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PMID:8608920

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Citation

Eberl, DF and Hilliker, AJ (1988) Characterization of X-linked recessive lethal mutations affecting embryonic morphogenesis in Drosophila melanogaster. Genetics 118:109-20

Abstract

This study attempted to assay the zygotic contribution of X chromosome genes to the genetic control of embryonic morphogenesis in Drosophila melanogaster. A systematic screen for X-linked genes which affect the morphology of the embryo was undertaken, employing the phenotype of whole mount embryos as the major screening criterion. Of 800 EMS-induced lethal mutations analyzed, only 14% were embryonic lethal, and of these only a minority affected embryonic morphogenesis. By recombination and complementation analyses, the mutations that affected embryonic morphogenesis were sequestered into 26 complementation groups. Fourteen of the loci correspond to genes previously identified in a large-scale screen in which fixed cuticles were examined, and 12 new loci have been identified. Most of the mutations which disrupt embryonic morphology had specific and uniform mutant phenotypes. Mutations were recovered which disrupt major morphogenetic events such as gastrulation, germ band retraction and head involution. No mutations were found which arrest the embryos prior to blastoderm formation. However, a novel class was found, one comprised of mutations which interfere with the development of internal structures but not cuticular structures. Nevertheless, saturation of the X chromosome for genes important for embryonic morphogenesis is probably incomplete.

Links

PubMed PMC1203254

Keywords

Animals; Chromosome Mapping; Drosophila melanogaster/embryology; Drosophila melanogaster/genetics; Gene Expression Regulation, Developmental; Genes, Lethal; Genes, Recessive; Genetic Linkage; Morphogenesis/genetics; Mutation; Phenotype; X Chromosome

Significance

Annotations

Gene product Qualifier GO ID GO term name Evidence Code with/from Aspect Notes Status

FB:bly

GO:0007443

Malpighian tubule morphogenesis

IMP: Inferred from Mutant Phenotype

P

From FB


FB:btdl

GO:0001700

embryonic development via the syncytial blastoderm

IMP: Inferred from Mutant Phenotype

P

From FB


FB:cau

GO:0001700

embryonic development via the syncytial blastoderm

IMP: Inferred from Mutant Phenotype

P

From FB


FB:cgd

GO:0001700

embryonic development via the syncytial blastoderm

IMP: Inferred from Mutant Phenotype

P

From FB


FB:ctl

GO:0001700

embryonic development via the syncytial blastoderm

IMP: Inferred from Mutant Phenotype

P

From FB


FB:dsp

GO:0001700

embryonic development via the syncytial blastoderm

IMP: Inferred from Mutant Phenotype

P

From FB


FB:dsp

GO:0007443

Malpighian tubule morphogenesis

IMP: Inferred from Mutant Phenotype

P

From FB


FB:fcl

GO:0001700

embryonic development via the syncytial blastoderm

IMP: Inferred from Mutant Phenotype

P

From FB


FB:hap

GO:0007443

Malpighian tubule morphogenesis

IMP: Inferred from Mutant Phenotype

P

From FB


FB:hap

GO:0001700

embryonic development via the syncytial blastoderm

IMP: Inferred from Mutant Phenotype

P

From FB


FB:stf

GO:0001700

embryonic development via the syncytial blastoderm

IMP: Inferred from Mutant Phenotype

P

From FB


FB:stf

GO:0008258

head involution

IMP: Inferred from Mutant Phenotype

P

From FB


FB:stf

GO:0010004

gastrulation involving germ band extension

IMP: Inferred from Mutant Phenotype

P

From FB


FB:oc

GO:0001700

embryonic development via the syncytial blastoderm

IMP: Inferred from Mutant Phenotype

P

From FB


FB:Fs(1)10A

GO:0001700

embryonic development via the syncytial blastoderm

IMP: Inferred from Mutant Phenotype

P

From FB


DROME:HMOC

GO:0001700

embryonic development via the syncytial blastoderm

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

See also

References

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