DICDI:ERK1

Species (Taxon ID)	Dictyostelium discoideum (Slime mold). (44689)
Gene Name(s)	erkA (synonyms: erk1)
Protein Name(s)	Extracellular signal-regulated kinase 1 ERK1 MAP kinase 1
External Links
UniProt	P42525
EMBL	AAFI02000085 U11077
PIR	A56042
RefSeq	XP_637704.1
ProteinModelPortal	P42525
SMR	P42525
STRING	44689.DDB0201635
EnsemblProtists	DDB0201635
GeneID	8625569
KEGG	ddi:DDB_G0286353
dictyBase	DDB_G0286353
eggNOG	COG0515
InParanoid	P42525
KO	K04371
OMA	ICNIANE
PhylomeDB	P42525
BRENDA	2.7.11.24
Reactome	REACT_272501 REACT_279090 REACT_282923 REACT_295608 REACT_298687 REACT_308449 REACT_323395 REACT_352710 REACT_357093 REACT_361571 REACT_361578 REACT_362645
PRO	PR:P42525
Proteomes	UP000002195 UP000002195
GO	GO:0005829 GO:0005524 GO:0004707 GO:0004672 GO:0031152 GO:0051301 GO:0043327 GO:0042742 GO:0000165 GO:0007067 GO:0006468 GO:0030587
InterPro	IPR011009 IPR003527 IPR008352 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00069
PRINTS	PR01773
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS01351 PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
acts_upstream_of_or_within	GO:1903669	positive regulation of chemorepellent activity	PMID:30462573^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20079430^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:20079430^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031157	regulation of aggregate size involved in sorocarp development	PMID:25451080^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007186	G protein-coupled receptor signaling pathway	PMID:20019085^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P34043	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019954	asexual reproduction	PMID:7935416^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031152	aggregation involved in sorocarp development	PMID:7935416^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P34138	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031153	slug development involved in sorocarp development	PMID:7935416^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	PMID:19748467^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0110094	polyphosphate-mediated signaling	PMID:28584190^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043327	chemotaxis to cAMP	PMID:12062087^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0031252	cell leading edge	PMID:12062087^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031152	aggregation involved in sorocarp development	PMID:12062087^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030587	sorocarp development	PMID:17659086^[9]	ECO:0007001	high throughput mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:12062087^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0005938	cell cortex	PMID:12062087^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0071320)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:12062087^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:12062087^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	activated_by:(CHEBI:17489)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000165	MAPK cascade	PMID:12062087^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071310	cellular response to organic substance	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001172432 RGD:70500	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106908 MGI:MGI:1201387 MGI:MGI:1201408 MGI:MGI:1346865 PANTHER:PTN000622075 RGD:3046 RGD:70500 RGD:71050 UniProtKB:P78362 UniProtKB:Q16539 UniProtKB:Q96SB4 UniProtKB:Q9UPZ9 WB:WBGene00004055 WB:WBGene00004056	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346861 PANTHER:PTN000622075 UniProtKB:A9T142	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0052703 FB:FBgn0267339 MGI:MGI:1201408 MGI:MGI:1346347 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346861 MGI:MGI:1346862 MGI:MGI:1346863 MGI:MGI:1346865 MGI:MGI:1354946 MGI:MGI:2444559 PANTHER:PTN000622075 PomBase:SPAC24B11.06c PomBase:SPBC119.08 PomBase:SPBC530.14c RGD:3046 RGD:621506 RGD:628847 RGD:70500 RGD:70975 RGD:71050 SGD:S000000112 SGD:S000004103 SGD:S000004829 TAIR:locus:2024887 TAIR:locus:2124943 UniProtKB:A9T142 UniProtKB:O77306 UniProtKB:P28482 UniProtKB:P78362 UniProtKB:Q10N20 UniProtKB:Q13164 UniProtKB:Q96SB4 WB:WBGene00002178 WB:WBGene00002187 WB:WBGene00003048 WB:WBGene00003401 WB:WBGene00004056 WB:WBGene00004057	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003256 FB:FBgn0015765 MGI:MGI:1201387 MGI:MGI:1201408 MGI:MGI:1336881 MGI:MGI:1346347 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346861 MGI:MGI:1346865 MGI:MGI:1354946 MGI:MGI:1934157 MGI:MGI:2444559 MGI:MGI:96913 PANTHER:PTN000622075 PomBase:SPAC24B11.06c PomBase:SPAC31G5.09c PomBase:SPBC119.08 PomBase:SPBC530.14c RGD:3046 RGD:3663 RGD:621505 RGD:621506 RGD:628675 RGD:628847 RGD:70496 RGD:70500 SGD:S000000112 SGD:S000001072 SGD:S000003272 SGD:S000003642 SGD:S000004103 TAIR:locus:2024887 TAIR:locus:2124943 UniProtKB:A9T142 UniProtKB:O77306 UniProtKB:P20794 UniProtKB:P28482 UniProtKB:P45983 UniProtKB:P78362 UniProtKB:Q10N20 UniProtKB:Q13164 UniProtKB:Q5AZN7 UniProtKB:Q8GYQ5 UniProtKB:Q96SB4 UniProtKB:Q9LV37 UniProtKB:Q9P419 WB:WBGene00002178 WB:WBGene00003048 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004057 dictyBase:DDB_G0283903 dictyBase:DDB_G0286353	C		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015765 FB:FBgn0024846 FB:FBgn0267339 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346865 MGI:MGI:1354946 PANTHER:PTN001172432 PomBase:SPAC31G5.09c PomBase:SPBC119.08 RGD:1309340 RGD:3045 RGD:3046 RGD:621505 RGD:70496 RGD:70500 RGD:70975 SGD:S000000112 SGD:S000003272 SGD:S000006258 UniProtKB:A0A1D8PFT5 UniProtKB:A0A1D8PT38 UniProtKB:O15264 UniProtKB:P27361 UniProtKB:Q15759 UniProtKB:Q16539 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004056 dictyBase:DDB_G0286353	F		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000183747 FB:FBgn0015765 FB:FBgn0024846 FB:FBgn0267339 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346865 MGI:MGI:1354946 PANTHER:PTN002372889 PomBase:SPAC31G5.09c PomBase:SPBC119.08 RGD:1309340 RGD:3045 RGD:3046 RGD:621505 RGD:70496 RGD:70500 RGD:70975 SGD:S000000112 SGD:S000003272 SGD:S000006258 UniProtKB:A0A1D8PFT5 UniProtKB:A0A1D8PT38 UniProtKB:O15264 UniProtKB:P27361 UniProtKB:Q15759 UniProtKB:Q16539 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004056 dictyBase:DDB_G0286353	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003527 InterPro:IPR008352	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR003527 InterPro:IPR008352 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR003527 InterPro:IPR008271 InterPro:IPR008352	P		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.24	F		Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Rijal, R et al. (2019) An endogenous chemorepellent directs cell movement by inhibiting pseudopods at one side of cells. Mol. Biol. Cell 30 242-255 PubMed GONUTS page
↑ ^2.0 ^2.1 Nguyen, HN et al. (2010) MAP kinases have different functions in Dictyostelium G protein-mediated signaling. Cell. Signal. 22 836-47 PubMed GONUTS page
↑ Schwebs, DJ & Hadwiger, JA (2015) The Dictyostelium MAPK ERK1 is phosphorylated in a secondary response to early developmental signaling. Cell. Signal. 27 147-55 PubMed GONUTS page
↑ Raisley, B et al. (2010) G{alpha}5 subunit-mediated signalling requires a D-motif and the MAPK ERK1 in Dictyostelium. Microbiology (Reading, Engl.) 156 789-97 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Gaskins, C et al. (1994) Identification and functional analysis of a developmentally regulated extracellular signal-regulated kinase gene in Dictyostelium discoideum. Mol. Cell. Biol. 14 6996-7012 PubMed GONUTS page
↑ Li, Z et al. (2009) The amoebal MAP kinase response to Legionella pneumophila is regulated by DupA. Cell Host Microbe 6 253-67 PubMed GONUTS page
↑ Suess, PM et al. (2017) Extracellular polyphosphate signals through Ras and Akt to prime cells for development. J. Cell. Sci. 130 2394-2404 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 Sobko, A et al. (2002) Regulated SUMOylation and ubiquitination of DdMEK1 is required for proper chemotaxis. Dev. Cell 2 745-56 PubMed GONUTS page
↑ Sawai, S et al. (2007) High-throughput analysis of spatio-temporal dynamics in Dictyostelium. Genome Biol. 8 R144 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:30462573-1] Rijal, R et al. (2019) An endogenous chemorepellent directs cell movement by inhibiting pseudopods at one side of cells. Mol. Biol. Cell 30 242-255 PubMed GONUTS page

[PMID:20079430-2] 2.0 ^2.1 Nguyen, HN et al. (2010) MAP kinases have different functions in Dictyostelium G protein-mediated signaling. Cell. Signal. 22 836-47 PubMed GONUTS page

[PMID:25451080-3] Schwebs, DJ & Hadwiger, JA (2015) The Dictyostelium MAPK ERK1 is phosphorylated in a secondary response to early developmental signaling. Cell. Signal. 27 147-55 PubMed GONUTS page

[PMID:20019085-4] Raisley, B et al. (2010) G{alpha}5 subunit-mediated signalling requires a D-motif and the MAPK ERK1 in Dictyostelium. Microbiology (Reading, Engl.) 156 789-97 PubMed GONUTS page

[PMID:7935416-5] 5.0 ^5.1 ^5.2 Gaskins, C et al. (1994) Identification and functional analysis of a developmentally regulated extracellular signal-regulated kinase gene in Dictyostelium discoideum. Mol. Cell. Biol. 14 6996-7012 PubMed GONUTS page

[PMID:19748467-6] Li, Z et al. (2009) The amoebal MAP kinase response to Legionella pneumophila is regulated by DupA. Cell Host Microbe 6 253-67 PubMed GONUTS page

[PMID:28584190-7] Suess, PM et al. (2017) Extracellular polyphosphate signals through Ras and Akt to prime cells for development. J. Cell. Sci. 130 2394-2404 PubMed GONUTS page

[PMID:12062087-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 Sobko, A et al. (2002) Regulated SUMOylation and ubiquitination of DdMEK1 is required for proper chemotaxis. Dev. Cell 2 745-56 PubMed GONUTS page

[PMID:17659086-9] Sawai, S et al. (2007) High-throughput analysis of spatio-temporal dynamics in Dictyostelium. Genome Biol. 8 R144 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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DICDI:ERK1

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