HUMAN:ATR

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ATR (synonyms: FRP1)
Protein Name(s)	Serine/threonine-protein kinase ATR Ataxia telangiectasia and Rad3-related protein FRAP-related protein 1
External Links
UniProt	Q13535
EMBL	Y09077 U76308 U49844 AF325699 AB208847
CCDS	CCDS3124.1
RefSeq	NP_001175.2
UniGene	Hs.271791
ProteinModelPortal	Q13535
SMR	Q13535
BioGrid	107027
DIP	DIP-35308N
IntAct	Q13535
MINT	MINT-194575
STRING	9606.ENSP00000343741
BindingDB	Q13535
ChEMBL	CHEMBL5024
GuidetoPHARMACOLOGY	1935
PhosphoSite	Q13535
DMDM	62286460
MaxQB	Q13535
PaxDb	Q13535
PRIDE	Q13535
DNASU	545
Ensembl	ENST00000350721
GeneID	545
KEGG	hsa:545
UCSC	uc003eux.4
CTD	545
GeneCards	GC03M142168
GeneReviews	ATR
H-InvDB	HIX0030886
HGNC	HGNC:882
HPA	HPA028264
MIM	210600 601215 614564
neXtProt	NX_Q13535
Orphanet	313846 808
PharmGKB	PA74
eggNOG	COG5032
GeneTree	ENSGT00770000120527
HOGENOM	HOG000034221
HOVERGEN	HBG050619
InParanoid	Q13535
KO	K06640
OMA	WRRFPEH
OrthoDB	EOG7Z95K8
PhylomeDB	Q13535
TreeFam	TF101183
Reactome	REACT_18265 REACT_200780 REACT_6769 REACT_75792 REACT_897
SignaLink	Q13535
ChiTaRS	ATR
GeneWiki	Ataxia_telangiectasia_and_Rad3_related
GenomeRNAi	545
NextBio	2253
PRO	PR:Q13535
Proteomes	UP000005640
Bgee	Q13535
CleanEx	HS_ATR
ExpressionAtlas	Q13535
Genevestigator	Q13535
GO	GO:0005694 GO:0005654 GO:0016605 GO:0001741 GO:0005524 GO:0003677 GO:0032405 GO:0032407 GO:0004672 GO:0004674 GO:0007049 GO:0006974 GO:0071480 GO:0034644 GO:0000077 GO:0006281 GO:0006260 GO:0007275 GO:0008156 GO:0018105 GO:0043517 GO:0046777 GO:0043393 GO:0090399 GO:0042493
Gene3D	1.10.1070.11 1.25.10.10 1.25.40.10
InterPro	IPR011989 IPR016024 IPR003152 IPR021133 IPR011009 IPR000403 IPR018936 IPR003151 IPR014009 IPR011990 IPR012993
Pfam	PF02259 PF02260 PF00454 PF08064
SMART	SM00146 SM00802
SUPFAM	SSF48371 SSF56112
PROSITE	PS51189 PS51190 PS50077 PS00916 PS50290

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:27723717^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:27723720^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:27723717^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:27723720^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0097695	establishment of protein-containing complex localization to telomere	PMID:26586433^[3]	ECO:0000305	curator inference used in manual assertion	GO:0097694	P	transports_or_maintains_localization_of:(ComplexPortal:CPX-17)	Seeded From UniProt	complete
involved_in	GO:1904884	positive regulation of telomerase catalytic core complex assembly	PMID:26586433^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0000784	nuclear chromosome, telomeric region	PMID:26586433^[3]	ECO:0000305	curator inference used in manual assertion	GO:0097694	C		Seeded From UniProt	complete
involved_in	GO:0070198	protein localization to chromosome, telomeric region	PMID:21829167^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032212	positive regulation of telomere maintenance via telomerase	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9JKK8	P		Seeded From UniProt	complete
involved_in	GO:0097694	establishment of RNA localization to telomere	PMID:26586433^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_at:(GO:0000781)	Seeded From UniProt	complete
involved_in	GO:0090399	replicative senescence	PMID:15149599^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071480	cellular response to gamma radiation	PMID:9925639^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:9733515^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	PMID:9925639^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034644	cellular response to UV	PMID:9925639^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:9733515^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:9733515^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:9925639^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0016605	PML body	PMID:12814551^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0008156	negative regulation of DNA replication	PMID:14657349^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9JKK8	C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:14657349^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000077	DNA damage checkpoint	PMID:14657349^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0045035 FB:FBgn0053554 MGI:MGI:104779 MGI:MGI:1928394 PANTHER:PTN000124197 RGD:1593265 RGD:68371 SGD:S000000340 SGD:S000001141 SGD:S000003827 UniProtKB:P78527 UniProtKB:Q13315 UniProtKB:Q96Q15 UniProtKB:Q9FR53 UniProtKB:Q9Y4A5 WB:WBGene00000226 WB:WBGene00007028	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001673376 PomBase:SPBC216.05 UniProtKB:Q13535	F		Seeded From UniProt	complete
involved_in	GO:0000723	telomere maintenance	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004367 PANTHER:PTN001673376 PomBase:SPBC216.05 SGD:S000000340	P		Seeded From UniProt	complete
involved_in	GO:0000077	DNA damage checkpoint	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004367 MGI:MGI:108028 PANTHER:PTN001673376 UniProtKB:C8VB89 UniProtKB:Q13535 WB:WBGene00000226	P		Seeded From UniProt	complete
enables	GO:0032407	MutSalpha complex binding	PMID:16713580^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0032405	MutLalpha complex binding	PMID:16713580^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3Z822 ensembl:ENSRNOP00000043760	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012993	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018936 InterPro:IPR036940	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	PMID:9590286^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	PMID:8610130^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:8610130^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:15538388^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901796	regulation of signal transduction by p53 class mediator	Reactome:R-HSA-5633007	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900034	regulation of cellular response to heat	Reactome:R-HSA-3371453	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036297	interstrand cross-link repair	Reactome:R-HSA-6783310	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	Reactome:R-HSA-5684887 Reactome:R-HSA-5684875 Reactome:R-HSA-176298 Reactome:R-HSA-176250 Reactome:R-HSA-176116	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-6799332 Reactome:R-HSA-6797712 Reactome:R-HSA-6788392 Reactome:R-HSA-6788385 Reactome:R-HSA-5693580 Reactome:R-HSA-5693564 Reactome:R-HSA-5693561 Reactome:R-HSA-5686657 Reactome:R-HSA-5686642 Reactome:R-HSA-5685156 Reactome:R-HSA-5685011 Reactome:R-HSA-5684887 Reactome:R-HSA-5684882 Reactome:R-HSA-5684875 Reactome:R-HSA-3371567 Reactome:R-HSA-176298 Reactome:R-HSA-176250 Reactome:R-HSA-176116	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	Reactome:R-HSA-6788392 Reactome:R-HSA-176298 Reactome:R-HSA-176116	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0465	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Haahr, P et al. (2016) Activation of the ATR kinase by the RPA-binding protein ETAA1. Nat. Cell Biol. 18 1196-1207 PubMed GONUTS page
↑ ^2.0 ^2.1 Bass, TE et al. (2016) ETAA1 acts at stalled replication forks to maintain genome integrity. Nat. Cell Biol. 18 1185-1195 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Tong, AS et al. (2015) ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres. Cell Rep 13 1633-46 PubMed GONUTS page
↑ Chawla, R et al. (2011) Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication. EMBO J. 30 4047-58 PubMed GONUTS page
↑ Herbig, U et al. (2004) Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol. Cell 14 501-13 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Tibbetts, RS et al. (1999) A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev. 13 152-7 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Canman, CE et al. (1998) Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281 1677-9 PubMed GONUTS page
↑ Barr, SM et al. (2003) ATR kinase activity regulates the intranuclear translocation of ATR and RPA following ionizing radiation. Curr. Biol. 13 1047-51 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Wang, Y & Qin, J (2003) MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation. Proc. Natl. Acad. Sci. U.S.A. 100 15387-92 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^11.0 ^11.1 Yoshioka, K et al. (2006) ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. Mol. Cell 22 501-10 PubMed GONUTS page
↑ Smith, L et al. (1998) Duplication of ATR inhibits MyoD, induces aneuploidy and eliminates radiation-induced G1 arrest. Nat. Genet. 19 39-46 PubMed GONUTS page
↑ ^13.0 ^13.1 Cimprich, KA et al. (1996) cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein. Proc. Natl. Acad. Sci. U.S.A. 93 2850-5 PubMed GONUTS page
↑ Tsao, CC et al. (2004) Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling. EMBO J. 23 4660-9 PubMed GONUTS page

[PMID:27723717-1] 1.0 ^1.1 Haahr, P et al. (2016) Activation of the ATR kinase by the RPA-binding protein ETAA1. Nat. Cell Biol. 18 1196-1207 PubMed GONUTS page

[PMID:27723720-2] 2.0 ^2.1 Bass, TE et al. (2016) ETAA1 acts at stalled replication forks to maintain genome integrity. Nat. Cell Biol. 18 1185-1195 PubMed GONUTS page

[PMID:26586433-3] 3.0 ^3.1 ^3.2 ^3.3 Tong, AS et al. (2015) ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres. Cell Rep 13 1633-46 PubMed GONUTS page

[PMID:21829167-4] Chawla, R et al. (2011) Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication. EMBO J. 30 4047-58 PubMed GONUTS page

[PMID:15149599-5] Herbig, U et al. (2004) Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol. Cell 14 501-13 PubMed GONUTS page

[PMID:9925639-6] 6.0 ^6.1 ^6.2 ^6.3 Tibbetts, RS et al. (1999) A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev. 13 152-7 PubMed GONUTS page

[PMID:9733515-7] 7.0 ^7.1 ^7.2 Canman, CE et al. (1998) Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281 1677-9 PubMed GONUTS page

[PMID:12814551-8] Barr, SM et al. (2003) ATR kinase activity regulates the intranuclear translocation of ATR and RPA following ionizing radiation. Curr. Biol. 13 1047-51 PubMed GONUTS page

[PMID:14657349-9] 9.0 ^9.1 ^9.2 Wang, Y & Qin, J (2003) MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation. Proc. Natl. Acad. Sci. U.S.A. 100 15387-92 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 ^10.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16713580-11] 11.0 ^11.1 Yoshioka, K et al. (2006) ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. Mol. Cell 22 501-10 PubMed GONUTS page

[PMID:9590286-12] Smith, L et al. (1998) Duplication of ATR inhibits MyoD, induces aneuploidy and eliminates radiation-induced G1 arrest. Nat. Genet. 19 39-46 PubMed GONUTS page

[PMID:8610130-13] 13.0 ^13.1 Cimprich, KA et al. (1996) cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein. Proc. Natl. Acad. Sci. U.S.A. 93 2850-5 PubMed GONUTS page

[PMID:15538388-14] Tsao, CC et al. (2004) Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling. EMBO J. 23 4660-9 PubMed GONUTS page

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HUMAN:ATR

Contents

Annotations

Notes

References

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