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DROME:HP1

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Su(var)205 (synonyms: HP1)
Protein Name(s) Heterochromatin protein 1

HP1 Non-histone chromosomal protein C1A9 antigen

External Links
UniProt P05205
EMBL M57574
M14131
FJ218607
FJ218612
FJ218613
FJ218614
FJ218615
FJ218616
FJ218617
FJ218618
FJ218619
FJ218620
FJ218621
FJ218622
FJ218623
FJ218624
FJ218625
FJ218626
FJ218627
FJ218628
FJ218629
FJ218630
FJ218631
FJ218632
FJ218633
FJ218634
FJ218635
FJ218636
FJ218637
FJ218638
FJ218639
AE014134
AE014134
AY061119
PIR A39268
RefSeq NP_476755.1
NP_723361.1
UniGene Dm.3713
PDB 1KNA
1KNE
1Q3L
3P7J
PDBsum 1KNA
1KNE
1Q3L
3P7J
ProteinModelPortal P05205
SMR P05205
BioGrid 60248
DIP DIP-21869N
IntAct P05205
MINT MINT-271388
PaxDb P05205
EnsemblMetazoa FBtr0079635
FBtr0079636
GeneID 34119
KEGG dme:Dmel_CG8409
UCSC CG8409-RB
CTD 34119
FlyBase FBgn0003607
eggNOG NOG132879
GeneTree ENSGT00510000046310
InParanoid P05205
KO K11587
OMA WEPENNL
OrthoDB EOG7QRQWW
PhylomeDB P05205
SignaLink P05205
EvolutionaryTrace P05205
GenomeRNAi 34119
NextBio 786946
Proteomes UP000000803
Bgee P05205
GO GO:0005694
GO:0000775
GO:0000781
GO:0000793
GO:0000780
GO:0000791
GO:0000792
GO:0005720
GO:0005654
GO:0005634
GO:0005721
GO:0005700
GO:0005704
GO:0005701
GO:0005703
GO:0035012
GO:0003682
GO:0042393
GO:0035064
GO:0003729
GO:0000182
GO:0003723
GO:0003696
GO:0006342
GO:0030702
GO:0051276
GO:0044026
GO:0006343
GO:0016458
GO:0031507
GO:0034773
GO:0045892
GO:0022008
GO:0033697
GO:1900111
GO:0045893
GO:0042981
GO:0031060
GO:0006355
GO:0000723
GO:0006351
InterPro IPR017984
IPR023780
IPR000953
IPR008251
IPR016197
IPR023779
Pfam PF00385
PF01393
PRINTS PR00504
SMART SM00298
SM00300
SUPFAM SSF54160
PROSITE PS00598
PS50013

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000792

heterochromatin

PMID:21966530[1]

IDA: Inferred from Direct Assay

C

Figure 1. Interaction of MU2 and HP1a.

complete
CACAO 2103

GO:0005701

polytene chromosome chromocenter

PMID:21966530[1]

IMP: Inferred from Mutant Phenotype

C

Figure 3. Effects of HP1a depletion on focal movement.

complete
CACAO 2108

GO:0010369

chromocenter

PMID:21966530[1]

IDA: Inferred from Direct Assay

C

Figure 4. HP1a is not recruited to IRIF and laser induced breaks.

complete
CACAO 2110

GO:0007067

mitosis

PMID:21966530[1]

IDA: Inferred from Direct Assay

P

Fig 7. Treatment of S2 cells with HP1a dsRNA leads to a decrease in the number of cells in S phase and an apparent increase in the number of cells at both G1 and G2/M.

complete
CACAO 2115

GO:0000182

rDNA binding

PMID:16675949[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0000723

telomere maintenance

PMID:15304225[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0000775

chromosome, centromeric region

PMID:12771122[4]

NAS: Non-traceable Author Statement

C

Seeded From UniProt

complete

GO:0000775

chromosome, centromeric region

PMID:14579245[5]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0000780

condensed nuclear chromosome, centromeric region

PMID:16675949[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0000781

chromosome, telomeric region

PMID:20057353[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0000781

chromosome, telomeric region

PMID:21093267[7]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0000791

euchromatin

PMID:19487560[8]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0000792

heterochromatin

PMID:12771122[4]

NAS: Non-traceable Author Statement

C

Seeded From UniProt

complete

GO:0000792

heterochromatin

PMID:14579245[5]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0000792

heterochromatin

PMID:16980400[9]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0000793

condensed chromosome

PMID:16980400[9]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0003682

chromatin binding

PMID:18020713[10]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0003696

satellite DNA binding

PMID:16675949[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0003723

RNA binding

PMID:24990964[11]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0003729

mRNA binding

PMID:12771122[4]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:12808023[12]

IPI: Inferred from Physical Interaction

UniProtKB:Q9VIE6

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:12826664[13]

IPI: Inferred from Physical Interaction

UniProtKB:Q95RV2

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:14605208[14]

IPI: Inferred from Physical Interaction

UniProtKB:Q95RV2

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:20057353[6]

IPI: Inferred from Physical Interaction

UniProtKB:Q95RV2

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:21703449[15]

IPI: Inferred from Physical Interaction

UniProtKB:Q9W0Z5

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:24990964[11]

IPI: Inferred from Physical Interaction

FB:FBgn0026573

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:24990964[11]

IPI: Inferred from Physical Interaction

FB:FBgn0037027

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:9311988[16]

IPI: Inferred from Physical Interaction

FB:FBgn0003598

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008251

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:16675949[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:9311988[16]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005654

nucleoplasm

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0190

C

Seeded From UniProt

complete

GO:0005694

chromosome

PMID:19750210[17]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005700

polytene chromosome

PMID:17909832[18]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005700

polytene chromosome

PMID:24990964[11]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005701

polytene chromosome chromocenter

PMID:12723693[19]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005701

polytene chromosome chromocenter

PMID:12756231[20]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005701

polytene chromosome chromocenter

PMID:14579245[5]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005701

polytene chromosome chromocenter

PMID:18981478[21]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005701

polytene chromosome chromocenter

PMID:19487560[8]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005701

polytene chromosome chromocenter

PMID:21703449[15]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005703

polytene chromosome puff

PMID:12723693[19]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005703

polytene chromosome puff

PMID:12756231[20]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005703

polytene chromosome puff

PMID:12771122[4]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005704

polytene chromosome band

PMID:21703449[15]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005720

nuclear heterochromatin

PMID:12376620[22]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005721

pericentric heterochromatin

PMID:24990964[11]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006342

chromatin silencing

PMID:11901117[23]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006343

establishment of chromatin silencing

PMID:11179225[24]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006351

transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

PMID:16258543[25]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007067

mitotic nuclear division

PMID:21966530[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0016458

gene silencing

PMID:19487560[8]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0016458

gene silencing

PMID:19487560[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016568

chromatin modification

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0156

P

Seeded From UniProt

complete

GO:0022008

neurogenesis

PMID:21549331[26]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030702

chromatin silencing at centromere

PMID:11901117[23]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0031060

regulation of histone methylation

PMID:16258543[25]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0031507

heterochromatin assembly

PMID:19487560[8]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0033697

positive regulation of extent of heterochromatin assembly

PMID:19487560[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0034773

histone H4-K20 trimethylation

PMID:18296440[27]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0035012

polytene chromosome, telomeric region

PMID:12723693[19]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0035012

polytene chromosome, telomeric region

PMID:12756231[20]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0035012

polytene chromosome, telomeric region

PMID:14579245[5]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0035012

polytene chromosome, telomeric region

PMID:19487560[8]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0035064

methylated histone binding

PMID:14585615[28]

TAS: Traceable Author Statement

F

Seeded From UniProt

complete

GO:0042393

histone binding

PMID:12771122[4]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

complete

GO:0042981

regulation of apoptotic process

PMID:16258543[25]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0044026

DNA hypermethylation

PMID:20498723[29]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045892

negative regulation of transcription, DNA-templated

PMID:12771122[4]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0045893

positive regulation of transcription, DNA-templated

PMID:12771122[4]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0051276

chromosome organization

PMID:17151257[30]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:1900111

positive regulation of histone H3-K9 dimethylation

PMID:19487560[8]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:1900111

positive regulation of histone H3-K9 dimethylation

PMID:19487560[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Dronamraju, R & Mason, JM (2011) MU2 and HP1a regulate the recognition of double strand breaks in Drosophila melanogaster. PLoS ONE 6 e25439 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Blattes, R et al. (2006) Displacement of D1, HP1 and topoisomerase II from satellite heterochromatin by a specific polyamide. EMBO J. 25 2397-408 PubMed GONUTS page
  3. Perrini, B et al. (2004) HP1 controls telomere capping, telomere elongation, and telomere silencing by two different mechanisms in Drosophila. Mol. Cell 15 467-76 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Kellum, R (2003) Is HP1 an RNA detector that functions both in repression and activation? J. Cell Biol. 161 671-2 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 Zhimulev, IF & Belyaeva, ES (2003) Intercalary heterochromatin and genetic silencing. Bioessays 25 1040-51 PubMed GONUTS page
  6. 6.0 6.1 Gao, G et al. (2010) HipHop interacts with HOAP and HP1 to protect Drosophila telomeres in a sequence-independent manner. EMBO J. 29 819-29 PubMed GONUTS page
  7. Dubruille, R et al. (2010) Specialization of a Drosophila capping protein essential for the protection of sperm telomeres. Curr. Biol. 20 2090-9 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 8.4 8.5 8.6 8.7 8.8 Hines, KA et al. (2009) Domains of heterochromatin protein 1 required for Drosophila melanogaster heterochromatin spreading. Genetics 182 967-77 PubMed GONUTS page
  9. 9.0 9.1 Shaffer, CD et al. (2006) The large isoform of Drosophila melanogaster heterochromatin protein 2 plays a critical role in gene silencing and chromosome structure. Genetics 174 1189-204 PubMed GONUTS page
  10. Johansson, AM et al. (2007) POF and HP1 bind expressed exons, suggesting a balancing mechanism for gene regulation. PLoS Genet. 3 e209 PubMed GONUTS page
  11. 11.0 11.1 11.2 11.3 11.4 Alekseyenko, AA et al. (2014) Heterochromatin-associated interactions of Drosophila HP1a with dADD1, HIPP1, and repetitive RNAs. Genes Dev. 28 1445-60 PubMed GONUTS page
  12. Christensen, TW & Tye, BK (2003) Drosophila MCM10 interacts with members of the prereplication complex and is required for proper chromosome condensation. Mol. Biol. Cell 14 2206-15 PubMed GONUTS page
  13. Badugu, R et al. (2003) Novel Drosophila heterochromatin protein 1 (HP1)/origin recognition complex-associated protein (HOAP) repeat motif in HP1/HOAP interactions and chromocenter associations. J. Biol. Chem. 278 34491-8 PubMed GONUTS page
  14. Giot, L et al. (2003) A protein interaction map of Drosophila melanogaster. Science 302 1727-36 PubMed GONUTS page
  15. 15.0 15.1 15.2 Seong, KH et al. (2011) Inheritance of stress-induced, ATF-2-dependent epigenetic change. Cell 145 1049-61 PubMed GONUTS page
  16. 16.0 16.1 Cléard, F et al. (1997) SU(VAR)3-7, a Drosophila heterochromatin-associated protein and companion of HP1 in the genomic silencing of position-effect variegation. EMBO J. 16 5280-8 PubMed GONUTS page
  17. Koch, CM et al. (2009) Windei, the Drosophila homolog of mAM/MCAF1, is an essential cofactor of the H3K9 methyl transferase dSETDB1/Eggless in germ line development. PLoS Genet. 5 e1000644 PubMed GONUTS page
  18. Gause, M et al. (2008) Functional links between Drosophila Nipped-B and cohesin in somatic and meiotic cells. Chromosoma 117 51-66 PubMed GONUTS page
  19. 19.0 19.1 19.2 Fanti, L et al. (2003) Chromosomal distribution of heterochromatin protein 1 (HP1) in Drosophila: a cytological map of euchromatic HP1 binding sites. Genetica 117 135-47 PubMed GONUTS page
  20. 20.0 20.1 20.2 Piacentini, L et al. (2003) Heterochromatin protein 1 (HP1) is associated with induced gene expression in Drosophila euchromatin. J. Cell Biol. 161 707-14 PubMed GONUTS page
  21. Font-Burgada, J et al. (2008) Drosophila HP1c isoform interacts with the zinc-finger proteins WOC and Relative-of-WOC to regulate gene expression. Genes Dev. 22 3007-23 PubMed GONUTS page
  22. Shaffer, CD et al. (2002) Heterochromatin protein 2 (HP2), a partner of HP1 in Drosophila heterochromatin. Proc. Natl. Acad. Sci. U.S.A. 99 14332-7 PubMed GONUTS page
  23. 23.0 23.1 Donaldson, KM et al. (2002) Modifiers of terminal deficiency-associated position effect variegation in Drosophila. Genetics 160 995-1009 PubMed GONUTS page
  24. Seum, C et al. (2001) Ectopic HP1 promotes chromosome loops and variegated silencing in Drosophila. EMBO J. 20 812-8 PubMed GONUTS page
  25. 25.0 25.1 25.2 Liu, LP et al. (2005) Sex-specific role of Drosophila melanogaster HP1 in regulating chromatin structure and gene transcription. Nat. Genet. 37 1361-6 PubMed GONUTS page
  26. Neumüller, RA et al. (2011) Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi. Cell Stem Cell 8 580-93 PubMed GONUTS page
  27. Yang, H et al. (2008) Preferential dimethylation of histone H4 lysine 20 by Suv4-20. J. Biol. Chem. 283 12085-92 PubMed GONUTS page
  28. Sims, RJ 3rd et al. (2003) Histone lysine methylation: a signature for chromatin function. Trends Genet. 19 629-39 PubMed GONUTS page
  29. Gou, D et al. (2010) SETDB1 is involved in postembryonic DNA methylation and gene silencing in Drosophila. PLoS ONE 5 e10581 PubMed GONUTS page
  30. Demakova, OV et al. (2007) The SU(VAR)3-9/HP1 complex differentially regulates the compaction state and degree of underreplication of X chromosome pericentric heterochromatin in Drosophila melanogaster. Genetics 175 609-20 PubMed GONUTS page