HUMAN:A2SUH6

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	No Information Provided.
Protein Name(s)	Survivin variant 3 alpha
External Links
UniProt	A2SUH6
EMBL	DQ227257
IPI	IPI00784873
UniGene	Hs.514527 Hs.728893
ProteinModelPortal	A2SUH6
SMR	A2SUH6
STRING	A2SUH6
PRIDE	A2SUH6
HOVERGEN	HBG080756
OrthoDB	EOG4MSD0R
GO	GO:0005622
InterPro	IPR001370
Gene3D	G3DSA:1.10.1170.10
Pfam	PF00653
SMART	SM00238
PROSITE	PS50143

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0060769	positive regulation of epithelial cell proliferation involved in prostate gland development	PMID:21229552^[1]	ECO:0000314			P	Fig 1:Western blot and one step RT-PCR showing expression of survivin in normal and prostate lesions and cell lines. (There is only one surivivin human protein available on QuickGo. I dont know if it's the right one, as it is unreviewed and it doesnt mention its anti-apoptotic properties.)	complete
	GO:0006916	anti-apoptosis	PMID:21229552^[1]	ECO:0000314			P	Figure 7: Confirms that the survivin protein is anti-apoptotic.	complete
involved_in	GO:0007605	sensory perception of sound	PMID:20627126^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20627126^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:20627126^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:20627126^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21364656^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21364656^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:21364656^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000054	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	PMID:18086682^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10809	F	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:20826784^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:21536684^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0032133	chromosome passenger complex	PMID:18591255^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q53HL2	C	Seeded From UniProt	complete
part_of	GO:0032133	chromosome passenger complex	PMID:18591255^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q96GD4	C	Seeded From UniProt	complete
part_of	GO:0032133	chromosome passenger complex	PMID:15260989^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q53HL2	C	Seeded From UniProt	complete
involved_in	GO:0031503	protein-containing complex localization	PMID:16239925^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0030496	midbody	PMID:15665297^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:16322459^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q93008	F	Seeded From UniProt	complete
enables	GO:0008536	Ran GTPase binding	PMID:18591255^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P62826	F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:21252625^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:18591255^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20826784^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15665297^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0000777	condensed chromosome kinetochore	PMID:15665297^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0000775	chromosome, centromeric region	PMID:16322459^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0000228	nuclear chromosome	PMID:16322459^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0090307	mitotic spindle assembly	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005168 ZFIN:ZDB-GENE-030826-2	P	Seeded From UniProt	complete
part_of	GO:0005876	spindle microtubule	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005168 UniProtKB:O15392	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0260635 MGI:MGI:107572 MGI:MGI:1203517 PANTHER:PTN000005166 RGD:620692 UniProtKB:O15392 UniProtKB:P98170 UniProtKB:Q13489 UniProtKB:Q13490 UniProtKB:Q96CA5	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0260635 PANTHER:PTN000005166 PomBase:SPCC962.02c RGD:620690 RGD:620692 UniProtKB:O15392 UniProtKB:P98170 UniProtKB:Q13489 UniProtKB:Q13490 UniProtKB:Q96CA5	C	Seeded From UniProt	complete
part_of	GO:0030496	midbody	PMID:11084331^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0000775	chromosome, centromeric region	PMID:11084331^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:23251006^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O15392	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:17099693^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O15392	F	Seeded From UniProt	complete
involved_in	GO:0010951	negative regulation of endopeptidase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004869	P	Seeded From UniProt	complete
involved_in	GO:0051303	establishment of chromosome localization	PMID:12805209^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051301	cell division	PMID:12805209^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0050897	cobalt ion binding	PMID:10949039^[18]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0048037	cofactor binding	PMID:12773388^[19]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:16291752^[20]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045931	positive regulation of mitotic cell cycle	PMID:16291752^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:9859993^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:12773388^[19]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:9256286^[22]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:10626797^[23]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:12773388^[19]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:9859993^[21]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	PMID:9859993^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:16291752^[20]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O15392-1	F	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:10949039^[18]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:10876248^[24]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007094	mitotic spindle assembly checkpoint	PMID:12805209^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031536	positive regulation of exit from mitosis	PMID:12805209^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0031021	interphase microtubule organizing center	PMID:9859993^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0030496	midbody	PMID:11069302^[25]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0030496	midbody	PMID:9859993^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0030496	midbody	PMID:16291752^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0015631	tubulin binding	PMID:9859993^[21]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:10876248^[24]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:10949039^[18]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:9859993^[21]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005881	cytoplasmic microtubule	PMID:9859993^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005876	spindle microtubule	PMID:11069302^[25]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005876	spindle microtubule	PMID:9859993^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:12773388^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005814	centriole	PMID:9859993^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:9256286^[22]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0000281	mitotic cytokinesis	PMID:12805209^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0000775	chromosome, centromeric region	PMID:11516652^[26]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0000775	chromosome, centromeric region	PMID:16291752^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0000086	G2/M transition of mitotic cell cycle	PMID:9859993^[21]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:16291752^[20]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O15392-1	F	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0043027	P	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:16291752^[20]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:10626797^[23]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16291752^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:16344111^[27]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:21536684^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	Reactome:R-HSA-5633008	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6785807	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8956026 Reactome:R-HSA-5666169 Reactome:R-HSA-5666160 Reactome:R-HSA-5666129 Reactome:R-HSA-4655355 Reactome:R-HSA-375302 Reactome:R-HSA-2484822 Reactome:R-HSA-2468287 Reactome:R-HSA-2467811 Reactome:R-HSA-2467809 Reactome:R-HSA-1638821 Reactome:R-HSA-1638803 Reactome:R-HSA-141439 Reactome:R-HSA-141431 Reactome:R-HSA-141422 Reactome:R-HSA-141409	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-6797763 Reactome:R-HSA-6790036 Reactome:R-HSA-4655355	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007059	chromosome segregation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0159	P	Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0995	C	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
enables	GO:0030414	peptidase inhibitor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0646	F	Seeded From UniProt	complete
enables	GO:0004869	cysteine-type endopeptidase inhibitor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0789	F	Seeded From UniProt	complete
involved_in	GO:0010466	negative regulation of peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0646	P	Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0493	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C	Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P	Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P	Seeded From UniProt	complete
part_of	GO:0000775	chromosome, centromeric region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0137 UniProtKB-SubCell:SL-0047	C	Seeded From UniProt	complete
part_of	GO:0000777	condensed chromosome kinetochore	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0149	C	Seeded From UniProt	complete
part_of	GO:0005819	spindle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0251	C	Seeded From UniProt	complete
part_of	GO:0030496	midbody	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0469	C	Seeded From UniProt	complete
involved_in	GO:0000278	mitotic cell cycle	PMID:16291752^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 () PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Habtemichael, N et al. (2010) Expression analysis suggests a potential cytoprotective role of Birc5 in the inner ear. Mol. Cell. Neurosci. 45 297-305 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Knauer, SK et al. (2010) An otoprotective role for the apoptosis inhibitor protein survivin. Cell Death Dis 1 e51 PubMed GONUTS page
↑ Ghosh, JC et al. (2008) Hsp60 regulation of tumor cell apoptosis. J. Biol. Chem. 283 5188-94 PubMed GONUTS page
↑ ^5.0 ^5.1 Wang, H et al. (2010) Acetylation directs survivin nuclear localization to repress STAT3 oncogenic activity. J. Biol. Chem. 285 36129-37 PubMed GONUTS page
↑ ^6.0 ^6.1 Pavlyukov, MS et al. (2011) Survivin monomer plays an essential role in apoptosis regulation. J. Biol. Chem. 286 23296-307 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Xia, F et al. (2008) A survivin-ran complex regulates spindle formation in tumor cells. Mol. Cell. Biol. 28 5299-311 PubMed GONUTS page
↑ Sampath, SC et al. (2004) The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly. Cell 118 187-202 PubMed GONUTS page
↑ Vader, G et al. (2006) Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody. EMBO Rep. 7 85-92 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Samuel, T et al. (2005) cIAP1 Localizes to the nuclear compartment and modulates the cell cycle. Cancer Res. 65 210-8 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Vong, QP et al. (2005) Chromosome alignment and segregation regulated by ubiquitination of survivin. Science 310 1499-504 PubMed GONUTS page
↑ Barrett, RM et al. (2011) Threonine 48 in the BIR domain of survivin is critical to its mitotic and anti-apoptotic activities and can be phosphorylated by CK2 in vitro. Cell Cycle 10 538-48 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^14.0 ^14.1 Uren, AG et al. (2000) Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype. Curr. Biol. 10 1319-28 PubMed GONUTS page
↑ Guvenc, H et al. (2013) Impairment of glioma stem cell survival and growth by a novel inhibitor for Survivin-Ran protein complex. Clin. Cancer Res. 19 631-42 PubMed GONUTS page
↑ Knauer, SK et al. (2006) The Survivin-Crm1 interaction is essential for chromosomal passenger complex localization and function. EMBO Rep. 7 1259-65 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 Lens, SM et al. (2003) Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension. EMBO J. 22 2934-47 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Chantalat, L et al. (2000) Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions. Mol. Cell 6 183-9 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 Marusawa, H et al. (2003) HBXIP functions as a cofactor of survivin in apoptosis suppression. EMBO J. 22 2729-40 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 ^20.4 ^20.5 ^20.6 ^20.7 ^20.8 Noton, EA et al. (2006) Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis. J. Biol. Chem. 281 1286-95 PubMed GONUTS page
↑ ^21.00 ^21.01 ^21.02 ^21.03 ^21.04 ^21.05 ^21.06 ^21.07 ^21.08 ^21.09 ^21.10 Li, F et al. (1998) Control of apoptosis and mitotic spindle checkpoint by survivin. Nature 396 580-4 PubMed GONUTS page
↑ ^22.0 ^22.1 Ambrosini, G et al. (1997) A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat. Med. 3 917-21 PubMed GONUTS page
↑ ^23.0 ^23.1 Mahotka, C et al. (1999) Survivin-deltaEx3 and survivin-2B: two novel splice variants of the apoptosis inhibitor survivin with different antiapoptotic properties. Cancer Res. 59 6097-102 PubMed GONUTS page
↑ ^24.0 ^24.1 Verdecia, MA et al. (2000) Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement. Nat. Struct. Biol. 7 602-8 PubMed GONUTS page
↑ ^25.0 ^25.1 O'Connor, DS et al. (2000) Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin. Proc. Natl. Acad. Sci. U.S.A. 97 13103-7 PubMed GONUTS page
↑ Wheatley, SP et al. (2001) INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis. Curr. Biol. 11 886-90 PubMed GONUTS page
↑ Wheatley, SP & McNeish, IA (2005) Survivin: a protein with dual roles in mitosis and apoptosis. Int. Rev. Cytol. 247 35-88 PubMed GONUTS page

[PMID:21229552-1] 1.0 ^1.1 () PubMed GONUTS page

[PMID:20627126-2] 2.0 ^2.1 ^2.2 ^2.3 Habtemichael, N et al. (2010) Expression analysis suggests a potential cytoprotective role of Birc5 in the inner ear. Mol. Cell. Neurosci. 45 297-305 PubMed GONUTS page

[PMID:21364656-3] 3.0 ^3.1 ^3.2 Knauer, SK et al. (2010) An otoprotective role for the apoptosis inhibitor protein survivin. Cell Death Dis 1 e51 PubMed GONUTS page

[PMID:18086682-4] Ghosh, JC et al. (2008) Hsp60 regulation of tumor cell apoptosis. J. Biol. Chem. 283 5188-94 PubMed GONUTS page

[PMID:20826784-5] 5.0 ^5.1 Wang, H et al. (2010) Acetylation directs survivin nuclear localization to repress STAT3 oncogenic activity. J. Biol. Chem. 285 36129-37 PubMed GONUTS page

[PMID:21536684-6] 6.0 ^6.1 Pavlyukov, MS et al. (2011) Survivin monomer plays an essential role in apoptosis regulation. J. Biol. Chem. 286 23296-307 PubMed GONUTS page

[PMID:18591255-7] 7.0 ^7.1 ^7.2 ^7.3 Xia, F et al. (2008) A survivin-ran complex regulates spindle formation in tumor cells. Mol. Cell. Biol. 28 5299-311 PubMed GONUTS page

[PMID:15260989-8] Sampath, SC et al. (2004) The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly. Cell 118 187-202 PubMed GONUTS page

[PMID:16239925-9] Vader, G et al. (2006) Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody. EMBO Rep. 7 85-92 PubMed GONUTS page

[PMID:15665297-10] 10.0 ^10.1 ^10.2 Samuel, T et al. (2005) cIAP1 Localizes to the nuclear compartment and modulates the cell cycle. Cancer Res. 65 210-8 PubMed GONUTS page

[PMID:16322459-11] 11.0 ^11.1 ^11.2 Vong, QP et al. (2005) Chromosome alignment and segregation regulated by ubiquitination of survivin. Science 310 1499-504 PubMed GONUTS page

[PMID:21252625-12] Barrett, RM et al. (2011) Threonine 48 in the BIR domain of survivin is critical to its mitotic and anti-apoptotic activities and can be phosphorylated by CK2 in vitro. Cell Cycle 10 538-48 PubMed GONUTS page

[PMID:21873635-13] 13.0 ^13.1 ^13.2 ^13.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11084331-14] 14.0 ^14.1 Uren, AG et al. (2000) Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype. Curr. Biol. 10 1319-28 PubMed GONUTS page

[PMID:23251006-15] Guvenc, H et al. (2013) Impairment of glioma stem cell survival and growth by a novel inhibitor for Survivin-Ran protein complex. Clin. Cancer Res. 19 631-42 PubMed GONUTS page

[PMID:17099693-16] Knauer, SK et al. (2006) The Survivin-Crm1 interaction is essential for chromosomal passenger complex localization and function. EMBO Rep. 7 1259-65 PubMed GONUTS page

[PMID:12805209-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 Lens, SM et al. (2003) Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension. EMBO J. 22 2934-47 PubMed GONUTS page

[PMID:10949039-18] 18.0 ^18.1 ^18.2 Chantalat, L et al. (2000) Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions. Mol. Cell 6 183-9 PubMed GONUTS page

[PMID:12773388-19] 19.0 ^19.1 ^19.2 ^19.3 Marusawa, H et al. (2003) HBXIP functions as a cofactor of survivin in apoptosis suppression. EMBO J. 22 2729-40 PubMed GONUTS page

[PMID:16291752-20] 20.0 ^20.1 ^20.2 ^20.3 ^20.4 ^20.5 ^20.6 ^20.7 ^20.8 Noton, EA et al. (2006) Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis. J. Biol. Chem. 281 1286-95 PubMed GONUTS page

[PMID:9859993-21] 21.00 ^21.01 ^21.02 ^21.03 ^21.04 ^21.05 ^21.06 ^21.07 ^21.08 ^21.09 ^21.10 Li, F et al. (1998) Control of apoptosis and mitotic spindle checkpoint by survivin. Nature 396 580-4 PubMed GONUTS page

[PMID:9256286-22] 22.0 ^22.1 Ambrosini, G et al. (1997) A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat. Med. 3 917-21 PubMed GONUTS page

[PMID:10626797-23] 23.0 ^23.1 Mahotka, C et al. (1999) Survivin-deltaEx3 and survivin-2B: two novel splice variants of the apoptosis inhibitor survivin with different antiapoptotic properties. Cancer Res. 59 6097-102 PubMed GONUTS page

[PMID:10876248-24] 24.0 ^24.1 Verdecia, MA et al. (2000) Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement. Nat. Struct. Biol. 7 602-8 PubMed GONUTS page

[PMID:11069302-25] 25.0 ^25.1 O'Connor, DS et al. (2000) Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin. Proc. Natl. Acad. Sci. U.S.A. 97 13103-7 PubMed GONUTS page

[PMID:11516652-26] Wheatley, SP et al. (2001) INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis. Curr. Biol. 11 886-90 PubMed GONUTS page

[PMID:16344111-27] Wheatley, SP & McNeish, IA (2005) Survivin: a protein with dual roles in mitosis and apoptosis. Int. Rev. Cytol. 247 35-88 PubMed GONUTS page

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