HUMAN:JAK1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	JAK1 (synonyms: JAK1A, JAK1B)
Protein Name(s)	Tyrosine-protein kinase JAK1 Janus kinase 1 JAK-1
External Links
UniProt	P23458
EMBL	M64174 AB209057 AC093427 CH471059 BC132729
CCDS	CCDS41346.1
PIR	A39577
RefSeq	NP_002218.2 XP_005270898.1 XP_006710687.1
UniGene	Hs.207538
PDB	3EYG 3EYH 4E4L 4E4N 4E5W 4EHZ 4EI4 4FK6 4GS0 4I5C 4IVB 4IVC 4IVD 4K6Z 4K77 4L00 4L01
PDBsum	3EYG 3EYH 4E4L 4E4N 4E5W 4EHZ 4EI4 4FK6 4GS0 4I5C 4IVB 4IVC 4IVD 4K6Z 4K77 4L00 4L01
ProteinModelPortal	P23458
SMR	P23458
BioGrid	109919
DIP	DIP-133N
IntAct	P23458
MINT	MINT-145830
STRING	9606.ENSP00000343204
BindingDB	P23458
ChEMBL	CHEMBL3038491
DrugBank	DB08877 DB08895
GuidetoPHARMACOLOGY	2047
PhosphoSite	P23458
DMDM	215274013
MaxQB	P23458
PaxDb	P23458
PRIDE	P23458
Ensembl	ENST00000342505
GeneID	3716
KEGG	hsa:3716
UCSC	uc001dbu.1
CTD	3716
GeneCards	GC01M065247
HGNC	HGNC:6190
HPA	CAB013088
MIM	147795
neXtProt	NX_P23458
PharmGKB	PA29988
eggNOG	COG0515
GeneTree	ENSGT00760000118799
HOGENOM	HOG000049158
HOVERGEN	HBG006195
InParanoid	P23458
KO	K11217
OMA	IMRDINK
OrthoDB	EOG7BW0HM
PhylomeDB	P23458
TreeFam	TF327041
BRENDA	2.7.10.2
Reactome	REACT_115529 REACT_115831 REACT_1183 REACT_1391 REACT_1695 REACT_19290 REACT_23891 REACT_24980 REACT_25078 REACT_25162 REACT_25216 REACT_27283 REACT_27307
SignaLink	P23458
ChiTaRS	JAK1
EvolutionaryTrace	P23458
GeneWiki	Janus_kinase_1
GenomeRNAi	3716
NextBio	14563
PRO	PR:P23458
Proteomes	UP000005640
Bgee	P23458
CleanEx	HS_JAK1
Genevestigator	P23458
GO	GO:0005737 GO:0005856 GO:0005829 GO:0012505 GO:0005925 GO:0016020 GO:0005634 GO:0005524 GO:0005131 GO:0004715 GO:0019903 GO:0004713 GO:0019221 GO:0007167 GO:0060333 GO:0038110 GO:0035556 GO:0046777 GO:0006468 GO:0060334 GO:0060338 GO:0046677 GO:0060337
Gene3D	3.30.505.10
InterPro	IPR019749 IPR019748 IPR000299 IPR011009 IPR000719 IPR017441 IPR001245 IPR000980 IPR008266 IPR020635 IPR016251 IPR020776
Pfam	PF07714
PIRSF	PIRSF000636
PRINTS	PR01823 PR01824 PR00109
SMART	SM00295 SM00252 SM00219
SUPFAM	SSF47031 SSF55550 SSF56112
PROSITE	PS50057 PS00107 PS50011 PS00109 PS50001

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0031625	ubiquitin protein ligase binding	PMID:24882218^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9C030	F	occurs_in:(CL:0001056) happens_during:(GO:0032496)\|occurs_in(CL:0001056) happens_during:(GO:0009615)\|occurs_in(CL:0001056) has_input:(UniProtKB:P01574)	Seeded From UniProt	complete
involved_in	GO:1903672	positive regulation of sprouting angiogenesis	PMID:20299512^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS00002075FA_9606	P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:21423176^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10502458^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10502458^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005131	growth hormone receptor binding	PMID:10502458^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P52332	F		Seeded From UniProt	complete
involved_in	GO:0038110	interleukin-2-mediated signaling pathway	PMID:11909529^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	PMID:11909529^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P17706	F		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96628 PANTHER:PTN000723621	P		Seeded From UniProt	complete
enables	GO:0005131	growth hormone receptor binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96628 PANTHER:PTN000723621 RGD:69056	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:8232552^[7]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:1386289^[8]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:10825200^[9]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0046677	response to antibiotic	PMID:16280321^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004715	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004713	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004713	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004713	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004713	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004713	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004715	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004715	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004713	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004715	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004715	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004713	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004713	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004715	P		Seeded From UniProt	complete
	GO:0060337	type I interferon signaling pathway	PMID:24665409^[11]	ECO:0000314			P		Figure 5 shows that JAK is a critical component IFNγ/TNFα-induced signaling cascade	complete CACAO 10110
enables	GO:0031730	CCR5 chemokine receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V9W2 ensembl:ENSRNOP00000061649	F		Seeded From UniProt	complete
enables	GO:0005131	growth hormone receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V9W2 ensembl:ENSRNOP00000061649	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635	F		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016251 InterPro:IPR020776	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR016251 InterPro:IPR017441 InterPro:IPR020776	F		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000299	C		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266 InterPro:IPR016251 InterPro:IPR020635 InterPro:IPR020776	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016251 InterPro:IPR020776	C		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016251 InterPro:IPR020776	P		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.2	F		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:8232552^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:1848670^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:1848670^[12] Reactome:R-HSA-873924 Reactome:R-HSA-452122	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0070757	interleukin-35-mediated signaling pathway	Reactome:R-HSA-8984722	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070106	interleukin-27-mediated signaling pathway	Reactome:R-HSA-9020956	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070102	interleukin-6-mediated signaling pathway	Reactome:R-HSA-1059683	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060337	type I interferon signaling pathway	Reactome:R-HSA-909733	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060334	regulation of interferon-gamma-mediated signaling pathway	Reactome:R-HSA-877312	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060333	interferon-gamma-mediated signaling pathway	Reactome:R-HSA-877300	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038114	interleukin-21-mediated signaling pathway	Reactome:R-HSA-9020958	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038113	interleukin-9-mediated signaling pathway	Reactome:R-HSA-8985947	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038111	interleukin-7-mediated signaling pathway	Reactome:R-HSA-1266695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038110	interleukin-2-mediated signaling pathway	Reactome:R-HSA-9020558	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035723	interleukin-15-mediated signaling pathway	Reactome:R-HSA-8983432	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035722	interleukin-12-mediated signaling pathway	Reactome:R-HSA-9020591	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-8854691 Reactome:R-HSA-6785807 Reactome:R-HSA-6783783 Reactome:R-HSA-6783589 Reactome:R-HSA-512988 Reactome:R-HSA-451927 Reactome:R-HSA-449836	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-997314 Reactome:R-HSA-997311 Reactome:R-HSA-997309 Reactome:R-HSA-919404 Reactome:R-HSA-913424 Reactome:R-HSA-913374 Reactome:R-HSA-912527 Reactome:R-HSA-909732 Reactome:R-HSA-909730 Reactome:R-HSA-909729 Reactome:R-HSA-909726 Reactome:R-HSA-909724 Reactome:R-HSA-909722 Reactome:R-HSA-909720 Reactome:R-HSA-909719 Reactome:R-HSA-909718 Reactome:R-HSA-909552 Reactome:R-HSA-9025969 Reactome:R-HSA-9011748 Reactome:R-HSA-9009227 Reactome:R-HSA-9006873 Reactome:R-HSA-9006870 Reactome:R-HSA-9006850 Reactome:R-HSA-9006844 Reactome:R-HSA-9005980 Reactome:R-HSA-8987270 Reactome:R-HSA-8987266 Reactome:R-HSA-8987255 Reactome:R-HSA-8987236 Reactome:R-HSA-8987230 Reactome:R-HSA-8987220 Reactome:R-HSA-8987202 Reactome:R-HSA-8987179 Reactome:R-HSA-8987161 Reactome:R-HSA-8987156 Reactome:R-HSA-8987150 Reactome:R-HSA-8987141 Reactome:R-HSA-8987132 Reactome:R-HSA-8987129 Reactome:R-HSA-8987120 Reactome:R-HSA-8987105 Reactome:R-HSA-8987104 Reactome:R-HSA-8987097 Reactome:R-HSA-8987096 Reactome:R-HSA-8987084 Reactome:R-HSA-8987080 Reactome:R-HSA-8987070 Reactome:R-HSA-8987063 Reactome:R-HSA-8987043 Reactome:R-HSA-8987042 Reactome:R-HSA-8987040 Reactome:R-HSA-8987039 Reactome:R-HSA-8987033 Reactome:R-HSA-8987015 Reactome:R-HSA-8987014 Reactome:R-HSA-8987012 Reactome:R-HSA-8986995 Reactome:R-HSA-8986994 Reactome:R-HSA-8986985 Reactome:R-HSA-8986972 Reactome:R-HSA-8986480 Reactome:R-HSA-8986446 Reactome:R-HSA-8985988 Reactome:R-HSA-8985973 Reactome:R-HSA-8985929 Reactome:R-HSA-8985914 Reactome:R-HSA-8985900 Reactome:R-HSA-8984023 Reactome:R-HSA-8984021 Reactome:R-HSA-8984014 Reactome:R-HSA-8984012 Reactome:R-HSA-8984001 Reactome:R-HSA-8983996 Reactome:R-HSA-8983983 Reactome:R-HSA-8983845 Reactome:R-HSA-8983841 Reactome:R-HSA-8983835 Reactome:R-HSA-8983834 Reactome:R-HSA-8983518 Reactome:R-HSA-8983384 Reactome:R-HSA-8983378 Reactome:R-HSA-8983374 Reactome:R-HSA-8983371 Reactome:R-HSA-8983335 Reactome:R-HSA-8983300 Reactome:R-HSA-8983298 Reactome:R-HSA-8983063 Reactome:R-HSA-8983003 Reactome:R-HSA-8982165 Reactome:R-HSA-8982163 Reactome:R-HSA-8982162 Reactome:R-HSA-8963734 Reactome:R-HSA-8952807 Reactome:R-HSA-8950757 Reactome:R-HSA-8950537 Reactome:R-HSA-8950518 Reactome:R-HSA-8950485 Reactome:R-HSA-8950453 Reactome:R-HSA-8950448 Reactome:R-HSA-8950441 Reactome:R-HSA-8950405 Reactome:R-HSA-8950340 Reactome:R-HSA-8950210 Reactome:R-HSA-8854645 Reactome:R-HSA-877269 Reactome:R-HSA-873927 Reactome:R-HSA-873926 Reactome:R-HSA-873924 Reactome:R-HSA-873922 Reactome:R-HSA-873921 Reactome:R-HSA-873919 Reactome:R-HSA-873918 Reactome:R-HSA-6809140 Reactome:R-HSA-6788628 Reactome:R-HSA-6788582 Reactome:R-HSA-6788571 Reactome:R-HSA-6786124 Reactome:R-HSA-6786110 Reactome:R-HSA-6786096 Reactome:R-HSA-6786095 Reactome:R-HSA-6786072 Reactome:R-HSA-6786058 Reactome:R-HSA-6786050 Reactome:R-HSA-6785165 Reactome:R-HSA-6784791 Reactome:R-HSA-6784324 Reactome:R-HSA-6784323 Reactome:R-HSA-6784319 Reactome:R-HSA-6784204 Reactome:R-HSA-6784189 Reactome:R-HSA-6784006 Reactome:R-HSA-6783681 Reactome:R-HSA-6783556 Reactome:R-HSA-6783552 Reactome:R-HSA-6783530 Reactome:R-HSA-6783524 Reactome:R-HSA-5696482 Reactome:R-HSA-5672965 Reactome:R-HSA-508292 Reactome:R-HSA-508282 Reactome:R-HSA-508247 Reactome:R-HSA-453111 Reactome:R-HSA-453104 Reactome:R-HSA-452122 Reactome:R-HSA-452108 Reactome:R-HSA-452100 Reactome:R-HSA-452097 Reactome:R-HSA-452091 Reactome:R-HSA-451942 Reactome:R-HSA-451900 Reactome:R-HSA-450063 Reactome:R-HSA-450027 Reactome:R-HSA-449978 Reactome:R-HSA-449976 Reactome:R-HSA-449958 Reactome:R-HSA-449811 Reactome:R-HSA-449803 Reactome:R-HSA-449115 Reactome:R-HSA-448744 Reactome:R-HSA-448728 Reactome:R-HSA-448708 Reactome:R-HSA-448661 Reactome:R-HSA-448660 Reactome:R-HSA-448480 Reactome:R-HSA-448427 Reactome:R-HSA-1678841 Reactome:R-HSA-1295540 Reactome:R-HSA-1169406 Reactome:R-HSA-1112755 Reactome:R-HSA-1112727 Reactome:R-HSA-1112708 Reactome:R-HSA-1112703 Reactome:R-HSA-1112690 Reactome:R-HSA-1112604 Reactome:R-HSA-1112602 Reactome:R-HSA-1112565 Reactome:R-HSA-1112514 Reactome:R-HSA-1112510 Reactome:R-HSA-1067688 Reactome:R-HSA-1067659 Reactome:R-HSA-1067651	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	Reactome:R-HSA-8983335	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	Reactome:R-HSA-6786096 Reactome:R-HSA-6786095 Reactome:R-HSA-1112703 Reactome:R-HSA-1112602	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	Reactome:R-HSA-5673001	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F		Seeded From UniProt	complete
part_of	GO:0012505	endomembrane system	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0147	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Rajsbaum, R et al. (2014) Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response. Immunity 40 880-95 PubMed GONUTS page
↑ Doebele, C et al. (2010) Members of the microRNA-17-92 cluster exhibit a cell-intrinsic antiangiogenic function in endothelial cells. Blood 115 4944-50 PubMed GONUTS page
↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Hellgren, G et al. (1999) The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver. Growth Horm. IGF Res. 9 212-8 PubMed GONUTS page
↑ ^5.0 ^5.1 Simoncic, PD et al. (2002) The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3. Curr. Biol. 12 446-53 PubMed GONUTS page
↑ ^6.0 ^6.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^7.0 ^7.1 Müller, M et al. (1993) The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction. Nature 366 129-35 PubMed GONUTS page
↑ Velazquez, L et al. (1992) A protein tyrosine kinase in the interferon alpha/beta signaling pathway. Cell 70 313-22 PubMed GONUTS page
↑ Zhou, YJ et al. (2000) Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation. Mol. Cell. Biol. 20 4371-80 PubMed GONUTS page
↑ Shang, L & Tomasi, TB (2006) The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons. J. Biol. Chem. 281 1876-84 PubMed GONUTS page
↑ Naydenov, NG et al. (2013) Novel mechanism of cytokine-induced disruption of epithelial barriers: Janus kinase and protein kinase D-dependent downregulation of junction protein expression. Tissue Barriers 1 e25231 PubMed GONUTS page
↑ ^12.0 ^12.1 Wilks, AF et al. (1991) Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase. Mol. Cell. Biol. 11 2057-65 PubMed GONUTS page

[PMID:24882218-1] Rajsbaum, R et al. (2014) Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response. Immunity 40 880-95 PubMed GONUTS page

[PMID:20299512-2] Doebele, C et al. (2010) Members of the microRNA-17-92 cluster exhibit a cell-intrinsic antiangiogenic function in endothelial cells. Blood 115 4944-50 PubMed GONUTS page

[PMID:21423176-3] Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page

[PMID:10502458-4] 4.0 ^4.1 ^4.2 Hellgren, G et al. (1999) The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver. Growth Horm. IGF Res. 9 212-8 PubMed GONUTS page

[PMID:11909529-5] 5.0 ^5.1 Simoncic, PD et al. (2002) The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3. Curr. Biol. 12 446-53 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:8232552-7] 7.0 ^7.1 Müller, M et al. (1993) The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction. Nature 366 129-35 PubMed GONUTS page

[PMID:1386289-8] Velazquez, L et al. (1992) A protein tyrosine kinase in the interferon alpha/beta signaling pathway. Cell 70 313-22 PubMed GONUTS page

[PMID:10825200-9] Zhou, YJ et al. (2000) Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation. Mol. Cell. Biol. 20 4371-80 PubMed GONUTS page

[PMID:16280321-10] Shang, L & Tomasi, TB (2006) The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons. J. Biol. Chem. 281 1876-84 PubMed GONUTS page

[PMID:24665409-11] Naydenov, NG et al. (2013) Novel mechanism of cytokine-induced disruption of epithelial barriers: Janus kinase and protein kinase D-dependent downregulation of junction protein expression. Tissue Barriers 1 e25231 PubMed GONUTS page

[PMID:1848670-12] 12.0 ^12.1 Wilks, AF et al. (1991) Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase. Mol. Cell. Biol. 11 2057-65 PubMed GONUTS page

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