DANRE:FOXH1

Species (Taxon ID)	Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s)	foxh1 (synonyms: fast1, sur)
Protein Name(s)	Forkhead box protein H1 Forkhead activin signal transducer 1 Fast-1 Schmalspur protein
External Links
UniProt	Q9I9E1
EMBL	AF263000 AF264751 BC044340
RefSeq	NP_571577.1
UniGene	Dr.7743
ProteinModelPortal	Q9I9E1
GeneID	57930
KEGG	dre:57930
CTD	8928
ZFIN	ZDB-GENE-000616-15
eggNOG	COG5025
HOGENOM	HOG000169991
HOVERGEN	HBG051646
InParanoid	Q9I9E1
KO	K09400
PhylomeDB	Q9I9E1
NextBio	20891944
PRO	PR:Q9I9E1
Proteomes	UP000000437
GO	GO:0005634 GO:0043565 GO:0000981 GO:0046332 GO:0048319 GO:0048327 GO:0001568 GO:0060070 GO:0042074 GO:0007368 GO:0009953 GO:0060971 GO:0003143 GO:0001706 GO:0021508 GO:0001947 GO:0048382 GO:0001707 GO:0000122 GO:0014028 GO:0021501 GO:2000223 GO:0010468 GO:0006357 GO:0032525 GO:0010159 GO:0060063 GO:0006366
Gene3D	1.10.10.10
InterPro	IPR001766 IPR018122 IPR011991
Pfam	PF00250
PRINTS	PR00053
SMART	SM00339
PROSITE	PS00658 PS50039

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0071345	cellular response to cytokine stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O75593	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O75593	P	Seeded From UniProt	complete
involved_in	GO:2000223	regulation of BMP signaling pathway involved in heart jogging	PMID:9334285^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1029	P	Seeded From UniProt	complete
involved_in	GO:2000223	regulation of BMP signaling pathway involved in heart jogging	PMID:23358434^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-141202-2	P	Seeded From UniProt	complete
involved_in	GO:0060971	embryonic heart tube left/right pattern formation	PMID:21637786^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-111207-2	P	Seeded From UniProt	complete
involved_in	GO:0060063	Spemann organizer formation at the embryonic shield	PMID:10996071^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-070529-4	P	Seeded From UniProt	complete
involved_in	GO:0048854	brain morphogenesis	PMID:9007238^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-260	P	Seeded From UniProt	complete
involved_in	GO:0048382	mesendoderm development	PMID:21637786^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-001228-1 ZFIN:ZDB-GENO-111207-2	P	Seeded From UniProt	complete
involved_in	GO:0048327	axial mesodermal cell fate specification	PMID:21637786^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-111207-2	P	Seeded From UniProt	complete
involved_in	GO:0048319	axial mesoderm morphogenesis	PMID:21637786^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-111207-3	P	Seeded From UniProt	complete
involved_in	GO:0046619	optic placode formation involved in camera-type eye formation	PMID:9007234^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-260	P	Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:21637786^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-111207-2	F	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:21637786^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-111207-3	F	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:26618989^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0042074	cell migration involved in gastrulation	PMID:17719025^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-080110-2	P	Seeded From UniProt	complete
involved_in	GO:0042074	cell migration involved in gastrulation	PMID:17719025^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-080110-1	P	Seeded From UniProt	complete
involved_in	GO:0033504	floor plate development	PMID:9007234^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-260	P	Seeded From UniProt	complete
involved_in	GO:0032525	somite rostral/caudal axis specification	PMID:21637786^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-111207-2	P	Seeded From UniProt	complete
involved_in	GO:0030903	notochord development	PMID:9007234^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-260	P	Seeded From UniProt	complete
involved_in	GO:0021854	hypothalamus development	PMID:9007238^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-260	P	Seeded From UniProt	complete
involved_in	GO:0021508	floor plate formation	PMID:10694427^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1029	P	Seeded From UniProt	complete
involved_in	GO:0021501	prechordal plate formation	PMID:21637786^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-111207-2	P	Seeded From UniProt	complete
involved_in	GO:0014028	notochord formation	PMID:21637786^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-111207-3	P	Seeded From UniProt	complete
involved_in	GO:0014028	notochord formation	PMID:21637786^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-111207-2	P	Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:10996071^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-070529-4	P	Seeded From UniProt	complete
involved_in	GO:0010159	specification of animal organ position	PMID:10903181^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1029	P	Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	PMID:10996071^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-070529-4	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:9334285^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1029	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:10903181^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1029	P	Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:17306248^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-070529-5	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17306248^[11]	ECO:0000305	curator inference used in manual assertion	GO:0043565	C	Seeded From UniProt	complete
involved_in	GO:0003143	embryonic heart tube morphogenesis	PMID:9334285^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1029	P	Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	PMID:9334285^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1029	P	Seeded From UniProt	complete
involved_in	GO:0001707	mesoderm formation	PMID:10996071^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-070529-4	P	Seeded From UniProt	complete
involved_in	GO:0001706	endoderm formation	PMID:10996071^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-070529-4	P	Seeded From UniProt	complete
involved_in	GO:0001568	blood vessel development	PMID:17306248^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-070529-4	P	Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:26618989^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:17306248^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-070529-5	F	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:17306248^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-070529-4	F	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:17306248^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:26618989^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:26618989^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0000785	chromatin	PMID:26618989^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:17306248^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-070529-4	P	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:26618989^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:17306248^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000930906 WB:WBGene00004013	P	Seeded From UniProt	complete
involved_in	GO:0009653	anatomical structure morphogenesis	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1347476 PANTHER:PTN000930906	P	Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000659 MGI:MGI:1347472 MGI:MGI:1347477 PANTHER:PTN000930906 UniProtKB:O00358 UniProtKB:Q9Y261 ZFIN:ZDB-GENE-000616-15	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000659 FB:FBgn0003430 FB:FBgn0004895 FB:FBgn0014143 MGI:MGI:1347466 MGI:MGI:1347472 MGI:MGI:1347476 MGI:MGI:1347477 MGI:MGI:1349428 MGI:MGI:1353569 MGI:MGI:1927549 MGI:MGI:95546 PANTHER:PTN000930906 PomBase:SPBC32H8.11 PomBase:SPBC4C3.12 RGD:2807 RGD:2808 RGD:2809 SGD:S000000661 SGD:S000001393 UniProtKB:O00358 UniProtKB:P55317 UniProtKB:P58012 UniProtKB:Q12948 UniProtKB:Q13461 UniProtKB:Q5AS72 UniProtKB:Q99958 UniProtKB:Q9Y261 WB:WBGene00001434 WB:WBGene00001441 WB:WBGene00002601 WB:WBGene00003017 WB:WBGene00004013 WB:WBGene00006853	C	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000659 PANTHER:PTN000930906 RGD:621723 UniProtKB:O00358 WB:WBGene00004013 ZFIN:ZDB-GENE-000616-15	F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR030456	F	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR030456	P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR030456	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Chen, JN et al. (1997) Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish. Development 124 4373-82 PubMed GONUTS page
↑ Lenhart, KF et al. (2013) Integration of nodal and BMP signals in the heart requires FoxH1 to create left-right differences in cell migration rates that direct cardiac asymmetry. PLoS Genet. 9 e1003109 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 ^3.9 Slagle, CE et al. (2011) Nodal-dependent mesendoderm specification requires the combinatorial activities of FoxH1 and Eomesodermin. PLoS Genet. 7 e1002072 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Pogoda, HM et al. (2000) The zebrafish forkhead transcription factor FoxH1/Fast1 is a modulator of nodal signaling required for organizer formation. Curr. Biol. 10 1041-9 PubMed GONUTS page
↑ ^5.0 ^5.1 Schier, AF et al. (1996) Mutations affecting the development of the embryonic zebrafish brain. Development 123 165-78 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Stemple, DL et al. (1996) Mutations affecting development of the notochord in zebrafish. Development 123 117-28 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Chen, H et al. (2015) Nmnat1-Rbp7 Is a Conserved Fusion-Protein That Combines NAD+ Catalysis of Nmnat1 with Subcellular Localization of Rbp7. PLoS ONE 10 e0143825 PubMed GONUTS page
↑ ^8.0 ^8.1 Pei, W et al. (2007) An early requirement for maternal FoxH1 during zebrafish gastrulation. Dev. Biol. 310 10-22 PubMed GONUTS page
↑ Odenthal, J et al. (2000) Two distinct cell populations in the floor plate of the zebrafish are induced by different pathways. Dev. Biol. 219 350-63 PubMed GONUTS page
↑ ^10.0 ^10.1 Bisgrove, BW et al. (2000) Multiple pathways in the midline regulate concordant brain, heart and gut left-right asymmetry. Development 127 3567-79 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 Choi, J et al. (2007) FoxH1 negatively modulates flk1 gene expression and vascular formation in zebrafish. Dev. Biol. 304 735-44 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9334285-1] 1.0 ^1.1 ^1.2 ^1.3 Chen, JN et al. (1997) Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish. Development 124 4373-82 PubMed GONUTS page

[PMID:23358434-2] Lenhart, KF et al. (2013) Integration of nodal and BMP signals in the heart requires FoxH1 to create left-right differences in cell migration rates that direct cardiac asymmetry. PLoS Genet. 9 e1003109 PubMed GONUTS page

[PMID:21637786-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 ^3.9 Slagle, CE et al. (2011) Nodal-dependent mesendoderm specification requires the combinatorial activities of FoxH1 and Eomesodermin. PLoS Genet. 7 e1002072 PubMed GONUTS page

[PMID:10996071-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Pogoda, HM et al. (2000) The zebrafish forkhead transcription factor FoxH1/Fast1 is a modulator of nodal signaling required for organizer formation. Curr. Biol. 10 1041-9 PubMed GONUTS page

[PMID:9007238-5] 5.0 ^5.1 Schier, AF et al. (1996) Mutations affecting the development of the embryonic zebrafish brain. Development 123 165-78 PubMed GONUTS page

[PMID:9007234-6] 6.0 ^6.1 ^6.2 Stemple, DL et al. (1996) Mutations affecting development of the notochord in zebrafish. Development 123 117-28 PubMed GONUTS page

[PMID:26618989-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Chen, H et al. (2015) Nmnat1-Rbp7 Is a Conserved Fusion-Protein That Combines NAD+ Catalysis of Nmnat1 with Subcellular Localization of Rbp7. PLoS ONE 10 e0143825 PubMed GONUTS page

[PMID:17719025-8] 8.0 ^8.1 Pei, W et al. (2007) An early requirement for maternal FoxH1 during zebrafish gastrulation. Dev. Biol. 310 10-22 PubMed GONUTS page

[PMID:10694427-9] Odenthal, J et al. (2000) Two distinct cell populations in the floor plate of the zebrafish are induced by different pathways. Dev. Biol. 219 350-63 PubMed GONUTS page

[PMID:10903181-10] 10.0 ^10.1 Bisgrove, BW et al. (2000) Multiple pathways in the midline regulate concordant brain, heart and gut left-right asymmetry. Development 127 3567-79 PubMed GONUTS page

[PMID:17306248-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 Choi, J et al. (2007) FoxH1 negatively modulates flk1 gene expression and vascular formation in zebrafish. Dev. Biol. 304 735-44 PubMed GONUTS page

[PMID:21873635-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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DANRE:FOXH1

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