HUMAN:MCPH1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MCPH1
Protein Name(s)	Microcephalin
External Links
UniProt	Q8NEM0
EMBL	AX087870 AK022909 AK301702 AC016065 AC018398 AF287957 BC030702 BK004076
CCDS	CCDS43689.1 CCDS55190.1 CCDS55191.1
RefSeq	NP_001166045.1 NP_001166046.1 NP_078872.2
UniGene	Hs.656769 Hs.708770
PDB	2WT8 3KTF 3PA6 3SHT 3SHV 3SZM 3T1N 3U3Z
PDBsum	2WT8 3KTF 3PA6 3SHT 3SHV 3SZM 3T1N 3U3Z
ProteinModelPortal	Q8NEM0
SMR	Q8NEM0
BioGrid	122776
DIP	DIP-39802N
IntAct	Q8NEM0
STRING	9606.ENSP00000342924
PhosphoSite	Q8NEM0
DMDM	296439305
MaxQB	Q8NEM0
PaxDb	Q8NEM0
PRIDE	Q8NEM0
Ensembl	ENST00000519480 ENST00000522905
GeneID	79648
KEGG	hsa:79648
UCSC	uc003wqi.3
CTD	79648
GeneCards	GC08P006276
GeneReviews	MCPH1
HGNC	HGNC:6954
HPA	CAB012177 HPA008238
MIM	251200 607117
neXtProt	NX_Q8NEM0
Orphanet	2512 52183
PharmGKB	PA30701
eggNOG	NOG293743
GeneTree	ENSGT00390000018842
HOGENOM	HOG000113501
HOVERGEN	HBG052433
InParanoid	Q8NEM0
OrthoDB	EOG7VX8X3
PhylomeDB	Q8NEM0
TreeFam	TF332942
Reactome	REACT_172744
SignaLink	Q8NEM0
ChiTaRS	MCPH1
EvolutionaryTrace	Q8NEM0
GenomeRNAi	79648
NextBio	35501988
PRO	PR:Q8NEM0
Proteomes	UP000005640
Bgee	Q8NEM0
CleanEx	HS_MCPH1
ExpressionAtlas	Q8NEM0
Genevestigator	Q8NEM0
GO	GO:0005737 GO:0005815 GO:0005654 GO:0042802 GO:0021987 GO:0000278
Gene3D	3.40.50.10190
InterPro	IPR001357 IPR022047 IPR029504
PANTHER	PTHR14625
Pfam	PF00533 PF12258 PF12738
SMART	SM00292
SUPFAM	SSF52113
PROSITE	PS50172

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0071850	mitotic cell cycle arrest	PMID:24633962	ECO:0000314			P		Figure 5: Shows that cells with overexpression of MCPH1 protein induces S phase cell cycle arrest	complete CACAO 10024
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:12837246	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000164362)	Seeded From UniProt	complete
involved_in	GO:0071850	mitotic cell cycle arrest	PMID:24633962	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding		ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8NEM0	F		Seeded From UniProt	complete
involved_in	GO:0097150	neuronal stem cell population maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TT79 ensembl:ENSMUSP00000037000	P		Seeded From UniProt	complete
involved_in	GO:0071539	protein localization to centrosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TT79 ensembl:ENSMUSP00000037000	P		Seeded From UniProt	complete
involved_in	GO:0060623	regulation of chromosome condensation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TT79 ensembl:ENSMUSP00000037000	P		Seeded From UniProt	complete
involved_in	GO:0060348	bone development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TT79 ensembl:ENSMUSP00000037000	P		Seeded From UniProt	complete
involved_in	GO:0050727	regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TT79 ensembl:ENSMUSP00000037000	P		Seeded From UniProt	complete
involved_in	GO:0046605	regulation of centrosome cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TT79 ensembl:ENSMUSP00000037000	P		Seeded From UniProt	complete
involved_in	GO:0043549	regulation of kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TT79 ensembl:ENSMUSP00000037000	P		Seeded From UniProt	complete
involved_in	GO:0021987	cerebral cortex development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TT79 ensembl:ENSMUSP00000037000	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TT79 ensembl:ENSMUSP00000037000	P		Seeded From UniProt	complete
involved_in	GO:0000132	establishment of mitotic spindle orientation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TT79 ensembl:ENSMUSP00000037000	P		Seeded From UniProt	complete
involved_in	GO:0021987	cerebral cortex development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029504	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-2429719	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C		Seeded From UniProt	complete
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