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Krämer, H, Cagan, RL and Zipursky, SL (1991) Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor. Nature 352:207-12
During development of the Drosophila retina, the R8 photoreceptor neuron induces a neighbouring cell to assume an R7 cell fate. Genetic data suggest that the induction is mediated by two transmembrane proteins encoded by bride of sevenless and sevenless. A direct interaction between these two proteins was demonstrated by the heterotypic aggregation of cell lines expressing them. In the developing eye the sevenless-dependent internalization of bride of sevenless by the R7 precursor cell provides evidence for a direct interaction between these two proteins in vivo.
Animals; Cell Aggregation; DNA/genetics; Drosophila/genetics; Drosophila/physiology; Drosophila Proteins; Eye Proteins/genetics; Eye Proteins/physiology; Ligands; Membrane Glycoproteins; Membrane Proteins/genetics; Membrane Proteins/physiology; Mosaicism; Mutation; Neurons/cytology; Neurons/physiology; Photoreceptor Cells/cytology; Photoreceptor Cells/physiology; Protein-Tyrosine Kinases/physiology; Receptor Protein-Tyrosine Kinases
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