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PMID:9007234
| Citation |
Stemple, DL, Solnica-Krezel, L, Zwartkruis, F, Neuhauss, SC, Schier, AF, Malicki, J, Stainier, DY, Abdelilah, S, Rangini, Z, Mountcastle-Shah, E and Driever, W (1996) Mutations affecting development of the notochord in zebrafish. Development 123:117-28 |
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| Abstract |
The notochord is critical for the normal development of vertebrate embryos. It serves both as the major skeletal element of the embryo and as a signaling source for the establishment of pattern within the neurectoderm, the paraxial mesoderm and other tissues. In a large-scale systematic screen of mutations affecting embryogenesis in zebrafish we identified 65 mutations that fall into 29 complementation groups, each leading to a defect in the formation and/or maintenance of the notochord. These mutations produce phenotypic abnormalities at numerous stages of notochord development, thereby establishing a phenotypic pathway, which in turn suggests a genetic pathway for the development of the notochord. Perturbations within adjacent tissues in mutant embryos further indicate the importance of notochord-derived signals for patterning within the embryo and suggest that these mutations will yield additional insight into the cues that regulate these patterning processes. |
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| Keywords |
Animals; Brain/embryology; Cell Differentiation/genetics; Gene Expression Regulation, Developmental; Mesoderm/physiology; Mutation; Notochord/anatomy & histology; Notochord/cytology; Notochord/embryology; Phenotype; Zebrafish/embryology; Zebrafish/genetics |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
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