HUMAN:ARF

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CDKN2A (ECO:0000312 with EMBL:AAM77919.1, ECO:0000312 with HGNC:HGNC:1787) (synonyms: CDKN2 (ECO:0000312 with EMBL:AAC60649.1), MLM)
Protein Name(s)	Tumor suppressor ARF (ECO:0000305) Alternative reading frame (ECO:0000303 with PMID:9724636^[1]) ARF (ECO:0000303 with PMID:9724636^[1]) Cyclin-dependent kinase inhibitor 2A (ECO:0000312 with HGNC:HGNC:1787) p14ARF (ECO:0000303 with PMID:9724636^[1])
External Links
UniProt	Q8N726
EMBL	S78535 U38945 AF527803 AL449423 CH471071 CH471071 BC015960 BC021998 U26727 BT007020
CCDS	CCDS6511.2
PIR	I39004
RefSeq	NP_478102.2
UniGene	Hs.512599
ProteinModelPortal	Q8N726
SMR	Q8N726
BioGrid	107463
CORUM	Q8N726
DIP	DIP-24171N
IntAct	Q8N726
MINT	Q8N726
iPTMnet	Q8N726
BioMuta	UBR5
DMDM	384872321
MaxQB	Q8N726
PeptideAtlas	Q8N726
PRIDE	Q8N726
ProteomicsDB	72258
DNASU	1029
Ensembl	ENST00000530628 ENST00000579755
GeneID	1029
UCSC	uc003zpl.4
CTD	1029
DisGeNET	1029
EuPathDB	HostDB:ENSG00000147889.16
GeneCards	CDKN2A
HGNC	HGNC:1787
HPA	CAB000093 CAB000445 CAB018232 HPA047838
MalaCards	CDKN2A
MIM	600160
neXtProt	NX_Q8N726
OpenTargets	ENSG00000147889
PharmGKB	PA106
GeneTree	ENSGT00390000004527
HOGENOM	HOG000111485
HOVERGEN	HBG071056
Reactome	R-HSA-2559580 R-HSA-2559585 R-HSA-3108214 R-HSA-3232118 R-HSA-6804757 R-HSA-69541 R-HSA-8941858
SIGNOR	Q8N726
ChiTaRS	CDKN2A
GenomeRNAi	1029
Proteomes	UP000005640
Bgee	ENSG00000147889
CleanEx	HS_CDKN2A
ExpressionAtlas	Q8N726
Genevisible	Q8N726
GO	GO:0005739 GO:0005730 GO:0005654 GO:0005634 GO:0032991 GO:0097718 GO:0003677 GO:0097371 GO:0002039 GO:0019789 GO:0008134 GO:1990948 GO:0055105 GO:0006919 GO:1990000 GO:0008637 GO:0000422 GO:0007050 GO:0090398 GO:0051882 GO:0030889 GO:0008285 GO:0033088 GO:0006469 GO:2000435 GO:1903051 GO:1904667 GO:2000059 GO:0051444 GO:0043065 GO:0071158 GO:0043517 GO:0010628 GO:1900182 GO:0033235 GO:1901798 GO:0045944 GO:0045893 GO:0031648 GO:0070534 GO:0000209 GO:0050821 GO:1902510 GO:0010389 GO:0046825 GO:0031647 GO:1903214 GO:0006364 GO:0048103 GO:0006351
InterPro	IPR010868
Pfam	PF07392

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:2000435	negative regulation of protein neddylation	PMID:18560357^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904667	negative regulation of ubiquitin protein ligase activity	PMID:18560357^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	PMID:18560357^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:1990948	ubiquitin ligase inhibitor activity	PMID:18560357^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1990000	amyloid fibril formation	PMID:12630860^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0097718	disordered domain specific binding	PMID:12630860^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q00987	F		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:27323397^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:17310983^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	PMID:17310983^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:22094112^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:22094112^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1902510	regulation of apoptotic DNA fragmentation	PMID:12082630^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090398	cellular senescence	PMID:14966292^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0055105	ubiquitin-protein transferase inhibitor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64364	F		Seeded From UniProt	complete
involved_in	GO:0051444	negative regulation of ubiquitin-protein transferase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64364	P		Seeded From UniProt	complete
involved_in	GO:0048103	somatic stem cell division	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64364	P		Seeded From UniProt	complete
involved_in	GO:0033235	positive regulation of protein sumoylation	PMID:19057511^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033088	negative regulation of immature T cell proliferation in thymus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64364	P		Seeded From UniProt	complete
involved_in	GO:0031648	protein destabilization	PMID:9529249^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031647	regulation of protein stability	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64364	P		Seeded From UniProt	complete
involved_in	GO:0030889	negative regulation of B cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64364	P		Seeded From UniProt	complete
involved_in	GO:0010389	regulation of G2/M transition of mitotic cell cycle	PMID:15582998^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008637	apoptotic mitochondrial changes	PMID:12082630^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:19057511^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P18146	F		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	PMID:15582998^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:12082630^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006469	negative regulation of protein kinase activity	PMID:15582998^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:17110379^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:17110379^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11800646^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070534	protein K63-linked ubiquitination	PMID:18305112^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17569660^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17569660^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:17569660^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:18305112^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:18305112^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000209	protein polyubiquitination	PMID:18305112^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019789	SUMO transferase activity	PMID:15355988^[16]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016925	protein sumoylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0019789	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010868	P		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010868	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010868	P		Seeded From UniProt	complete
involved_in	GO:1900182	positive regulation of protein localization to nucleus	PMID:16173922^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901798	positive regulation of signal transduction by p53 class mediator	PMID:16173922^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	PMID:16173922^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0097371	MDM2/MDM4 family protein binding	PMID:16173922^[17]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q00987	F		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:16173922^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0097371	MDM2/MDM4 family protein binding	PMID:9529249^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q00987	F		Seeded From UniProt	complete
involved_in	GO:0071158	positive regulation of cell cycle arrest	PMID:9529249^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	PMID:9529249^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	PMID:10360174^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046825	regulation of protein export from nucleus	PMID:10360174^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	PMID:9529249^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:9529249^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0031648	protein destabilization	PMID:9529249^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0016604	nuclear body	PMID:10360174^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:10360174^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:10360174^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0002039	p53 binding	PMID:9529249^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
involved_in	GO:1903214	regulation of protein targeting to mitochondrion	PMID:25217637^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	UniProtKB:Q9BXM7	P	has_regulation_target:(UniProtKB:O60260)	Seeded From UniProt	complete
involved_in	GO:1903051	negative regulation of proteolysis involved in cellular protein catabolic process	PMID:25217637^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	UniProtKB:Q9BXM7	P	has_regulation_target:(UniProtKB:Q9BXM7)	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:25217637^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000422	autophagy of mitochondrion	PMID:25217637^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:O60260) has_input:(UniProtKB:Q9BXM7) occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0051882	mitochondrial depolarization	PMID:25217637^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-6804998 Reactome:R-HSA-6804996 Reactome:R-HSA-4568846 Reactome:R-HSA-3209111 Reactome:R-HSA-2997706	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006364	rRNA processing	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0698	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0190	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Stott, FJ et al. (1998) The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2. EMBO J. 17 5001-14 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Horn, HF & Vousden, KH (2008) Cooperation between the ribosomal proteins L5 and L11 in the p53 pathway. Oncogene 27 5774-84 PubMed GONUTS page
↑ ^3.0 ^3.1 Bothner, B et al. (2003) Peptides derived from two dynamically disordered proteins self-assemble into amyloid-like fibrils. J. Am. Chem. Soc. 125 3200-1 PubMed GONUTS page
↑ Lee, S et al. (2017) GLTSCR2 promotes the nucleoplasmic translocation and subsequent degradation of nucleolar ARF. Oncotarget 8 16293-16302 PubMed GONUTS page
↑ ^5.0 ^5.1 Chen, D et al. (2007) Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. Oncogene 26 5029-37 PubMed GONUTS page
↑ ^6.0 ^6.1 Watari, A et al. (2012) A novel proapoptotic gene PANO encodes a post-translational modulator of the tumor suppressor p14ARF. Exp. Cell Res. 318 187-95 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Hemmati, PG et al. (2002) Adenovirus-mediated overexpression of p14(ARF) induces p53 and Bax-independent apoptosis. Oncogene 21 3149-61 PubMed GONUTS page
↑ Shamanin, VA & Androphy, EJ (2004) Immortalization of human mammary epithelial cells is associated with inactivation of the p14ARF-p53 pathway. Mol. Cell. Biol. 24 2144-52 PubMed GONUTS page
↑ ^9.0 ^9.1 Yu, J et al. (2009) PTEN regulation by Akt-EGR1-ARF-PTEN axis. EMBO J. 28 21-33 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 Zhang, Y et al. (1998) ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 92 725-34 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Normand, G et al. (2005) p14ARF induces G2 cell cycle arrest in p53- and p21-deficient cells by down-regulating p34cdc2 kinase activity. J. Biol. Chem. 280 7118-30 PubMed GONUTS page
↑ ^12.0 ^12.1 Tompkins, VS et al. (2007) A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability. J. Biol. Chem. 282 1322-33 PubMed GONUTS page
↑ Korshunov, A & Golanov, A (2002) Immunohistochemical analysis of p18INK4C and p14ARF protein expression in 117 oligodendrogliomas: correlation with tumor grade and clinical outcome. Arch. Pathol. Lab. Med. 126 42-8 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Huang, Y et al. (2008) Tumor suppressor ARF promotes non-classic proteasome-independent polyubiquitination of COMMD1. J. Biol. Chem. 283 11453-60 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Zhou, Y et al. (2007) Activation of p53 by MEG3 non-coding RNA. J. Biol. Chem. 282 24731-42 PubMed GONUTS page
↑ Woods, YL et al. (2004) p14 Arf promotes small ubiquitin-like modifier conjugation of Werners helicase. J. Biol. Chem. 279 50157-66 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 Wang, J et al. (2006) A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2. Biochem. J. 393 489-501 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 ^18.4 Zhang, Y & Xiong, Y (1999) Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53. Mol. Cell 3 579-91 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 Grenier, K et al. (2014) Short mitochondrial ARF triggers Parkin/PINK1-dependent mitophagy. J. Biol. Chem. 289 29519-30 PubMed GONUTS page

[PMID:9724636-1] 1.0 ^1.1 ^1.2 Stott, FJ et al. (1998) The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2. EMBO J. 17 5001-14 PubMed GONUTS page

[PMID:18560357-2] 2.0 ^2.1 ^2.2 ^2.3 Horn, HF & Vousden, KH (2008) Cooperation between the ribosomal proteins L5 and L11 in the p53 pathway. Oncogene 27 5774-84 PubMed GONUTS page

[PMID:12630860-3] 3.0 ^3.1 Bothner, B et al. (2003) Peptides derived from two dynamically disordered proteins self-assemble into amyloid-like fibrils. J. Am. Chem. Soc. 125 3200-1 PubMed GONUTS page

[PMID:27323397-4] Lee, S et al. (2017) GLTSCR2 promotes the nucleoplasmic translocation and subsequent degradation of nucleolar ARF. Oncotarget 8 16293-16302 PubMed GONUTS page

[PMID:17310983-5] 5.0 ^5.1 Chen, D et al. (2007) Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. Oncogene 26 5029-37 PubMed GONUTS page

[PMID:22094112-6] 6.0 ^6.1 Watari, A et al. (2012) A novel proapoptotic gene PANO encodes a post-translational modulator of the tumor suppressor p14ARF. Exp. Cell Res. 318 187-95 PubMed GONUTS page

[PMID:12082630-7] 7.0 ^7.1 ^7.2 Hemmati, PG et al. (2002) Adenovirus-mediated overexpression of p14(ARF) induces p53 and Bax-independent apoptosis. Oncogene 21 3149-61 PubMed GONUTS page

[PMID:14966292-8] Shamanin, VA & Androphy, EJ (2004) Immortalization of human mammary epithelial cells is associated with inactivation of the p14ARF-p53 pathway. Mol. Cell. Biol. 24 2144-52 PubMed GONUTS page

[PMID:19057511-9] 9.0 ^9.1 Yu, J et al. (2009) PTEN regulation by Akt-EGR1-ARF-PTEN axis. EMBO J. 28 21-33 PubMed GONUTS page

[PMID:9529249-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 Zhang, Y et al. (1998) ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 92 725-34 PubMed GONUTS page

[PMID:15582998-11] 11.0 ^11.1 ^11.2 Normand, G et al. (2005) p14ARF induces G2 cell cycle arrest in p53- and p21-deficient cells by down-regulating p34cdc2 kinase activity. J. Biol. Chem. 280 7118-30 PubMed GONUTS page

[PMID:17110379-12] 12.0 ^12.1 Tompkins, VS et al. (2007) A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability. J. Biol. Chem. 282 1322-33 PubMed GONUTS page

[PMID:11800646-13] Korshunov, A & Golanov, A (2002) Immunohistochemical analysis of p18INK4C and p14ARF protein expression in 117 oligodendrogliomas: correlation with tumor grade and clinical outcome. Arch. Pathol. Lab. Med. 126 42-8 PubMed GONUTS page

[PMID:18305112-14] 14.0 ^14.1 ^14.2 ^14.3 Huang, Y et al. (2008) Tumor suppressor ARF promotes non-classic proteasome-independent polyubiquitination of COMMD1. J. Biol. Chem. 283 11453-60 PubMed GONUTS page

[PMID:17569660-15] 15.0 ^15.1 ^15.2 Zhou, Y et al. (2007) Activation of p53 by MEG3 non-coding RNA. J. Biol. Chem. 282 24731-42 PubMed GONUTS page

[PMID:15355988-16] Woods, YL et al. (2004) p14 Arf promotes small ubiquitin-like modifier conjugation of Werners helicase. J. Biol. Chem. 279 50157-66 PubMed GONUTS page

[PMID:16173922-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 Wang, J et al. (2006) A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2. Biochem. J. 393 489-501 PubMed GONUTS page

[PMID:10360174-18] 18.0 ^18.1 ^18.2 ^18.3 ^18.4 Zhang, Y & Xiong, Y (1999) Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53. Mol. Cell 3 579-91 PubMed GONUTS page

[PMID:25217637-19] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 Grenier, K et al. (2014) Short mitochondrial ARF triggers Parkin/PINK1-dependent mitophagy. J. Biol. Chem. 289 29519-30 PubMed GONUTS page

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HUMAN:ARF

Contents

Annotations

Notes

References

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