GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:2882857

From GONUTS
Jump to: navigation, search
Citation

Banerjee, U, Renfranz, PJ, Pollock, JA and Benzer, S (1987) Molecular characterization and expression of sevenless, a gene involved in neuronal pattern formation in the Drosophila eye. Cell 49:281-91

Abstract

The Drosophila sevenless mutation results in lack of a single neuron (photoreceptor cell R7) in every ommatidium of the compound eye; the developmental defect occurs in the larval eye disc. We created P-element-induced alleles and used them to isolate the sev gene. An 8.2 kb transcript is expressed in the eye disc, behind the morphogenetic furrow, coincident with recruitment and differentiation of photoreceptor clusters. The transcript becomes localized at the apical surface, persists in the prepupa, and fades out at pupation. It is again detected in the adult head. In some alleles the 8.2 kb transcript is absent. In others, the transcript is expressed, in spite of the absence of cell R7. Localization of the gene product in the eye disc was obtained with antibody raised against sev protein.

Links

PubMed

Keywords

Alleles; Animals; Chromosome Mapping; Cloning, Molecular; DNA Transposable Elements; Drosophila melanogaster/embryology; Drosophila melanogaster/genetics; Eye/embryology; Morphogenesis; Neurons/physiology; Polymorphism, Restriction Fragment Length; RNA, Messenger/genetics; Transcription, Genetic

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:7LESS

involved_in

GO:0007465: R7 cell fate commitment

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:7LESS

involved_in

GO:0045500: sevenless signaling pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

Notes

See also

References

See Help:References for how to manage references in GONUTS.