DROME:HP1

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	Su(var)205 (synonyms: HP1)
Protein Name(s)	Heterochromatin protein 1 HP1 Non-histone chromosomal protein C1A9 antigen
External Links
UniProt	P05205
EMBL	M57574 M14131 FJ218607 FJ218612 FJ218613 FJ218614 FJ218615 FJ218616 FJ218617 FJ218618 FJ218619 FJ218620 FJ218621 FJ218622 FJ218623 FJ218624 FJ218625 FJ218626 FJ218627 FJ218628 FJ218629 FJ218630 FJ218631 FJ218632 FJ218633 FJ218634 FJ218635 FJ218636 FJ218637 FJ218638 FJ218639 AE014134 AE014134 AY061119
PIR	A39268
RefSeq	NP_476755.1 NP_723361.1
UniGene	Dm.3713
PDB	1KNA 1KNE 1Q3L 3P7J
PDBsum	1KNA 1KNE 1Q3L 3P7J
ProteinModelPortal	P05205
SMR	P05205
BioGrid	60248
DIP	DIP-21869N
IntAct	P05205
MINT	MINT-271388
PaxDb	P05205
EnsemblMetazoa	FBtr0079635 FBtr0079636
GeneID	34119
KEGG	dme:Dmel_CG8409
UCSC	CG8409-RB
CTD	34119
FlyBase	FBgn0003607
eggNOG	NOG132879
GeneTree	ENSGT00510000046310
InParanoid	P05205
KO	K11587
OMA	WEPENNL
OrthoDB	EOG7QRQWW
PhylomeDB	P05205
SignaLink	P05205
EvolutionaryTrace	P05205
GenomeRNAi	34119
NextBio	786946
Proteomes	UP000000803
Bgee	P05205
GO	GO:0005694 GO:0000775 GO:0000781 GO:0000793 GO:0000780 GO:0000791 GO:0000792 GO:0005720 GO:0005654 GO:0005634 GO:0005721 GO:0005700 GO:0005704 GO:0005701 GO:0005703 GO:0035012 GO:0003682 GO:0042393 GO:0035064 GO:0003729 GO:0000182 GO:0003723 GO:0003696 GO:0006342 GO:0030702 GO:0051276 GO:0044026 GO:0006343 GO:0016458 GO:0031507 GO:0034773 GO:0045892 GO:0022008 GO:0033697 GO:1900111 GO:0045893 GO:0042981 GO:0031060 GO:0006355 GO:0000723 GO:0006351
InterPro	IPR017984 IPR023780 IPR000953 IPR008251 IPR016197 IPR023779
Pfam	PF00385 PF01393
PRINTS	PR00504
SMART	SM00298 SM00300
SUPFAM	SSF54160
PROSITE	PS00598 PS50013

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0000792	heterochromatin	PMID:21966530^[1]	ECO:0000314			C		Figure 1. Interaction of MU2 and HP1a.	complete CACAO 2103
	GO:0005701	polytene chromosome chromocenter	PMID:21966530^[1]	ECO:0000315			C		Figure 3. Effects of HP1a depletion on focal movement.	complete CACAO 2108
	GO:0010369	chromocenter	PMID:21966530^[1]	ECO:0000314			C		Figure 4. HP1a is not recruited to IRIF and laser induced breaks.	complete CACAO 2110
	GO:0007067	mitosis	PMID:21966530^[1]	ECO:0000314			P		Fig 7. Treatment of S2 cells with HP1a dsRNA leads to a decrease in the number of cells in S phase and an apparent increase in the number of cells at both G1 and G2/M.	complete CACAO 2115
part_of	GO:0005634	nucleus	PMID:29746464^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20889714^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:20889714^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0061408	positive regulation of transcription from RNA polymerase II promoter in response to heat stress	PMID:20889714^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P02828)	Seeded From UniProt	complete
enables	GO:0070063	RNA polymerase binding	PMID:20889714^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0030674	protein binding, bridging	PMID:20889714^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0099122	RNA polymerase II C-terminal domain binding	PMID:20889714^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
colocalizes_with	GO:0005705	polytene chromosome interband	PMID:20889714^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0030544	Hsp70 protein binding	PMID:20889714^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	happens_during:(GO:0009408)	Seeded From UniProt	complete
colocalizes_with	GO:0005703	polytene chromosome puff	PMID:20889714^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0034605)	Seeded From UniProt	complete
involved_in	GO:1905634	regulation of protein localization to chromatin	PMID:20889714^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q05344) happens_during:(GO:0009408)	Seeded From UniProt	complete
involved_in	GO:1905632	protein localization to euchromatin	PMID:20889714^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q05344) has_input:(UniProtKB:Q8IRG6)	Seeded From UniProt	complete
involved_in	GO:0000278	mitotic cell cycle	PMID:21966530^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1905646	positive regulation of FACT complex assembly	PMID:20889714^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:26494711^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0086908	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:26494711^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:26494711^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:26494711^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0070868	heterochromatin organization involved in chromatin silencing	PMID:26494711^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090309	positive regulation of methylation-dependent chromatin silencing	PMID:26472911^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:24990964^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005721	pericentric heterochromatin	PMID:24990964^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005700	polytene chromosome	PMID:24990964^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005704	polytene chromosome band	PMID:21703449^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005701	polytene chromosome chromocenter	PMID:21703449^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000781	chromosome, telomeric region	PMID:21093267^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000781	chromosome, telomeric region	PMID:20057353^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	PMID:19750210^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016458	gene silencing	PMID:19487560^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035012	polytene chromosome, telomeric region	PMID:19487560^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016458	gene silencing	PMID:19487560^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005701	polytene chromosome chromocenter	PMID:19487560^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1900111	positive regulation of histone H3-K9 dimethylation	PMID:19487560^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033697	positive regulation of extent of heterochromatin assembly	PMID:19487560^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031507	heterochromatin assembly	PMID:19487560^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900111	positive regulation of histone H3-K9 dimethylation	PMID:19487560^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0000791	euchromatin	PMID:19487560^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005701	polytene chromosome chromocenter	PMID:18981478^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0034773	histone H4-K20 trimethylation	PMID:18296440^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005700	polytene chromosome	PMID:17909832^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:18020713^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051276	chromosome organization	PMID:17151257^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16675949^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000780	condensed nuclear chromosome, centromeric region	PMID:16675949^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0000182	rDNA binding	PMID:16675949^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003696	satellite DNA binding	PMID:16675949^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000792	heterochromatin	PMID:16980400^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000793	condensed chromosome	PMID:16980400^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	PMID:16258543^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031060	regulation of histone methylation	PMID:16258543^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:16258543^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000723	telomere maintenance	PMID:15304225^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035012	polytene chromosome, telomeric region	PMID:12756231^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005701	polytene chromosome chromocenter	PMID:12756231^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005703	polytene chromosome puff	PMID:12756231^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	PMID:12771122^[22]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042393	histone binding	PMID:12771122^[22]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000792	heterochromatin	PMID:12771122^[22]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:12771122^[22]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0000775	chromosome, centromeric region	PMID:12771122^[22]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0035012	polytene chromosome, telomeric region	PMID:12723693^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005701	polytene chromosome chromocenter	PMID:12723693^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005703	polytene chromosome puff	PMID:12723693^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005720	nuclear heterochromatin	PMID:12376620^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006342	chromatin silencing	PMID:11901117^[25]	ECO:0007001	high throughput mutant phenotypic evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030702	chromatin silencing at centromere	PMID:11901117^[25]	ECO:0007001	high throughput mutant phenotypic evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006343	establishment of chromatin silencing	PMID:11179225^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9311988^[27]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:17318176^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005700	polytene chromosome	PMID:17318176^[28]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008251	C		Seeded From UniProt	complete
part_of	GO:0035012	polytene chromosome, telomeric region	PMID:14579245^[29]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000775	chromosome, centromeric region	PMID:14579245^[29]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005701	polytene chromosome chromocenter	PMID:14579245^[29]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000792	heterochromatin	PMID:14579245^[29]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0035064	methylated histone binding	PMID:14585615^[30]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005703	polytene chromosome puff	PMID:12771122^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:12771122^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0190	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Dronamraju, R & Mason, JM (2011) MU2 and HP1a regulate the recognition of double strand breaks in Drosophila melanogaster. PLoS ONE 6 e25439 PubMed GONUTS page
↑ Seller, CA & O'Farrell, PH (2018) Rif1 prolongs the embryonic S phase at the Drosophila mid-blastula transition. PLoS Biol. 16 e2005687 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 Kwon, SH et al. (2010) Heterochromatin protein 1 (HP1) connects the FACT histone chaperone complex to the phosphorylated CTD of RNA polymerase II. Genes Dev. 24 2133-45 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Sienski, G et al. (2015) Silencio/CG9754 connects the Piwi-piRNA complex to the cellular heterochromatin machinery. Genes Dev. 29 2258-71 PubMed GONUTS page
↑ Yu, Y et al. (2015) Panoramix enforces piRNA-dependent cotranscriptional silencing. Science 350 339-42 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Alekseyenko, AA et al. (2014) Heterochromatin-associated interactions of Drosophila HP1a with dADD1, HIPP1, and repetitive RNAs. Genes Dev. 28 1445-60 PubMed GONUTS page
↑ ^7.0 ^7.1 Seong, KH et al. (2011) Inheritance of stress-induced, ATF-2-dependent epigenetic change. Cell 145 1049-61 PubMed GONUTS page
↑ Dubruille, R et al. (2010) Specialization of a Drosophila capping protein essential for the protection of sperm telomeres. Curr. Biol. 20 2090-9 PubMed GONUTS page
↑ Gao, G et al. (2010) HipHop interacts with HOAP and HP1 to protect Drosophila telomeres in a sequence-independent manner. EMBO J. 29 819-29 PubMed GONUTS page
↑ Koch, CM et al. (2009) Windei, the Drosophila homolog of mAM/MCAF1, is an essential cofactor of the H3K9 methyl transferase dSETDB1/Eggless in germ line development. PLoS Genet. 5 e1000644 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 ^11.8 Hines, KA et al. (2009) Domains of heterochromatin protein 1 required for Drosophila melanogaster heterochromatin spreading. Genetics 182 967-77 PubMed GONUTS page
↑ Font-Burgada, J et al. (2008) Drosophila HP1c isoform interacts with the zinc-finger proteins WOC and Relative-of-WOC to regulate gene expression. Genes Dev. 22 3007-23 PubMed GONUTS page
↑ Yang, H et al. (2008) Preferential dimethylation of histone H4 lysine 20 by Suv4-20. J. Biol. Chem. 283 12085-92 PubMed GONUTS page
↑ Gause, M et al. (2008) Functional links between Drosophila Nipped-B and cohesin in somatic and meiotic cells. Chromosoma 117 51-66 PubMed GONUTS page
↑ Johansson, AM et al. (2007) POF and HP1 bind expressed exons, suggesting a balancing mechanism for gene regulation. PLoS Genet. 3 e209 PubMed GONUTS page
↑ Demakova, OV et al. (2007) The SU(VAR)3-9/HP1 complex differentially regulates the compaction state and degree of underreplication of X chromosome pericentric heterochromatin in Drosophila melanogaster. Genetics 175 609-20 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 Blattes, R et al. (2006) Displacement of D1, HP1 and topoisomerase II from satellite heterochromatin by a specific polyamide. EMBO J. 25 2397-408 PubMed GONUTS page
↑ ^18.0 ^18.1 Shaffer, CD et al. (2006) The large isoform of Drosophila melanogaster heterochromatin protein 2 plays a critical role in gene silencing and chromosome structure. Genetics 174 1189-204 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 Liu, LP et al. (2005) Sex-specific role of Drosophila melanogaster HP1 in regulating chromatin structure and gene transcription. Nat. Genet. 37 1361-6 PubMed GONUTS page
↑ Perrini, B et al. (2004) HP1 controls telomere capping, telomere elongation, and telomere silencing by two different mechanisms in Drosophila. Mol. Cell 15 467-76 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 Piacentini, L et al. (2003) Heterochromatin protein 1 (HP1) is associated with induced gene expression in Drosophila euchromatin. J. Cell Biol. 161 707-14 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 ^22.4 ^22.5 ^22.6 Kellum, R (2003) Is HP1 an RNA detector that functions both in repression and activation? J. Cell Biol. 161 671-2 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 Fanti, L et al. (2003) Chromosomal distribution of heterochromatin protein 1 (HP1) in Drosophila: a cytological map of euchromatic HP1 binding sites. Genetica 117 135-47 PubMed GONUTS page
↑ Shaffer, CD et al. (2002) Heterochromatin protein 2 (HP2), a partner of HP1 in Drosophila heterochromatin. Proc. Natl. Acad. Sci. U.S.A. 99 14332-7 PubMed GONUTS page
↑ ^25.0 ^25.1 Donaldson, KM et al. (2002) Modifiers of terminal deficiency-associated position effect variegation in Drosophila. Genetics 160 995-1009 PubMed GONUTS page
↑ Seum, C et al. (2001) Ectopic HP1 promotes chromosome loops and variegated silencing in Drosophila. EMBO J. 20 812-8 PubMed GONUTS page
↑ Cléard, F et al. (1997) SU(VAR)3-7, a Drosophila heterochromatin-associated protein and companion of HP1 in the genomic silencing of position-effect variegation. EMBO J. 16 5280-8 PubMed GONUTS page
↑ ^28.0 ^28.1 Johansson, AM et al. (2007) Painting of fourth and chromosome-wide regulation of the 4th chromosome in Drosophila melanogaster. EMBO J. 26 2307-16 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 ^29.3 Zhimulev, IF & Belyaeva, ES (2003) Intercalary heterochromatin and genetic silencing. Bioessays 25 1040-51 PubMed GONUTS page
↑ Sims, RJ 3rd et al. (2003) Histone lysine methylation: a signature for chromatin function. Trends Genet. 19 629-39 PubMed GONUTS page

[PMID:21966530-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Dronamraju, R & Mason, JM (2011) MU2 and HP1a regulate the recognition of double strand breaks in Drosophila melanogaster. PLoS ONE 6 e25439 PubMed GONUTS page

[PMID:29746464-2] Seller, CA & O'Farrell, PH (2018) Rif1 prolongs the embryonic S phase at the Drosophila mid-blastula transition. PLoS Biol. 16 e2005687 PubMed GONUTS page

[PMID:20889714-3] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 Kwon, SH et al. (2010) Heterochromatin protein 1 (HP1) connects the FACT histone chaperone complex to the phosphorylated CTD of RNA polymerase II. Genes Dev. 24 2133-45 PubMed GONUTS page

[PMID:26494711-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Sienski, G et al. (2015) Silencio/CG9754 connects the Piwi-piRNA complex to the cellular heterochromatin machinery. Genes Dev. 29 2258-71 PubMed GONUTS page

[PMID:26472911-5] Yu, Y et al. (2015) Panoramix enforces piRNA-dependent cotranscriptional silencing. Science 350 339-42 PubMed GONUTS page

[PMID:24990964-6] 6.0 ^6.1 ^6.2 Alekseyenko, AA et al. (2014) Heterochromatin-associated interactions of Drosophila HP1a with dADD1, HIPP1, and repetitive RNAs. Genes Dev. 28 1445-60 PubMed GONUTS page

[PMID:21703449-7] 7.0 ^7.1 Seong, KH et al. (2011) Inheritance of stress-induced, ATF-2-dependent epigenetic change. Cell 145 1049-61 PubMed GONUTS page

[PMID:21093267-8] Dubruille, R et al. (2010) Specialization of a Drosophila capping protein essential for the protection of sperm telomeres. Curr. Biol. 20 2090-9 PubMed GONUTS page

[PMID:20057353-9] Gao, G et al. (2010) HipHop interacts with HOAP and HP1 to protect Drosophila telomeres in a sequence-independent manner. EMBO J. 29 819-29 PubMed GONUTS page

[PMID:19750210-10] Koch, CM et al. (2009) Windei, the Drosophila homolog of mAM/MCAF1, is an essential cofactor of the H3K9 methyl transferase dSETDB1/Eggless in germ line development. PLoS Genet. 5 e1000644 PubMed GONUTS page

[PMID:19487560-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 ^11.8 Hines, KA et al. (2009) Domains of heterochromatin protein 1 required for Drosophila melanogaster heterochromatin spreading. Genetics 182 967-77 PubMed GONUTS page

[PMID:18981478-12] Font-Burgada, J et al. (2008) Drosophila HP1c isoform interacts with the zinc-finger proteins WOC and Relative-of-WOC to regulate gene expression. Genes Dev. 22 3007-23 PubMed GONUTS page

[PMID:18296440-13] Yang, H et al. (2008) Preferential dimethylation of histone H4 lysine 20 by Suv4-20. J. Biol. Chem. 283 12085-92 PubMed GONUTS page

[PMID:17909832-14] Gause, M et al. (2008) Functional links between Drosophila Nipped-B and cohesin in somatic and meiotic cells. Chromosoma 117 51-66 PubMed GONUTS page

[PMID:18020713-15] Johansson, AM et al. (2007) POF and HP1 bind expressed exons, suggesting a balancing mechanism for gene regulation. PLoS Genet. 3 e209 PubMed GONUTS page

[PMID:17151257-16] Demakova, OV et al. (2007) The SU(VAR)3-9/HP1 complex differentially regulates the compaction state and degree of underreplication of X chromosome pericentric heterochromatin in Drosophila melanogaster. Genetics 175 609-20 PubMed GONUTS page

[PMID:16675949-17] 17.0 ^17.1 ^17.2 ^17.3 Blattes, R et al. (2006) Displacement of D1, HP1 and topoisomerase II from satellite heterochromatin by a specific polyamide. EMBO J. 25 2397-408 PubMed GONUTS page

[PMID:16980400-18] 18.0 ^18.1 Shaffer, CD et al. (2006) The large isoform of Drosophila melanogaster heterochromatin protein 2 plays a critical role in gene silencing and chromosome structure. Genetics 174 1189-204 PubMed GONUTS page

[PMID:16258543-19] 19.0 ^19.1 ^19.2 Liu, LP et al. (2005) Sex-specific role of Drosophila melanogaster HP1 in regulating chromatin structure and gene transcription. Nat. Genet. 37 1361-6 PubMed GONUTS page

[PMID:15304225-20] Perrini, B et al. (2004) HP1 controls telomere capping, telomere elongation, and telomere silencing by two different mechanisms in Drosophila. Mol. Cell 15 467-76 PubMed GONUTS page

[PMID:12756231-21] 21.0 ^21.1 ^21.2 Piacentini, L et al. (2003) Heterochromatin protein 1 (HP1) is associated with induced gene expression in Drosophila euchromatin. J. Cell Biol. 161 707-14 PubMed GONUTS page

[PMID:12771122-22] 22.0 ^22.1 ^22.2 ^22.3 ^22.4 ^22.5 ^22.6 Kellum, R (2003) Is HP1 an RNA detector that functions both in repression and activation? J. Cell Biol. 161 671-2 PubMed GONUTS page

[PMID:12723693-23] 23.0 ^23.1 ^23.2 Fanti, L et al. (2003) Chromosomal distribution of heterochromatin protein 1 (HP1) in Drosophila: a cytological map of euchromatic HP1 binding sites. Genetica 117 135-47 PubMed GONUTS page

[PMID:12376620-24] Shaffer, CD et al. (2002) Heterochromatin protein 2 (HP2), a partner of HP1 in Drosophila heterochromatin. Proc. Natl. Acad. Sci. U.S.A. 99 14332-7 PubMed GONUTS page

[PMID:11901117-25] 25.0 ^25.1 Donaldson, KM et al. (2002) Modifiers of terminal deficiency-associated position effect variegation in Drosophila. Genetics 160 995-1009 PubMed GONUTS page

[PMID:11179225-26] Seum, C et al. (2001) Ectopic HP1 promotes chromosome loops and variegated silencing in Drosophila. EMBO J. 20 812-8 PubMed GONUTS page

[PMID:9311988-27] Cléard, F et al. (1997) SU(VAR)3-7, a Drosophila heterochromatin-associated protein and companion of HP1 in the genomic silencing of position-effect variegation. EMBO J. 16 5280-8 PubMed GONUTS page

[PMID:17318176-28] 28.0 ^28.1 Johansson, AM et al. (2007) Painting of fourth and chromosome-wide regulation of the 4th chromosome in Drosophila melanogaster. EMBO J. 26 2307-16 PubMed GONUTS page

[PMID:14579245-29] 29.0 ^29.1 ^29.2 ^29.3 Zhimulev, IF & Belyaeva, ES (2003) Intercalary heterochromatin and genetic silencing. Bioessays 25 1040-51 PubMed GONUTS page

[PMID:14585615-30] Sims, RJ 3rd et al. (2003) Histone lysine methylation: a signature for chromatin function. Trends Genet. 19 629-39 PubMed GONUTS page

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