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CHICK:TF65

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) RELA
Protein Name(s) Transcription factor p65

Nuclear factor NF-kappa-B p65 subunit

External Links
UniProt P98152
EMBL D13721
PIR JC2004
RefSeq NP_990460.1
UniGene Gga.604
ProteinModelPortal P98152
SMR P98152
GeneID 396027
KEGG gga:396027
CTD 5970
HOVERGEN HBG017916
InParanoid P98152
KO K04735
PhylomeDB P98152
Reactome REACT_25145
REACT_25296
REACT_75895
NextBio 20816089
PRO PR:P98152
Proteomes UP000000539
GO GO:0005737
GO:0005634
GO:0003677
GO:0003700
GO:0002218
GO:0035419
GO:0007250
GO:0070301
GO:0071356
GO:0045087
GO:0002755
GO:0043066
GO:0008284
GO:0043123
GO:0051092
GO:0045944
GO:0035681
GO:0034134
GO:0035682
GO:0034138
GO:0034142
GO:0034146
GO:0034154
GO:0002224
GO:0006351
Gene3D 2.60.40.10
2.60.40.340
InterPro IPR013783
IPR014756
IPR002909
IPR000451
IPR008967
IPR011539
Pfam PF00554
PRINTS PR00057
SMART SM00429
SUPFAM SSF49417
SSF81296
PROSITE PS01204
PS50254

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0002755

MyD88-dependent toll-like receptor signaling pathway

PMID:20053507[1]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071356

cellular response to tumor necrosis factor

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q04206

P

Seeded From UniProt

complete

involved_in

GO:0070301

cellular response to hydrogen peroxide

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q04206

P

Seeded From UniProt

complete

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q04207

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q04206

P

Seeded From UniProt

complete

involved_in

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q04207

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q04206

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q04207

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q04206

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q04206

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q04207

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q04206

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q04206

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0011274
FB:FBgn0260632
MGI:MGI:103289
PANTHER:PTN000652441
UniProtKB:Q04206
UniProtKB:Q04864

P

Seeded From UniProt

complete

involved_in

GO:0038061

NIK/NF-kappaB signaling

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103289
PANTHER:PTN000652441

P

Seeded From UniProt

complete

involved_in

GO:0034097

response to cytokine

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000652441
RGD:727889

P

Seeded From UniProt

complete

involved_in

GO:0007249

I-kappaB kinase/NF-kappaB signaling

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000652441
RGD:1311231

P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000652441
UniProtKB:Q04206

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103289
MGI:MGI:103290
PANTHER:PTN000652441
RGD:727889
UniProtKB:Q01201
UniProtKB:Q04206

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000652441
UniProtKB:Q01201

C

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103290
PANTHER:PTN000652441
UniProtKB:Q04206

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000652441
ZFIN:ZDB-GENE-040825-4

F

Seeded From UniProt

complete

enables

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0260632
MGI:MGI:103290
PANTHER:PTN000652441
UniProtKB:Q04206

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103290
PANTHER:PTN000652441
UniProtKB:Q04206

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011539
InterPro:IPR037059

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000451
InterPro:IPR008967
InterPro:IPR011539
InterPro:IPR030495
InterPro:IPR037059

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000451
InterPro:IPR030495

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000451
InterPro:IPR030495

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000451
InterPro:IPR008967
InterPro:IPR011539
InterPro:IPR037059

P

Seeded From UniProt

complete

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030495

P

Seeded From UniProt

complete

part_of

GO:0071159

NF-kappaB complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030495

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Li, P et al. (2010) Up-regulation of the MyD88-dependent pathway of TLR signaling in spleen and caecum of young chickens infected with Salmonella serovar Pullorum. Vet. Microbiol. 143 346-51 PubMed GONUTS page
  2. 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page