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DROME:7LESS

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) sev (synonyms: HD-265)
Protein Name(s) Protein sevenless
External Links
UniProt P13368
EMBL J03158
X13666
X13666
AE014298
AJ002917
PIR A28912
RefSeq NP_511114.2
ProteinModelPortal P13368
BioGrid 58454
IntAct P13368
MINT MINT-839177
PaxDb P13368
GeneID 32039
KEGG dme:Dmel_CG18085
UCSC CG18085-RA
CTD 32039
FlyBase FBgn0003366
eggNOG COG0515
InParanoid P13368
KO K05088
OrthoDB EOG7GN2KT
PhylomeDB P13368
BRENDA 2.7.10.1
SignaLink P13368
ChiTaRS sev
GenomeRNAi 32039
NextBio 776500
PRO PR:P13368
Proteomes UP000000803
Bgee P13368
ExpressionAtlas P13368
GO GO:0005887
GO:0005886
GO:0005524
GO:0004713
GO:0004714
GO:0008595
GO:0042067
GO:0018108
GO:0046534
GO:0045678
GO:0006468
GO:0045467
GO:0045466
GO:0007465
GO:0045464
GO:0008293
GO:0007601
Gene3D 2.120.10.30
2.60.40.10
InterPro IPR011042
IPR003961
IPR013783
IPR011009
IPR000033
IPR000719
IPR017441
IPR001245
IPR008266
IPR020635
IPR002011
Pfam PF00041
PF07714
PRINTS PR00109
SMART SM00060
SM00135
SM00219
SUPFAM SSF49265
SSF56112
PROSITE PS50853
PS00107
PS50011
PS00109
PS00239

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

GO:0004672

protein kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR001245
InterPro:IPR008266

F

Seeded From UniProt

complete

GO:0004713

protein tyrosine kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020635

F

Seeded From UniProt

complete

GO:0004713

protein tyrosine kinase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0829

F

Seeded From UniProt

complete

GO:0004713

protein tyrosine kinase activity

PMID:10908587[1]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

complete

GO:0004713

protein tyrosine kinase activity

PMID:2682647[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0004714

transmembrane receptor protein tyrosine kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002011

F

Seeded From UniProt

complete

GO:0004714

transmembrane receptor protein tyrosine kinase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.7.10.1

F

Seeded From UniProt

complete

GO:0004714

transmembrane receptor protein tyrosine kinase activity

PMID:2840202[3]

ISS: Inferred from Sequence or Structural Similarity

F

Seeded From UniProt

Missing: with/from

GO:0004714

transmembrane receptor protein tyrosine kinase activity

PMID:7680109[4]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:1857416[5]

IPI: Inferred from Physical Interaction

FB:FBgn0000206

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:8462098[6]

IPI: Inferred from Physical Interaction

FB:FBgn0004638

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:8462098[6]

IPI: Inferred from Physical Interaction

UniProtKB:Q08012

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:9671493[7]

IPI: Inferred from Physical Interaction

FB:FBgn0000414

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:9671493[7]

IPI: Inferred from Physical Interaction

UniProtKB:P98081

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR002011
InterPro:IPR017441

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

GO:0005886

plasma membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-1003

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

PMID:2682647[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005887

integral component of plasma membrane

PMID:7680109[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR001245
InterPro:IPR002011
InterPro:IPR008266
InterPro:IPR020635

P

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

PMID:10908587[1]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002011

P

Seeded From UniProt

complete

GO:0007465

R7 cell fate commitment

PMID:17985474[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007601

visual perception

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0844

P

Seeded From UniProt

complete

GO:0008293

torso signaling pathway

PMID:10494038[9]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0008595

anterior/posterior axis specification, embryo

PMID:10494038[9]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002011

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

GO:0016301

kinase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

GO:0016310

phosphorylation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

GO:0016740

transferase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

GO:0018108

peptidyl-tyrosine phosphorylation

PMID:7680109[4]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0042067

establishment of ommatidial planar polarity

PMID:22355117[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045464

R8 cell fate specification

PMID:16143107[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045466

R7 cell differentiation

PMID:12671657[12]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0045466

R7 cell differentiation

PMID:14505358[13]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0045467

R7 cell development

PMID:11880339[14]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0045678

positive regulation of R7 cell differentiation

PMID:20980384[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046534

positive regulation of photoreceptor cell differentiation

PMID:16763554[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0050896

response to stimulus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0716

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Morrison, DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J. Cell Biol. 150 F57-62 PubMed GONUTS page
  2. 2.0 2.1 Simon, MA et al. (1989) Structure and activity of the sevenless protein: a protein tyrosine kinase receptor required for photoreceptor development in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 86 8333-7 PubMed GONUTS page
  3. Basler, K & Hafen, E (1988) Control of photoreceptor cell fate by the sevenless protein requires a functional tyrosine kinase domain. Cell 54 299-311 PubMed GONUTS page
  4. 4.0 4.1 4.2 Hart, AC et al. (1993) Extracellular domain of the boss transmembrane ligand acts as an antagonist of the sev receptor. Nature 361 732-6 PubMed GONUTS page
  5. Krämer, H et al. (1991) Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor. Nature 352 207-12 PubMed GONUTS page
  6. 6.0 6.1 Olivier, JP et al. (1993) A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos. Cell 73 179-91 PubMed GONUTS page
  7. 7.0 7.1 Le, N & Simon, MA (1998) Disabled is a putative adaptor protein that functions during signaling by the sevenless receptor tyrosine kinase. Mol. Cell. Biol. 18 4844-54 PubMed GONUTS page
  8. Tomlinson, A & Ready, DF (1987) Cell fate in the Drosophila ommatidium. Dev. Biol. 123 264-75 PubMed GONUTS page
  9. 9.0 9.1 Baek, KH & Lee, KY () Signal transduction pathway for anterior-posterior development in Drosophila. J. Biomed. Sci. 6 314-9 PubMed GONUTS page
  10. Mavromatakis, YE & Tomlinson, A (2012) The role of the small GTPase Rap in Drosophila R7 photoreceptor specification. Proc. Natl. Acad. Sci. U.S.A. 109 3844-9 PubMed GONUTS page
  11. Mikeladze-Dvali, T et al. (2005) The growth regulators warts/lats and melted interact in a bistable loop to specify opposite fates in Drosophila R8 photoreceptors. Cell 122 775-87 PubMed GONUTS page
  12. Rutherford, SL (2003) Between genotype and phenotype: protein chaperones and evolvability. Nat. Rev. Genet. 4 263-74 PubMed GONUTS page
  13. Cook, T (2003) Cell diversity in the retina: more than meets the eye. Bioessays 25 921-5 PubMed GONUTS page
  14. Frankfort, BJ & Mardon, G (2002) R8 development in the Drosophila eye: a paradigm for neural selection and differentiation. Development 129 1295-306 PubMed GONUTS page
  15. Almudi, I et al. (2010) Competition between SOCS36E and Drk modulates Sevenless receptor tyrosine kinase activity. J. Cell. Sci. 123 3857-62 PubMed GONUTS page
  16. Kim, M et al. (2006) Inhibition of ERK-MAP kinase signaling by RSK during Drosophila development. EMBO J. 25 3056-67 PubMed GONUTS page