DROME:AKT1

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	Akt1
Protein Name(s)	RAC serine/threonine-protein kinase DAkt DRAC-PK Dakt1 Akt Protein kinase B PKB
External Links
UniProt	Q8INB9
EMBL	Z26242 X83510 X83510 AE014297 AE014297 AY069856
PIR	A55888
RefSeq	NP_001287353.1 NP_001287354.1 NP_732113.3 NP_732114.1 NP_732115.1
UniGene	Dm.1219
ProteinModelPortal	Q8INB9
SMR	Q8INB9
BioGrid	67008
DIP	DIP-49060N
IntAct	Q8INB9
MINT	MINT-291950
PaxDb	Q8INB9
PRIDE	Q8INB9
EnsemblMetazoa	FBtr0083228
GeneID	41957
KEGG	dme:Dmel_CG4006
CTD	207
FlyBase	FBgn0010379
eggNOG	COG0515
GeneTree	ENSGT00770000120449
InParanoid	Q8INB9
KO	K04456
OMA	RGCQIMA
OrthoDB	EOG7Q5HCW
PhylomeDB	Q8INB9
Reactome	REACT_180302 REACT_180799 REACT_180850 REACT_180852 REACT_184384 REACT_207784 REACT_208852 REACT_219214 REACT_229887 REACT_234406 REACT_235896 REACT_236156 REACT_242850 REACT_246558 REACT_249658 REACT_250535 REACT_250808 REACT_256638 REACT_258006 REACT_262697
SignaLink	Q8INB9
ChiTaRS	Akt1
GenomeRNAi	41957
NextBio	826461
PRO	PR:Q8INB9
Proteomes	UP000000803
Bgee	Q8INB9
ExpressionAtlas	Q8INB9
GO	GO:0009986 GO:0005737 GO:0005829 GO:0043025 GO:0005886 GO:0005524 GO:0035091 GO:0004672 GO:0004674 GO:0006915 GO:0008362 GO:0007623 GO:0031104 GO:0007427 GO:0008286 GO:0035556 GO:0006629 GO:0019915 GO:0060292 GO:0035264 GO:0007520 GO:0043066 GO:0045886 GO:0007424 GO:0048680 GO:0030307 GO:0045793 GO:0040018 GO:0046622 GO:0006468 GO:0008360 GO:0008361 GO:0050773 GO:0035206 GO:0040014 GO:0046620 GO:0042306 GO:0006979 GO:0007525
Gene3D	2.30.29.30
InterPro	IPR000961 IPR011009 IPR001849 IPR011993 IPR017892 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00169 PF00069 PF00433
SMART	SM00233 SM00133 SM00220
SUPFAM	SSF56112
PROSITE	PS51285 PS50003 PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0046622	positive regulation of organ growth	PMID:10587646^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:10962553^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P91634	P		Seeded From UniProt	complete
involved_in	GO:0030307	positive regulation of cell growth	PMID:15712201^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030307	positive regulation of cell growth	PMID:10962553^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030307	positive regulation of cell growth	PMID:10587646^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030307	positive regulation of cell growth	PMID:12172554^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:10962553^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P91634	P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:10587646^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:10587646^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007427	epithelial cell migration, open tracheal system	PMID:14525946^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:12172554^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:12172554^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003744 FB:FBgn0010379 MGI:MGI:97601 PANTHER:PTN000683254 PomBase:SPAC1B9.02c PomBase:SPAC22E12.14c PomBase:SPAPB18E9.02c RGD:3395 RGD:3399 RGD:61925 RGD:620968 RGD:67383 SGD:S000000201 UniProtKB:O15530 UniProtKB:P31749 UniProtKB:Q15208 UniProtKB:Q9NRM7 UniProtKB:Q9Y2H1	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87986 PANTHER:PTN000683254 RGD:2081 RGD:3395 RGD:3399 RGD:3668 RGD:61925 SGD:S000001609 SGD:S000001861 SGD:S000002898 SGD:S000005460 UniProtKB:A0A1D5PUY5 UniProtKB:P31749 UniProtKB:P41743 UniProtKB:Q02156 UniProtKB:Q05513 UniProtKB:Q05655 WB:WBGene00000102 WB:WBGene00000103 WB:WBGene00004033 WB:WBGene00004034 WB:WBGene00004789 WB:WBGene00006599	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003091 FB:FBgn0003744 FB:FBgn0010379 FB:FBgn0260399 FB:FBgn0261854 MGI:MGI:104874 MGI:MGI:2182368 MGI:MGI:87986 MGI:MGI:894676 MGI:MGI:97595 MGI:MGI:97596 MGI:MGI:97599 MGI:MGI:97602 PANTHER:PTN000683254 PomBase:SPAC1B9.02c PomBase:SPAC22E12.14c PomBase:SPAC24B11.11c PomBase:SPAC821.12 PomBase:SPAPB18E9.02c PomBase:SPCC576.15c RGD:2081 RGD:2082 RGD:3399 RGD:3668 RGD:620146 RGD:620968 RGD:62390 SGD:S000001248 SGD:S000001609 SGD:S000001861 SGD:S000002898 SGD:S000003324 SGD:S000005105 SGD:S000005460 SGD:S000006315 TAIR:locus:2088515 UniProtKB:O15530 UniProtKB:O95835 UniProtKB:P05771 UniProtKB:P17252 UniProtKB:P31749 UniProtKB:P31751 UniProtKB:P41743 UniProtKB:Q02156 UniProtKB:Q04759 UniProtKB:Q05513 UniProtKB:Q05655 UniProtKB:Q09013 UniProtKB:Q15208 UniProtKB:Q16512 UniProtKB:Q16513 UniProtKB:Q96GX5 UniProtKB:Q9NRM7 UniProtKB:Q9XF67 UniProtKB:Q9Y243 UniProtKB:Q9Y2H1 WB:WBGene00000102 WB:WBGene00000103 WB:WBGene00004034 WB:WBGene00004789 WB:WBGene00006599 dictyBase:DDB_G0268620	F		Seeded From UniProt	complete
involved_in	GO:0040014	regulation of multicellular organism growth	PMID:10962553^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045886	negative regulation of synaptic growth at neuromuscular junction	PMID:23393158^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048680	positive regulation of axon regeneration	PMID:22759636^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031104	dendrite regeneration	PMID:22759636^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	PMID:17895391^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	PMID:17895391^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	PMID:21464442^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035264	multicellular organism growth	PMID:21464442^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045793	positive regulation of cell size	PMID:10962553^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046622	positive regulation of organ growth	PMID:10962553^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045793	positive regulation of cell size	PMID:10587646^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:9601646^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:9601646^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:7876156^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0035091	phosphatidylinositol binding	PMID:12559758^[13]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0008362	chitin-based embryonic cuticle biosynthetic process	PMID:11740943^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0020622	P		Seeded From UniProt	complete
involved_in	GO:0007424	open tracheal system development	PMID:11740943^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035206	regulation of hemocyte proliferation	PMID:20688956^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050773	regulation of dendrite development	PMID:19778508^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:17079271^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	PMID:17079271^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010884	positive regulation of lipid storage	PMID:17079271^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0026379	P		Seeded From UniProt	complete
involved_in	GO:0060292	long-term synaptic depression	PMID:16611817^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030307	positive regulation of cell growth	PMID:29514084^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	PMID:19216764^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0003079	P		Seeded From UniProt	complete
involved_in	GO:0045793	positive regulation of cell size	PMID:19216764^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:12893776^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0010379	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:12893776^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_direct_input:(FB:FBgn0038197) part_of:(GO:0008286)	Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	PMID:25749252^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:22242005^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010897	negative regulation of triglyceride catabolic process	PMID:21565616^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21565616^[24]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(FB:FBgn0262103) part_of:(GO:0008286)	Seeded From UniProt	complete
involved_in	GO:0030307	positive regulation of cell growth	PMID:17462592^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:17369395^[26]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:17369395^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	PMID:17369395^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:10962553^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:10962553^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:17183368^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:14645523^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0040018	positive regulation of multicellular organism growth	PMID:29514084^[19]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0262473	P		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:27326933^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	PMID:24916379^[30]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0015946	P		Seeded From UniProt	complete
involved_in	GO:0090278	negative regulation of peptide hormone secretion	PMID:25101872^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048477	oogenesis	PMID:24786828^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007525	somatic muscle development	PMID:24191061^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007520	myoblast fusion	PMID:24191061^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:24068890^[34]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:15337530^[35]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:12841848^[36]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904263	positive regulation of TORC1 signaling	PMID:28829944^[37]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:12172554^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904262	negative regulation of TORC1 signaling	PMID:12172554^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0005198,FB:FBgn0026317	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:12172554^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(FB:FBgn0005198) part_of:(GO:0008286) part_of:(GO:0030307) part_of:(GO:0032007)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17079271^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010884	positive regulation of lipid storage	PMID:18827008^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:18827008^[38]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000961 InterPro:IPR017892 InterPro:IPR039029	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR000961 InterPro:IPR017441 InterPro:IPR017892	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR000961 InterPro:IPR008271 InterPro:IPR017892	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039029	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-DME-110468 Reactome:R-DME-110463	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-DME-169828 Reactome:R-DME-110475 Reactome:R-DME-110468 Reactome:R-DME-110463	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	Reactome:R-DME-169828 Reactome:R-DME-110475	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0040008	regulation of growth	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0341	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Verdu, J et al. (1999) Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB. Nat. Cell Biol. 1 500-6 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Scanga, SE et al. (2000) The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila. Oncogene 19 3971-7 PubMed GONUTS page
↑ Cavaliere, V et al. (2005) dAkt kinase controls follicle cell size during Drosophila oogenesis. Dev. Dyn. 232 845-54 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Potter, CJ et al. (2002) Akt regulates growth by directly phosphorylating Tsc2. Nat. Cell Biol. 4 658-65 PubMed GONUTS page
↑ Lavenburg, KR et al. (2003) Coordinated functions of Akt/PKB and ETS1 in tubule formation. FASEB J. 17 2278-80 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Natarajan, R et al. (2013) Tuberous sclerosis complex regulates Drosophila neuromuscular junction growth via the TORC2/Akt pathway. Hum. Mol. Genet. 22 2010-23 PubMed GONUTS page
↑ ^8.0 ^8.1 Song, Y et al. (2012) Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam. Genes Dev. 26 1612-25 PubMed GONUTS page
↑ ^9.0 ^9.1 Zheng, X et al. (2007) FOXO and insulin signaling regulate sensitivity of the circadian clock to oxidative stress. Proc. Natl. Acad. Sci. U.S.A. 104 15899-904 PubMed GONUTS page
↑ ^10.0 ^10.1 Murillo-Maldonado, JM et al. (2011) Drosophila insulin pathway mutants affect visual physiology and brain function besides growth, lipid, and carbohydrate metabolism. Diabetes 60 1632-6 PubMed GONUTS page
↑ ^11.0 ^11.1 Staveley, BE et al. (1998) Genetic analysis of protein kinase B (AKT) in Drosophila. Curr. Biol. 8 599-602 PubMed GONUTS page
↑ Andjelković, M et al. (1995) Developmental regulation of expression and activity of multiple forms of the Drosophila RAC protein kinase. J. Biol. Chem. 270 4066-75 PubMed GONUTS page
↑ Oldham, S & Hafen, E (2003) Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control. Trends Cell Biol. 13 79-85 PubMed GONUTS page
↑ ^14.0 ^14.1 Jin, J et al. (2001) Regulation of Drosophila tracheal system development by protein kinase B. Dev. Cell 1 817-27 PubMed GONUTS page
↑ Sinenko, SA et al. (2010) Genetic manipulation of AML1-ETO-induced expansion of hematopoietic precursors in a Drosophila model. Blood 116 4612-20 PubMed GONUTS page
↑ Parrish, JZ et al. (2009) The microRNA bantam functions in epithelial cells to regulate scaling growth of dendrite arbors in drosophila sensory neurons. Neuron 63 788-802 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 Vereshchagina, N & Wilson, C (2006) Cytoplasmic activated protein kinase Akt regulates lipid-droplet accumulation in Drosophila nurse cells. Development 133 4731-5 PubMed GONUTS page
↑ Guo, HF & Zhong, Y (2006) Requirement of Akt to mediate long-term synaptic depression in Drosophila. J. Neurosci. 26 4004-14 PubMed GONUTS page
↑ ^19.0 ^19.1 Roth, SW et al. (2018) Innate Immune Signaling in Drosophila Blocks Insulin Signaling by Uncoupling PI(3,4,5)P Production and Akt Activation. Cell Rep 22 2550-2556 PubMed GONUTS page
↑ ^20.0 ^20.1 Sims, D et al. (2009) PDGF/VEGF signaling controls cell size in Drosophila. Genome Biol. 10 R20 PubMed GONUTS page
↑ ^21.0 ^21.1 Puig, O et al. (2003) Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway. Genes Dev. 17 2006-20 PubMed GONUTS page
↑ Sopko, R et al. (2015) A systems-level interrogation identifies regulators of Drosophila blood cell number and survival. PLoS Genet. 11 e1005056 PubMed GONUTS page
↑ Zhang, W et al. (2011) MAPK/ERK signaling regulates insulin sensitivity to control glucose metabolism in Drosophila. PLoS Genet. 7 e1002429 PubMed GONUTS page
↑ ^24.0 ^24.1 Wang, B et al. (2011) A hormone-dependent module regulating energy balance. Cell 145 596-606 PubMed GONUTS page
↑ Lee, G & Chung, J (2007) Discrete functions of rictor and raptor in cell growth regulation in Drosophila. Biochem. Biophys. Res. Commun. 357 1154-9 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 Hietakangas, V & Cohen, SM (2007) Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth. Genes Dev. 21 632-7 PubMed GONUTS page
↑ Wu, MY et al. (2007) Insulin delays the progression of Drosophila cells through G2/M by activating the dTOR/dRaptor complex. EMBO J. 26 371-9 PubMed GONUTS page
↑ Miron, M et al. (2003) Signaling from Akt to FRAP/TOR targets both 4E-BP and S6K in Drosophila melanogaster. Mol. Cell. Biol. 23 9117-26 PubMed GONUTS page
↑ Danielsen, ET et al. (2016) A Drosophila Genome-Wide Screen Identifies Regulators of Steroid Hormone Production and Developmental Timing. Dev. Cell 37 558-70 PubMed GONUTS page
↑ Chuang, CL et al. (2014) Genetic dissection reveals that Akt is the critical kinase downstream of LRRK2 to phosphorylate and inhibit FOXO1, and promotes neuron survival. Hum. Mol. Genet. 23 5649-58 PubMed GONUTS page
↑ Park, S et al. (2014) A genetic strategy to measure circulating Drosophila insulin reveals genes regulating insulin production and secretion. PLoS Genet. 10 e1004555 PubMed GONUTS page
↑ Wei, Y & Lilly, MA (2014) The TORC1 inhibitors Nprl2 and Nprl3 mediate an adaptive response to amino-acid starvation in Drosophila. Cell Death Differ. 21 1460-8 PubMed GONUTS page
↑ ^33.0 ^33.1 Tixier, V et al. (2013) Glycolysis supports embryonic muscle growth by promoting myoblast fusion. Proc. Natl. Acad. Sci. U.S.A. 110 18982-7 PubMed GONUTS page
↑ Wong, JJ et al. (2013) A Cullin1-based SCF E3 ubiquitin ligase targets the InR/PI3K/TOR pathway to regulate neuronal pruning. PLoS Biol. 11 e1001657 PubMed GONUTS page
↑ Kim, SE et al. (2004) Drosophila PI3 kinase and Akt involved in insulin-stimulated proliferation and ERK pathway activation in Schneider cells. Cell. Signal. 16 1309-17 PubMed GONUTS page
↑ Lizcano, JM et al. (2003) Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B. Biochem. J. 374 297-306 PubMed GONUTS page
↑ Kim, W et al. (2017) Spatial Activation of TORC1 Is Regulated by Hedgehog and E2F1 Signaling in the Drosophila Eye. Dev. Cell 42 363-375.e4 PubMed GONUTS page
↑ ^38.0 ^38.1 Vereshchagina, N et al. (2008) The protein phosphatase PP2A-B' subunit Widerborst is a negative regulator of cytoplasmic activated Akt and lipid metabolism in Drosophila. J. Cell. Sci. 121 3383-92 PubMed GONUTS page

[PMID:10587646-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Verdu, J et al. (1999) Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB. Nat. Cell Biol. 1 500-6 PubMed GONUTS page

[PMID:10962553-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Scanga, SE et al. (2000) The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila. Oncogene 19 3971-7 PubMed GONUTS page

[PMID:15712201-3] Cavaliere, V et al. (2005) dAkt kinase controls follicle cell size during Drosophila oogenesis. Dev. Dyn. 232 845-54 PubMed GONUTS page

[PMID:12172554-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Potter, CJ et al. (2002) Akt regulates growth by directly phosphorylating Tsc2. Nat. Cell Biol. 4 658-65 PubMed GONUTS page

[PMID:14525946-5] Lavenburg, KR et al. (2003) Coordinated functions of Akt/PKB and ETS1 in tubule formation. FASEB J. 17 2278-80 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23393158-7] Natarajan, R et al. (2013) Tuberous sclerosis complex regulates Drosophila neuromuscular junction growth via the TORC2/Akt pathway. Hum. Mol. Genet. 22 2010-23 PubMed GONUTS page

[PMID:22759636-8] 8.0 ^8.1 Song, Y et al. (2012) Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam. Genes Dev. 26 1612-25 PubMed GONUTS page

[PMID:17895391-9] 9.0 ^9.1 Zheng, X et al. (2007) FOXO and insulin signaling regulate sensitivity of the circadian clock to oxidative stress. Proc. Natl. Acad. Sci. U.S.A. 104 15899-904 PubMed GONUTS page

[PMID:21464442-10] 10.0 ^10.1 Murillo-Maldonado, JM et al. (2011) Drosophila insulin pathway mutants affect visual physiology and brain function besides growth, lipid, and carbohydrate metabolism. Diabetes 60 1632-6 PubMed GONUTS page

[PMID:9601646-11] 11.0 ^11.1 Staveley, BE et al. (1998) Genetic analysis of protein kinase B (AKT) in Drosophila. Curr. Biol. 8 599-602 PubMed GONUTS page

[PMID:7876156-12] Andjelković, M et al. (1995) Developmental regulation of expression and activity of multiple forms of the Drosophila RAC protein kinase. J. Biol. Chem. 270 4066-75 PubMed GONUTS page

[PMID:12559758-13] Oldham, S & Hafen, E (2003) Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control. Trends Cell Biol. 13 79-85 PubMed GONUTS page

[PMID:11740943-14] 14.0 ^14.1 Jin, J et al. (2001) Regulation of Drosophila tracheal system development by protein kinase B. Dev. Cell 1 817-27 PubMed GONUTS page

[PMID:20688956-15] Sinenko, SA et al. (2010) Genetic manipulation of AML1-ETO-induced expansion of hematopoietic precursors in a Drosophila model. Blood 116 4612-20 PubMed GONUTS page

[PMID:19778508-16] Parrish, JZ et al. (2009) The microRNA bantam functions in epithelial cells to regulate scaling growth of dendrite arbors in drosophila sensory neurons. Neuron 63 788-802 PubMed GONUTS page

[PMID:17079271-17] 17.0 ^17.1 ^17.2 ^17.3 Vereshchagina, N & Wilson, C (2006) Cytoplasmic activated protein kinase Akt regulates lipid-droplet accumulation in Drosophila nurse cells. Development 133 4731-5 PubMed GONUTS page

[PMID:16611817-18] Guo, HF & Zhong, Y (2006) Requirement of Akt to mediate long-term synaptic depression in Drosophila. J. Neurosci. 26 4004-14 PubMed GONUTS page

[PMID:29514084-19] 19.0 ^19.1 Roth, SW et al. (2018) Innate Immune Signaling in Drosophila Blocks Insulin Signaling by Uncoupling PI(3,4,5)P Production and Akt Activation. Cell Rep 22 2550-2556 PubMed GONUTS page

[PMID:19216764-20] 20.0 ^20.1 Sims, D et al. (2009) PDGF/VEGF signaling controls cell size in Drosophila. Genome Biol. 10 R20 PubMed GONUTS page

[PMID:12893776-21] 21.0 ^21.1 Puig, O et al. (2003) Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway. Genes Dev. 17 2006-20 PubMed GONUTS page

[PMID:25749252-22] Sopko, R et al. (2015) A systems-level interrogation identifies regulators of Drosophila blood cell number and survival. PLoS Genet. 11 e1005056 PubMed GONUTS page

[PMID:22242005-23] Zhang, W et al. (2011) MAPK/ERK signaling regulates insulin sensitivity to control glucose metabolism in Drosophila. PLoS Genet. 7 e1002429 PubMed GONUTS page

[PMID:21565616-24] 24.0 ^24.1 Wang, B et al. (2011) A hormone-dependent module regulating energy balance. Cell 145 596-606 PubMed GONUTS page

[PMID:17462592-25] Lee, G & Chung, J (2007) Discrete functions of rictor and raptor in cell growth regulation in Drosophila. Biochem. Biophys. Res. Commun. 357 1154-9 PubMed GONUTS page

[PMID:17369395-26] 26.0 ^26.1 ^26.2 Hietakangas, V & Cohen, SM (2007) Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth. Genes Dev. 21 632-7 PubMed GONUTS page

[PMID:17183368-27] Wu, MY et al. (2007) Insulin delays the progression of Drosophila cells through G2/M by activating the dTOR/dRaptor complex. EMBO J. 26 371-9 PubMed GONUTS page

[PMID:14645523-28] Miron, M et al. (2003) Signaling from Akt to FRAP/TOR targets both 4E-BP and S6K in Drosophila melanogaster. Mol. Cell. Biol. 23 9117-26 PubMed GONUTS page

[PMID:27326933-29] Danielsen, ET et al. (2016) A Drosophila Genome-Wide Screen Identifies Regulators of Steroid Hormone Production and Developmental Timing. Dev. Cell 37 558-70 PubMed GONUTS page

[PMID:24916379-30] Chuang, CL et al. (2014) Genetic dissection reveals that Akt is the critical kinase downstream of LRRK2 to phosphorylate and inhibit FOXO1, and promotes neuron survival. Hum. Mol. Genet. 23 5649-58 PubMed GONUTS page

[PMID:25101872-31] Park, S et al. (2014) A genetic strategy to measure circulating Drosophila insulin reveals genes regulating insulin production and secretion. PLoS Genet. 10 e1004555 PubMed GONUTS page

[PMID:24786828-32] Wei, Y & Lilly, MA (2014) The TORC1 inhibitors Nprl2 and Nprl3 mediate an adaptive response to amino-acid starvation in Drosophila. Cell Death Differ. 21 1460-8 PubMed GONUTS page

[PMID:24191061-33] 33.0 ^33.1 Tixier, V et al. (2013) Glycolysis supports embryonic muscle growth by promoting myoblast fusion. Proc. Natl. Acad. Sci. U.S.A. 110 18982-7 PubMed GONUTS page

[PMID:24068890-34] Wong, JJ et al. (2013) A Cullin1-based SCF E3 ubiquitin ligase targets the InR/PI3K/TOR pathway to regulate neuronal pruning. PLoS Biol. 11 e1001657 PubMed GONUTS page

[PMID:15337530-35] Kim, SE et al. (2004) Drosophila PI3 kinase and Akt involved in insulin-stimulated proliferation and ERK pathway activation in Schneider cells. Cell. Signal. 16 1309-17 PubMed GONUTS page

[PMID:12841848-36] Lizcano, JM et al. (2003) Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B. Biochem. J. 374 297-306 PubMed GONUTS page

[PMID:28829944-37] Kim, W et al. (2017) Spatial Activation of TORC1 Is Regulated by Hedgehog and E2F1 Signaling in the Drosophila Eye. Dev. Cell 42 363-375.e4 PubMed GONUTS page

[PMID:18827008-38] 38.0 ^38.1 Vereshchagina, N et al. (2008) The protein phosphatase PP2A-B' subunit Widerborst is a negative regulator of cytoplasmic activated Akt and lipid metabolism in Drosophila. J. Cell. Sci. 121 3383-92 PubMed GONUTS page

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[26]

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