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DROME:AKT1

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Akt1
Protein Name(s) RAC serine/threonine-protein kinase

DAkt DRAC-PK Dakt1 Akt Protein kinase B PKB

External Links
UniProt Q8INB9
EMBL Z26242
X83510
X83510
AE014297
AE014297
AY069856
PIR A55888
RefSeq NP_001287353.1
NP_001287354.1
NP_732113.3
NP_732114.1
NP_732115.1
UniGene Dm.1219
ProteinModelPortal Q8INB9
SMR Q8INB9
BioGrid 67008
DIP DIP-49060N
IntAct Q8INB9
MINT MINT-291950
PaxDb Q8INB9
PRIDE Q8INB9
EnsemblMetazoa FBtr0083228
GeneID 41957
KEGG dme:Dmel_CG4006
CTD 207
FlyBase FBgn0010379
eggNOG COG0515
GeneTree ENSGT00770000120449
InParanoid Q8INB9
KO K04456
OMA RGCQIMA
OrthoDB EOG7Q5HCW
PhylomeDB Q8INB9
Reactome REACT_180302
REACT_180799
REACT_180850
REACT_180852
REACT_184384
REACT_207784
REACT_208852
REACT_219214
REACT_229887
REACT_234406
REACT_235896
REACT_236156
REACT_242850
REACT_246558
REACT_249658
REACT_250535
REACT_250808
REACT_256638
REACT_258006
REACT_262697
SignaLink Q8INB9
ChiTaRS Akt1
GenomeRNAi 41957
NextBio 826461
PRO PR:Q8INB9
Proteomes UP000000803
Bgee Q8INB9
ExpressionAtlas Q8INB9
GO GO:0009986
GO:0005737
GO:0005829
GO:0043025
GO:0005886
GO:0005524
GO:0035091
GO:0004672
GO:0004674
GO:0006915
GO:0008362
GO:0007623
GO:0031104
GO:0007427
GO:0008286
GO:0035556
GO:0006629
GO:0019915
GO:0060292
GO:0035264
GO:0007520
GO:0043066
GO:0045886
GO:0007424
GO:0048680
GO:0030307
GO:0045793
GO:0040018
GO:0046622
GO:0006468
GO:0008360
GO:0008361
GO:0050773
GO:0035206
GO:0040014
GO:0046620
GO:0042306
GO:0006979
GO:0007525
Gene3D 2.30.29.30
InterPro IPR000961
IPR011009
IPR001849
IPR011993
IPR017892
IPR000719
IPR017441
IPR002290
IPR008271
Pfam PF00169
PF00069
PF00433
SMART SM00233
SM00133
SM00220
SUPFAM SSF56112
PROSITE PS51285
PS50003
PS00107
PS50011
PS00108

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

GO:0004672

protein kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR002290
InterPro:IPR008271

F

Seeded From UniProt

complete

GO:0004672

protein kinase activity

PMID:7876156[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000961
InterPro:IPR017892

F

Seeded From UniProt

complete

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

GO:0004674

protein serine/threonine kinase activity

PMID:10908587[2]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

complete

GO:0004674

protein serine/threonine kinase activity

PMID:12172554[3]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0004674

protein serine/threonine kinase activity

PMID:7876156[1]

ISS: Inferred from Sequence or Structural Similarity

F

Seeded From UniProt

Missing: with/from

GO:0004674

protein serine/threonine kinase activity

PMID:9601646[4]

IMP: Inferred from Mutant Phenotype

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:15808505[5]

IPI: Inferred from Physical Interaction

UniProtKB:Q9VJ07

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR000961
InterPro:IPR002290
InterPro:IPR017441
InterPro:IPR017892

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:17079271[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005829

cytosol

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0091

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-1003

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

PMID:12559758[7]

NAS: Non-traceable Author Statement

C

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR000961
InterPro:IPR002290
InterPro:IPR008271
InterPro:IPR017892

P

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

PMID:10908587[2]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

PMID:12172554[3]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0006629

lipid metabolic process

PMID:21464442[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

GO:0006979

response to oxidative stress

PMID:17895391[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0007424

open tracheal system development

PMID:11740943[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007424

open tracheal system development

PMID:12325126[11]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007424

open tracheal system development

PMID:14570584[12]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007427

epithelial cell migration, open tracheal system

PMID:14525946[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007520

myoblast fusion

PMID:24191061[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007525

somatic muscle development

PMID:24191061[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007623

circadian rhythm

PMID:17895391[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008286

insulin receptor signaling pathway

PMID:10587646[15]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0008286

insulin receptor signaling pathway

PMID:10962553[16]

IGI: Inferred from Genetic Interaction

UniProtKB:P91634

P

Seeded From UniProt

complete

GO:0008286

insulin receptor signaling pathway

PMID:11782950[17]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0008286

insulin receptor signaling pathway

PMID:11897402[18]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008360

regulation of cell shape

PMID:14527345[19]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008361

regulation of cell size

PMID:11897402[18]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0008362

chitin-based embryonic cuticle biosynthetic process

PMID:11740943[10]

IGI: Inferred from Genetic Interaction

FB:FBgn0020622

P

Seeded From UniProt

complete

GO:0009986

cell surface

PMID:17079271[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016301

kinase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

GO:0016310

phosphorylation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

GO:0016740

transferase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

GO:0019915

lipid storage

PMID:17079271[6]

IGI: Inferred from Genetic Interaction

FB:FBgn0026379

P

Seeded From UniProt

complete

GO:0030307

positive regulation of cell growth

PMID:10587646[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030307

positive regulation of cell growth

PMID:10679387[20]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0030307

positive regulation of cell growth

PMID:10962553[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030307

positive regulation of cell growth

PMID:11782950[17]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0030307

positive regulation of cell growth

PMID:12172554[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030307

positive regulation of cell growth

PMID:12559758[7]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0030307

positive regulation of cell growth

PMID:15712201[21]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0031104

dendrite regeneration

PMID:22759636[22]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0035091

phosphatidylinositol binding

PMID:12559758[7]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

complete

GO:0035206

regulation of hemocyte proliferation

PMID:20688956[23]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0035264

multicellular organism growth

PMID:21464442[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0035556

intracellular signal transduction

PMID:10962553[16]

IGI: Inferred from Genetic Interaction

UniProtKB:P91634

P

Seeded From UniProt

complete

GO:0040008

regulation of growth

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0341

P

Seeded From UniProt

complete

GO:0040014

regulation of multicellular organism growth

PMID:10962553[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0040014

regulation of multicellular organism growth

PMID:11897402[18]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0040018

positive regulation of multicellular organism growth

PMID:10679387[20]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0040018

positive regulation of multicellular organism growth

PMID:11128988[24]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0040018

positive regulation of multicellular organism growth

PMID:12559758[7]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0042306

regulation of protein import into nucleus

PMID:14570584[12]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0043025

neuronal cell body

PMID:24068890[25]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0043066

negative regulation of apoptotic process

PMID:9601646[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045793

positive regulation of cell size

PMID:10587646[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045793

positive regulation of cell size

PMID:10962553[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045793

positive regulation of cell size

PMID:11128988[24]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0045793

positive regulation of cell size

PMID:11377964[26]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0045793

positive regulation of cell size

PMID:12563289[27]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0045886

negative regulation of synaptic growth at neuromuscular junction

PMID:23393158[28]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046620

regulation of organ growth

PMID:10679387[20]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0046620

regulation of organ growth

PMID:11897402[18]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0046622

positive regulation of organ growth

PMID:10587646[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046622

positive regulation of organ growth

PMID:10962553[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046622

positive regulation of organ growth

PMID:11377964[26]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0046622

positive regulation of organ growth

PMID:12559758[7]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0046622

positive regulation of organ growth

PMID:14691557[29]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0048477

oogenesis

PMID:24786828[30]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048680

positive regulation of axon regeneration

PMID:22759636[22]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0050773

regulation of dendrite development

PMID:19778508[31]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0060292

long term synaptic depression

PMID:16611817[32]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:1901215

negative regulation of neuron death

PMID:24916379[33]

IGI: Inferred from Genetic Interaction

FB:FBgn0015946

P

Seeded From UniProt

complete

NOT

GO:0008284

positive regulation of cell proliferation

PMID:10587646[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Andjelković, M et al. (1995) Developmental regulation of expression and activity of multiple forms of the Drosophila RAC protein kinase. J. Biol. Chem. 270 4066-75 PubMed GONUTS page
  2. 2.0 2.1 Morrison, DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J. Cell Biol. 150 F57-62 PubMed GONUTS page
  3. 3.0 3.1 3.2 Potter, CJ et al. (2002) Akt regulates growth by directly phosphorylating Tsc2. Nat. Cell Biol. 4 658-65 PubMed GONUTS page
  4. 4.0 4.1 Staveley, BE et al. (1998) Genetic analysis of protein kinase B (AKT) in Drosophila. Curr. Biol. 8 599-602 PubMed GONUTS page
  5. Gao, T et al. (2005) PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol. Cell 18 13-24 PubMed GONUTS page
  6. 6.0 6.1 6.2 Vereshchagina, N & Wilson, C (2006) Cytoplasmic activated protein kinase Akt regulates lipid-droplet accumulation in Drosophila nurse cells. Development 133 4731-5 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 7.4 Oldham, S & Hafen, E (2003) Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control. Trends Cell Biol. 13 79-85 PubMed GONUTS page
  8. 8.0 8.1 Murillo-Maldonado, JM et al. (2011) Drosophila insulin pathway mutants affect visual physiology and brain function besides growth, lipid, and carbohydrate metabolism. Diabetes 60 1632-6 PubMed GONUTS page
  9. 9.0 9.1 Zheng, X et al. (2007) FOXO and insulin signaling regulate sensitivity of the circadian clock to oxidative stress. Proc. Natl. Acad. Sci. U.S.A. 104 15899-904 PubMed GONUTS page
  10. 10.0 10.1 Jin, J et al. (2001) Regulation of Drosophila tracheal system development by protein kinase B. Dev. Cell 1 817-27 PubMed GONUTS page
  11. Davies, JA (2002) Do different branching epithelia use a conserved developmental mechanism? Bioessays 24 937-48 PubMed GONUTS page
  12. 12.0 12.1 Ghabrial, A et al. (2003) Branching morphogenesis of the Drosophila tracheal system. Annu. Rev. Cell Dev. Biol. 19 623-47 PubMed GONUTS page
  13. Lavenburg, KR et al. (2003) Coordinated functions of Akt/PKB and ETS1 in tubule formation. FASEB J. 17 2278-80 PubMed GONUTS page
  14. 14.0 14.1 Tixier, V et al. (2013) Glycolysis supports embryonic muscle growth by promoting myoblast fusion. Proc. Natl. Acad. Sci. U.S.A. 110 18982-7 PubMed GONUTS page
  15. 15.0 15.1 15.2 15.3 15.4 Verdu, J et al. (1999) Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB. Nat. Cell Biol. 1 500-6 PubMed GONUTS page
  16. 16.0 16.1 16.2 16.3 16.4 16.5 Scanga, SE et al. (2000) The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila. Oncogene 19 3971-7 PubMed GONUTS page
  17. 17.0 17.1 Johnston, LA & Gallant, P (2002) Control of growth and organ size in Drosophila. Bioessays 24 54-64 PubMed GONUTS page
  18. 18.0 18.1 18.2 18.3 Claeys, I et al. (2002) Insulin-related peptides and their conserved signal transduction pathway. Peptides 23 807-16 PubMed GONUTS page
  19. Kiger, AA et al. (2003) A functional genomic analysis of cell morphology using RNA interference. J. Biol. 2 27 PubMed GONUTS page
  20. 20.0 20.1 20.2 Weinkove, D & Leevers, SJ (2000) The genetic control of organ growth: insights from Drosophila. Curr. Opin. Genet. Dev. 10 75-80 PubMed GONUTS page
  21. Cavaliere, V et al. (2005) dAkt kinase controls follicle cell size during Drosophila oogenesis. Dev. Dyn. 232 845-54 PubMed GONUTS page
  22. 22.0 22.1 Song, Y et al. (2012) Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam. Genes Dev. 26 1612-25 PubMed GONUTS page
  23. Sinenko, SA et al. (2010) Genetic manipulation of AML1-ETO-induced expansion of hematopoietic precursors in a Drosophila model. Blood 116 4612-20 PubMed GONUTS page
  24. 24.0 24.1 Oldham, S et al. (2000) Genetic control of size in Drosophila. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 945-52 PubMed GONUTS page
  25. Wong, JJ et al. (2013) A Cullin1-based SCF E3 ubiquitin ligase targets the InR/PI3K/TOR pathway to regulate neuronal pruning. PLoS Biol. 11 e1001657 PubMed GONUTS page
  26. 26.0 26.1 Potter, CJ & Xu, T (2001) Mechanisms of size control. Curr. Opin. Genet. Dev. 11 279-86 PubMed GONUTS page
  27. Jacinto, E & Hall, MN (2003) Tor signalling in bugs, brain and brawn. Nat. Rev. Mol. Cell Biol. 4 117-26 PubMed GONUTS page
  28. Natarajan, R et al. (2013) Tuberous sclerosis complex regulates Drosophila neuromuscular junction growth via the TORC2/Akt pathway. Hum. Mol. Genet. 22 2010-23 PubMed GONUTS page
  29. Hafen, E & Stocker, H (2003) How are the sizes of cells, organs, and bodies controlled? PLoS Biol. 1 E86 PubMed GONUTS page
  30. Wei, Y & Lilly, MA (2014) The TORC1 inhibitors Nprl2 and Nprl3 mediate an adaptive response to amino-acid starvation in Drosophila. Cell Death Differ. 21 1460-8 PubMed GONUTS page
  31. Parrish, JZ et al. (2009) The microRNA bantam functions in epithelial cells to regulate scaling growth of dendrite arbors in drosophila sensory neurons. Neuron 63 788-802 PubMed GONUTS page
  32. Guo, HF & Zhong, Y (2006) Requirement of Akt to mediate long-term synaptic depression in Drosophila. J. Neurosci. 26 4004-14 PubMed GONUTS page
  33. Chuang, CL et al. (2014) Genetic dissection reveals that Akt is the critical kinase downstream of LRRK2 to phosphorylate and inhibit FOXO1, and promotes neuron survival. Hum. Mol. Genet. 23 5649-58 PubMed GONUTS page