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HUMAN:B2MG
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | B2M | |
Protein Name(s) | Beta-2-microglobulin
Beta-2-microglobulin form pI 5.3 | |
External Links | ||
UniProt | P61769 | |
EMBL | M17987 M17986 AY187687 AB021288 DQ217933 AF072097 AY007153 CR457066 AK315776 CH471082 BC032589 BC064910 V00567 | |
CCDS | CCDS10113.1 | |
PIR | A90976 | |
RefSeq | NP_004039.1 | |
UniGene | Hs.534255 | |
PDB | 1A1M 1A1N 1A1O 1A6Z 1A9B 1A9E 1AGB 1AGC 1AGD 1AGE 1AGF 1AKJ 1AO7 1B0G 1B0R 1BD2 1C16 1CE6 1CG9 1DE4 1DUY 1DUZ 1E27 1E28 1EEY 1EEZ 1EFX 1EXU 1GZP 1GZQ 1HHG 1HHH 1HHI 1HHJ 1HHK 1HLA 1HSA 1HSB 1I1F 1I1Y 1I4F 1I7R 1I7T 1I7U 1IM3 1IM9 1JF1 1JGD 1JGE 1JHT 1JNJ 1K5N 1KPR 1KTL 1LDS 1LP9 1M05 1M6O 1MHE 1MI5 1N2R 1OF2 1OGA 1OGT 1ONQ 1P7Q 1PY4 1Q94 1QEW 1QLF 1QQD 1QR1 1QRN 1QSE 1QSF 1QVO 1R3H 1S8D 1S9W 1S9X 1S9Y 1SYS 1SYV 1T1W 1T1X 1T1Y 1T1Z 1T20 1T21 1T22 1TMC 1TVB 1TVH 1UQS 1UR7 1UXS 1UXW 1VGK 1W0V 1W0W 1W72 1X7Q 1XH3 1XR8 1XR9 1XZ0 1YDP 1YPZ 1ZHK 1ZHL 1ZS8 1ZSD 1ZT4 1ZVS 2A83 2AK4 2AV1 2AV7 2AXF 2AXG 2BCK 2BNQ 2BNR 2BSR 2BSS 2BST 2BVO 2BVP 2BVQ 2C7U 2CII 2CIK 2CLR 2D31 2D4D 2D4F 2DYP 2E8D 2ESV 2F53 2F54 2F74 2F8O 2FYY 2FZ3 2GIT 2GJ6 2GT9 2GTW 2GTZ 2GUO 2H26 2H6P 2HJK 2HJL 2HLA 2HN7 2J8U 2JCC 2NW3 2NX5 2P5E 2P5W 2PO6 2PYE 2RFX 2UWE 2V2W 2V2X 2VB5 2VLJ 2VLK 2VLL 2VLR 2X4N 2X4O 2X4P 2X4Q 2X4R 2X4S 2X4T 2X4U 2X70 2X89 2XKS 2XKU 2XPG 2YPK 2YPL 2YXF 2Z9T 3AM8 3B3I 3B6S 3BGM 3BH8 3BH9 3BHB 3BO8 3BP4 3BP7 3BVN 3BW9 3BWA 3BXN 3BZE 3BZF 3C9N 3CDG 3CII 3CIQ 3CZF 3D18 3D25 3D2U 3D39 3D3V 3DBX 3DHJ 3DHM 3DTX 3DX6 3DX7 3DX8 3DXA 3EKC 3FFC 3FQN 3FQR 3FQT 3FQU 3FQW 3FQX 3FT2 3FT3 3FT4 3GIV 3GJF 3GSN 3GSO 3GSQ 3GSR 3GSU 3GSV 3GSW 3GSX 3H7B 3H9H 3H9S 3HAE 3HCV 3HG1 3HLA 3HPJ 3HUJ 3I6G 3I6K 3I6L 3IB4 3IXA 3JTS 3KLA 3KPL 3KPM 3KPN 3KPO 3KPP 3KPQ 3KPR 3KPS 3KWW 3KXF 3KYN 3KYO 3L3D 3L3G 3L3I 3L3J 3L3K 3LKN 3LKO 3LKP 3LKQ 3LKR 3LKS 3LN4 3LN5 3LOW 3LOZ 3LV3 3M17 3M1B 3MGO 3MGT 3MR9 3MRB 3MRC 3MRD 3MRE 3MRF 3MRG 3MRH 3MRI 3MRJ 3MRK 3MRL 3MRM 3MRN 3MRO 3MRP 3MRQ 3MRR 3MV7 3MV8 3MV9 3MYJ 3MYZ 3MZT 3NA4 3NFN 3O3A 3O3B 3O3D 3O3E 3O4L 3OV6 3OX8 3OXR 3OXS 3PWJ 3PWL 3PWN 3PWP 3QDA 3QDG 3QDJ 3QDM 3QEQ 3QFD 3QFJ 3QZW 3REW 3RL1 3RL2 3RWJ 3S6C 3SDX 3SJV 3SKM 3SKO 3SPV 3T8X 3TID 3TIE 3TLR 3TM6 3TO2 3TZV 3U0P 3UPR 3UTQ 3UTS 3UTT 3V5D 3V5H 3V5K 3VCL 3VFM 3VFN 3VFO 3VFP 3VFR 3VFS 3VFT 3VFU 3VFV 3VFW 3VH8 3VRI 3VRJ 3VWJ 3VWK 3VXM 3VXN 3VXO 3VXP 3VXR 3VXS 3VXU 3W0W 3W39 3WL9 3WLB 3WUW 4BEO 4E0K 4E0L 4E5X 4EN3 4EUP 4EUQ 4F7M 4F7P 4F7T 4FTV 4FXL 4G8G 4G8I 4G9D 4G9F 4GKN 4GKS 4GUP 4HKJ 4HWZ 4HX1 4I48 4I4W 4JFD 4JFE 4JFF 4JFO 4JFP 4JFQ 4JQV 4JQX 4JRX 4JRY 4K71 4K7F 4KDT 4L29 4L3C 4L3E 4L4T 4L4V 4LCW 4LCY 4LHU 4LNR 4M8V 4MJ5 4MJ6 4MJI 4MNQ 4N0F 4N0U 4N8V 4NQC 4NQD 4NQE 4NQV 4NQX 4NT6 4O2C 4O2E 4O2F 4ONO 4PJ5 4PJ7 4PJ8 4PJ9 4PJA 4PJB 4PJC 4PJD 4PJE 4PJF 4PJG 4PJH 4PJI 4PJX 4PR5 4PRA 4PRB 4PRD 4PRE 4PRH 4PRI 4PRN 4PRP 4QRP 4QRT 4UQ2 4UQ3 4WJ5 | |
PDBsum | 1A1M 1A1N 1A1O 1A6Z 1A9B 1A9E 1AGB 1AGC 1AGD 1AGE 1AGF 1AKJ 1AO7 1B0G 1B0R 1BD2 1C16 1CE6 1CG9 1DE4 1DUY 1DUZ 1E27 1E28 1EEY 1EEZ 1EFX 1EXU 1GZP 1GZQ 1HHG 1HHH 1HHI 1HHJ 1HHK 1HLA 1HSA 1HSB 1I1F 1I1Y 1I4F 1I7R 1I7T 1I7U 1IM3 1IM9 1JF1 1JGD 1JGE 1JHT 1JNJ 1K5N 1KPR 1KTL 1LDS 1LP9 1M05 1M6O 1MHE 1MI5 1N2R 1OF2 1OGA 1OGT 1ONQ 1P7Q 1PY4 1Q94 1QEW 1QLF 1QQD 1QR1 1QRN 1QSE 1QSF 1QVO 1R3H 1S8D 1S9W 1S9X 1S9Y 1SYS 1SYV 1T1W 1T1X 1T1Y 1T1Z 1T20 1T21 1T22 1TMC 1TVB 1TVH 1UQS 1UR7 1UXS 1UXW 1VGK 1W0V 1W0W 1W72 1X7Q 1XH3 1XR8 1XR9 1XZ0 1YDP 1YPZ 1ZHK 1ZHL 1ZS8 1ZSD 1ZT4 1ZVS 2A83 2AK4 2AV1 2AV7 2AXF 2AXG 2BCK 2BNQ 2BNR 2BSR 2BSS 2BST 2BVO 2BVP 2BVQ 2C7U 2CII 2CIK 2CLR 2D31 2D4D 2D4F 2DYP 2E8D 2ESV 2F53 2F54 2F74 2F8O 2FYY 2FZ3 2GIT 2GJ6 2GT9 2GTW 2GTZ 2GUO 2H26 2H6P 2HJK 2HJL 2HLA 2HN7 2J8U 2JCC 2NW3 2NX5 2P5E 2P5W 2PO6 2PYE 2RFX 2UWE 2V2W 2V2X 2VB5 2VLJ 2VLK 2VLL 2VLR 2X4N 2X4O 2X4P 2X4Q 2X4R 2X4S 2X4T 2X4U 2X70 2X89 2XKS 2XKU 2XPG 2YPK 2YPL 2YXF 2Z9T 3AM8 3B3I 3B6S 3BGM 3BH8 3BH9 3BHB 3BO8 3BP4 3BP7 3BVN 3BW9 3BWA 3BXN 3BZE 3BZF 3C9N 3CDG 3CII 3CIQ 3CZF 3D18 3D25 3D2U 3D39 3D3V 3DBX 3DHJ 3DHM 3DTX 3DX6 3DX7 3DX8 3DXA 3EKC 3FFC 3FQN 3FQR 3FQT 3FQU 3FQW 3FQX 3FT2 3FT3 3FT4 3GIV 3GJF 3GSN 3GSO 3GSQ 3GSR 3GSU 3GSV 3GSW 3GSX 3H7B 3H9H 3H9S 3HAE 3HCV 3HG1 3HLA 3HPJ 3HUJ 3I6G 3I6K 3I6L 3IB4 3IXA 3JTS 3KLA 3KPL 3KPM 3KPN 3KPO 3KPP 3KPQ 3KPR 3KPS 3KWW 3KXF 3KYN 3KYO 3L3D 3L3G 3L3I 3L3J 3L3K 3LKN 3LKO 3LKP 3LKQ 3LKR 3LKS 3LN4 3LN5 3LOW 3LOZ 3LV3 3M17 3M1B 3MGO 3MGT 3MR9 3MRB 3MRC 3MRD 3MRE 3MRF 3MRG 3MRH 3MRI 3MRJ 3MRK 3MRL 3MRM 3MRN 3MRO 3MRP 3MRQ 3MRR 3MV7 3MV8 3MV9 3MYJ 3MYZ 3MZT 3NA4 3NFN 3O3A 3O3B 3O3D 3O3E 3O4L 3OV6 3OX8 3OXR 3OXS 3PWJ 3PWL 3PWN 3PWP 3QDA 3QDG 3QDJ 3QDM 3QEQ 3QFD 3QFJ 3QZW 3REW 3RL1 3RL2 3RWJ 3S6C 3SDX 3SJV 3SKM 3SKO 3SPV 3T8X 3TID 3TIE 3TLR 3TM6 3TO2 3TZV 3U0P 3UPR 3UTQ 3UTS 3UTT 3V5D 3V5H 3V5K 3VCL 3VFM 3VFN 3VFO 3VFP 3VFR 3VFS 3VFT 3VFU 3VFV 3VFW 3VH8 3VRI 3VRJ 3VWJ 3VWK 3VXM 3VXN 3VXO 3VXP 3VXR 3VXS 3VXU 3W0W 3W39 3WL9 3WLB 3WUW 4BEO 4E0K 4E0L 4E5X 4EN3 4EUP 4EUQ 4F7M 4F7P 4F7T 4FTV 4FXL 4G8G 4G8I 4G9D 4G9F 4GKN 4GKS 4GUP 4HKJ 4HWZ 4HX1 4I48 4I4W 4JFD 4JFE 4JFF 4JFO 4JFP 4JFQ 4JQV 4JQX 4JRX 4JRY 4K71 4K7F 4KDT 4L29 4L3C 4L3E 4L4T 4L4V 4LCW 4LCY 4LHU 4LNR 4M8V 4MJ5 4MJ6 4MJI 4MNQ 4N0F 4N0U 4N8V 4NQC 4NQD 4NQE 4NQV 4NQX 4NT6 4O2C 4O2E 4O2F 4ONO 4PJ5 4PJ7 4PJ8 4PJ9 4PJA 4PJB 4PJC 4PJD 4PJE 4PJF 4PJG 4PJH 4PJI 4PJX 4PR5 4PRA 4PRB 4PRD 4PRE 4PRH 4PRI 4PRN 4PRP 4QRP 4QRT 4UQ2 4UQ3 4WJ5 | |
ProteinModelPortal | P61769 | |
SMR | P61769 | |
BioGrid | 107044 | |
DIP | DIP-6055N | |
IntAct | P61769 | |
MINT | MINT-85778 | |
STRING | 9606.ENSP00000340858 | |
BindingDB | P61769 | |
PhosphoSite | P61769 | |
DMDM | 48428791 | |
DOSAC-COBS-2DPAGE | P61769 | |
OGP | P61769 | |
SWISS-2DPAGE | P61769 | |
MaxQB | P61769 | |
PaxDb | P61769 | |
PeptideAtlas | P61769 | |
PRIDE | P61769 | |
DNASU | 567 | |
Ensembl | ENST00000558401 ENST00000559916 ENST00000561424 ENST00000617605 | |
GeneID | 567 | |
KEGG | hsa:567 | |
UCSC | uc001zuc.3 | |
CTD | 567 | |
GeneCards | GC15P045003 | |
HGNC | HGNC:914 | |
HPA | CAB002572 HPA006361 | |
MIM | 109700 241600 | |
neXtProt | NX_P61769 | |
Orphanet | 314652 | |
PharmGKB | PA25207 | |
eggNOG | NOG40777 | |
GeneTree | ENSGT00690000102227 | |
HOVERGEN | HBG006197 | |
InParanoid | P61769 | |
KO | K08055 | |
OrthoDB | EOG7RFTKJ | |
PhylomeDB | P61769 | |
TreeFam | TF334167 | |
Reactome | REACT_11103 REACT_111168 REACT_111178 REACT_11152 REACT_147694 REACT_147814 REACT_25078 REACT_75795 REACT_75925 | |
ChiTaRS | B2M | |
EvolutionaryTrace | P61769 | |
GeneWiki | Beta-2_microglobulin | |
GenomeRNAi | 567 | |
NextBio | 2313 | |
PRO | PR:P61769 | |
Proteomes | UP000005640 UP000005640 | |
Bgee | P61769 | |
CleanEx | HS_B2M | |
ExpressionAtlas | P61769 | |
Genevestigator | P61769 | |
GO | GO:0005737 GO:0031905 GO:0031901 GO:0005788 GO:0012507 GO:0009897 GO:0005576 GO:0005615 GO:0070062 GO:0005925 GO:0005794 GO:0000139 GO:0016020 GO:0042612 GO:0030670 GO:0005886 GO:0042802 GO:0042590 GO:0002479 GO:0002480 GO:0002481 GO:0002474 GO:0019221 GO:0045087 GO:0060333 GO:0001916 GO:0042026 GO:0050690 GO:0050776 GO:0046686 GO:0042493 GO:0002237 GO:0001895 GO:0033077 GO:0016032 | |
Gene3D | 2.60.40.10 | |
InterPro | IPR007110 IPR013783 IPR003006 IPR003597 | |
Pfam | PF07654 | |
SMART | SM00407 | |
PROSITE | PS50835 PS00290 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
part_of |
GO:0042824 |
MHC class I peptide loading complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0055072 |
iron ion homeostasis |
ECO:0000305 |
curator inference used in manual assertion |
GO:0071281 |
P |
part_of:(GO:0071281) |
Seeded From UniProt |
complete | |
involved_in |
GO:0071281 |
cellular response to iron ion |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
UniProtKB:P02787,UniProtKB:Q07891,UniProtKB:Q30201,UniProtKB:Q9UP52 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048260 |
positive regulation of receptor-mediated endocytosis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
UniProtKB:P02787,UniProtKB:Q07891,UniProtKB:Q30201,UniProtKB:Q9UP52 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002726 |
positive regulation of T cell cytokine production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:P13236)|has_regulation_target:(UniProtKB:P13501)|has_regulation_target:(UniProtKB:P20333-2)|has_regulation_target:(UniProtKB:P10145)|has_regulation_target:(UniProtKB:P10147)|has_regulation_target:(UniProtKB:P35225)|has_regulation_target:(UniProtKB:P05113)|has_regulation_target:(UniProtKB:P48023:PRO_0000034501)|has_regulation_target:(UniProtKB:P01579) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0019885 |
antigen processing and presentation of endogenous peptide antigen via MHC class I |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:1900121 |
negative regulation of receptor binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:P02787) |
Seeded From UniProt |
complete | ||
part_of |
GO:1990712 |
HFE-transferrin receptor complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:1904437 |
positive regulation of transferrin receptor binding |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
UniProtKB:P02786 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034756 |
regulation of iron ion transport |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
UniProtKB:P02786 |
P |
|
Seeded From UniProt |
complete | |
involved_in |
GO:1904434 |
positive regulation of ferrous iron binding |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
UniProtKB:P02786 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1900122 |
positive regulation of receptor binding |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
UniProtKB:P02787,UniProtKB:Q07891,UniProtKB:Q30201,UniProtKB:Q9UP52 |
P |
has_regulation_target:(UniProtKB:P02787) |
Seeded From UniProt |
complete | |
involved_in |
GO:0032092 |
positive regulation of protein binding |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
UniProtKB:P02787,UniProtKB:Q07891,UniProtKB:Q30201,UniProtKB:Q9UP52 |
P |
has_regulation_target:(UniProtKB:Q9UP52) |
Seeded From UniProt |
complete | |
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005925 |
focal adhesion |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0000057) |
Seeded From UniProt |
complete | ||
part_of |
GO:0016020 |
membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001831) |
Seeded From UniProt |
complete | ||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001088) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005615 |
extracellular space |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001914) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005615 |
extracellular space |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001827) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001895 |
retina homeostasis |
ECO:0007007 |
high throughput expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071283 |
cellular response to iron(III) ion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P01887 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0055072 |
iron ion homeostasis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P01887 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045646 |
regulation of erythrocyte differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P01887 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042026 |
protein refolding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P01887 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0033077 |
T cell differentiation in thymus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P01887 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010977 |
negative regulation of neuron projection development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P01887 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0009897 |
external side of plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P01887 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006826 |
iron ion transport |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P01887 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002481 |
antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P01887 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002237 |
response to molecule of bacterial origin |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P01887 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001916 |
positive regulation of T cell mediated cytotoxicity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P01887 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0046686 |
response to cadmium ion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07151 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042493 |
response to drug |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07151 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005615 |
extracellular space |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07151 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006955 |
immune response |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0042612 |
MHC class I protein complex |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0061844 |
antimicrobial humoral immune response mediated by antimicrobial peptide |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071222 |
cellular response to lipopolysaccharide |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(CL:0002536) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0003254 |
regulation of membrane depolarization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
happens_during:(GO:0050829) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0019731 |
antibacterial humoral response |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(UBERON:0000173) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050830 |
defense response to Gram-positive bacterium |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(UBERON:0000173) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050829 |
defense response to Gram-negative bacterium |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045087 |
innate immune response |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(UBERON:0000173) |
Seeded From UniProt |
complete | ||
part_of |
GO:1904724 |
tertiary granule lumen |
Reactome:R-HSA-6798745 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060333 |
interferon-gamma-mediated signaling pathway |
Reactome:R-HSA-877300 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0055038 |
recycling endosome membrane |
Reactome:R-HSA-8863973 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050776 |
regulation of immune response |
Reactome:R-HSA-198933 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050690 |
regulation of defense response to virus by virus |
Reactome:R-HSA-164940 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045087 |
innate immune response |
Reactome:R-HSA-168249 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0044267 |
cellular protein metabolic process |
Reactome:R-HSA-392499 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043312 |
neutrophil degranulation |
Reactome:R-HSA-6798695 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0035580 |
specific granule lumen |
Reactome:R-HSA-6798749 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0031905 |
early endosome lumen |
Reactome:R-HSA-1236964 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
part_of |
GO:0031901 |
early endosome membrane |
Reactome:R-HSA-182286 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
part_of |
GO:0030670 |
phagocytic vesicle membrane |
Reactome:R-HSA-8863973 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
part_of |
GO:0012507 |
ER to Golgi transport vesicle membrane |
Reactome:R-HSA-983424 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-983427 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
part_of |
GO:0005788 |
endoplasmic reticulum lumen |
Reactome:R-HSA-983426 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-977136 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
involved_in |
GO:0002480 |
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent |
Reactome:R-HSA-1236977 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002479 |
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent |
Reactome:R-HSA-1236974 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002474 |
antigen processing and presentation of peptide antigen via MHC class I |
Reactome:R-HSA-983169 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0000139 |
Golgi membrane |
Reactome:R-HSA-983427 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
part_of |
GO:0042612 |
MHC class I protein complex |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002474 |
antigen processing and presentation of peptide antigen via MHC class I |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002376 |
immune system process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0009986 |
cell surface |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Rizvi, SM et al. (2011) Distinct functions for the glycans of tapasin and heavy chains in the assembly of MHC class I molecules. J. Immunol. 186 2309-20 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Waheed, A et al. (2008) HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron. Arch. Biochem. Biophys. 474 193-7 PubMed GONUTS page
- ↑ 3.0 3.1 Reuben, A et al. (2014) The WT hemochromatosis protein HFE inhibits CD8⁺ T-lymphocyte activation. Eur. J. Immunol. 44 1604-14 PubMed GONUTS page
- ↑ Feder, JN et al. (1998) The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Proc. Natl. Acad. Sci. U.S.A. 95 1472-7 PubMed GONUTS page
- ↑ Waheed, A et al. (1999) Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum. Proc. Natl. Acad. Sci. U.S.A. 96 1579-84 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
- ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
- ↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
- ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
- ↑ Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
- ↑ Böhm, D et al. (2012) Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Oncol. Rep. 28 429-38 PubMed GONUTS page
- ↑ Pieragostino, D et al. (2013) Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. Mol Biosyst 9 1108-16 PubMed GONUTS page
- ↑ Chen, J et al. (2012) Fibrillogenic propensity of the GroEL apical domain: a Janus-faced minichaperone. FEBS Lett. 586 1120-7 PubMed GONUTS page
- ↑ Colombo, M et al. (2012) A recurrent D-strand association interface is observed in β-2 microglobulin oligomers. FEBS J. 279 1131-43 PubMed GONUTS page
- ↑ Azinas, S et al. (2011) D-strand perturbation and amyloid propensity in beta-2 microglobulin. FEBS J. 278 2349-58 PubMed GONUTS page
- ↑ Domanska, K et al. (2011) Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic beta2-microglobulin variant. Proc. Natl. Acad. Sci. U.S.A. 108 1314-9 PubMed GONUTS page
- ↑ Liu, C et al. (2011) β₂-microglobulin forms three-dimensional domain-swapped amyloid fibrils with disulfide linkages. Nat. Struct. Mol. Biol. 18 49-55 PubMed GONUTS page
- ↑ Wolfe, LS et al. (2010) Protein-induced photophysical changes to the amyloid indicator dye thioflavin T. Proc. Natl. Acad. Sci. U.S.A. 107 16863-8 PubMed GONUTS page
- ↑ Chatani, E et al. (2009) Ultrasonication-dependent production and breakdown lead to minimum-sized amyloid fibrils. Proc. Natl. Acad. Sci. U.S.A. 106 11119-24 PubMed GONUTS page
- ↑ Calabrese, MF et al. (2008) A regulatable switch mediates self-association in an immunoglobulin fold. Nat. Struct. Mol. Biol. 15 965-71 PubMed GONUTS page
- ↑ Xue, WF et al. (2008) Systematic analysis of nucleation-dependent polymerization reveals new insights into the mechanism of amyloid self-assembly. Proc. Natl. Acad. Sci. U.S.A. 105 8926-31 PubMed GONUTS page
- ↑ Iwata, K et al. (2006) 3D structure of amyloid protofilaments of beta2-microglobulin fragment probed by solid-state NMR. Proc. Natl. Acad. Sci. U.S.A. 103 18119-24 PubMed GONUTS page
- ↑ 24.0 24.1 24.2 24.3 24.4 24.5 24.6 Kim, JY et al. (2012) Novel antibacterial activity of β(2)-microglobulin in human amniotic fluid. PLoS ONE 7 e47642 PubMed GONUTS page
a
- GO:0019731 ! antibacterial humoral response
- GO:0002481 ! antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
- GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I
- GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I
- GO:0002479 ! antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
- GO:0002480 ! antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
- GO:0061844 ! antimicrobial humoral immune response mediated by antimicrobial peptide
c
d
e
- GO:0031901 ! early endosome membrane
- GO:0031905 ! early endosome lumen
- GO:0005788 ! endoplasmic reticulum lumen
- GO:0005768 ! endosome
- GO:0012507 ! ER to Golgi transport vesicle membrane
- Euarchontoglires
- Eukaryota
- Euteleostomi
- Eutheria
- GO:0009897 ! external side of plasma membrane
- GO:0005576 ! extracellular region
- GO:0005615 ! extracellular space
- GO:0070062 ! extracellular exosome
i
m
n
p
- GO:0030670 ! phagocytic vesicle membrane
- GO:0005886 ! plasma membrane
- GO:0002726 ! positive regulation of T cell cytokine production
- GO:0032092 ! positive regulation of protein binding
- GO:1904437 ! positive regulation of transferrin receptor binding
- GO:0001916 ! positive regulation of T cell mediated cytotoxicity
- GO:0048260 ! positive regulation of receptor-mediated endocytosis
- GO:1904434 ! positive regulation of ferrous iron binding
- GO:1900122 ! positive regulation of receptor binding
- Primates
- GO:0042026 ! protein refolding
r
- GO:0055038 ! recycling endosome membrane
- GO:0034756 ! regulation of iron ion transport
- GO:0050690 ! regulation of defense response to virus by virus
- GO:0003254 ! regulation of membrane depolarization
- GO:0045646 ! regulation of erythrocyte differentiation
- GO:0050776 ! regulation of immune response
- GO:0002237 ! response to molecule of bacterial origin
- GO:0046686 ! response to cadmium ion
- GO:0042493 ! response to drug
- GO:0001895 ! retina homeostasis
t