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CHICK:WNT3A

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) WNT3A
Protein Name(s) Protein Wnt-3a
External Links
UniProt Q2LMP1
EMBL AB024080
DQ022307
EF068232
RefSeq NP_001165072.1
NP_990006.2
UniGene Gga.209
STRING 9031.ENSGALP00000030667
PaxDb Q2LMP1
Ensembl ENSGALT00000031304
GeneID 395396
KEGG gga:395396
CTD 89780
eggNOG NOG284879
GeneTree ENSGT00760000118943
HOGENOM HOG000039529
HOVERGEN HBG001595
InParanoid Q2LMP1
KO K00312
PhylomeDB Q2LMP1
Reactome REACT_197822
REACT_203291
REACT_203925
REACT_208332
REACT_224234
REACT_243814
REACT_245585
NextBio 20815480
PRO PR:Q2LMP1
Proteomes UP000000539
ExpressionAtlas Q2LMP1
GO GO:0009986
GO:0005615
GO:0005578
GO:0005109
GO:0003713
GO:0090245
GO:0007411
GO:0030509
GO:0060070
GO:0061317
GO:0045165
GO:0021846
GO:0034613
GO:0010387
GO:0061303
GO:0048263
GO:0021904
GO:0009953
GO:0030198
GO:0001947
GO:0030097
GO:0021766
GO:0042472
GO:0060173
GO:0035108
GO:0048843
GO:0045599
GO:0003136
GO:0030182
GO:0001649
GO:0060021
GO:0048343
GO:0070527
GO:0030890
GO:2000081
GO:2000727
GO:0035413
GO:2000049
GO:0048697
GO:0043280
GO:0061184
GO:0045743
GO:0048337
GO:0033138
GO:0032092
GO:0061098
GO:0002092
GO:0051091
GO:0045944
GO:0036342
GO:0070507
GO:0035914
GO:0021527
GO:0021874
InterPro IPR005817
IPR009141
IPR018161
PANTHER PTHR12027
Pfam PF00110
PRINTS PR01843
PR01349
SMART SM00097
PROSITE PS00246

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0045944

positive regulation of transcription from RNA polymerase II promoter

PMID:12006981[1]

ECO:0000316

UniProtKB:Q90722


P

Figure 2 B Shows that both Wnt3A and FGF8 together induce the expression of wnt8c in stage 4 rostral forebrain cells. The method they used was RT-PCR.

complete
CACAO 11023

involved_in

GO:0090263

positive regulation of canonical Wnt signaling pathway

PMID:11290326[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060828

regulation of canonical Wnt signaling pathway

PMID:11290326[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060070

canonical Wnt signaling pathway

PMID:9596583[3]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048263

determination of dorsal identity

PMID:9473323[4]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060070

canonical Wnt signaling pathway

PMID:9596583[3]

ECO:0000303

author statement without traceable support used in manual assertion

P

part_of:(GO:0035108)

Seeded From UniProt

complete

involved_in

GO:0035108

limb morphogenesis

PMID:9596583[3]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0061303

cornea development in camera-type eye

PMID:16258938[5]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060070

canonical Wnt signaling pathway

PMID:17488271[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050679

positive regulation of epithelial cell proliferation

PMID:15110715[7]

ECO:0000314

direct assay evidence used in manual assertion

P

  • occurs_in:(UBERON:0002329)
  • occurs_in:(UBERON:0004290)
  • occurs_in:(UBERON:0003082)

Seeded From UniProt

complete

involved_in

GO:0045663

positive regulation of myoblast differentiation

PMID:18037380[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042472

inner ear morphogenesis

PMID:12941626[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010831

positive regulation of myotube differentiation

PMID:18037380[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:15110715[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:18037380[8]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:17488271[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005640

nuclear outer membrane

PMID:15110715[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:18037380[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:17488271[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045165

cell fate commitment

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98957
PANTHER:PTN000246517
UniProtKB:P49339
ZFIN:ZDB-GENE-980526-332

P

Seeded From UniProt

complete

involved_in

GO:0030182

neuron differentiation

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000246517
RGD:69250
UniProtKB:P56706
UniProtKB:Q98SN7

P

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010194
MGI:MGI:108061
MGI:MGI:1197020
MGI:MGI:98953
MGI:MGI:98954
MGI:MGI:98956
MGI:MGI:98958
MGI:MGI:98960
MGI:MGI:98961
MGI:MGI:98962
PANTHER:PTN000246517
UniProtKB:P41221
UniProtKB:Q98SN7
WB:WBGene00000858
WB:WBGene00003029
ZFIN:ZDB-GENE-980526-332

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004009
MGI:MGI:98956
MGI:MGI:98957
PANTHER:PTN000246517
RGD:1311441
RGD:69250
UniProtKB:P41221
UniProtKB:P56704
UniProtKB:P56705
UniProtKB:Q2LMP1
UniProtKB:Q9UBV4
UniProtKB:Q9YGX6

C

Seeded From UniProt

complete

enables

GO:0005109

frizzled binding

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004009
FB:FBgn0004360
FB:FBgn0010453
FB:FBgn0038134
MGI:MGI:98956
MGI:MGI:98957
MGI:MGI:98958
MGI:MGI:98961
MGI:MGI:98962
PANTHER:PTN000246517
RGD:69079
UniProtKB:P09544
UniProtKB:P41221
UniProtKB:P56703
UniProtKB:Q98SN7

F

Seeded From UniProt

complete

involved_in

GO:0030509

BMP signaling pathway

PMID:19850029[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817
InterPro:IPR009141

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817
InterPro:IPR009141

C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817
InterPro:IPR009141

P

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817
InterPro:IPR009141

P

Seeded From UniProt

complete

NOT|involved_in

GO:0060070

canonical Wnt signaling pathway

PMID:17488271[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050679

positive regulation of epithelial cell proliferation

PMID:15110715[7]

ECO:0000314

direct assay evidence used in manual assertion

P

  • occurs_in:(UBERON:0002329)
  • occurs_in:(UBERON:0004290)
  • occurs_in:(UBERON:0003082)

Seeded From UniProt

complete

involved_in

GO:0042472

inner ear morphogenesis

PMID:12941626[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:15110715[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:17488271[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005640

nuclear outer membrane

PMID:15110715[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0040036

regulation of fibroblast growth factor receptor signaling pathway

PMID:11290326[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060173

limb development

PMID:11290326[2]
PMID:16575901[12]
PMID:16575901[12]

ECO:0000304

author statement supported by traceable reference used in manual assertion



P

Seeded From UniProt

complete

involved_in

GO:0048263

determination of dorsal identity

PMID:9473323[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045743

positive regulation of fibroblast growth factor receptor signaling pathway

PMID:11290326[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009953

dorsal/ventral pattern formation

PMID:9473323[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0879

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Nordström, U et al. (2002) Progressive induction of caudal neural character by graded Wnt signaling. Nat. Neurosci. 5 525-32 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 Kawakami, Y et al. (2001) WNT signals control FGF-dependent limb initiation and AER induction in the chick embryo. Cell 104 891-900 PubMed GONUTS page
  3. 3.0 3.1 3.2 Kengaku, M et al. (1998) Distinct WNT pathways regulating AER formation and dorsoventral polarity in the chick limb bud. Science 280 1274-7 PubMed GONUTS page
  4. 4.0 4.1 4.2 Capdevila, J et al. (1998) Control of dorsoventral somite patterning by Wnt-1 and beta-catenin. Dev. Biol. 193 182-94 PubMed GONUTS page
  5. Fokina, VM & Frolova, EI (2006) Expression patterns of Wnt genes during development of an anterior part of the chicken eye. Dev. Dyn. 235 496-505 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 Narita, T et al. (2007) A Wnt3a variant participates in chick apical ectodermal ridge formation: distinct biological activities of Wnt3a splice variants in chick limb development. Dev. Growth Differ. 49 493-501 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 7.4 7.5 Galli, LM et al. (2004) A proliferative role for Wnt-3a in chick somites. Dev. Biol. 269 489-504 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 Portilho, DM et al. (2007) A soluble and active form of Wnt-3a protein is involved in myogenic differentiation after cholesterol depletion. FEBS Lett. 581 5787-95 PubMed GONUTS page
  9. 9.0 9.1 Stevens, CB et al. (2003) Forced activation of Wnt signaling alters morphogenesis and sensory organ identity in the chicken inner ear. Dev. Biol. 261 149-64 PubMed GONUTS page
  10. 10.0 10.1 10.2 10.3 10.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  11. Misra, K & Matise, MP (2010) A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling. Dev. Biol. 337 74-83 PubMed GONUTS page
  12. 12.0 12.1 Dong, YF et al. (2006) Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor. J. Cell. Physiol. 208 77-86 PubMed GONUTS page