DROME:CCNA

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	CycA
Protein Name(s)	G2/mitotic-specific cyclin-A
External Links
UniProt	P14785
EMBL	D10857 D10858 M24841 AE014296 AE014296 AY058712 BT001635
PIR	JC1390
RefSeq	NP_524030.2
UniGene	Dm.2549
ProteinModelPortal	P14785
SMR	P14785
BioGrid	64701
DIP	DIP-22019N
IntAct	P14785
MINT	MINT-301152
PaxDb	P14785
EnsemblMetazoa	FBtr0076075
GeneID	39340
KEGG	dme:Dmel_CG5940
CTD	39340
FlyBase	FBgn0000404
eggNOG	COG5024
GeneTree	ENSGT00760000118939
InParanoid	P14785
KO	K06627
OMA	MASFQIH
OrthoDB	EOG7G7KQ0
PhylomeDB	P14785
Reactome	REACT_104865 REACT_180285 REACT_180658 REACT_182058 REACT_209388 REACT_218589 REACT_224351 REACT_234707 REACT_246054 REACT_251099
SignaLink	P14785
ChiTaRS	CycA
GenomeRNAi	39340
NextBio	813171
Proteomes	UP000000803
Bgee	P14785
ExpressionAtlas	P14785
GO	GO:0005737 GO:0045169 GO:0005634 GO:0045170 GO:0016538 GO:0055059 GO:0009987 GO:0046331 GO:0007067 GO:0000070 GO:0045841 GO:0022008 GO:0007422 GO:0035561 GO:0007096 GO:0007088 GO:0009794 GO:0045859 GO:0035186
Gene3D	1.10.472.10
InterPro	IPR013763 IPR014400 IPR004367 IPR006671
Pfam	PF02984 PF00134
PIRSF	PIRSF001771
SMART	SM00385
SUPFAM	SSF47954
PROSITE	PS00292

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0045169	fusome	PMID:27170181^[1]	ECO:0000314			C	Organism: Drosophila (fruit fly) Protein:G2/mitotic-specific cyclin-A Figure 1E: Arrows shown in myt1/+ mature spermatocytes indicate Cyclin A enrichment at fusomes	complete CACAO 12422
	GO:0005737	cytoplasm	PMID:27170181^[1]	ECO:0000314			C	Organism: Drosphila (fruit fly) Protein: G2/mitotic-specific cyclin-A Figure 1E)Cyclin A is detected primarily in the cytoplasm in stage S6 myt1/+ and myt1 mutant spermatocytes	complete CACAO 12423
	GO:0001673	nucleus	PMID:27170181^[1]	ECO:0000314			C	Organism: Drosophila (fruit fly) Protein: G2/mitotic-specific cyclin-A Figure 1E) Cyclin A is detected primarily in the cytoplasm in stage S6 myt1/+ and myt1 mutant spermatocytes, but by prometaphase I, it can also be seen in the nucleus.	complete CACAO 12424
enables	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	PMID:2564316^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007088	regulation of mitotic nuclear division	PMID:2564316^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:2564316^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:2564316^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0045787	positive regulation of cell cycle	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88302 PANTHER:PTN000019791	P	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108069 MGI:MGI:88313 MGI:MGI:88315 MGI:MGI:88316 PANTHER:PTN000019791 RGD:1307783 RGD:2291 RGD:2293 RGD:2294 RGD:621083 RGD:68384 UniProtKB:P14635 UniProtKB:P20248 UniProtKB:P24385 UniProtKB:P30279 UniProtKB:P30281	F	Seeded From UniProt	complete
enables	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000175354 FB:FBgn0000404 FB:FBgn0000405 FB:FBgn0010315 FB:FBgn0010317 FB:FBgn0010382 MGI:MGI:1329034 MGI:MGI:88313 MGI:MGI:88316 PANTHER:PTN000019791 PomBase:SPBC19F5.01c SGD:S000000038 SGD:S000002314 SGD:S000003340 SGD:S000003341 SGD:S000004200 SGD:S000004812 SGD:S000006177 SGD:S000006323 SGD:S000006324 WB:WBGene00000865 WB:WBGene00000868 WB:WBGene00000871	F	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000019791 RGD:2293 RGD:621083 RGD:68384 UniProtKB:P30279 WB:WBGene00000871	P	Seeded From UniProt	complete
involved_in	GO:0007088	regulation of mitotic nuclear division	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000404 PANTHER:PTN000019791 WB:WBGene00000871	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000404 MGI:MGI:108069 MGI:MGI:2145534 MGI:MGI:88302 MGI:MGI:88313 MGI:MGI:88314 MGI:MGI:88315 PANTHER:PTN000019791 PomBase:SPBC582.03 RGD:2291 RGD:2294 RGD:68384 SGD:S000002314 SGD:S000003340 SGD:S000004200 SGD:S000004812 SGD:S000006177 SGD:S000006323 TAIR:locus:2031407 TAIR:locus:2142504 TAIR:locus:2160722 TAIR:locus:2205871 UniProtKB:P14635 UniProtKB:P20248 UniProtKB:P22674 UniProtKB:Q9C6A9 WB:WBGene00000865 WB:WBGene00000868	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000404 FB:FBgn0000405 FB:FBgn0010382 FB:FBgn0015625 MGI:MGI:108069 MGI:MGI:88302 MGI:MGI:88313 MGI:MGI:88314 MGI:MGI:88315 MGI:MGI:88316 PANTHER:PTN000019791 PomBase:SPBC582.03 RGD:2291 RGD:2294 RGD:2295 RGD:621059 RGD:68384 SGD:S000000038 SGD:S000002314 SGD:S000003340 SGD:S000004200 SGD:S000004812 SGD:S000006177 SGD:S000006323 SGD:S000006324 TAIR:locus:2031407 TAIR:locus:2034250 TAIR:locus:2120081 TAIR:locus:2124331 TAIR:locus:2142504 TAIR:locus:2196563 TAIR:locus:2205871 UniProtKB:P14635 UniProtKB:P20248 UniProtKB:P24385 UniProtKB:P24864 UniProtKB:P30279 UniProtKB:P41002 UniProtKB:Q9C6A9 WB:WBGene00000865 WB:WBGene00000868 WB:WBGene00000871	C	Seeded From UniProt	complete
contributes_to	GO:0004672	protein kinase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88313 PANTHER:PTN000019791	F	Seeded From UniProt	complete
part_of	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88313 MGI:MGI:88316 PANTHER:PTN000019791 PomBase:SPAPB2B4.03 SGD:S000003340 SGD:S000006177 UniProtKB:P20248 UniProtKB:P24385 UniProtKB:P30279 UniProtKB:P30281 UniProtKB:P43449	C	Seeded From UniProt	complete
involved_in	GO:0000278	mitotic cell cycle	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000404 FB:FBgn0010317 FB:FBgn0015625 PANTHER:PTN000019791 RGD:2291 UniProtKB:P22674 WB:WBGene00000865 WB:WBGene00000868	P	Seeded From UniProt	complete
involved_in	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000175354 CGD:CAL0000185532 PANTHER:PTN000019791 SGD:S000000038 SGD:S000002314 SGD:S000003340 SGD:S000003341 SGD:S000004200 SGD:S000004812 SGD:S000006177 SGD:S000006323 SGD:S000006324 UniProtKB:Q59YH3	P	Seeded From UniProt	complete
part_of	GO:0045170	spectrosome	PMID:22024320^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22024320^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:22024320^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0035561	regulation of chromatin binding	PMID:18955499^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0015270	P	Seeded From UniProt	complete
involved_in	GO:0035186	syncytial blastoderm mitotic cell cycle	PMID:18291653^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0000405,FB:FBgn0015625	P	Seeded From UniProt	complete
involved_in	GO:0007096	regulation of exit from mitosis	PMID:16854973^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009794	regulation of mitotic cell cycle, embryonic	PMID:16854973^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0055059	asymmetric neuroblast division	PMID:16139215^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000070	mitotic sister chromatid segregation	PMID:11369230^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000278	mitotic cell cycle	PMID:11350926^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11027291^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11027291^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	PMID:1531147^[12]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:1902808	positive regulation of cell cycle G1/S phase transition	PMID:28829944^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004672	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004367	C	Seeded From UniProt	complete
involved_in	GO:0009794	regulation of mitotic cell cycle, embryonic	PMID:14616073^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000278	mitotic cell cycle	PMID:11448787^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045841	negative regulation of mitotic metaphase/anaphase transition	PMID:11448787^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007422	peripheral nervous system development	PMID:8060613^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P	Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Varadarajan, R et al. (2016) Myt1 inhibition of Cyclin A/Cdk1 is essential for fusome integrity and premeiotic centriole engagement in Drosophila spermatocytes. Mol. Biol. Cell 27 2051-63 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Lehner, CF & O'Farrell, PH (1989) Expression and function of Drosophila cyclin A during embryonic cell cycle progression. Cell 56 957-68 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Yuan, H et al. (2012) Regulation of cyclin A localization downstream of Par-1 function is critical for the centrosome orientation checkpoint in Drosophila male germline stem cells. Dev. Biol. 361 57-67 PubMed GONUTS page
↑ Baldinger, T & Gossen, M (2009) Binding of Drosophila ORC proteins to anaphase chromosomes requires cessation of mitotic cyclin-dependent kinase activity. Mol. Cell. Biol. 29 140-9 PubMed GONUTS page
↑ McCleland, ML & O'Farrell, PH (2008) RNAi of mitotic cyclins in Drosophila uncouples the nuclear and centrosome cycle. Curr. Biol. 18 245-54 PubMed GONUTS page
↑ ^7.0 ^7.1 Reber, A et al. (2006) Terminal mitoses require negative regulation of Fzr/Cdh1 by Cyclin A, preventing premature degradation of mitotic cyclins and String/Cdc25. Development 133 3201-11 PubMed GONUTS page
↑ Bhalerao, S et al. (2005) Localization-dependent and -independent roles of numb contribute to cell-fate specification in Drosophila. Curr. Biol. 15 1583-90 PubMed GONUTS page
↑ Parry, DH & O'Farrell, PH (2001) The schedule of destruction of three mitotic cyclins can dictate the timing of events during exit from mitosis. Curr. Biol. 11 671-83 PubMed GONUTS page
↑ Jacobs, HW et al. (2001) A complex degradation signal in Cyclin A required for G1 arrest, and a C-terminal region for mitosis. EMBO J. 20 2376-86 PubMed GONUTS page
↑ ^11.0 ^11.1 Avedisov, SN et al. (2000) Roughex mediates G(1) arrest through a physical association with cyclin A. Mol. Cell. Biol. 20 8220-9 PubMed GONUTS page
↑ Maldonado-Codina, G & Glover, DM (1992) Cyclins A and B associate with chromatin and the polar regions of spindles, respectively, and do not undergo complete degradation at anaphase in syncytial Drosophila embryos. J. Cell Biol. 116 967-76 PubMed GONUTS page
↑ Kim, W et al. (2017) Spatial Activation of TORC1 Is Regulated by Hedgehog and E2F1 Signaling in the Drosophila Eye. Dev. Cell 42 363-375.e4 PubMed GONUTS page
↑ Lee, LA & Orr-Weaver, TL (2003) Regulation of cell cycles in Drosophila development: intrinsic and extrinsic cues. Annu. Rev. Genet. 37 545-78 PubMed GONUTS page
↑ ^15.0 ^15.1 Tin Su, T (2001) Cell cycle: how, when and why cells get rid of cyclin A. Curr. Biol. 11 R467-9 PubMed GONUTS page
↑ Salzberg, A et al. (1994) Mutations affecting the pattern of the PNS in Drosophila reveal novel aspects of neuronal development. Neuron 13 269-87 PubMed GONUTS page

[PMID:27170181-1] 1.0 ^1.1 ^1.2 Varadarajan, R et al. (2016) Myt1 inhibition of Cyclin A/Cdk1 is essential for fusome integrity and premeiotic centriole engagement in Drosophila spermatocytes. Mol. Biol. Cell 27 2051-63 PubMed GONUTS page

[PMID:2564316-2] 2.0 ^2.1 ^2.2 ^2.3 Lehner, CF & O'Farrell, PH (1989) Expression and function of Drosophila cyclin A during embryonic cell cycle progression. Cell 56 957-68 PubMed GONUTS page

[PMID:21873635-3] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22024320-4] 4.0 ^4.1 ^4.2 Yuan, H et al. (2012) Regulation of cyclin A localization downstream of Par-1 function is critical for the centrosome orientation checkpoint in Drosophila male germline stem cells. Dev. Biol. 361 57-67 PubMed GONUTS page

[PMID:18955499-5] Baldinger, T & Gossen, M (2009) Binding of Drosophila ORC proteins to anaphase chromosomes requires cessation of mitotic cyclin-dependent kinase activity. Mol. Cell. Biol. 29 140-9 PubMed GONUTS page

[PMID:18291653-6] McCleland, ML & O'Farrell, PH (2008) RNAi of mitotic cyclins in Drosophila uncouples the nuclear and centrosome cycle. Curr. Biol. 18 245-54 PubMed GONUTS page

[PMID:16854973-7] 7.0 ^7.1 Reber, A et al. (2006) Terminal mitoses require negative regulation of Fzr/Cdh1 by Cyclin A, preventing premature degradation of mitotic cyclins and String/Cdc25. Development 133 3201-11 PubMed GONUTS page

[PMID:16139215-8] Bhalerao, S et al. (2005) Localization-dependent and -independent roles of numb contribute to cell-fate specification in Drosophila. Curr. Biol. 15 1583-90 PubMed GONUTS page

[PMID:11369230-9] Parry, DH & O'Farrell, PH (2001) The schedule of destruction of three mitotic cyclins can dictate the timing of events during exit from mitosis. Curr. Biol. 11 671-83 PubMed GONUTS page

[PMID:11350926-10] Jacobs, HW et al. (2001) A complex degradation signal in Cyclin A required for G1 arrest, and a C-terminal region for mitosis. EMBO J. 20 2376-86 PubMed GONUTS page

[PMID:11027291-11] 11.0 ^11.1 Avedisov, SN et al. (2000) Roughex mediates G(1) arrest through a physical association with cyclin A. Mol. Cell. Biol. 20 8220-9 PubMed GONUTS page

[PMID:1531147-12] Maldonado-Codina, G & Glover, DM (1992) Cyclins A and B associate with chromatin and the polar regions of spindles, respectively, and do not undergo complete degradation at anaphase in syncytial Drosophila embryos. J. Cell Biol. 116 967-76 PubMed GONUTS page

[PMID:28829944-13] Kim, W et al. (2017) Spatial Activation of TORC1 Is Regulated by Hedgehog and E2F1 Signaling in the Drosophila Eye. Dev. Cell 42 363-375.e4 PubMed GONUTS page

[PMID:14616073-14] Lee, LA & Orr-Weaver, TL (2003) Regulation of cell cycles in Drosophila development: intrinsic and extrinsic cues. Annu. Rev. Genet. 37 545-78 PubMed GONUTS page

[PMID:11448787-15] 15.0 ^15.1 Tin Su, T (2001) Cell cycle: how, when and why cells get rid of cyclin A. Curr. Biol. 11 R467-9 PubMed GONUTS page

[PMID:8060613-16] Salzberg, A et al. (1994) Mutations affecting the pattern of the PNS in Drosophila reveal novel aspects of neuronal development. Neuron 13 269-87 PubMed GONUTS page

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DROME:CCNA

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References

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