HUMAN:CBX5

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CBX5 (synonyms: HP1A)
Protein Name(s)	Chromobox protein homolog 5 Antigen p25 Heterochromatin protein 1 homolog alpha HP1 alpha
External Links
UniProt	P45973
EMBL	S62077 L07515 AK313506 CH471054 BC006821 U26311
CCDS	CCDS8875.1
PIR	G01808
RefSeq	NP_001120793.1 NP_001120794.1 NP_036249.1
UniGene	Hs.349283
PDB	3FDT 3I3C
PDBsum	3FDT 3I3C
ProteinModelPortal	P45973
SMR	P45973
BioGrid	117030
DIP	DIP-5986N
IntAct	P45973
MINT	MINT-1178082
STRING	9606.ENSP00000209875
PhosphoSite	P45973
DMDM	1170338
MaxQB	P45973
PaxDb	P45973
PeptideAtlas	P45973
PRIDE	P45973
DNASU	23468
Ensembl	ENST00000209875 ENST00000439541 ENST00000550411
GeneID	23468
KEGG	hsa:23468
UCSC	uc001sfh.4
CTD	23468
GeneCards	GC12M054624
HGNC	HGNC:1555
HPA	CAB017548 HPA016699
MIM	604478
neXtProt	NX_P45973
PharmGKB	PA26130
eggNOG	NOG132879
HOGENOM	HOG000220852
HOVERGEN	HBG000400
InParanoid	P45973
KO	K11587
OMA	SEFMKTY
OrthoDB	EOG7QRQWW
PhylomeDB	P45973
TreeFam	TF350503
Reactome	REACT_24970
ChiTaRS	CBX5
EvolutionaryTrace	P45973
GeneWiki	CBX5_(gene)
GenomeRNAi	23468
NextBio	45793
PRO	PR:P45973
Proteomes	UP000005640
Bgee	P45973
CleanEx	HS_CBX5
ExpressionAtlas	P45973
Genevestigator	P45973
GO	GO:0010369 GO:0000118 GO:0035097 GO:0000776 GO:0005635 GO:0005720 GO:0031618 GO:0005730 GO:0005654 GO:0005634 GO:0017053 GO:0003682 GO:0035064 GO:0030674 GO:0070491 GO:0007596 GO:0045892 GO:0016032
InterPro	IPR017984 IPR023780 IPR000953 IPR008251 IPR016197 IPR023779
Pfam	PF00385 PF01393
PRINTS	PR00504
SMART	SM00298 SM00300
SUPFAM	SSF54160
PROSITE	PS00598 PS50013

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:27248496^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_at:(GO:0005634)	Seeded From UniProt	complete
part_of	GO:0090734	site of DNA damage	PMID:27248496^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	part_of:(GO:0005634)	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:19617346^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:1990904	ribonucleoprotein complex	PMID:19617346^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19617346^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:19617346^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043021	ribonucleoprotein complex binding	PMID:19617346^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:19617346^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	PMID:19135898^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005721	pericentric heterochromatin	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61686	C		Seeded From UniProt	complete
enables	GO:0070491	repressing transcription factor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61686	F		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:9636146^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:9636147^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035097	histone methyltransferase complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61686	C		Seeded From UniProt	complete
part_of	GO:0031618	nuclear pericentric heterochromatin	PMID:16177824^[6]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0030674	protein binding, bridging	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61686	F		Seeded From UniProt	complete
part_of	GO:0017053	transcriptional repressor complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61686	C		Seeded From UniProt	complete
colocalizes_with	GO:0016605	PML body	PMID:9636146^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:9636146^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9636146^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000118	histone deacetylase complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61686	C		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:9636147^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035064	methylated histone binding	PMID:21029866^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0035064	methylated histone binding	PMID:19783980^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19783980^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21888893^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P45973	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:18716626^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P45973	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0070491	repressing transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61686 ensembl:ENSMUSP00000113157	F		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61686 ensembl:ENSMUSP00000113157	P		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61686 ensembl:ENSMUSP00000113157	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61686 ensembl:ENSMUSP00000113157	F		Seeded From UniProt	complete
part_of	GO:0035097	histone methyltransferase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61686 ensembl:ENSMUSP00000113157	C		Seeded From UniProt	complete
enables	GO:0035064	methylated histone binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61686 ensembl:ENSMUSP00000113157	F		Seeded From UniProt	complete
enables	GO:0030674	protein binding, bridging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61686 ensembl:ENSMUSP00000113157	F		Seeded From UniProt	complete
part_of	GO:0017053	transcriptional repressor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61686 ensembl:ENSMUSP00000113157	C		Seeded From UniProt	complete
part_of	GO:0010369	chromocenter	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61686 ensembl:ENSMUSP00000113157	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61686 ensembl:ENSMUSP00000113157	C		Seeded From UniProt	complete
part_of	GO:0005721	pericentric heterochromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61686 ensembl:ENSMUSP00000113157	C		Seeded From UniProt	complete
part_of	GO:0005720	nuclear heterochromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61686 ensembl:ENSMUSP00000113157	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61686 ensembl:ENSMUSP00000113157	C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61686 ensembl:ENSMUSP00000113157	F		Seeded From UniProt	complete
part_of	GO:0000792	heterochromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61686 ensembl:ENSMUSP00000113157	C		Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61686 ensembl:ENSMUSP00000113157	C		Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61686 ensembl:ENSMUSP00000113157	C		Seeded From UniProt	complete
part_of	GO:0000118	histone deacetylase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61686 ensembl:ENSMUSP00000113157	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008251	C		Seeded From UniProt	complete
part_of	GO:0005720	nuclear heterochromatin	PMID:8663349^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	PMID:8663349^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070317	negative regulation of G0 to G1 transition	Reactome:R-HSA-8953750	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	Reactome:R-HSA-109582	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-994106 Reactome:R-HSA-9007646	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000775	chromosome, centromeric region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0137 UniProtKB-SubCell:SL-0047	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Gilmore, JM et al. (2016) WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage. PLoS ONE 11 e0155492 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Ameyar-Zazoua, M et al. (2009) Physical and functional interaction between heterochromatin protein 1alpha and the RNA-binding protein heterogeneous nuclear ribonucleoprotein U. J. Biol. Chem. 284 27974-9 PubMed GONUTS page
↑ Déjardin, J & Kingston, RE (2009) Purification of proteins associated with specific genomic Loci. Cell 136 175-86 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Seeler, JS et al. (1998) Interaction of SP100 with HP1 proteins: a link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment. Proc. Natl. Acad. Sci. U.S.A. 95 7316-21 PubMed GONUTS page
↑ ^5.0 ^5.1 Lehming, N et al. (1998) Chromatin components as part of a putative transcriptional repressing complex. Proc. Natl. Acad. Sci. U.S.A. 95 7322-6 PubMed GONUTS page
↑ Ling, PD et al. (2005) Mediation of Epstein-Barr virus EBNA-LP transcriptional coactivation by Sp100. EMBO J. 24 3565-75 PubMed GONUTS page
↑ Bartke, T et al. (2010) Nucleosome-interacting proteins regulated by DNA and histone methylation. Cell 143 470-84 PubMed GONUTS page
↑ ^8.0 ^8.1 Dawson, MA et al. (2009) JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature 461 819-22 PubMed GONUTS page
↑ Rosnoblet, C et al. (2011) Analysis of the human HP1 interactome reveals novel binding partners. Biochem. Biophys. Res. Commun. 413 206-11 PubMed GONUTS page
↑ Yamagishi, Y et al. (2008) Heterochromatin links to centromeric protection by recruiting shugoshin. Nature 455 251-5 PubMed GONUTS page
↑ ^11.0 ^11.1 Ye, Q & Worman, HJ (1996) Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1. J. Biol. Chem. 271 14653-6 PubMed GONUTS page

[PMID:27248496-1] 1.0 ^1.1 Gilmore, JM et al. (2016) WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage. PLoS ONE 11 e0155492 PubMed GONUTS page

[PMID:19617346-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Ameyar-Zazoua, M et al. (2009) Physical and functional interaction between heterochromatin protein 1alpha and the RNA-binding protein heterogeneous nuclear ribonucleoprotein U. J. Biol. Chem. 284 27974-9 PubMed GONUTS page

[PMID:19135898-3] Déjardin, J & Kingston, RE (2009) Purification of proteins associated with specific genomic Loci. Cell 136 175-86 PubMed GONUTS page

[PMID:9636146-4] 4.0 ^4.1 ^4.2 ^4.3 Seeler, JS et al. (1998) Interaction of SP100 with HP1 proteins: a link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment. Proc. Natl. Acad. Sci. U.S.A. 95 7316-21 PubMed GONUTS page

[PMID:9636147-5] 5.0 ^5.1 Lehming, N et al. (1998) Chromatin components as part of a putative transcriptional repressing complex. Proc. Natl. Acad. Sci. U.S.A. 95 7322-6 PubMed GONUTS page

[PMID:16177824-6] Ling, PD et al. (2005) Mediation of Epstein-Barr virus EBNA-LP transcriptional coactivation by Sp100. EMBO J. 24 3565-75 PubMed GONUTS page

[PMID:21029866-7] Bartke, T et al. (2010) Nucleosome-interacting proteins regulated by DNA and histone methylation. Cell 143 470-84 PubMed GONUTS page

[PMID:19783980-8] 8.0 ^8.1 Dawson, MA et al. (2009) JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature 461 819-22 PubMed GONUTS page

[PMID:21888893-9] Rosnoblet, C et al. (2011) Analysis of the human HP1 interactome reveals novel binding partners. Biochem. Biophys. Res. Commun. 413 206-11 PubMed GONUTS page

[PMID:18716626-10] Yamagishi, Y et al. (2008) Heterochromatin links to centromeric protection by recruiting shugoshin. Nature 455 251-5 PubMed GONUTS page

[PMID:8663349-11] 11.0 ^11.1 Ye, Q & Worman, HJ (1996) Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1. J. Biol. Chem. 271 14653-6 PubMed GONUTS page

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HUMAN:CBX5

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Annotations

Notes

References

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