensembl:ENSRNOP00000070138	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39951 ensembl:ENSRNOP00000070138	P		Seeded From UniProt	complete
involved_in	GO:0010243	response to organonitrogen compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39951 ensembl:ENSRNOP00000070138	P		Seeded From UniProt	complete
involved_in	GO:0009636	response to toxic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39951 ensembl:ENSRNOP00000070138	P		Seeded From UniProt	complete
involved_in	GO:0007569	cell aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39951 ensembl:ENSRNOP00000070138	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39951 ensembl:ENSRNOP00000070138	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39951 ensembl:ENSRNOP00000070138	C		Seeded From UniProt	complete
enables	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39951 ensembl:ENSRNOP00000070138	F		Seeded From UniProt	complete
involved_in	GO:0000278	mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39951 ensembl:ENSRNOP00000070138	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
enables	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.23	F		Seeded From UniProt	complete
enables	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.22	F		Seeded From UniProt	complete
involved_in	GO:0045995	regulation of embryonic development	PMID:21535261^[26]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:17200138^[27]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014038	regulation of Schwann cell differentiation	PMID:17200138^[27]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007344	pronuclear fusion	PMID:21535261^[26]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007098	centrosome cycle	PMID:19364923^[28]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	PMID:21655336^[29]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	PMID:21655336^[29]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:19917720^[30]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000226	microtubule cytoskeleton organization	PMID:21655336^[29]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901990	regulation of mitotic cell cycle phase transition	Reactome:R-HSA-176412	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097711	ciliary basal body-plasma membrane docking	Reactome:R-HSA-5620912	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031145	anaphase-promoting complex-dependent catabolic process	Reactome:R-HSA-174184 Reactome:R-HSA-174143 Reactome:R-HSA-174048	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	Reactome:R-HSA-5688426	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010389	regulation of G2/M transition of mitotic cell cycle	Reactome:R-HSA-8854518	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007077	mitotic nuclear envelope disassembly	Reactome:R-HSA-2980766	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	Reactome:R-HSA-6791312	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006367	transcription initiation from RNA polymerase II promoter	Reactome:R-HSA-212436	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-NUL-2422970 Reactome:R-HSA-8853419 Reactome:R-HSA-8853405 Reactome:R-HSA-6803875 Reactome:R-HSA-5638009 Reactome:R-HSA-5626699 Reactome:R-HSA-5626681 Reactome:R-HSA-5626228 Reactome:R-HSA-5626227 Reactome:R-HSA-5626223 Reactome:R-HSA-5626220 Reactome:R-HSA-5617816 Reactome:R-HSA-4086410 Reactome:R-HSA-380508 Reactome:R-HSA-380455 Reactome:R-HSA-380316 Reactome:R-HSA-380311 Reactome:R-HSA-380303 Reactome:R-HSA-380294 Reactome:R-HSA-380283 Reactome:R-HSA-380272 Reactome:R-HSA-3000319 Reactome:R-HSA-3000310 Reactome:R-HSA-2990882 Reactome:R-HSA-2984220 Reactome:R-HSA-2574845 Reactome:R-HSA-2574840 Reactome:R-HSA-2468293 Reactome:R-HSA-2468287 Reactome:R-HSA-174255 Reactome:R-HSA-174227 Reactome:R-HSA-174171 Reactome:R-HSA-174157 Reactome:R-HSA-174120 Reactome:R-HSA-174104 Reactome:R-HSA-170161 Reactome:R-HSA-170131 Reactome:R-HSA-170126 Reactome:R-HSA-170088 Reactome:R-HSA-170084 Reactome:R-HSA-170072 Reactome:R-HSA-170057 Reactome:R-HSA-170055 Reactome:R-HSA-170044 Reactome:R-HSA-112342	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	Reactome:R-HSA-8940100	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-NUL-2434198 Reactome:R-HSA-9009282 Reactome:R-HSA-69756 Reactome:R-HSA-69754 Reactome:R-HSA-6793661 Reactome:R-HSA-5692755 Reactome:R-HSA-5244669 Reactome:R-HSA-5195402 Reactome:R-HSA-4088024 Reactome:R-HSA-380278 Reactome:R-HSA-2294600 Reactome:R-HSA-2245218 Reactome:R-HSA-174251 Reactome:R-HSA-174132 Reactome:R-HSA-174122 Reactome:R-HSA-170158 Reactome:R-HSA-170153 Reactome:R-HSA-170131 Reactome:R-HSA-170088 Reactome:R-HSA-170087 Reactome:R-HSA-170076 Reactome:R-HSA-170072 Reactome:R-HSA-170070 Reactome:R-HSA-170044	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	Reactome:R-HSA-69756 Reactome:R-HSA-69754 Reactome:R-HSA-5692755 Reactome:R-HSA-4088024	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	Reactome:R-HSA-8940100 Reactome:R-HSA-112342	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	Reactome:R-HSA-112409	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000086	G2/M transition of mitotic cell cycle	Reactome:R-HSA-69275	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001618	virus receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1183	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C		Seeded From UniProt	complete
part_of	GO:0005819	spindle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0251	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ White, TE et al. (2013) The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation. Cell Host Microbe 13 441-51 PubMed GONUTS page
↑ ^2.0 ^2.1 Zhao, X et al. (2016) Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation. Cell 165 1644-1657 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Pagano, M et al. (1992) Cyclin A is required at two points in the human cell cycle. EMBO J. 11 961-71 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Wang, Z et al. (2014) Cyclin B1/Cdk1 coordinates mitochondrial respiration for cell-cycle G2/M progression. Dev. Cell 29 217-32 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Yoon, IS et al. (2011) Ribosomal protein S3 is phosphorylated by Cdk1/cdc2 during G2/M phase. BMB Rep 44 529-34 PubMed GONUTS page
↑ Déjardin, J & Kingston, RE (2009) Purification of proteins associated with specific genomic Loci. Cell 136 175-86 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Ostvold, AC et al. (2001) Molecular cloning of a mammalian nuclear phosphoprotein NUCKS, which serves as a substrate for Cdk1 in vivo. Eur. J. Biochem. 268 2430-40 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ Buhrke, T et al. (2011) Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2. Dev. Growth Differ. 53 411-26 PubMed GONUTS page
↑ ^11.0 ^11.1 Cheng, KC et al. (2009) Regulation of MBK-2/DYRK by CDK-1 and the pseudophosphatases EGG-4 and EGG-5 during the oocyte-to-embryo transition. Cell 139 560-72 PubMed GONUTS page
↑ ^12.0 ^12.1 Zhu, M et al. (2013) MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression. J. Cell Biol. 200 773-87 PubMed GONUTS page
↑ Liu, F et al. (1997) The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex. Mol. Cell. Biol. 17 571-83 PubMed GONUTS page
↑ Chen, Q et al. (2008) Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis. Cell Res. 18 268-80 PubMed GONUTS page
↑ ^15.0 ^15.1 North, BJ & Verdin, E (2007) Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation. J. Biol. Chem. 282 19546-55 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 O'Connor, DS et al. (2000) Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin. Proc. Natl. Acad. Sci. U.S.A. 97 13103-7 PubMed GONUTS page
↑ Yeo, M et al. (2003) A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. J. Biol. Chem. 278 26078-85 PubMed GONUTS page
↑ Yamashiro, S et al. (2008) Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1. Dev. Cell 14 787-97 PubMed GONUTS page
↑ ^19.0 ^19.1 Maier, B et al. (2013) The novel actin/focal adhesion-associated protein MISP is involved in mitotic spindle positioning in human cells. Cell Cycle 12 1457-71 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 ^20.4 ^20.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Hirai, H et al. (1995) Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. Mol. Cell. Biol. 15 2672-81 PubMed GONUTS page
↑ Jang, MK et al. (2005) The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription. Mol. Cell 19 523-34 PubMed GONUTS page
↑ Jordan, PW et al. (2012) Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes. J. Cell. Sci. 125 5061-72 PubMed GONUTS page
↑ Iimori, M et al. (2016) Phosphorylation of EB2 by Aurora B and CDK1 ensures mitotic progression and genome stability. Nat Commun 7 11117 PubMed GONUTS page
↑ ^25.0 ^25.1 Davy, CE et al. (2005) Human papillomavirus type 16 E1 E4-induced G2 arrest is associated with cytoplasmic retention of active Cdk1/cyclin B1 complexes. J. Virol. 79 3998-4011 PubMed GONUTS page
↑ ^26.0 ^26.1 Hu, X & Moscinski, LC (2011) Cdc2: a monopotent or pluripotent CDK? Cell Prolif. 44 205-11 PubMed GONUTS page
↑ ^27.0 ^27.1 Han, IS et al. (2007) Cdc2-mediated Schwann cell migration during peripheral nerve regeneration. J. Cell. Sci. 120 246-55 PubMed GONUTS page
↑ Lindqvist, A et al. (2009) The decision to enter mitosis: feedback and redundancy in the mitotic entry network. J. Cell Biol. 185 193-202 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 Medema, RH & Macurek, L (2011) Checkpoint recovery in cells: how a molecular understanding can help in the fight against cancer. F1000 Biol Rep 3 10 PubMed GONUTS page
↑ Terrano, DT et al. (2010) Cyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosis. Mol. Cell. Biol. 30 640-56 PubMed GONUTS page

[PMID:23601106-1] White, TE et al. (2013) The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation. Cell Host Microbe 13 441-51 PubMed GONUTS page

[PMID:27238018-2] 2.0 ^2.1 Zhao, X et al. (2016) Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation. Cell 165 1644-1657 PubMed GONUTS page

[PMID:1312467-3] 3.0 ^3.1 ^3.2 Pagano, M et al. (1992) Cyclin A is required at two points in the human cell cycle. EMBO J. 11 961-71 PubMed GONUTS page

[PMID:24746669-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Wang, Z et al. (2014) Cyclin B1/Cdk1 coordinates mitochondrial respiration for cell-cycle G2/M progression. Dev. Cell 29 217-32 PubMed GONUTS page

[PMID:21871177-5] 5.0 ^5.1 ^5.2 Yoon, IS et al. (2011) Ribosomal protein S3 is phosphorylated by Cdk1/cdc2 during G2/M phase. BMB Rep 44 529-34 PubMed GONUTS page

[PMID:19135898-6] Déjardin, J & Kingston, RE (2009) Purification of proteins associated with specific genomic Loci. Cell 136 175-86 PubMed GONUTS page

[PMID:11298763-7] 7.0 ^7.1 ^7.2 Ostvold, AC et al. (2001) Molecular cloning of a mammalian nuclear phosphoprotein NUCKS, which serves as a substrate for Cdk1 in vivo. Eur. J. Biochem. 268 2430-40 PubMed GONUTS page

[PMID:19946888-8] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:19056867-9] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:21492153-10] Buhrke, T et al. (2011) Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2. Dev. Growth Differ. 53 411-26 PubMed GONUTS page

[PMID:19879842-11] 11.0 ^11.1 Cheng, KC et al. (2009) Regulation of MBK-2/DYRK by CDK-1 and the pseudophosphatases EGG-4 and EGG-5 during the oocyte-to-embryo transition. Cell 139 560-72 PubMed GONUTS page

[PMID:23509069-12] 12.0 ^12.1 Zhu, M et al. (2013) MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression. J. Cell Biol. 200 773-87 PubMed GONUTS page

[PMID:9001210-13] Liu, F et al. (1997) The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex. Mol. Cell. Biol. 17 571-83 PubMed GONUTS page

[PMID:18195732-14] Chen, Q et al. (2008) Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis. Cell Res. 18 268-80 PubMed GONUTS page

[PMID:17488717-15] 15.0 ^15.1 North, BJ & Verdin, E (2007) Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation. J. Biol. Chem. 282 19546-55 PubMed GONUTS page

[PMID:11069302-16] 16.0 ^16.1 ^16.2 ^16.3 O'Connor, DS et al. (2000) Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin. Proc. Natl. Acad. Sci. U.S.A. 97 13103-7 PubMed GONUTS page

[PMID:12721286-17] Yeo, M et al. (2003) A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. J. Biol. Chem. 278 26078-85 PubMed GONUTS page

[PMID:18477460-18] Yamashiro, S et al. (2008) Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1. Dev. Cell 14 787-97 PubMed GONUTS page

[PMID:23574715-19] 19.0 ^19.1 Maier, B et al. (2013) The novel actin/focal adhesion-associated protein MISP is involved in mitotic spindle positioning in human cells. Cell Cycle 12 1457-71 PubMed GONUTS page

[PMID:21873635-20] 20.0 ^20.1 ^20.2 ^20.3 ^20.4 ^20.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:7739547-21] Hirai, H et al. (1995) Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. Mol. Cell. Biol. 15 2672-81 PubMed GONUTS page

[PMID:16109376-22] Jang, MK et al. (2005) The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription. Mol. Cell 19 523-34 PubMed GONUTS page

[PMID:22854038-23] Jordan, PW et al. (2012) Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes. J. Cell. Sci. 125 5061-72 PubMed GONUTS page

[PMID:27030108-24] Iimori, M et al. (2016) Phosphorylation of EB2 by Aurora B and CDK1 ensures mitotic progression and genome stability. Nat Commun 7 11117 PubMed GONUTS page

[PMID:15767402-25] 25.0 ^25.1 Davy, CE et al. (2005) Human papillomavirus type 16 E1 E4-induced G2 arrest is associated with cytoplasmic retention of active Cdk1/cyclin B1 complexes. J. Virol. 79 3998-4011 PubMed GONUTS page

[PMID:21535261-26] 26.0 ^26.1 Hu, X & Moscinski, LC (2011) Cdc2: a monopotent or pluripotent CDK? Cell Prolif. 44 205-11 PubMed GONUTS page

[PMID:17200138-27] 27.0 ^27.1 Han, IS et al. (2007) Cdc2-mediated Schwann cell migration during peripheral nerve regeneration. J. Cell. Sci. 120 246-55 PubMed GONUTS page

[PMID:19364923-28] Lindqvist, A et al. (2009) The decision to enter mitosis: feedback and redundancy in the mitotic entry network. J. Cell Biol. 185 193-202 PubMed GONUTS page

[PMID:21655336-29] 29.0 ^29.1 ^29.2 Medema, RH & Macurek, L (2011) Checkpoint recovery in cells: how a molecular understanding can help in the fight against cancer. F1000 Biol Rep 3 10 PubMed GONUTS page

[PMID:19917720-30] Terrano, DT et al. (2010) Cyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosis. Mol. Cell. Biol. 30 640-56 PubMed GONUTS page

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HUMAN:CDK1

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