GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:2882603

From GONUTS
Jump to: navigation, search
Citation

Hafen, E, Basler, K, Edstroem, JE and Rubin, GM (1987) Sevenless, a cell-specific homeotic gene of Drosophila, encodes a putative transmembrane receptor with a tyrosine kinase domain. Science 236:55-63

Abstract

The determination of cell fates during the assembly of the ommatidia in the compound eye of Drosophila appears to be controlled by cell-cell interactions. In this process, the sevenless gene is essential for the development of a single type of photoreceptor cell. In the absence of proper sevenless function the cells that would normally become the R7 photoreceptors instead become nonneuronal cells. Previous morphological and genetic analysis has indicated that the product of the sevenless gene is involved in reading or interpreting the positional information that specifies this particular developmental pathway. The sevenless gene has now been isolated and characterized. The data indicate that sevenless encodes a transmembrane protein with a tyrosine kinase domain. This structural similarity between sevenless and certain hormone receptors suggests that similar mechanisms are involved in developmental decisions based on cell-cell interaction and physiological or developmental changes induced by diffusible factors.

Links

PubMed

Keywords

Amino Acid Sequence; Animals; Base Sequence; Chromosome Mapping; Cloning, Molecular; DNA Restriction Enzymes; Drosophila melanogaster/embryology; Drosophila melanogaster/genetics; Eye/cytology; Eye/embryology; Gene Expression Regulation; Genes; Genes, Homeobox; Growth Substances/physiology; Membrane Proteins/genetics; Phenotype; Protein-Tyrosine Kinases/genetics; Protein-Tyrosine Kinases/physiology; Receptors, Cell Surface/genetics; Receptors, Cell Surface/physiology; Transcription, Genetic

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:7LESS

involved_in

GO:0045500: sevenless signaling pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:7LESS

involved_in

GO:0007465: R7 cell fate commitment

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

Notes

See also

References

See Help:References for how to manage references in GONUTS.