GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HUMAN:CBX3
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | CBX3 | |
| Protein Name(s) | Chromobox protein homolog 3
HECH Heterochromatin protein 1 homolog gamma HP1 gamma Modifier 2 protein | |
| External Links | ||
| UniProt | Q13185 | |
| EMBL | U26312 AB030905 AF136630 BC000954 BC014380 | |
| CCDS | CCDS5398.1 | |
| RefSeq | NP_009207.2 NP_057671.2 XP_005249668.1 | |
| UniGene | Hs.381189 | |
| PDB | 2L11 3DM1 3KUP 3TZD | |
| PDBsum | 2L11 3DM1 3KUP 3TZD | |
| ProteinModelPortal | Q13185 | |
| SMR | Q13185 | |
| BioGrid | 116463 | |
| DIP | DIP-5985N | |
| IntAct | Q13185 | |
| MINT | MINT-5002782 | |
| STRING | 9606.ENSP00000336687 | |
| PhosphoSite | Q13185 | |
| DMDM | 116241284 | |
| SWISS-2DPAGE | Q13185 | |
| MaxQB | Q13185 | |
| PaxDb | Q13185 | |
| PeptideAtlas | Q13185 | |
| PRIDE | Q13185 | |
| DNASU | 11335 | |
| Ensembl | ENST00000337620 ENST00000396386 | |
| GeneID | 11335 | |
| KEGG | hsa:11335 | |
| UCSC | uc003sxt.3 | |
| CTD | 11335 | |
| GeneCards | GC07P026240 | |
| HGNC | HGNC:1553 | |
| HPA | CAB001973 HPA004902 | |
| MIM | 604477 | |
| neXtProt | NX_Q13185 | |
| PharmGKB | PA26128 | |
| eggNOG | NOG264487 | |
| GeneTree | ENSGT00510000046310 | |
| HOGENOM | HOG000220852 | |
| HOVERGEN | HBG000400 | |
| InParanoid | Q13185 | |
| KO | K11586 | |
| OMA | RESADKP | |
| OrthoDB | EOG7QRQWW | |
| PhylomeDB | Q13185 | |
| TreeFam | TF350503 | |
| Reactome | REACT_2204 | |
| ChiTaRS | CBX3 | |
| EvolutionaryTrace | Q13185 | |
| GeneWiki | CBX3 | |
| GenomeRNAi | 11335 | |
| NextBio | 43065 | |
| PRO | PR:Q13185 | |
| Proteomes | UP000005640 | |
| Bgee | Q13185 | |
| CleanEx | HS_CBX3 | |
| ExpressionAtlas | Q13185 | |
| Genevestigator | Q13185 | |
| GO | GO:0000785 GO:0000779 GO:0005635 GO:0005719 GO:0005720 GO:0005637 GO:0031618 GO:0005634 GO:0005819 GO:0019899 GO:1990226 GO:0042802 GO:0019904 GO:0006338 GO:0045892 GO:0048511 GO:0006351 | |
| InterPro | IPR017984 IPR023780 IPR000953 IPR008251 IPR016197 IPR023779 | |
| Pfam | PF00385 PF01393 | |
| PRINTS | PR00504 | |
| SMART | SM00298 SM00300 | |
| SUPFAM | SSF54160 | |
| PROSITE | PS00598 PS50013 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_at:(GO:0005634) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0090734 |
site of DNA damage |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
part_of:(GO:0005634) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000784 |
nuclear chromosome, telomeric region |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000775 |
chromosome, centromeric region |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:1990226 |
histone methyltransferase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0000775 |
chromosome, centromeric region |
ECO:0000314 |
C |
Fig.1 |
complete | |||||
|
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031618 |
nuclear pericentric heterochromatin |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019904 |
protein domain specific binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019904 |
protein domain specific binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019899 |
enzyme binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006338 |
chromatin remodeling |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005819 |
spindle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005720 |
nuclear heterochromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005719 |
nuclear euchromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005637 |
nuclear inner membrane |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005635 |
nuclear envelope |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000785 |
chromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000779 |
condensed chromosome, centromeric region |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
occurs_in:(GO:0005634) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
occurs_in:(GO:0005634) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071549 |
cellular response to dexamethasone stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5RJK5 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0035985 |
senescence-associated heterochromatin focus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5RJK5 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5RJK5 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005719 |
nuclear euchromatin |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070317 |
negative regulation of G0 to G1 transition |
Reactome:R-HSA-8953750 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-9007467 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0006325 |
chromatin organization |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048511 |
rhythmic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Gilmore, JM et al. (2016) WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage. PLoS ONE 11 e0155492 PubMed GONUTS page
- ↑ Déjardin, J & Kingston, RE (2009) Purification of proteins associated with specific genomic Loci. Cell 136 175-86 PubMed GONUTS page
- ↑ 3.0 3.1 Everett, RD et al. (1999) A dynamic connection between centromeres and ND10 proteins. J. Cell. Sci. 112 ( Pt 20) 3443-54 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Souza, PP et al. (2009) The histone methyltransferase SUV420H2 and Heterochromatin Proteins HP1 interact but show different dynamic behaviours. BMC Cell Biol. 10 41 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Lehming, N et al. (1998) Chromatin components as part of a putative transcriptional repressing complex. Proc. Natl. Acad. Sci. U.S.A. 95 7322-6 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Ye, Q & Worman, HJ (1996) Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1. J. Biol. Chem. 271 14653-6 PubMed GONUTS page
- ↑ 7.0 7.1 Kourmouli, N et al. (2000) Dynamic associations of heterochromatin protein 1 with the nuclear envelope. EMBO J. 19 6558-68 PubMed GONUTS page
- ↑ 8.0 8.1 Minc, E et al. (2000) HP1gamma associates with euchromatin and heterochromatin in mammalian nuclei and chromosomes. Cytogenet. Cell Genet. 90 279-84 PubMed GONUTS page
- ↑ Trojer, P et al. (2007) L3MBTL1, a histone-methylation-dependent chromatin lock. Cell 129 915-28 PubMed GONUTS page
- ↑ Rosnoblet, C et al. (2011) Analysis of the human HP1 interactome reveals novel binding partners. Biochem. Biophys. Res. Commun. 413 206-11 PubMed GONUTS page
c
n
- GO:0045892 ! negative regulation of DNA-templated transcription
- GO:0070317 ! negative regulation of G0 to G1 transition
- GO:0000784 ! nuclear chromosome, telomeric region
- GO:0005635 ! nuclear envelope
- GO:0005719 ! nuclear euchromatin
- GO:0005720 ! nuclear heterochromatin
- GO:0005637 ! nuclear inner membrane
- GO:0031618 ! nuclear pericentric heterochromatin
- GO:0005654 ! nucleoplasm
- GO:0005634 ! nucleus
s
