Category:MichSt14A 32

Status	Page	User	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
requireschanges	HUMAN:AKT1	Egbertr1, MichSt14A 32	2014-04-06 17:50:30 CDT	GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process (P)	PMID:24601882	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 1C shows a constitutively active Akt1 decreases caspase3 compared to the WT control	challenge
unacceptable	HUMAN:JAK1	Egbertr1, MichSt14A 32	2014-04-06 16:56:15 CDT	GO:0060337 type I interferon signaling pathway (P)	PMID:24665409	ECO:0000314 direct assay evidence used in manual assertion	Figure 5 shows that JAK is a critical component IFNγ/TNFα-induced signaling cascade	challenge
unacceptable	HUMAN:JMJD6	Egbertr1, MichSt14A 32	2014-04-06 15:50:17 CDT	GO:0070815 peptidyl-lysine 5-dioxygenase activity (F)	PMID:24667498	ECO:0000314 direct assay evidence used in manual assertion	Figure 2 shows the hydroxylase activity on the tumor suppressor p53 at lysine 382	challenge
updatedbyinstructor	HUMAN:MCPH1	Egbertr1, MichSt14A 32	2014-04-06 13:45:41 CDT	GO:0071850 mitotic cell cycle arrest (P)	PMID:24633962	ECO:0000314 direct assay evidence used in manual assertion	Figure 5: Shows that cells with overexpression of MCPH1 protein induces S phase cell cycle arrest	challenge

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