HUMAN:BRCA2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	BRCA2 (synonyms: FACD, FANCD1)
Protein Name(s)	Breast cancer type 2 susceptibility protein Fanconi anemia group D1 protein
External Links
UniProt	P51587
EMBL	X95152 X95153 X95154 X95155 X95156 X95157 X95158 X95159 X95160 X95161 X95162 X95163 X95164 X95165 X95166 X95167 X95168 X95169 X95170 X95171 X95172 X95173 X95174 X95175 X95176 X95177 U43746 AY436640 AL137247 AL445212 AL445212 AL137247 Z74739 Z73359
CCDS	CCDS9344.1
PIR	G02334
RefSeq	NP_000050.2
UniGene	Hs.34012
PDB	1N0W 3EU7
PDBsum	1N0W 3EU7
ProteinModelPortal	P51587
SMR	P51587
BioGrid	107142
DIP	DIP-24214N
IntAct	P51587
MINT	MINT-1540184
STRING	9606.ENSP00000369497
PhosphoSite	P51587
DMDM	14424438
MaxQB	P51587
PaxDb	P51587
PRIDE	P51587
DNASU	675
Ensembl	ENST00000380152 ENST00000544455
GeneID	675
KEGG	hsa:675
UCSC	uc001uub.1
CTD	675
GeneCards	GC13P032889
GeneReviews	BRCA2
HGNC	HGNC:1101
HPA	HPA026815 HPA056112
MIM	114480 227650 600185 605724 612555 613029 613347
neXtProt	NX_P51587
Orphanet	1333 1331 84 145 227535 213524 319462
PharmGKB	PA25412
eggNOG	NOG331296
HOGENOM	HOG000139693
HOVERGEN	HBG050731
InParanoid	P51587
KO	K08775
OrthoDB	EOG75TMB1
PhylomeDB	P51587
TreeFam	TF105041
Reactome	REACT_18410 REACT_27271 REACT_408
SignaLink	P51587
EvolutionaryTrace	P51587
GeneWiki	BRCA2
GenomeRNAi	675
NextBio	2780
PRO	PR:P51587
Proteomes	UP000005640
Bgee	P51587
CleanEx	HS_BRCA2
ExpressionAtlas	P51587
Genevestigator	P51587
GO	GO:0033593 GO:0005813 GO:0005737 GO:0005654 GO:0005634 GO:0043234 GO:0030141 GO:0043015 GO:0010484 GO:0010485 GO:0002020 GO:0003697 GO:0007420 GO:0007569 GO:0051298 GO:0000910 GO:0006978 GO:0006281 GO:0006302 GO:0000724 GO:0008585 GO:0030097 GO:0043966 GO:0043967 GO:0001833 GO:0042771 GO:0007141 GO:0033600 GO:0006289 GO:0001556 GO:0045931 GO:0045893 GO:0032465 GO:0048478 GO:0010332 GO:0010225 GO:0010165 GO:0007283
Gene3D	2.40.50.140
InterPro	IPR015525 IPR015252 IPR015187 IPR015188 IPR002093 IPR012340 IPR015205
PANTHER	PTHR11289
Pfam	PF09169 PF09103 PF09104 PF00634 PF09121
PIRSF	PIRSF002397
SUPFAM	SSF50249 SSF81872
PROSITE	PS50138

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0000784	nuclear chromosome, telomeric region	PMID:21076401^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0000084)	Seeded From UniProt	complete
involved_in	GO:1990426	mitotic recombination-dependent replication fork processing	PMID:21076401^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(GO:0000784)	Seeded From UniProt	complete
involved_in	GO:0070200	establishment of protein localization to telomere	PMID:21076401^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q06609)	Seeded From UniProt	complete
involved_in	GO:0000724	double-strand break repair via homologous recombination	PMID:21719596^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051298	centrosome duplication	PMID:17286961^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:9126734^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043967	histone H4 acetylation	PMID:9619837^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043966	histone H3 acetylation	PMID:9619837^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:9774970^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0043015	gamma-tubulin binding	PMID:17286961^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P23258	F		Seeded From UniProt	complete
involved_in	GO:0033600	negative regulation of mammary gland epithelial cell proliferation	PMID:15930293^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0033593	BRCA2-MAGE-D1 complex	PMID:15930293^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	PMID:8589722^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0010485	H4 histone acetyltransferase activity	PMID:9619837^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0010484	H3 histone acetyltransferase activity	PMID:9619837^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:16845393^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006289	nucleotide-excision repair	PMID:16845393^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:21276791^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:17286961^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9560268^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17286961^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9774970^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
NOT\|enables	GO:0004402	histone acetyltransferase activity	PMID:9824164^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003697	single-stranded DNA binding	PMID:20729832^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:15314155^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P51784	F		Seeded From UniProt	complete
involved_in	GO:0000281	mitotic cytokinesis	PMID:17286961^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000724	double-strand break repair via homologous recombination	PMID:20729832^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0050169 MGI:MGI:109337 PANTHER:PTN000139032 UniProtKB:P51587	C		Seeded From UniProt	complete
involved_in	GO:0000724	double-strand break repair via homologous recombination	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0050169 MGI:MGI:109337 PANTHER:PTN000139030 TAIR:locus:2149800 UniProtKB:P51587	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:9774970^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:9774970^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000800	lateral element	PMID:9774970^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25282148^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P51587	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21601571^[17]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P51587	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070200	establishment of protein localization to telomere	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97929 ensembl:ENSMUSP00000038576	P		Seeded From UniProt	complete
involved_in	GO:0051276	chromosome organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97929 ensembl:ENSMUSP00000038576	P		Seeded From UniProt	complete
involved_in	GO:0048478	replication fork protection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97929 ensembl:ENSMUSP00000038576	P		Seeded From UniProt	complete
involved_in	GO:0045931	positive regulation of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97929 ensembl:ENSMUSP00000038576	P		Seeded From UniProt	complete
involved_in	GO:0043009	chordate embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97929 ensembl:ENSMUSP00000038576	P		Seeded From UniProt	complete
involved_in	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97929 ensembl:ENSMUSP00000038576	P		Seeded From UniProt	complete
involved_in	GO:0032465	regulation of cytokinesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97929 ensembl:ENSMUSP00000038576	P		Seeded From UniProt	complete
involved_in	GO:0030097	hemopoiesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97929 ensembl:ENSMUSP00000038576	P		Seeded From UniProt	complete
involved_in	GO:0010332	response to gamma radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97929 ensembl:ENSMUSP00000038576	P		Seeded From UniProt	complete
involved_in	GO:0010225	response to UV-C	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97929 ensembl:ENSMUSP00000038576	P		Seeded From UniProt	complete
involved_in	GO:0010165	response to X-ray	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97929 ensembl:ENSMUSP00000038576	P		Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97929 ensembl:ENSMUSP00000038576	P		Seeded From UniProt	complete
involved_in	GO:0008585	female gonad development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97929 ensembl:ENSMUSP00000038576	P		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97929 ensembl:ENSMUSP00000038576	P		Seeded From UniProt	complete
involved_in	GO:0007569	cell aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97929 ensembl:ENSMUSP00000038576	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97929 ensembl:ENSMUSP00000038576	P		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97929 ensembl:ENSMUSP00000038576	P		Seeded From UniProt	complete
involved_in	GO:0007141	male meiosis I	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97929 ensembl:ENSMUSP00000038576	P		Seeded From UniProt	complete
involved_in	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97929 ensembl:ENSMUSP00000038576	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97929 ensembl:ENSMUSP00000038576	P		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97929 ensembl:ENSMUSP00000038576	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97929 ensembl:ENSMUSP00000038576	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97929 ensembl:ENSMUSP00000038576	C		Seeded From UniProt	complete
involved_in	GO:0001833	inner cell mass cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97929 ensembl:ENSMUSP00000038576	P		Seeded From UniProt	complete
involved_in	GO:0001556	oocyte maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97929 ensembl:ENSMUSP00000038576	P		Seeded From UniProt	complete
involved_in	GO:0000724	double-strand break repair via homologous recombination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97929 ensembl:ENSMUSP00000038576	P		Seeded From UniProt	complete
involved_in	GO:0000722	telomere maintenance via recombination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97929 ensembl:ENSMUSP00000038576	P		Seeded From UniProt	complete
involved_in	GO:0000724	double-strand break repair via homologous recombination	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015187 InterPro:IPR015525	P		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015525	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-5693620 Reactome:R-HSA-5693593 Reactome:R-HSA-5693589 Reactome:R-HSA-5693584 Reactome:R-HSA-5693561 Reactome:R-HSA-5693539 Reactome:R-HSA-5686483 Reactome:R-HSA-5686469 Reactome:R-HSA-5686440 Reactome:R-HSA-5686410 Reactome:R-HSA-5685838 Reactome:R-HSA-5685341 Reactome:R-HSA-5685242	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006310	DNA recombination	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0233	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Badie, S et al. (2010) BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping. Nat. Struct. Mol. Biol. 17 1461-9 PubMed GONUTS page
↑ Biswas, K et al. (2011) A comprehensive functional characterization of BRCA2 variants associated with Fanconi anemia using mouse ES cell-based assay. Blood 118 2430-42 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Nakanishi, A et al. (2007) Interference with BRCA2, which localizes to the centrosome during S and early M phase, leads to abnormal nuclear division. Biochem. Biophys. Res. Commun. 355 34-40 PubMed GONUTS page
↑ Milner, J et al. (1997) Transcriptional activation functions in BRCA2. Nature 386 772-3 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Siddique, H et al. (1998) The BRCA2 is a histone acetyltransferase. Oncogene 16 2283-5 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Chen, J et al. (1998) Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol. Cell 2 317-28 PubMed GONUTS page
↑ ^7.0 ^7.1 Tian, XX et al. (2005) BRCA2 suppresses cell proliferation via stabilizing MAGE-D1. Cancer Res. 65 4747-53 PubMed GONUTS page
↑ Jensen, RA et al. (1996) BRCA1 is secreted and exhibits properties of a granin. Nat. Genet. 12 303-8 PubMed GONUTS page
↑ ^9.0 ^9.1 Cipak, L et al. (2006) The role of BRCA2 in replication-coupled DNA interstrand cross-link repair in vitro. Nat. Struct. Mol. Biol. 13 729-33 PubMed GONUTS page
↑ Cappelli, E et al. (2011) Homologous recombination proteins are associated with centrosomes and are required for mitotic stability. Exp. Cell Res. 317 1203-13 PubMed GONUTS page
↑ Chen, PL et al. (1998) The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment. Proc. Natl. Acad. Sci. U.S.A. 95 5287-92 PubMed GONUTS page
↑ Fuks, F et al. (1998) BRCA2 associates with acetyltransferase activity when bound to P/CAF. Oncogene 17 2531-4 PubMed GONUTS page
↑ ^13.0 ^13.1 Jensen, RB et al. (2010) Purified human BRCA2 stimulates RAD51-mediated recombination. Nature 467 678-83 PubMed GONUTS page
↑ Schoenfeld, AR et al. (2004) BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage. Mol. Cell. Biol. 24 7444-55 PubMed GONUTS page
↑ ^15.0 ^15.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Shahid, T et al. (2014) Structure and mechanism of action of the BRCA2 breast cancer tumor suppressor. Nat. Struct. Mol. Biol. 21 962-968 PubMed GONUTS page
↑ Ochiai, K et al. (2011) Valine 1532 of human BRC repeat 4 plays an important role in the interaction between BRCA2 and RAD51. FEBS Lett. 585 1771-7 PubMed GONUTS page

[PMID:21076401-1] 1.0 ^1.1 ^1.2 Badie, S et al. (2010) BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping. Nat. Struct. Mol. Biol. 17 1461-9 PubMed GONUTS page

[PMID:21719596-2] Biswas, K et al. (2011) A comprehensive functional characterization of BRCA2 variants associated with Fanconi anemia using mouse ES cell-based assay. Blood 118 2430-42 PubMed GONUTS page

[PMID:17286961-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Nakanishi, A et al. (2007) Interference with BRCA2, which localizes to the centrosome during S and early M phase, leads to abnormal nuclear division. Biochem. Biophys. Res. Commun. 355 34-40 PubMed GONUTS page

[PMID:9126734-4] Milner, J et al. (1997) Transcriptional activation functions in BRCA2. Nature 386 772-3 PubMed GONUTS page

[PMID:9619837-5] 5.0 ^5.1 ^5.2 ^5.3 Siddique, H et al. (1998) The BRCA2 is a histone acetyltransferase. Oncogene 16 2283-5 PubMed GONUTS page

[PMID:9774970-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Chen, J et al. (1998) Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol. Cell 2 317-28 PubMed GONUTS page

[PMID:15930293-7] 7.0 ^7.1 Tian, XX et al. (2005) BRCA2 suppresses cell proliferation via stabilizing MAGE-D1. Cancer Res. 65 4747-53 PubMed GONUTS page

[PMID:8589722-8] Jensen, RA et al. (1996) BRCA1 is secreted and exhibits properties of a granin. Nat. Genet. 12 303-8 PubMed GONUTS page

[PMID:16845393-9] 9.0 ^9.1 Cipak, L et al. (2006) The role of BRCA2 in replication-coupled DNA interstrand cross-link repair in vitro. Nat. Struct. Mol. Biol. 13 729-33 PubMed GONUTS page

[PMID:21276791-10] Cappelli, E et al. (2011) Homologous recombination proteins are associated with centrosomes and are required for mitotic stability. Exp. Cell Res. 317 1203-13 PubMed GONUTS page

[PMID:9560268-11] Chen, PL et al. (1998) The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment. Proc. Natl. Acad. Sci. U.S.A. 95 5287-92 PubMed GONUTS page

[PMID:9824164-12] Fuks, F et al. (1998) BRCA2 associates with acetyltransferase activity when bound to P/CAF. Oncogene 17 2531-4 PubMed GONUTS page

[PMID:20729832-13] 13.0 ^13.1 Jensen, RB et al. (2010) Purified human BRCA2 stimulates RAD51-mediated recombination. Nature 467 678-83 PubMed GONUTS page

[PMID:15314155-14] Schoenfeld, AR et al. (2004) BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage. Mol. Cell. Biol. 24 7444-55 PubMed GONUTS page

[PMID:21873635-15] 15.0 ^15.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25282148-16] Shahid, T et al. (2014) Structure and mechanism of action of the BRCA2 breast cancer tumor suppressor. Nat. Struct. Mol. Biol. 21 962-968 PubMed GONUTS page

[PMID:21601571-17] Ochiai, K et al. (2011) Valine 1532 of human BRC repeat 4 plays an important role in the interaction between BRCA2 and RAD51. FEBS Lett. 585 1771-7 PubMed GONUTS page

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HUMAN:BRCA2

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