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Category:GO:0042824 ! MHC class I peptide loading complex
name: MHC class I peptide loading complex
namespace: cellular_component
def: "A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules." [GOC:jl, PMID:10631934]
comment: Note that although this complex is located in the endoplasmic reticulum, there is some evidence that it may also be found in the Golgi.
subset: goslim_pir
synonym: "peptide-loading complex" EXACT [GOC:bhm]
synonym: "PLC" RELATED [GOC:bhm]
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex
relationship: part_of: GO:0005789 ! endoplasmic reticulum membrane
AmiGO
<GOterm>GO:0042824</GOterm>
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