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PMID:16780588
| Citation |
Hu, YH, Warnatz, HJ, Vanhecke, D, Wagner, F, Fiebitz, A, Thamm, S, Kahlem, P, Lehrach, H, Yaspo, ML and Janitz, M (2006) Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. BMC Genomics 7:155 |
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| Abstract |
Trisomy of human chromosome 21 (Chr21) results in Down's syndrome, a complex developmental and neurodegenerative disease. Molecular analysis of Down's syndrome, however, poses a particular challenge, because the aneuploid region of Chr21 contains many genes of unknown function. Subcellular localization of human Chr21 proteins may contribute to further understanding of the functions and regulatory mechanisms of the genes that code for these proteins. Following this idea, we used a transfected-cell array technique to perform a rapid and cost-effective analysis of the intracellular distribution of Chr 21 proteins. |
| Links |
PubMed PMC1526728 Online version:10.1186/1471-2164-7-155 |
| Keywords |
Cell Cycle; Cell Nucleus/metabolism; Cells, Cultured; Chromosomes, Human, Pair 21; Cost-Benefit Analysis; Cytosol/metabolism; Down Syndrome/genetics; Down Syndrome/metabolism; Endoplasmic Reticulum/metabolism; Humans; Protein Array Analysis/methods; Protein Transport; Secretory Vesicles/metabolism; Signal Transduction; Tissue Array Analysis/methods; Tissue Distribution/genetics; Transfection |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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