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HUMAN:BACH1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | BACH1 | |
| Protein Name(s) | Transcription regulator protein BACH1
BTB and CNC homolog 1 HA2303 | |
| External Links | ||
| UniProt | O14867 | |
| EMBL | AF026199 AF026200 AB002803 AF124731 AK313791 CR450303 AL163249 AP001705 CH471079 BC063307 | |
| CCDS | CCDS13585.1 | |
| PIR | T00023 | |
| RefSeq | NP_001177.1 NP_996749.1 XP_005261069.1 XP_005261070.1 XP_005261071.1 | |
| UniGene | Hs.154276 | |
| PDB | 2IHC | |
| PDBsum | 2IHC | |
| ProteinModelPortal | O14867 | |
| SMR | O14867 | |
| BioGrid | 107047 | |
| DIP | DIP-24223N | |
| IntAct | O14867 | |
| MINT | MINT-196655 | |
| STRING | 9606.ENSP00000286800 | |
| PhosphoSite | O14867 | |
| MaxQB | O14867 | |
| PaxDb | O14867 | |
| PRIDE | O14867 | |
| DNASU | 571 | |
| Ensembl | ENST00000286800 ENST00000399921 | |
| GeneID | 571 | |
| KEGG | hsa:571 | |
| UCSC | uc002ynj.3 | |
| CTD | 571 | |
| GeneCards | GC21P030570 | |
| HGNC | HGNC:935 | |
| HPA | HPA003175 HPA034949 | |
| MIM | 602751 | |
| neXtProt | NX_O14867 | |
| PharmGKB | PA25234 | |
| eggNOG | NOG308993 | |
| GeneTree | ENSGT00550000074399 | |
| HOGENOM | HOG000231712 | |
| HOVERGEN | HBG099852 | |
| InParanoid | O14867 | |
| KO | K09042 | |
| OMA | ENKNVQT | |
| OrthoDB | EOG73V6JP | |
| PhylomeDB | O14867 | |
| TreeFam | TF326681 | |
| ChiTaRS | BACH1 | |
| EvolutionaryTrace | O14867 | |
| GeneWiki | BACH1 | |
| GenomeRNAi | 571 | |
| NextBio | 2323 | |
| PRO | PR:O14867 | |
| Proteomes | UP000005640 | |
| Bgee | O14867 | |
| CleanEx | HS_BACH1 | |
| ExpressionAtlas | O14867 | |
| Genevestigator | O14867 | |
| GO | GO:0005634 GO:0020037 GO:0001078 GO:0000980 GO:0001206 GO:0001205 GO:0003700 GO:0000122 GO:0061418 GO:0000083 GO:0000117 GO:0006355 | |
| Gene3D | 1.10.880.10 | |
| InterPro | IPR000210 IPR011333 IPR013069 IPR004827 IPR004826 IPR008917 | |
| Pfam | PF00651 PF03131 | |
| SMART | SM00338 SM00225 | |
| SUPFAM | SSF47454 SSF54695 | |
| PROSITE | PS50097 PS50217 PS00036 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0006281 |
DNA repair |
ECO:0000315 |
P |
Fig. 5 shows that the mutant interferes with BACH1 ability to timely repair double-strand breaks that BRCA1 usually makes. |
complete | |||||
|
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000255 |
match to sequence model evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001227 |
DNA-binding transcription repressor activity, RNA polymerase II-specific |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0005556 |
multiple sequence alignment evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006281 |
DNA repair |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061418 |
regulation of transcription from RNA polymerase II promoter in response to hypoxia |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:P09601) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0020037 |
heme binding |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0005829 |
cytosol |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0005634 |
nucleus |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001227 |
DNA-binding transcription repressor activity, RNA polymerase II-specific |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
|
Seeded From UniProt |
complete | ||
|
enables |
GO:0001227 |
DNA-binding transcription repressor activity, RNA polymerase II-specific |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000117 |
regulation of transcription involved in G2/M transition of mitotic cell cycle |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:Q16589) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000083 |
regulation of transcription involved in G1/S transition of mitotic cell cycle |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:P30279)|has_regulation_target:(UniProtKB:O96020) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97302 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97302 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97302 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97302 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97302 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97302 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0001227 |
DNA-binding transcription repressor activity, RNA polymerase II-specific |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97302 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000980 |
RNA polymerase II distal enhancer sequence-specific DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97302 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97302 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Cantor, SB et al. (2001) BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function. Cell 105 149-60 PubMed GONUTS page
- ↑ 2.0 2.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Tan, MK et al. (2013) Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover. Mol. Cell 52 9-24 PubMed GONUTS page
- ↑ 4.0 4.1 Sigal, A et al. (2006) Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins. Nat. Methods 3 525-31 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Kitamuro, T et al. (2003) Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells. J. Biol. Chem. 278 9125-33 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 Warnatz, HJ et al. (2011) The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle. J. Biol. Chem. 286 23521-32 PubMed GONUTS page
- ↑ 7.0 7.1 Hu, YH et al. (2006) Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. BMC Genomics 7 155 PubMed GONUTS page
d
- GO:0001227 ! DNA-binding transcription repressor activity, RNA polymerase II-specific
- GO:0003700 ! DNA-binding transcription factor activity
- GO:0001228 ! DNA-binding transcription activator activity, RNA polymerase II-specific
- GO:0000981 ! DNA-binding transcription factor activity, RNA polymerase II-specific
- GO:0003677 ! DNA binding
- GO:0006281 ! DNA repair
o
- GO:0000083 ! obsolete regulation of transcription involved in G1/S transition of mitotic cell cycle
- GO:0000117 ! obsolete regulation of transcription involved in G2/M transition of mitotic cell cycle
- GO:0061418 ! obsolete regulation of transcription from RNA polymerase II promoter in response to hypoxia
r
