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PMID:11448787
| Citation |
Tin Su, T (2001) Cell cycle: how, when and why cells get rid of cyclin A. Curr. Biol. 11:R467-9 |
|---|---|
| Abstract |
Sequences outside the 'destruction box' direct the degradation of cyclin A to completion before the metaphase-anaphase transition; cyclin A that escapes timely degradation can block the metaphase-anaphase transition, impede anaphase and telophase, and impair a cell's ability to arrest in G1 of the next cell cycle. |
| Links | |
| Keywords |
Amino Acid Motifs; Animals; Cell Cycle/physiology; Cyclin A/metabolism; Humans; Models, Biological; Spindle Apparatus/metabolism; Time Factors |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0045841: negative regulation of mitotic metaphase/anaphase transition |
ECO:0000304: author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000278: mitotic cell cycle |
ECO:0000304: author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
Notes
See also
References
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