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PMID:17985474

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Citation

Tomlinson, A and Ready, DF (1987) Cell fate in the Drosophila ommatidium. Dev. Biol. 123:264-75

Abstract

Lesions in the Drosophila gene sevenless cause the cell normally destined to differentiate as photoreceptor 7 of the ommatidium to become an accessory lens-secreting cell, the equatorial cone cell. In both P-element- and EMS-induced alleles, the developmental transformation occurs identically. The mutation is cell autonomous, showing that the developmental failure is intrinsic to the transformed cell. Histological and immunological analyses indicate that the cell fails to operate any photoreceptor differentiation machinery prior to adopting the cone cell pathway.

Links

PubMed

Keywords

Animals; Cell Differentiation; Cell Lineage; Drosophila/embryology; Drosophila/physiology; Microscopy, Electron, Transmission; Microscopy, Immunoelectron; Mutation; Photoreceptor Cells, Invertebrate/physiology; Photoreceptor Cells, Invertebrate/ultrastructure; Retina/cytology; Retina/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:7LESS

involved_in

GO:0007465: R7 cell fate commitment

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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