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DROME:CCNA

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) CycA
Protein Name(s) G2/mitotic-specific cyclin-A
External Links
UniProt P14785
EMBL D10857
D10858
M24841
AE014296
AE014296
AY058712
BT001635
PIR JC1390
RefSeq NP_524030.2
UniGene Dm.2549
ProteinModelPortal P14785
SMR P14785
BioGrid 64701
DIP DIP-22019N
IntAct P14785
MINT MINT-301152
PaxDb P14785
EnsemblMetazoa FBtr0076075
GeneID 39340
KEGG dme:Dmel_CG5940
CTD 39340
FlyBase FBgn0000404
eggNOG COG5024
GeneTree ENSGT00760000118939
InParanoid P14785
KO K06627
OMA MASFQIH
OrthoDB EOG7G7KQ0
PhylomeDB P14785
Reactome REACT_104865
REACT_180285
REACT_180658
REACT_182058
REACT_209388
REACT_218589
REACT_224351
REACT_234707
REACT_246054
REACT_251099
SignaLink P14785
ChiTaRS CycA
GenomeRNAi 39340
NextBio 813171
Proteomes UP000000803
Bgee P14785
ExpressionAtlas P14785
GO GO:0005737
GO:0045169
GO:0005634
GO:0045170
GO:0016538
GO:0055059
GO:0009987
GO:0046331
GO:0007067
GO:0000070
GO:0045841
GO:0022008
GO:0007422
GO:0035561
GO:0007096
GO:0007088
GO:0009794
GO:0045859
GO:0035186
Gene3D 1.10.472.10
InterPro IPR013763
IPR014400
IPR004367
IPR006671
Pfam PF02984
PF00134
PIRSF PIRSF001771
SMART SM00385
SUPFAM SSF47954
PROSITE PS00292

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0045169

fusome

PMID:27170181[1]

IDA: Inferred from Direct Assay

C

Organism: Drosophila (fruit fly) Protein:G2/mitotic-specific cyclin-A Figure 1E: Arrows shown in myt1/+ mature spermatocytes indicate Cyclin A enrichment at fusomes

complete

GO:0000070

mitotic sister chromatid segregation

PMID:11369230[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:27170181[1]

IDA: Inferred from Direct Assay

C

Organism: Drosphila (fruit fly) Protein: G2/mitotic-specific cyclin-A

Figure 1E)Cyclin A is detected primarily in the cytoplasm in stage S6 myt1/+ and myt1 mutant spermatocytes

complete

GO:0005515

protein binding

PMID:17431409[3]

IPI: Inferred from Physical Interaction

FB:FBgn0004052

F

Seeded From UniProt

complete

GO:0001673

nucleus

PMID:27170181[1]

IDA: Inferred from Direct Assay

C

Organism: Drosophila (fruit fly) Protein: G2/mitotic-specific cyclin-A

Figure 1E) Cyclin A is detected primarily in the cytoplasm in stage S6 myt1/+ and myt1 mutant spermatocytes, but by prometaphase I, it can also be seen in the nucleus.

complete
CACAO 12424

GO:0005515

protein binding

PMID:17431409[3]

IPI: Inferred from Physical Interaction

UniProtKB:P22469

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004367

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:11027291[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:22024320[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:2564316[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:11027291[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:22024320[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:2564316[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0007049

cell cycle

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

GO:0007067

mitotic nuclear division

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0498

P

Seeded From UniProt

complete

GO:0007067

mitotic nuclear division

PMID:11350926[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007067

mitotic nuclear division

PMID:11448787[8]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007088

regulation of mitotic nuclear division

PMID:2564316[6]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0007096

regulation of exit from mitosis

PMID:16854973[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007422

peripheral nervous system development

PMID:8060613[10]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0009794

regulation of mitotic cell cycle, embryonic

PMID:14616073[11]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0009794

regulation of mitotic cell cycle, embryonic

PMID:16854973[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016538

cyclin-dependent protein serine/threonine kinase regulator activity

PMID:1531147[12]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0016538

cyclin-dependent protein serine/threonine kinase regulator activity

PMID:2564316[6]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

complete

GO:0022008

neurogenesis

PMID:21549331[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0035186

syncytial blastoderm mitotic cell cycle

PMID:18291653[14]

IGI: Inferred from Genetic Interaction

FB:FBgn0000405
FB:FBgn0015625

P

Seeded From UniProt

complete

GO:0035561

regulation of chromatin binding

PMID:18955499[15]

IGI: Inferred from Genetic Interaction

FB:FBgn0015270

P

Seeded From UniProt

complete

GO:0045169

fusome

PMID:11131529[16]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0045170

spectrosome

PMID:11131529[16]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0045170

spectrosome

PMID:22024320[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0045841

negative regulation of mitotic metaphase/anaphase transition

PMID:11448787[8]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0045859

regulation of protein kinase activity

PMID:1531147[12]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0045859

regulation of protein kinase activity

PMID:2564316[6]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0046331

lateral inhibition

PMID:19363474[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0051301

cell division

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

GO:0055059

asymmetric neuroblast division

PMID:16139215[18]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Varadarajan, R et al. (2016) Myt1 inhibition of Cyclin A/Cdk1 is essential for fusome integrity and premeiotic centriole engagement in Drosophila spermatocytes. Mol. Biol. Cell 27 2051-63 PubMed GONUTS page
  2. Parry, DH & O'Farrell, PH (2001) The schedule of destruction of three mitotic cyclins can dictate the timing of events during exit from mitosis. Curr. Biol. 11 671-83 PubMed GONUTS page
  3. 3.0 3.1 Gawliński, P et al. (2007) The Drosophila mitotic inhibitor Frühstart specifically binds to the hydrophobic patch of cyclins. EMBO Rep. 8 490-6 PubMed GONUTS page
  4. 4.0 4.1 Avedisov, SN et al. (2000) Roughex mediates G(1) arrest through a physical association with cyclin A. Mol. Cell. Biol. 20 8220-9 PubMed GONUTS page
  5. 5.0 5.1 5.2 Yuan, H et al. (2012) Regulation of cyclin A localization downstream of Par-1 function is critical for the centrosome orientation checkpoint in Drosophila male germline stem cells. Dev. Biol. 361 57-67 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 Lehner, CF & O'Farrell, PH (1989) Expression and function of Drosophila cyclin A during embryonic cell cycle progression. Cell 56 957-68 PubMed GONUTS page
  7. Jacobs, HW et al. (2001) A complex degradation signal in Cyclin A required for G1 arrest, and a C-terminal region for mitosis. EMBO J. 20 2376-86 PubMed GONUTS page
  8. 8.0 8.1 Tin Su, T (2001) Cell cycle: how, when and why cells get rid of cyclin A. Curr. Biol. 11 R467-9 PubMed GONUTS page
  9. 9.0 9.1 Reber, A et al. (2006) Terminal mitoses require negative regulation of Fzr/Cdh1 by Cyclin A, preventing premature degradation of mitotic cyclins and String/Cdc25. Development 133 3201-11 PubMed GONUTS page
  10. Salzberg, A et al. (1994) Mutations affecting the pattern of the PNS in Drosophila reveal novel aspects of neuronal development. Neuron 13 269-87 PubMed GONUTS page
  11. Lee, LA & Orr-Weaver, TL (2003) Regulation of cell cycles in Drosophila development: intrinsic and extrinsic cues. Annu. Rev. Genet. 37 545-78 PubMed GONUTS page
  12. 12.0 12.1 Maldonado-Codina, G & Glover, DM (1992) Cyclins A and B associate with chromatin and the polar regions of spindles, respectively, and do not undergo complete degradation at anaphase in syncytial Drosophila embryos. J. Cell Biol. 116 967-76 PubMed GONUTS page
  13. Neumüller, RA et al. (2011) Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi. Cell Stem Cell 8 580-93 PubMed GONUTS page
  14. McCleland, ML & O'Farrell, PH (2008) RNAi of mitotic cyclins in Drosophila uncouples the nuclear and centrosome cycle. Curr. Biol. 18 245-54 PubMed GONUTS page
  15. Baldinger, T & Gossen, M (2009) Binding of Drosophila ORC proteins to anaphase chromosomes requires cessation of mitotic cyclin-dependent kinase activity. Mol. Cell. Biol. 29 140-9 PubMed GONUTS page
  16. 16.0 16.1 Deng, W & Lin, H (2001) Asymmetric germ cell division and oocyte determination during Drosophila oogenesis. Int. Rev. Cytol. 203 93-138 PubMed GONUTS page
  17. Mummery-Widmer, JL et al. (2009) Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Nature 458 987-92 PubMed GONUTS page
  18. Bhalerao, S et al. (2005) Localization-dependent and -independent roles of numb contribute to cell-fate specification in Drosophila. Curr. Biol. 15 1583-90 PubMed GONUTS page