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DANRE:Q6K197

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) rela (ECO:0000313 with ZFIN:ZDB-GENE-040825-4) (synonyms: relA (ECO:0000313 with EMBL:AAO26404.1))
Protein Name(s) p65 transcription factor (ECO:0000313 with EMBL:AAO26404.1)
External Links
UniProt Q6K197
EMBL AY163839
UniGene Dr.84126
ProteinModelPortal Q6K197
ZFIN ZDB-GENE-040825-4
eggNOG ENOG410IG8F
ENOG410XT64
HOVERGEN HBG017916
PhylomeDB Q6K197
GO GO:0005737
GO:0071159
GO:0005634
GO:0003677
GO:0000981
GO:0009948
GO:0007498
GO:0043066
GO:0043065
GO:0051092
CDD cd01177
Gene3D 2.60.40.10
2.60.40.340
InterPro IPR013783
IPR014756
IPR002909
IPR033926
IPR000451
IPR008967
IPR030495
IPR030492
IPR032397
IPR011539
IPR037059
PANTHER PTHR24169
PTHR24169:SF1
Pfam PF16179
PF00554
PRINTS PR00057
SMART SM00429
SUPFAM SSF49417
SSF81296
PROSITE PS01204
PS50254

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0007498

mesoderm development

PMID:15169890[1]

ECO:0000315

P

FIG:6 Zebra Fish p65

complete
CACAO 13302

GO:0060034

notochord cell differentiation

PMID:15169890[1]

ECO:0000315

P

Fig. 7, p65, Zebra fish. "NF-kB activity in vivo is important for notochord differentiation”

complete
CACAO 13303

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:19307597[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-060524-17

P

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:16507571[3]

ECO:0000316

genetic interaction evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-060331-1
ZFIN:ZDB-MRPHLNO-060524-17

P

Seeded From UniProt

complete

involved_in

GO:0009948

anterior/posterior axis specification

PMID:21439961[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-120229-2

P

Seeded From UniProt

complete

involved_in

GO:0007498

mesoderm development

PMID:15169890[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:19307597[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19307597[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0011274
FB:FBgn0260632
MGI:MGI:103289
PANTHER:PTN000652441
UniProtKB:Q04206
UniProtKB:Q04864

P

Seeded From UniProt

complete

involved_in

GO:0038061

NIK/NF-kappaB signaling

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103289
PANTHER:PTN000652441

P

Seeded From UniProt

complete

involved_in

GO:0034097

response to cytokine

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000652441
RGD:727889

P

Seeded From UniProt

complete

involved_in

GO:0007249

I-kappaB kinase/NF-kappaB signaling

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000652441
RGD:1311231

P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000652441
UniProtKB:Q04206

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103289
MGI:MGI:103290
PANTHER:PTN000652441
RGD:727889
UniProtKB:Q01201
UniProtKB:Q04206

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000652441
UniProtKB:Q01201

C

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103290
PANTHER:PTN000652441
UniProtKB:Q04206

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000652441
ZFIN:ZDB-GENE-040825-4

F

Seeded From UniProt

complete

enables

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0260632
MGI:MGI:103290
PANTHER:PTN000652441
UniProtKB:Q04206

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103290
PANTHER:PTN000652441
UniProtKB:Q04206

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011539
InterPro:IPR037059

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000451
InterPro:IPR008967
InterPro:IPR011539
InterPro:IPR030495
InterPro:IPR037059

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000451
InterPro:IPR030495

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000451
InterPro:IPR030495

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000451
InterPro:IPR008967
InterPro:IPR011539
InterPro:IPR037059

P

Seeded From UniProt

complete

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030495

P

Seeded From UniProt

complete

part_of

GO:0071159

NF-kappaB complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030495

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Correa, RG et al. (2004) Characterization of NF-kappa B/I kappa B proteins in zebra fish and their involvement in notochord development. Mol. Cell. Biol. 24 5257-68 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Liu, X et al. (2009) NF-kappaB and Snail1a coordinate the cell cycle with gastrulation. J. Cell Biol. 184 805-15 PubMed GONUTS page
  3. ↑ Zetterberg, H et al. (2006) The cytosolic loop of the gamma-secretase component presenilin enhancer 2 protects zebrafish embryos from apoptosis. J. Biol. Chem. 281 11933-9 PubMed GONUTS page
  4. ↑ Kanther, M et al. (2011) Microbial colonization induces dynamic temporal and spatial patterns of NF-κB activation in the zebrafish digestive tract. Gastroenterology 141 197-207 PubMed GONUTS page
  5. ↑ 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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