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DROME:HMOC

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) oc (synonyms: Otd)
Protein Name(s) Homeotic protein ocelliless

Protein orthodenticle

External Links
UniProt P22810
EMBL X58983
AE014298
BT011185
PIR A35912
RefSeq NP_001014727.2
NP_001259345.1
NP_001259346.1
UniGene Dm.2933
ProteinModelPortal P22810
SMR P22810
BioGrid 58261
IntAct P22810
MINT MINT-783578
PaxDb P22810
PRIDE P22810
EnsemblMetazoa FBtr0300106
FBtr0331305
FBtr0331738
GeneID 31802
KEGG dme:Dmel_CG12154
UCSC CG12154-RC
CTD 31802
FlyBase FBgn0004102
eggNOG NOG245767
GeneTree ENSGT00760000118908
InParanoid P22810
KO K09326
OrthoDB EOG74J98P
PhylomeDB P22810
ChiTaRS oc
GenomeRNAi 31802
NextBio 775387
Proteomes UP000000803
Bgee P22810
ExpressionAtlas P22810
GO GO:0005634
GO:0046982
GO:0042803
GO:0001077
GO:0043565
GO:0007628
GO:0035288
GO:0007355
GO:0007420
GO:0035284
GO:0007417
GO:0001745
GO:0042051
GO:0001700
GO:0045871
GO:0000122
GO:0007399
GO:0008056
GO:0048816
GO:0042463
GO:0007389
GO:0046552
GO:0045315
GO:0010628
GO:0045872
GO:0045944
GO:0045893
GO:0042052
GO:0061541
GO:0007419
Gene3D 1.10.10.60
InterPro IPR017970
IPR001356
IPR009057
Pfam PF00046
SMART SM00389
SUPFAM SSF46689
PROSITE PS00027
PS50071

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0042052

rhabdomere development

PMID:20667913[1]

IGI: Inferred from Genetic Interaction

UniProtKB:Q8T0V5


P

Fig 1B

complete

GO:0043565

sequence-specific DNA binding

PMID:20667913[1]

IDA: Inferred from Direct Assay

F

Fig S6

complete

GO:0016563

transcription activator activity

PMID:20667913[1]

IDA: Inferred from Direct Assay

F

Fig 7b

complete

GO:0045872

positive regulation of rhodopsin gene expression

PMID:20667913[1]

IDA: Inferred from Direct Assay

P

Fig 7b

complete

GO:0001700

embryonic development via the syncytial blastoderm

PMID:7576627[2]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0001700

embryonic development via the syncytial blastoderm

PMID:8608920[3]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0001745

compound eye morphogenesis

PMID:12967559[4]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012287

F

complete

GO:0003677

DNA binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0238

F

complete

GO:0003677

DNA binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0371

F

complete

GO:0003700

sequence-specific DNA binding transcription factor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001356

F

complete

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017970

C

complete

GO:0005634

nucleus

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0539

C

complete

GO:0005634

nucleus

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0191

C

complete

GO:0006351

transcription, DNA-dependent

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0804

P

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001356

P

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012287

P

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017970

P

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0805

P

complete

GO:0007275

multicellular organismal development

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0217

P

complete

GO:0007355

anterior region determination

PMID:12867048[5]

TAS: Traceable Author Statement

P

complete

GO:0007417

central nervous system development

PMID:8575625[6]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0007628

adult walking behavior

PMID:12490252[7]

TAS: Traceable Author Statement

P

complete

GO:0008056

ocellus development

PMID:20580700[8]

IGI: Inferred from Genetic Interaction

FB:FBgn0019650

P

complete

GO:0010628

positive regulation of gene expression

PMID:20580700[8]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0035284

brain segmentation

PMID:7576627[2]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0035288

anterior head segmentation

PMID:15382142[9]

TAS: Traceable Author Statement

P

complete

GO:0042051

compound eye photoreceptor development

PMID:14505358[10]

TAS: Traceable Author Statement

P

complete

GO:0042051

compound eye photoreceptor development

PMID:20667913[1]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0042052

rhabdomere development

PMID:12967559[4]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0042052

rhabdomere development

PMID:20667913[1]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0042052

rhabdomere development

PMID:8575625[6]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0042463

ocellus photoreceptor cell development

PMID:20667913[1]

IGI: Inferred from Genetic Interaction

FB:FBgn0023489

P

complete

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001356

F

complete

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

PMID:20732315[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017970

F

complete

GO:0001077

transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding

PMID:20732315[11]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0045893

positive regulation of transcription, DNA-dependent

PMID:20667913[1]

IDA: Inferred from Direct Assay

P

complete

GO:0001700

embryonic development via the syncytial blastoderm

PMID:7576627[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046552

photoreceptor cell fate commitment

PMID:8575625[6]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0001700

embryonic development via the syncytial blastoderm

PMID:8608920[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0001745

compound eye morphogenesis

PMID:12967559[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001356
InterPro:IPR009057

F

Seeded From UniProt

complete

GO:0003677

DNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

GO:0003677

DNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0371

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:20732315[11]

IC: Inferred by Curator

GO:0001077

C

Seeded From UniProt

complete

GO:0006351

transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017970

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

Seeded From UniProt

complete

GO:0006366

transcription from RNA polymerase II promoter

PMID:20732315[11]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0007355

anterior region determination

PMID:12867048[5]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007389

pattern specification process

PMID:15266339[12]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0007399

nervous system development

PMID:10049527[13]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007417

central nervous system development

PMID:8575625[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007419

ventral cord development

PMID:9521908[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007420

brain development

PMID:15266339[12]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0007420

brain development

PMID:9521908[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007628

adult walking behavior

PMID:12490252[7]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008056

ocellus development

PMID:20580700[8]

IGI: Inferred from Genetic Interaction

FB:FBgn0019650

P

Seeded From UniProt

complete

GO:0010628

positive regulation of gene expression

PMID:20580700[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0035284

brain segmentation

PMID:7576627[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0035288

anterior head segmentation

PMID:15382142[9]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0042051

compound eye photoreceptor development

PMID:14505358[10]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0042051

compound eye photoreceptor development

PMID:20667913[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042052

rhabdomere development

PMID:12967559[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042052

rhabdomere development

PMID:20667913[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042052

rhabdomere development

PMID:8575625[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042463

ocellus photoreceptor cell development

PMID:20667913[1]

IGI: Inferred from Genetic Interaction

FB:FBgn0023489

P

Seeded From UniProt

complete

GO:0042803

protein homodimerization activity

PMID:9449676[15]

IPI: Inferred from Physical Interaction

FB:FBgn0004102

F

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017970

F

Seeded From UniProt

complete

GO:0045315

positive regulation of compound eye photoreceptor development

PMID:22547825[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045871

negative regulation of rhodopsin gene expression

PMID:22113834[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045872

positive regulation of rhodopsin gene expression

PMID:22113834[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045893

positive regulation of transcription, DNA-templated

PMID:20667913[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

PMID:9449676[15]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0046552

photoreceptor cell fate commitment

PMID:8575625[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046982

protein heterodimerization activity

PMID:9449676[15]

IPI: Inferred from Physical Interaction

FB:FBgn0010323

F

Seeded From UniProt

complete

GO:0048816

ocellus morphogenesis

PMID:10049527[13]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0061541

rhabdomere morphogenesis

PMID:22113834[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 Mishra, M et al. (2010) Pph13 and orthodenticle define a dual regulatory pathway for photoreceptor cell morphogenesis and function. Development 137 2895-904 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Hirth, F et al. (1995) Developmental defects in brain segmentation caused by mutations of the homeobox genes orthodenticle and empty spiracles in Drosophila. Neuron 15 769-78 PubMed GONUTS page
  3. 3.0 3.1 Eberl, DF & Hilliker, AJ (1988) Characterization of X-linked recessive lethal mutations affecting embryonic morphogenesis in Drosophila melanogaster. Genetics 118 109-20 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Tahayato, A et al. (2003) Otd/Crx, a dual regulator for the specification of ommatidia subtypes in the Drosophila retina. Dev. Cell 5 391-402 PubMed GONUTS page
  5. 5.0 5.1 Lynch, J & Desplan, C (2003) Evolution of development: beyond bicoid. Curr. Biol. 13 R557-9 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 6.5 Vandendries, ER et al. (1996) orthodenticle is required for photoreceptor cell development in the Drosophila eye. Dev. Biol. 173 243-55 PubMed GONUTS page
  7. 7.0 7.1 Strauss, R (2002) The central complex and the genetic dissection of locomotor behaviour. Curr. Opin. Neurobiol. 12 633-8 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 Blanco, J et al. (2010) Genetic interactions of eyes absent, twin of eyeless and orthodenticle regulate sine oculis expression during ocellar development in Drosophila. Dev. Biol. 344 1088-99 PubMed GONUTS page
  9. 9.0 9.1 Peel, A (2004) The evolution of arthropod segmentation mechanisms. Bioessays 26 1108-16 PubMed GONUTS page
  10. 10.0 10.1 Cook, T (2003) Cell diversity in the retina: more than meets the eye. Bioessays 25 921-5 PubMed GONUTS page
  11. 11.0 11.1 11.2 11.3 McDonald, EC et al. (2010) Separable transcriptional regulatory domains within Otd control photoreceptor terminal differentiation events. Dev. Biol. 347 122-32 PubMed GONUTS page
  12. 12.0 12.1 Ball, EE et al. (2004) A simple plan--cnidarians and the origins of developmental mechanisms. Nat. Rev. Genet. 5 567-77 PubMed GONUTS page
  13. 13.0 13.1 Acampora, D et al. (1999) Otx genes and the genetic control of brain morphogenesis. Mol. Cell. Neurosci. 13 1-8 PubMed GONUTS page
  14. 14.0 14.1 Leuzinger, S et al. (1998) Equivalence of the fly orthodenticle gene and the human OTX genes in embryonic brain development of Drosophila. Development 125 1703-10 PubMed GONUTS page
  15. 15.0 15.1 15.2 Mailhos, C et al. (1998) Drosophila Goosecoid requires a conserved heptapeptide for repression of paired-class homeoprotein activators. Development 125 937-47 PubMed GONUTS page
  16. Fichelson, P et al. (2012) Orthodenticle and Kruppel homolog 1 regulate Drosophila photoreceptor maturation. Proc. Natl. Acad. Sci. U.S.A. 109 7893-8 PubMed GONUTS page
  17. 17.0 17.1 17.2 Terrell, D et al. (2012) OTX2 and CRX rescue overlapping and photoreceptor-specific functions in the Drosophila eye. Dev. Dyn. 241 215-28 PubMed GONUTS page