PMID:15712201

Citation	Cavaliere, V, Donati, A, Hsouna, A, Hsu, T and Gargiulo, G (2005) dAkt kinase controls follicle cell size during Drosophila oogenesis. Dev. Dyn. 232:845-54
Abstract	The Drosophila Akt (dAkt) serine/threonine kinase is a component of the insulin receptor/PI3K signaling pathway that regulates cell growth. Here, we show that this kinase is expressed during Drosophila oogenesis and is required for egg chamber development. Loss of dAkt function in follicle cells causes a cell-autonomous reduction of cell size while expression of the constitutively active myristylated form of this kinase (dAkt(myr)) causes increased cell size. Accordingly, expression of the antagonist dPTEN in the same follicular domains causes reduced follicle cell size. Perturbations of dAkt function do not affect follicle cell proliferation or cell death. Of interest, expression of dAkt(myr) in the posterior domain of the follicular epithelium causes a delay in the posterior movement of follicular epithelium and dumpless-like egg chambers. It appears that dAkt is required for maintaining the continuity of cell size within the follicular epithelium, which in turn is necessary for its proper morphogenesis.
Links	PubMed PMC2265433 Online version:10.1002/dvdy.20333
Keywords	Animals; Cell Size; Drosophila/embryology; Drosophila Proteins; Embryo, Nonmammalian; Female; Oogenesis/physiology; Ovarian Follicle/cytology; Ovarian Follicle/metabolism; Ovary/cytology; Protein-Serine-Threonine Kinases/metabolism; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins c-akt
edit table

Annotations

Gene product	Qualifier	GO ID	GO term name	Evidence Code	with/from	Aspect	Notes	Status
edit table

References

See Help:References for how to manage references in GONUTS.