DROME:HMOC

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	oc (synonyms: Otd)
Protein Name(s)	Homeotic protein ocelliless Protein orthodenticle
External Links
UniProt	P22810
EMBL	X58983 AE014298 BT011185
PIR	A35912
RefSeq	NP_001014727.2 NP_001259345.1 NP_001259346.1
UniGene	Dm.2933
ProteinModelPortal	P22810
SMR	P22810
BioGrid	58261
IntAct	P22810
MINT	MINT-783578
PaxDb	P22810
PRIDE	P22810
EnsemblMetazoa	FBtr0300106 FBtr0331305 FBtr0331738
GeneID	31802
KEGG	dme:Dmel_CG12154
UCSC	CG12154-RC
CTD	31802
FlyBase	FBgn0004102
eggNOG	NOG245767
GeneTree	ENSGT00760000118908
InParanoid	P22810
KO	K09326
OrthoDB	EOG74J98P
PhylomeDB	P22810
ChiTaRS	oc
GenomeRNAi	31802
NextBio	775387
Proteomes	UP000000803
Bgee	P22810
ExpressionAtlas	P22810
GO	GO:0005634 GO:0046982 GO:0042803 GO:0001077 GO:0043565 GO:0007628 GO:0035288 GO:0007355 GO:0007420 GO:0035284 GO:0007417 GO:0001745 GO:0042051 GO:0001700 GO:0045871 GO:0000122 GO:0007399 GO:0008056 GO:0048816 GO:0042463 GO:0007389 GO:0046552 GO:0045315 GO:0010628 GO:0045872 GO:0045944 GO:0045893 GO:0042052 GO:0061541 GO:0007419
Gene3D	1.10.10.60
InterPro	IPR017970 IPR001356 IPR009057
Pfam	PF00046
SMART	SM00389
SUPFAM	SSF46689
PROSITE	PS00027 PS50071

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0042052	rhabdomere development	PMID:20667913^[1]	ECO:0000316		UniProtKB:Q8T0V5	P	Fig 1B	complete
	GO:0043565	sequence-specific DNA binding	PMID:20667913^[1]	ECO:0000314			F	Fig S6	complete
	GO:0016563	transcription activator activity	PMID:20667913^[1]	ECO:0000314			F	Fig 7b	complete
	GO:0045872	positive regulation of rhodopsin gene expression	PMID:20667913^[1]	ECO:0000314			P	Fig 7b	complete
involved_in	GO:0046552	photoreceptor cell fate commitment	PMID:8575625^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042052	rhabdomere development	PMID:8575625^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	PMID:8575625^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001745	compound eye morphogenesis	PMID:12967559^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045315	positive regulation of compound eye photoreceptor development	PMID:22547825^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045871	negative regulation of rhodopsin gene expression	PMID:22113834^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045872	positive regulation of rhodopsin gene expression	PMID:22113834^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0061541	rhabdomere morphogenesis	PMID:22113834^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:20732315^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:20732315^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20732315^[6]	ECO:0000305	curator inference used in manual assertion	GO:0001228	C	Seeded From UniProt	complete
involved_in	GO:0042051	compound eye photoreceptor development	PMID:20667913^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042463	ocellus photoreceptor cell development	PMID:20667913^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0023489	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20667913^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042052	rhabdomere development	PMID:20667913^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008056	ocellus development	PMID:20580700^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0019650	P	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:20580700^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007389	pattern specification process	PMID:15266339^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007420	brain development	PMID:15266339^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042052	rhabdomere development	PMID:12967559^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048816	ocellus morphogenesis	PMID:10049527^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007419	ventral cord development	PMID:9521908^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007420	brain development	PMID:9521908^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9449676^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:9449676^[11]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0010323	F	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:9449676^[11]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0004102	F	Seeded From UniProt	complete
involved_in	GO:0035284	brain segmentation	PMID:7576627^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001700	embryonic development via the syncytial blastoderm	PMID:7576627^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001700	embryonic development via the syncytial blastoderm	PMID:8608920^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001356 InterPro:IPR009057	F	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	F	Seeded From UniProt	complete
involved_in	GO:0035288	anterior head segmentation	PMID:15382142^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042051	compound eye photoreceptor development	PMID:14505358^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007355	anterior region determination	PMID:12867048^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007628	adult walking behavior	PMID:12490252^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	PMID:10049527^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0371 UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Mishra, M et al. (2010) Pph13 and orthodenticle define a dual regulatory pathway for photoreceptor cell morphogenesis and function. Development 137 2895-904 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Vandendries, ER et al. (1996) orthodenticle is required for photoreceptor cell development in the Drosophila eye. Dev. Biol. 173 243-55 PubMed GONUTS page
↑ ^3.0 ^3.1 Tahayato, A et al. (2003) Otd/Crx, a dual regulator for the specification of ommatidia subtypes in the Drosophila retina. Dev. Cell 5 391-402 PubMed GONUTS page
↑ Fichelson, P et al. (2012) Orthodenticle and Kruppel homolog 1 regulate Drosophila photoreceptor maturation. Proc. Natl. Acad. Sci. U.S.A. 109 7893-8 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Terrell, D et al. (2012) OTX2 and CRX rescue overlapping and photoreceptor-specific functions in the Drosophila eye. Dev. Dyn. 241 215-28 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 McDonald, EC et al. (2010) Separable transcriptional regulatory domains within Otd control photoreceptor terminal differentiation events. Dev. Biol. 347 122-32 PubMed GONUTS page
↑ ^7.0 ^7.1 Blanco, J et al. (2010) Genetic interactions of eyes absent, twin of eyeless and orthodenticle regulate sine oculis expression during ocellar development in Drosophila. Dev. Biol. 344 1088-99 PubMed GONUTS page
↑ ^8.0 ^8.1 Ball, EE et al. (2004) A simple plan--cnidarians and the origins of developmental mechanisms. Nat. Rev. Genet. 5 567-77 PubMed GONUTS page
↑ ^9.0 ^9.1 Acampora, D et al. (1999) Otx genes and the genetic control of brain morphogenesis. Mol. Cell. Neurosci. 13 1-8 PubMed GONUTS page
↑ ^10.0 ^10.1 Leuzinger, S et al. (1998) Equivalence of the fly orthodenticle gene and the human OTX genes in embryonic brain development of Drosophila. Development 125 1703-10 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Mailhos, C et al. (1998) Drosophila Goosecoid requires a conserved heptapeptide for repression of paired-class homeoprotein activators. Development 125 937-47 PubMed GONUTS page
↑ ^12.0 ^12.1 Hirth, F et al. (1995) Developmental defects in brain segmentation caused by mutations of the homeobox genes orthodenticle and empty spiracles in Drosophila. Neuron 15 769-78 PubMed GONUTS page
↑ Eberl, DF & Hilliker, AJ (1988) Characterization of X-linked recessive lethal mutations affecting embryonic morphogenesis in Drosophila melanogaster. Genetics 118 109-20 PubMed GONUTS page
↑ Peel, A (2004) The evolution of arthropod segmentation mechanisms. Bioessays 26 1108-16 PubMed GONUTS page
↑ Cook, T (2003) Cell diversity in the retina: more than meets the eye. Bioessays 25 921-5 PubMed GONUTS page
↑ Lynch, J & Desplan, C (2003) Evolution of development: beyond bicoid. Curr. Biol. 13 R557-9 PubMed GONUTS page
↑ Strauss, R (2002) The central complex and the genetic dissection of locomotor behaviour. Curr. Opin. Neurobiol. 12 633-8 PubMed GONUTS page

[PMID:20667913-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Mishra, M et al. (2010) Pph13 and orthodenticle define a dual regulatory pathway for photoreceptor cell morphogenesis and function. Development 137 2895-904 PubMed GONUTS page

[PMID:8575625-2] 2.0 ^2.1 ^2.2 Vandendries, ER et al. (1996) orthodenticle is required for photoreceptor cell development in the Drosophila eye. Dev. Biol. 173 243-55 PubMed GONUTS page

[PMID:12967559-3] 3.0 ^3.1 Tahayato, A et al. (2003) Otd/Crx, a dual regulator for the specification of ommatidia subtypes in the Drosophila retina. Dev. Cell 5 391-402 PubMed GONUTS page

[PMID:22547825-4] Fichelson, P et al. (2012) Orthodenticle and Kruppel homolog 1 regulate Drosophila photoreceptor maturation. Proc. Natl. Acad. Sci. U.S.A. 109 7893-8 PubMed GONUTS page

[PMID:22113834-5] 5.0 ^5.1 ^5.2 Terrell, D et al. (2012) OTX2 and CRX rescue overlapping and photoreceptor-specific functions in the Drosophila eye. Dev. Dyn. 241 215-28 PubMed GONUTS page

[PMID:20732315-6] 6.0 ^6.1 ^6.2 McDonald, EC et al. (2010) Separable transcriptional regulatory domains within Otd control photoreceptor terminal differentiation events. Dev. Biol. 347 122-32 PubMed GONUTS page

[PMID:20580700-7] 7.0 ^7.1 Blanco, J et al. (2010) Genetic interactions of eyes absent, twin of eyeless and orthodenticle regulate sine oculis expression during ocellar development in Drosophila. Dev. Biol. 344 1088-99 PubMed GONUTS page

[PMID:15266339-8] 8.0 ^8.1 Ball, EE et al. (2004) A simple plan--cnidarians and the origins of developmental mechanisms. Nat. Rev. Genet. 5 567-77 PubMed GONUTS page

[PMID:10049527-9] 9.0 ^9.1 Acampora, D et al. (1999) Otx genes and the genetic control of brain morphogenesis. Mol. Cell. Neurosci. 13 1-8 PubMed GONUTS page

[PMID:9521908-10] 10.0 ^10.1 Leuzinger, S et al. (1998) Equivalence of the fly orthodenticle gene and the human OTX genes in embryonic brain development of Drosophila. Development 125 1703-10 PubMed GONUTS page

[PMID:9449676-11] 11.0 ^11.1 ^11.2 Mailhos, C et al. (1998) Drosophila Goosecoid requires a conserved heptapeptide for repression of paired-class homeoprotein activators. Development 125 937-47 PubMed GONUTS page

[PMID:7576627-12] 12.0 ^12.1 Hirth, F et al. (1995) Developmental defects in brain segmentation caused by mutations of the homeobox genes orthodenticle and empty spiracles in Drosophila. Neuron 15 769-78 PubMed GONUTS page

[PMID:8608920-13] Eberl, DF & Hilliker, AJ (1988) Characterization of X-linked recessive lethal mutations affecting embryonic morphogenesis in Drosophila melanogaster. Genetics 118 109-20 PubMed GONUTS page

[PMID:15382142-14] Peel, A (2004) The evolution of arthropod segmentation mechanisms. Bioessays 26 1108-16 PubMed GONUTS page

[PMID:14505358-15] Cook, T (2003) Cell diversity in the retina: more than meets the eye. Bioessays 25 921-5 PubMed GONUTS page

[PMID:12867048-16] Lynch, J & Desplan, C (2003) Evolution of development: beyond bicoid. Curr. Biol. 13 R557-9 PubMed GONUTS page

[PMID:12490252-17] Strauss, R (2002) The central complex and the genetic dissection of locomotor behaviour. Curr. Opin. Neurobiol. 12 633-8 PubMed GONUTS page

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DROME:HMOC

Contents

Annotations

Notes

References

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