HUMAN:AURKB

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	AURKB (synonyms: AIK2, AIM1, AIRK2, ARK2, STK1, STK12, STK5)
Protein Name(s)	Aurora kinase B Aurora 1 Aurora- and IPL1-like midbody-associated protein 1 AIM-1 Aurora/IPL1-related kinase 2 ARK-2 Aurora-related kinase 2 STK-1 Serine/threonine-protein kinase 12 Serine/threonine-protein kinase 5 Serine/threonine-protein kinase aurora-B
External Links
UniProt	Q96GD4
EMBL	AF008552 AB011450 AB011446 AF004022 AF015254 AB519677 AB519678 AB519679 BT019534 AK297976 AC135178 CH471108 CH471108 CH471108 BC000442 BC009751 BC013300 BC080581
CCDS	CCDS11134.1 CCDS58514.1 CCDS67162.1
RefSeq	NP_001243763.1 NP_001271455.1 NP_004208.2 XP_005256911.1
UniGene	Hs.442658
PDB	4AF3
PDBsum	4AF3
ProteinModelPortal	Q96GD4
SMR	Q96GD4
BioGrid	114646
DIP	DIP-34530N
IntAct	Q96GD4
MINT	MINT-1413997
STRING	9606.ENSP00000313950
BindingDB	Q96GD4
ChEMBL	CHEMBL2185
GuidetoPHARMACOLOGY	1937
PhosphoSite	Q96GD4
DMDM	317373473
MaxQB	Q96GD4
PaxDb	Q96GD4
PRIDE	Q96GD4
DNASU	9212
Ensembl	ENST00000316199 ENST00000534871 ENST00000578549 ENST00000585124
GeneID	9212
KEGG	hsa:9212
UCSC	uc002gkm.4 uc010cnu.3 uc021tpy.1
CTD	9212
GeneCards	GC17M008108
H-InvDB	HIX0019005
HGNC	HGNC:11390
HPA	CAB005862 HPA037708
MIM	604970
neXtProt	NX_Q96GD4
PharmGKB	PA36199
eggNOG	COG0515
GeneTree	ENSGT00770000120530
HOVERGEN	HBG108519
InParanoid	Q96GD4
KO	K11479
OMA	HPWVRAN
PhylomeDB	Q96GD4
TreeFam	TF351439
Reactome	REACT_150425 REACT_150471 REACT_6761 REACT_682
SignaLink	Q96GD4
GeneWiki	Aurora_B_kinase
GenomeRNAi	9212
NextBio	34535
PRO	PR:Q96GD4
Proteomes	UP000005640
Bgee	Q96GD4
CleanEx	HS_AIM1 HS_AURKB
ExpressionAtlas	Q96GD4
Genevestigator	Q96GD4
GO	GO:0010369 GO:0032133 GO:0000779 GO:0000780 GO:0005829 GO:0045171 GO:0030496 GO:0005634 GO:0005819 GO:0005524 GO:0035174 GO:0046872 GO:0004674 GO:0004712 GO:0009838 GO:0007568 GO:0031145 GO:0008608 GO:0008283 GO:0034644 GO:0036089 GO:0031565 GO:0043988 GO:0016570 GO:0000278 GO:0051256 GO:0002903 GO:0032466 GO:0032091 GO:0000122 GO:0032467 GO:0046777 GO:0034501 GO:0006468 GO:0051983 GO:0031577 GO:0043146
InterPro	IPR028772 IPR011009 IPR000719 IPR017441 IPR002290 IPR008271
PANTHER	PTHR24350:SF4
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0032467	positive regulation of cytokinesis	PMID:12458200^[1]	ECO:0000315			P		Figure 2 a-d shows Aurora-B's role in inhibiting Vimentin and promoting cytokinesis	complete CACAO 2331
	GO:0000776	kinetochore	PMID:22024163^[2]	ECO:0000314			C		Figure 2	complete CACAO 6579
enables	GO:0019900	kinase binding	PMID:23036704^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P53350	F		Seeded From UniProt	complete
involved_in	GO:1904355	positive regulation of telomere capping	PMID:21531765^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0032212) part_of:(GO:0051973)	Seeded From UniProt	complete
involved_in	GO:0032212	positive regulation of telomere maintenance via telomerase	PMID:21531765^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O14746)	Seeded From UniProt	complete
involved_in	GO:0051973	positive regulation of telomerase activity	PMID:21531765^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O14746)	Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	PMID:22024163^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000780	condensed nuclear chromosome, centromeric region	PMID:18195732^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051256	mitotic spindle midzone assembly	PMID:16103226^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043988	histone H3-S28 phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70126	P		Seeded From UniProt	complete
involved_in	GO:0007051	spindle organization	PMID:21820309^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036089	cleavage furrow formation	PMID:16103226^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035174	histone serine kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70126	F		Seeded From UniProt	complete
involved_in	GO:0034644	cellular response to UV	PMID:20959462^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034501	protein localization to kinetochore	PMID:19468067^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032467	positive regulation of cytokinesis	PMID:16103226^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032466	negative regulation of cytokinesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7YRC6	P		Seeded From UniProt	complete
part_of	GO:0032133	chromosome passenger complex	PMID:18591255^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O15392	C		Seeded From UniProt	complete
part_of	GO:0032133	chromosome passenger complex	PMID:15260989^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q53HL2	C		Seeded From UniProt	complete
	GO:1905116	positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore	PMID:28751710^[12]	ECO:0000314			P		Fig. 1 shows that in human cells, Aurora-B (Aurora Kinase B, AURKB) is very active on lateral kinetochores and that this activity promotes association of kinetochores and microtubules.	complete CACAO 13482
involved_in	GO:0032091	negative regulation of protein binding	PMID:21820309^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q86Y91) has_regulation_target:(UniProtKB:Q99661)	Seeded From UniProt	complete
	GO:0004674	protein serine/threonine kinase activity	PMID:28751710^[12]	ECO:0000314			F		Fig. 1 shows that in human cells, Aurora-B (Aurora Kinase B, AURKB) is responsible for phosphorylation of serine residues on the kinetochore HEC1 protein.	complete CACAO 13489
involved_in	GO:0044878	mitotic cytokinesis checkpoint	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7YRC6	P		Seeded From UniProt	complete
part_of	GO:0030496	midbody	PMID:17726514^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0009838	abscission	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7YRC6	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:21820309^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q86Y91) has_direct_input:(UniProtKB:Q99661)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20959462^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002903	negative regulation of B cell apoptotic process	PMID:20959462^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0000779	condensed chromosome, centromeric region	PMID:19465021^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:20959462^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0051233	spindle midzone	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0024227 PANTHER:PTN000681967 SGD:S000006130 UniProtKB:Q9UQB9 WB:WBGene00000099 dictyBase:DDB_G0279343	C		Seeded From UniProt	complete
enables	GO:0035174	histone serine kinase activity	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107168 MGI:MGI:894678 PANTHER:PTN000681967	F		Seeded From UniProt	complete
involved_in	GO:0032465	regulation of cytokinesis	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000681967 SGD:S000006130	P		Seeded From UniProt	complete
part_of	GO:0032133	chromosome passenger complex	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0024227 MGI:MGI:107168 PANTHER:PTN000681967 PomBase:SPCC320.13c SGD:S000006130 UniProtKB:Q96GD4 dictyBase:DDB_G0279343	C		Seeded From UniProt	complete
part_of	GO:0031616	spindle pole centrosome	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000681967 UniProtKB:O14965 WB:WBGene00000098	C		Seeded From UniProt	complete
involved_in	GO:0007052	mitotic spindle organization	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:894678 PANTHER:PTN000681967	P		Seeded From UniProt	complete
part_of	GO:0005876	spindle microtubule	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000681967 SGD:S000006130 UniProtKB:O14965	C		Seeded From UniProt	complete
part_of	GO:0000780	condensed nuclear chromosome, centromeric region	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0024227 MGI:MGI:107168 PANTHER:PTN000681967 UniProtKB:Q96GD4	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21397845^[16]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0030496	midbody	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:22724069^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:22724069^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036089	cleavage furrow formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55099 ensembl:ENSRNOP00000072371	P		Seeded From UniProt	complete
part_of	GO:0030496	midbody	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55099 ensembl:ENSRNOP00000072371	C		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55099 ensembl:ENSRNOP00000072371	P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55099 ensembl:ENSRNOP00000072371	P		Seeded From UniProt	complete
part_of	GO:0005819	spindle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55099 ensembl:ENSRNOP00000072371	C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55099 ensembl:ENSRNOP00000072371	F		Seeded From UniProt	complete
part_of	GO:1990023	mitotic spindle midzone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70126 ensembl:ENSMUSP00000021277	C		Seeded From UniProt	complete
involved_in	GO:0043988	histone H3-S28 phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70126 ensembl:ENSMUSP00000021277	P		Seeded From UniProt	complete
enables	GO:0035174	histone serine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70126 ensembl:ENSMUSP00000021277	F		Seeded From UniProt	complete
part_of	GO:0032133	chromosome passenger complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70126 ensembl:ENSMUSP00000021277	C		Seeded From UniProt	complete
part_of	GO:0030496	midbody	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70126 ensembl:ENSMUSP00000021277	C		Seeded From UniProt	complete
part_of	GO:0010369	chromocenter	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70126 ensembl:ENSMUSP00000021277	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70126 ensembl:ENSMUSP00000021277	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70126 ensembl:ENSMUSP00000021277	F		Seeded From UniProt	complete
part_of	GO:0000780	condensed nuclear chromosome, centromeric region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70126 ensembl:ENSMUSP00000021277	C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271 InterPro:IPR030616	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028772	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
involved_in	GO:0007094	mitotic spindle assembly checkpoint	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028772	P		Seeded From UniProt	complete
part_of	GO:0032133	chromosome passenger complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028772	C		Seeded From UniProt	complete
involved_in	GO:0032467	positive regulation of cytokinesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028772	P		Seeded From UniProt	complete
involved_in	GO:0043988	histone H3-S28 phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028772	P		Seeded From UniProt	complete
involved_in	GO:0051983	regulation of chromosome segregation	PMID:19774610^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051256	mitotic spindle midzone assembly	PMID:19774610^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:19774610^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032467	positive regulation of cytokinesis	PMID:19774610^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032133	chromosome passenger complex	PMID:19774610^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030496	midbody	PMID:19774610^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016570	histone modification	PMID:19774610^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008608	attachment of spindle microtubules to kinetochore	PMID:19774610^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005819	spindle	PMID:19774610^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004712	protein serine/threonine/tyrosine kinase activity	PMID:19774610^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1901796	regulation of signal transduction by p53 class mediator	Reactome:R-HSA-5633007	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031145	anaphase-promoting complex-dependent catabolic process	Reactome:R-HSA-174178	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	Reactome:R-HSA-174195	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-5666169 Reactome:R-HSA-5666160 Reactome:R-HSA-5666129 Reactome:R-HSA-4655355 Reactome:R-HSA-375302 Reactome:R-HSA-2484822 Reactome:R-HSA-2468287 Reactome:R-HSA-2467811 Reactome:R-HSA-2467809 Reactome:R-HSA-174195 Reactome:R-HSA-174105 Reactome:R-HSA-174088 Reactome:R-HSA-1638821 Reactome:R-HSA-1638803 Reactome:R-HSA-141439 Reactome:R-HSA-141431 Reactome:R-HSA-141422 Reactome:R-HSA-141409	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-6805126 Reactome:R-HSA-6805122 Reactome:R-HSA-4655355	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	Reactome:R-HSA-6805126	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0000775	chromosome, centromeric region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0137 UniProtKB-SubCell:SL-0047	C		Seeded From UniProt	complete
part_of	GO:0030496	midbody	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0469	C		Seeded From UniProt	complete
part_of	GO:0005819	spindle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0251	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Goto, H et al. (2003) Aurora-B regulates the cleavage furrow-specific vimentin phosphorylation in the cytokinetic process. J. Biol. Chem. 278 8526-30 PubMed GONUTS page
↑ ^2.0 ^2.1 Petsalaki, E et al. (2011) Phosphorylation at serine 331 is required for Aurora B activation. J. Cell Biol. 195 449-66 PubMed GONUTS page
↑ Izumiyama, T et al. (2012) A novel big protein TPRBK possessing 25 units of TPR motif is essential for the progress of mitosis and cytokinesis. Gene 511 202-17 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Cerone, MA et al. (2011) High-throughput RNAi screening reveals novel regulators of telomerase. Cancer Res. 71 3328-40 PubMed GONUTS page
↑ Chen, Q et al. (2008) Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis. Cell Res. 18 268-80 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Yüce, O et al. (2005) An ECT2-centralspindlin complex regulates the localization and function of RhoA. J. Cell Biol. 170 571-82 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Tanenbaum, ME et al. (2011) A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases. Curr. Biol. 21 1356-65 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Wu, L et al. (2011) Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. J. Biol. Chem. 286 2236-44 PubMed GONUTS page
↑ Chan, YW et al. (2009) Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly. J. Cell Biol. 185 859-74 PubMed GONUTS page
↑ Xia, F et al. (2008) A survivin-ran complex regulates spindle formation in tumor cells. Mol. Cell. Biol. 28 5299-311 PubMed GONUTS page
↑ Sampath, SC et al. (2004) The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly. Cell 118 187-202 PubMed GONUTS page
↑ ^12.0 ^12.1 Shrestha, RL et al. (2017) Aurora-B kinase pathway controls the lateral to end-on conversion of kinetochore-microtubule attachments in human cells. Nat Commun 8 150 PubMed GONUTS page
↑ North, BJ & Verdin, E (2007) Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis. PLoS ONE 2 e784 PubMed GONUTS page
↑ Gambe, AE et al. (2009) A nucleolar protein RRS1 contributes to chromosome congression. FEBS Lett. 583 1951-6 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 ^15.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Cheng, L et al. (2011) Aurora B regulates formin mDia3 in achieving metaphase chromosome alignment. Dev. Cell 20 342-52 PubMed GONUTS page
↑ ^17.0 ^17.1 Capalbo, L et al. (2012) The chromosomal passenger complex controls the function of endosomal sorting complex required for transport-III Snf7 proteins during cytokinesis. Open Biol 2 120070 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 ^18.7 ^18.8 ^18.9 Lukasiewicz, KB & Lingle, WL (2009) Aurora A, centrosome structure, and the centrosome cycle. Environ. Mol. Mutagen. 50 602-19 PubMed GONUTS page

[PMID:12458200-1] Goto, H et al. (2003) Aurora-B regulates the cleavage furrow-specific vimentin phosphorylation in the cytokinetic process. J. Biol. Chem. 278 8526-30 PubMed GONUTS page

[PMID:22024163-2] 2.0 ^2.1 Petsalaki, E et al. (2011) Phosphorylation at serine 331 is required for Aurora B activation. J. Cell Biol. 195 449-66 PubMed GONUTS page

[PMID:23036704-3] Izumiyama, T et al. (2012) A novel big protein TPRBK possessing 25 units of TPR motif is essential for the progress of mitosis and cytokinesis. Gene 511 202-17 PubMed GONUTS page

[PMID:21531765-4] 4.0 ^4.1 ^4.2 Cerone, MA et al. (2011) High-throughput RNAi screening reveals novel regulators of telomerase. Cancer Res. 71 3328-40 PubMed GONUTS page

[PMID:18195732-5] Chen, Q et al. (2008) Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis. Cell Res. 18 268-80 PubMed GONUTS page

[PMID:16103226-6] 6.0 ^6.1 ^6.2 Yüce, O et al. (2005) An ECT2-centralspindlin complex regulates the localization and function of RhoA. J. Cell Biol. 170 571-82 PubMed GONUTS page

[PMID:21820309-7] 7.0 ^7.1 ^7.2 Tanenbaum, ME et al. (2011) A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases. Curr. Biol. 21 1356-65 PubMed GONUTS page

[PMID:20959462-8] 8.0 ^8.1 ^8.2 ^8.3 Wu, L et al. (2011) Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. J. Biol. Chem. 286 2236-44 PubMed GONUTS page

[PMID:19468067-9] Chan, YW et al. (2009) Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly. J. Cell Biol. 185 859-74 PubMed GONUTS page

[PMID:18591255-10] Xia, F et al. (2008) A survivin-ran complex regulates spindle formation in tumor cells. Mol. Cell. Biol. 28 5299-311 PubMed GONUTS page

[PMID:15260989-11] Sampath, SC et al. (2004) The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly. Cell 118 187-202 PubMed GONUTS page

[PMID:28751710-12] 12.0 ^12.1 Shrestha, RL et al. (2017) Aurora-B kinase pathway controls the lateral to end-on conversion of kinetochore-microtubule attachments in human cells. Nat Commun 8 150 PubMed GONUTS page

[PMID:17726514-13] North, BJ & Verdin, E (2007) Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis. PLoS ONE 2 e784 PubMed GONUTS page

[PMID:19465021-14] Gambe, AE et al. (2009) A nucleolar protein RRS1 contributes to chromosome congression. FEBS Lett. 583 1951-6 PubMed GONUTS page

[PMID:21873635-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 ^15.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21397845-16] Cheng, L et al. (2011) Aurora B regulates formin mDia3 in achieving metaphase chromosome alignment. Dev. Cell 20 342-52 PubMed GONUTS page

[PMID:22724069-17] 17.0 ^17.1 Capalbo, L et al. (2012) The chromosomal passenger complex controls the function of endosomal sorting complex required for transport-III Snf7 proteins during cytokinesis. Open Biol 2 120070 PubMed GONUTS page

[PMID:19774610-18] 18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 ^18.7 ^18.8 ^18.9 Lukasiewicz, KB & Lingle, WL (2009) Aurora A, centrosome structure, and the centrosome cycle. Environ. Mol. Mutagen. 50 602-19 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

HUMAN:AURKB

Contents

Annotations

Notes

References

a

c

e

h

k

m

n

o

p

r

s

t

u

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools