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PMID:18291653

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Citation

McCleland, ML and O'Farrell, PH (2008) RNAi of mitotic cyclins in Drosophila uncouples the nuclear and centrosome cycle. Curr. Biol. 18:245-54

Abstract

Successful cell duplication requires orderly progression through a succession of dramatic cell-cycle events. Disruption of this precise coupling can compromise genomic integrity. The coordination of cell-cycle events is thought to arise from control by a single master regulator, cyclin:Cdk, whose activity oscillates. However, we still know very little of how individual cell-cycle events are coupled to this oscillator and how the timing of each event is controlled.

Links

PubMed PMC2698964 Online version:10.1016/j.cub.2008.01.041

Keywords

Animals; Blastoderm/metabolism; Centrosome/physiology; Colchicine; Cyclin-Dependent Kinases/metabolism; Cyclins/metabolism; Cycloheximide; Drosophila/embryology; Drosophila/metabolism; Mitosis/physiology; Myosins/metabolism; Protein Synthesis Inhibitors; RNA Interference; Tubulin Modulators

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:CCNB

involved_in

GO:0035186: syncytial blastoderm mitotic cell cycle

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0000404,FB:FBgn0015625

P

Seeded From UniProt

complete

DROME:CCNB3

involved_in

GO:0035186: syncytial blastoderm mitotic cell cycle

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0000404,FB:FBgn0000405

P

Seeded From UniProt

complete

DROME:CCNA

involved_in

GO:0035186: syncytial blastoderm mitotic cell cycle

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0000405,FB:FBgn0015625

P

Seeded From UniProt

complete


See also

References

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