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DANRE:FOXH1

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) foxh1 (synonyms: fast1, sur)
Protein Name(s) Forkhead box protein H1

Forkhead activin signal transducer 1 Fast-1 Schmalspur protein

External Links
UniProt Q9I9E1
EMBL AF263000
AF264751
BC044340
RefSeq NP_571577.1
UniGene Dr.7743
ProteinModelPortal Q9I9E1
GeneID 57930
KEGG dre:57930
CTD 8928
ZFIN ZDB-GENE-000616-15
eggNOG COG5025
HOGENOM HOG000169991
HOVERGEN HBG051646
InParanoid Q9I9E1
KO K09400
PhylomeDB Q9I9E1
NextBio 20891944
PRO PR:Q9I9E1
Proteomes UP000000437
GO GO:0005634
GO:0043565
GO:0000981
GO:0046332
GO:0048319
GO:0048327
GO:0001568
GO:0060070
GO:0042074
GO:0007368
GO:0009953
GO:0060971
GO:0003143
GO:0001706
GO:0021508
GO:0001947
GO:0048382
GO:0001707
GO:0000122
GO:0014028
GO:0021501
GO:2000223
GO:0010468
GO:0006357
GO:0032525
GO:0010159
GO:0060063
GO:0006366
Gene3D 1.10.10.10
InterPro IPR001766
IPR018122
IPR011991
Pfam PF00250
PRINTS PR00053
SMART SM00339
PROSITE PS00658
PS50039

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000122

negative regulation of transcription from RNA polymerase II promoter

PMID:17306248[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

PMID:17306248[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070529-4

P

Seeded From UniProt

complete

GO:0000981

RNA polymerase II transcription factor activity, sequence-specific DNA binding

PMID:17306248[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0000981

RNA polymerase II transcription factor activity, sequence-specific DNA binding

PMID:17306248[1]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-070529-5

F

Seeded From UniProt

complete

GO:0000981

RNA polymerase II transcription factor activity, sequence-specific DNA binding

PMID:17306248[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070529-4

F

Seeded From UniProt

complete

GO:0001568

blood vessel development

PMID:17306248[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070529-4

P

Seeded From UniProt

complete

GO:0001706

endoderm formation

PMID:10996071[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070529-4

P

Seeded From UniProt

complete

GO:0001707

mesoderm formation

PMID:10996071[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070529-4

P

Seeded From UniProt

complete

GO:0001947

heart looping

PMID:9334285[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1029

P

Seeded From UniProt

complete

GO:0003143

embryonic heart tube morphogenesis

PMID:9334285[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1029

P

Seeded From UniProt

complete

GO:0003677

DNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

GO:0003700

transcription factor activity, sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001766

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN001371846

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:17306248[1]

IC: Inferred by Curator

GO:0043565

C

Seeded From UniProt

complete

GO:0006351

transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001766

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

Seeded From UniProt

complete

GO:0006357

regulation of transcription from RNA polymerase II promoter

PMID:17306248[1]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-070529-5

P

Seeded From UniProt

complete

GO:0007368

determination of left/right symmetry

PMID:10903181[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1029

P

Seeded From UniProt

complete

GO:0007368

determination of left/right symmetry

PMID:9334285[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1029

P

Seeded From UniProt

complete

GO:0009953

dorsal/ventral pattern formation

PMID:10996071[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070529-4

P

Seeded From UniProt

complete

GO:0010159

specification of organ position

PMID:10903181[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1029

P

Seeded From UniProt

complete

GO:0010468

regulation of gene expression

PMID:10996071[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070529-4

P

Seeded From UniProt

complete

GO:0014028

notochord formation

PMID:21637786[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-111207-2

P

Seeded From UniProt

complete

GO:0014028

notochord formation

PMID:21637786[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-111207-3

P

Seeded From UniProt

complete

GO:0021501

prechordal plate formation

PMID:21637786[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-111207-2

P

Seeded From UniProt

complete

GO:0021508

floor plate formation

PMID:10694427[6]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1029

P

Seeded From UniProt

complete

GO:0030154

cell differentiation

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN001371846

P

Seeded From UniProt

complete

GO:0030903

notochord development

PMID:9007234[7]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-260

P

Seeded From UniProt

complete

GO:0032525

somite rostral/caudal axis specification

PMID:21637786[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-111207-2

P

Seeded From UniProt

complete

GO:0033504

floor plate development

PMID:9007234[7]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-260

P

Seeded From UniProt

complete

GO:0042074

cell migration involved in gastrulation

PMID:17719025[8]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-080110-1

P

Seeded From UniProt

complete

GO:0042074

cell migration involved in gastrulation

PMID:17719025[8]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-080110-2

P

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001766

F

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

PMID:21637786[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-111207-3

F

Seeded From UniProt

complete

GO:0046332

SMAD binding

PMID:21637786[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-111207-2

F

Seeded From UniProt

complete

GO:0046619

optic placode formation involved in camera-type eye formation

PMID:9007234[7]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-260

P

Seeded From UniProt

complete

GO:0048319

axial mesoderm morphogenesis

PMID:21637786[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-111207-3

P

Seeded From UniProt

complete

GO:0048327

axial mesodermal cell fate specification

PMID:21637786[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-111207-2

P

Seeded From UniProt

complete

GO:0048382

mesendoderm development

PMID:21637786[5]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENE-001228-1
ZFIN:ZDB-GENO-111207-2

P

Seeded From UniProt

complete

GO:0060063

Spemann organizer formation at the embryonic shield

PMID:10996071[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070529-4

P

Seeded From UniProt

complete

GO:0060070

canonical Wnt signaling pathway

PMID:10996071[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070529-4

P

Seeded From UniProt

complete

GO:0060971

embryonic heart tube left/right pattern formation

PMID:21637786[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-111207-2

P

Seeded From UniProt

complete

GO:2000223

regulation of BMP signaling pathway involved in heart jogging

PMID:23358434[9]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-141202-2

P

Seeded From UniProt

complete

GO:2000223

regulation of BMP signaling pathway involved in heart jogging

PMID:9334285[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1029

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Choi, J et al. (2007) FoxH1 negatively modulates flk1 gene expression and vascular formation in zebrafish. Dev. Biol. 304 735-44 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Pogoda, HM et al. (2000) The zebrafish forkhead transcription factor FoxH1/Fast1 is a modulator of nodal signaling required for organizer formation. Curr. Biol. 10 1041-9 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Chen, JN et al. (1997) Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish. Development 124 4373-82 PubMed GONUTS page
  4. 4.0 4.1 Bisgrove, BW et al. (2000) Multiple pathways in the midline regulate concordant brain, heart and gut left-right asymmetry. Development 127 3567-79 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 5.8 5.9 Slagle, CE et al. (2011) Nodal-dependent mesendoderm specification requires the combinatorial activities of FoxH1 and Eomesodermin. PLoS Genet. 7 e1002072 PubMed GONUTS page
  6. Odenthal, J et al. (2000) Two distinct cell populations in the floor plate of the zebrafish are induced by different pathways. Dev. Biol. 219 350-63 PubMed GONUTS page
  7. 7.0 7.1 7.2 Stemple, DL et al. (1996) Mutations affecting development of the notochord in zebrafish. Development 123 117-28 PubMed GONUTS page
  8. 8.0 8.1 Pei, W et al. (2007) An early requirement for maternal FoxH1 during zebrafish gastrulation. Dev. Biol. 310 10-22 PubMed GONUTS page
  9. Lenhart, KF et al. (2013) Integration of nodal and BMP signals in the heart requires FoxH1 to create left-right differences in cell migration rates that direct cardiac asymmetry. PLoS Genet. 9 e1003109 PubMed GONUTS page