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Category:Team I know Where You Live

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StatusPageUserDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
correctedthroughchallenges?Barre178, Team I know Where You Live2013-04-13 11:50:50 CDTGO:0048813 dendrite morphogenesis (Figure 2 shows Rex2 knockout results in defects in dendrite morphology.)PMID:18334636IMP: Inferred from Mutant Phenotype
challenge
requireschanges?Barre178, Team I know Where You Live2013-04-13 11:02:16 CDTGO:0003824 catalytic activity (Figure 3 shows transamination catalysis.)PMID:23280748IDA: Inferred from Direct Assay
challenge
requireschanges?Barre178, Team I know Where You Live2013-04-13 11:02:16 CDTGO:0019481 L-alanine catabolic process, by transamination (Figure 3 shows enzymatic activity involving transamination of ADMA to produce DMGV.)PMID:23280748IDA: Inferred from Direct Assay
challenge
updatedbyinstructorMOUSE:CAN7Placekje, Team I know Where You Live2013-04-11 12:25:17 CDTGO:0006508 proteolysis (P)PMID:14981075ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 1 shows identification of 2 calpain cleavage sites by deletion mutagenesis in the Htt protein. This paper suggests that calpains play a role in Htt proteolysis and HD pathology.

challenge
requireschanges?Barre178, Team I know Where You Live2013-04-11 12:25:02 CDTGO:0001764 neuron migration (Figure 4 shows how Cul5 regulates neuron migration.)PMID:20410119IDA: Inferred from Direct Assay
challenge
updatedbyinstructorHUMAN:Q6FGG5Barre178, Team I know Where You Live2013-04-11 11:08:41 CDTGO:0097168 mesenchymal stem cell proliferation (P)PMID:16188469ECO:0000314 direct assay evidence used in manual assertion

Figure 3 shows SCRG1 suppressing hMSC proliferation.

challenge
acceptableHUMAN:H0YD90Barre178, Team I know Where You Live2013-04-09 11:26:34 CDTGO:0033674 positive regulation of kinase activity (P)PMID:11084024ECO:0000314 direct assay evidence used in manual assertion

Figure 3 shows kinase activity when HA binds to CD44. This shows a correlation between receptor activity of CD44 and its regulation of src kinase activity

challenge
acceptableXENLA:O57537Barre178, Team I know Where You Live2013-04-08 09:53:27 CDTGO:0007398 ectoderm development (P)PMID:9512415ECO:0000314 direct assay evidence used in manual assertion

Figures 3 and 4 show expression in the ectoderm during development. Its expression is similar to other ectodermal markers.

challenge
updatedbyinstructorMOUSE:SC5ACBarre178, Team I know Where You Live2013-03-30 10:51:32 CDTGO:0015129 lactate transmembrane transporter activity (F)PMID:16104846ECO:0000314 direct assay evidence used in manual assertion

Figure 2 shows the transporters substrate specificity to monocarboxylates.

challenge
acceptableXENLA:O57537Barre178, Team I know Where You Live2013-03-30 10:43:03 CDTGO:0007155 cell adhesion (P)PMID:9512415ECO:0000314 direct assay evidence used in manual assertion

Cell mixing assays in Figures 5-7 compare NFPC to known adhesion molecules, supporting the assumption this is an adhesion molecule.

challenge

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Pages in category "Team I know Where You Live"

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