CHICK:LHX1

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	LHX1 (synonyms: LIM-1, LIM1)
Protein Name(s)	LIM/homeobox protein Lhx1 LIM homeobox protein 1 Homeobox protein Lim-1
External Links
UniProt	P53411
EMBL	L35569
PIR	I50375
RefSeq	NP_990744.1
UniGene	Gga.789
ProteinModelPortal	P53411
SMR	P53411
STRING	9031.ENSGALP00000008672
PaxDb	P53411
GeneID	396381
KEGG	gga:396381
CTD	3975
eggNOG	NOG257130
HOGENOM	HOG000231630
HOVERGEN	HBG006263
InParanoid	P53411
KO	K09372
PhylomeDB	P53411
NextBio	20816423
PRO	PR:P53411
Proteomes	UP000000539
GO	GO:0005634 GO:0043234 GO:0001071 GO:0043565 GO:0003700 GO:0003714 GO:0008270 GO:0048646 GO:0009653 GO:0009948 GO:0009952 GO:0007267 GO:0021702 GO:0021937 GO:0021549 GO:0072049 GO:0009953 GO:0001705 GO:0009880 GO:0060059 GO:0048703 GO:0001706 GO:0060429 GO:0021871 GO:0001702 GO:0060322 GO:0001822 GO:0060993 GO:0097477 GO:0008045 GO:0045892 GO:0072179 GO:0072178 GO:0061205 GO:0007389 GO:2000744 GO:0090190 GO:0040019 GO:2000543 GO:2000768 GO:0045893 GO:0009791 GO:0090009 GO:0010468 GO:2001141 GO:0072077 GO:0010842 GO:0072050 GO:0021527 GO:0021522 GO:0006366 GO:0001657 GO:0001655 GO:0021517
Gene3D	1.10.10.60 2.10.110.10
InterPro	IPR017970 IPR001356 IPR009057 IPR001781
Pfam	PF00046 PF00412
SMART	SM00389 SM00132
SUPFAM	SSF46689
PROSITE	PS00027 PS50071 PS00478 PS50023

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0032526	response to retinoic acid	PMID:9727493^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2001141	regulation of RNA biosynthetic process	PMID:12490201^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0072179	nephric duct formation	PMID:12490201^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060993	kidney morphogenesis	PMID:19450546^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12490201^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:2000768	positive regulation of nephron tubule epithelial cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:2000744	positive regulation of anterior head development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:2000543	positive regulation of gastrulation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0097477	lateral motor column neuron migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0090009	primitive streak formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0072178	nephric duct morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0072077	renal vesicle morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0072050	S-shaped body morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0072049	comma-shaped body morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0061205	paramesonephric duct development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0060429	epithelium development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0060322	head development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0060059	embryonic retina morphogenesis in camera-type eye	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0048703	embryonic viscerocranium morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0048646	anatomical structure formation involved in morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:20711475^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:19545367^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	C	Seeded From UniProt	complete
involved_in	GO:0040019	positive regulation of embryonic development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0021937	cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0021871	forebrain regionalization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0021702	cerebellar Purkinje cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0021549	cerebellum development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0021527	spinal cord association neuron differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0021522	spinal cord motor neuron differentiation	PMID:19545367^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0021517	ventral spinal cord development	PMID:20711475^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010842	retina layer formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0009948	anterior/posterior axis specification	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0009880	embryonic pattern specification	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0009791	post-embryonic development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0009653	anatomical structure morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0097379	dorsal spinal cord interneuron posterior axon guidance	PMID:19545367^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007389	pattern specification process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	C	Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	PMID:19545367^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:20711475^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	F	Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0001706	endoderm formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0001705	ectoderm formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0001702	gastrulation with mouth forming second	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0001657	ureteric bud development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0001655	urogenital system development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63006	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0267978 MGI:MGI:102673 MGI:MGI:1100513 MGI:MGI:1888519 MGI:MGI:96785 PANTHER:PTN000654232 UniProtKB:Q969G2 UniProtKB:Q9UBR4 WB:WBGene00000438 WB:WBGene00002988 WB:WBGene00003167 WB:WBGene00006654	P	Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002023 FB:FBgn0267978 MGI:MGI:101776 MGI:MGI:102673 MGI:MGI:107792 MGI:MGI:1096343 MGI:MGI:1100513 MGI:MGI:1306803 MGI:MGI:1888519 MGI:MGI:96785 MGI:MGI:99783 PANTHER:PTN000654232 RGD:71076 UniProtKB:P53411 UniProtKB:Q90881 WB:WBGene00000438 WB:WBGene00002988 WB:WBGene00003000 WB:WBGene00003167 WB:WBGene00006654 ZFIN:ZDB-GENE-050114-2 ZFIN:ZDB-GENE-050114-3 ZFIN:ZDB-GENE-050417-210 ZFIN:ZDB-GENE-051220-1 ZFIN:ZDB-GENE-060728-1 ZFIN:ZDB-GENE-980526-131	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0267978 MGI:MGI:1096343 MGI:MGI:1100513 MGI:MGI:1306803 MGI:MGI:96785 MGI:MGI:99783 PANTHER:PTN000654232 RGD:71074 UniProtKB:O60663 UniProtKB:O97581 UniProtKB:P53411 UniProtKB:Q9UPM6 WB:WBGene00000438 WB:WBGene00002987 WB:WBGene00002988 WB:WBGene00003167	C	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1100513 MGI:MGI:1888519 MGI:MGI:96785 PANTHER:PTN000654232 UniProtKB:Q9UBR4	F	Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0267978 MGI:MGI:1100513 MGI:MGI:1888519 MGI:MGI:96785 PANTHER:PTN000654232 WB:WBGene00000438 WB:WBGene00002987 WB:WBGene00006654	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001356 InterPro:IPR009057	F	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0371 UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Sockanathan, S & Jessell, TM (1998) Motor neuron-derived retinoid signaling specifies the subtype identity of spinal motor neurons. Cell 94 503-14 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 James, RG & Schultheiss, TM (2003) Patterning of the avian intermediate mesoderm by lateral plate and axial tissues. Dev. Biol. 253 109-24 PubMed GONUTS page
↑ Fukui, A et al. (2009) Integration of human mesenchymal stem cells into the Wolffian duct in chicken embryos. Biochem. Biophys. Res. Commun. 385 330-5 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Palmesino, E et al. (2010) Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling. PLoS Biol. 8 e1000446 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Avraham, O et al. (2009) Transcriptional control of axonal guidance and sorting in dorsal interneurons by the Lim-HD proteins Lhx9 and Lhx1. Neural Dev 4 21 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9727493-1] Sockanathan, S & Jessell, TM (1998) Motor neuron-derived retinoid signaling specifies the subtype identity of spinal motor neurons. Cell 94 503-14 PubMed GONUTS page

[PMID:12490201-2] 2.0 ^2.1 ^2.2 James, RG & Schultheiss, TM (2003) Patterning of the avian intermediate mesoderm by lateral plate and axial tissues. Dev. Biol. 253 109-24 PubMed GONUTS page

[PMID:19450546-3] Fukui, A et al. (2009) Integration of human mesenchymal stem cells into the Wolffian duct in chicken embryos. Biochem. Biophys. Res. Commun. 385 330-5 PubMed GONUTS page

[PMID:20711475-4] 4.0 ^4.1 ^4.2 Palmesino, E et al. (2010) Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling. PLoS Biol. 8 e1000446 PubMed GONUTS page

[PMID:19545367-5] 5.0 ^5.1 ^5.2 ^5.3 Avraham, O et al. (2009) Transcriptional control of axonal guidance and sorting in dorsal interneurons by the Lim-HD proteins Lhx9 and Lhx1. Neural Dev 4 21 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:LHX1

Contents

Annotations

Notes

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