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PMID:20711475

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Citation

Palmesino, E, Rousso, DL, Kao, TJ, Klar, A, Laufer, E, Uemura, O, Okamoto, H, Novitch, BG and Kania, A (2010) Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling. PLoS Biol. 8:e1000446

Abstract

Topographic neuronal maps arise as a consequence of axon trajectory choice correlated with the localisation of neuronal soma, but the identity of the pathways coordinating these processes is unknown. We addressed this question in the context of the myotopic map formed by limb muscles innervated by spinal lateral motor column (LMC) motor axons where the Eph receptor signals specifying growth cone trajectory are restricted by Foxp1 and Lhx1 transcription factors. We show that the localisation of LMC neuron cell bodies can be dissociated from axon trajectory choice by either the loss or gain of function of the Reelin signalling pathway. The response of LMC motor neurons to Reelin is gated by Foxp1- and Lhx1-mediated regulation of expression of the critical Reelin signalling intermediate Dab1. Together, these observations point to identical transcription factors that control motor axon guidance and soma migration and reveal the molecular hierarchy of myotopic organisation.

Links

PubMed PMC2919418 Online version:10.1371/journal.pbio.1000446

Keywords

Axons/metabolism; Axons/physiology; Cell Adhesion Molecules, Neuronal/genetics; Cell Adhesion Molecules, Neuronal/metabolism; Cell Movement/drug effects; Cell Movement/physiology; Extracellular Matrix Proteins/genetics; Extracellular Matrix Proteins/metabolism; Extremities/innervation; Forkhead Transcription Factors/genetics; Forkhead Transcription Factors/metabolism; Gene Expression Regulation, Developmental; Growth Cones/metabolism; Homeodomain Proteins/genetics; Homeodomain Proteins/metabolism; LIM-Homeodomain Proteins; Motor Neurons/metabolism; Motor Neurons/physiology; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Repressor Proteins/genetics; Repressor Proteins/metabolism; Serine Endopeptidases/genetics; Serine Endopeptidases/metabolism; Signal Transduction; Spinal Cord/metabolism; Transcription Factors

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:FOXP1

involved_in

GO:0021517: ventral spinal cord development

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:FOXP1

involved_in

GO:0008045: motor neuron axon guidance

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:FOXP1

involved_in

GO:0045893: positive regulation of transcription, DNA-templated

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:LHX1

involved_in

GO:0021517: ventral spinal cord development

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:LHX1

involved_in

GO:0008045: motor neuron axon guidance

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:LHX1

enables

GO:0003700: DNA-binding transcription factor activity

ECO:0000315: mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

MOUSE:LHX1

involved_in

GO:0045893: positive regulation of transcription, DNA-templated

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:LHX1

involved_in

GO:0097477: lateral motor column neuron migration

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:DAB1

involved_in

GO:0021517: ventral spinal cord development

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:DAB1

involved_in

GO:0097477: lateral motor column neuron migration

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

CHICK:FOXP1

involved_in

GO:0045893: positive regulation of transcription, DNA-templated

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P58462

P

Seeded From UniProt

complete

CHICK:FOXP1

involved_in

GO:0021517: ventral spinal cord development

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

CHICK:FOXP1

involved_in

GO:0008045: motor neuron axon guidance

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P58462

P

Seeded From UniProt

complete

CHICK:ISL1

involved_in

GO:0045892: negative regulation of transcription, DNA-templated

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

CHICK:LHX1

involved_in

GO:0021517: ventral spinal cord development

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

CHICK:LHX1

involved_in

GO:0045893: positive regulation of transcription, DNA-templated

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P63006

P

Seeded From UniProt

complete

CHICK:LHX1

enables

GO:0003700: DNA-binding transcription factor activity

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P63006

F

Seeded From UniProt

complete

CHICK:LRP8

involved_in

GO:0021517: ventral spinal cord development

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

CHICK:RELN

involved_in

GO:0021517: ventral spinal cord development

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

CHICK:VLDLR

involved_in

GO:0021517: ventral spinal cord development

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

CHICK:Q6XBN7

involved_in

GO:0097477: lateral motor column neuron migration

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

CHICK:Q6XBN7

involved_in

GO:0021517: ventral spinal cord development

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:LRP8

involved_in

GO:0021517: ventral spinal cord development

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:VLDLR

involved_in

GO:0021517: ventral spinal cord development

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:RELN

involved_in

GO:1902078: positive regulation of lateral motor column neuron migration

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:RELN

involved_in

GO:0021517: ventral spinal cord development

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:RELN

involved_in

GO:0097477: lateral motor column neuron migration

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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